Incidental Mutation 'R9399:Or8b39'
ID 711006
Institutional Source Beutler Lab
Gene Symbol Or8b39
Ensembl Gene ENSMUSG00000096167
Gene Name olfactory receptor family 8 subfamily B member 39
Synonyms GA_x6K02T2PVTD-31764095-31765024, MOR162-5, Olfr887
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R9399 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 37996134-37997063 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37997020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 296 (H296R)
Ref Sequence ENSEMBL: ENSMUSP00000148361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074681] [ENSMUST00000212502] [ENSMUST00000213091]
AlphaFold Q9EQA6
Predicted Effect probably benign
Transcript: ENSMUST00000074681
AA Change: H296R

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000074248
Gene: ENSMUSG00000096167
AA Change: H296R

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.7e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 253 3.1e-5 PFAM
Pfam:7tm_1 41 288 8.2e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212502
AA Change: H296R

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000213091
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A C 14: 32,384,615 (GRCm39) L450R probably damaging Het
4933427I04Rik T A 4: 123,754,413 (GRCm39) L109* probably null Het
Amotl2 T C 9: 102,606,531 (GRCm39) L576P probably damaging Het
Ankrd11 T C 8: 123,618,179 (GRCm39) N1891S probably benign Het
Arap2 T A 5: 62,763,455 (GRCm39) H1563L possibly damaging Het
Astn2 T C 4: 65,664,588 (GRCm39) T732A possibly damaging Het
Atp2b2 A G 6: 113,780,713 (GRCm39) I312T probably benign Het
Bcl9 C T 3: 97,113,289 (GRCm39) M1055I probably benign Het
Carm1 A G 9: 21,486,791 (GRCm39) N180D possibly damaging Het
Cd180 A T 13: 102,842,021 (GRCm39) T356S probably benign Het
Cdh18 A C 15: 23,173,899 (GRCm39) T38P probably damaging Het
Cdk7 G T 13: 100,840,988 (GRCm39) P308Q probably damaging Het
Chd5 C T 4: 152,468,592 (GRCm39) A1715V probably benign Het
Clptm1 A T 7: 19,367,842 (GRCm39) V590D probably damaging Het
Col18a1 C T 10: 76,916,584 (GRCm39) G364R unknown Het
Ddhd1 C T 14: 45,895,117 (GRCm39) G118R possibly damaging Het
Fgfr4 C T 13: 55,304,293 (GRCm39) T111M probably damaging Het
Fndc8 A T 11: 82,788,739 (GRCm39) T190S probably damaging Het
Foxp1 TTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGTTGCTGCTGCTGTTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG TTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGTTGCTGCTGCTGTTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG 6: 99,052,866 (GRCm39) probably benign Het
Glra3 T A 8: 56,542,079 (GRCm39) I274N probably damaging Het
Gpsm2 G A 3: 108,590,090 (GRCm39) R499* probably null Het
Gzme T A 14: 56,355,796 (GRCm39) D172V probably damaging Het
Ift88 T A 14: 57,717,385 (GRCm39) D536E probably benign Het
Itih3 T C 14: 30,643,335 (GRCm39) T151A probably benign Het
Kctd7 T C 5: 130,177,033 (GRCm39) Y95H probably damaging Het
Lipe A T 7: 25,097,227 (GRCm39) C239S probably benign Het
Lpcat3 T C 6: 124,640,283 (GRCm39) S38P probably benign Het
Mical2 C T 7: 111,946,082 (GRCm39) R1015C probably damaging Het
Midn C T 10: 79,992,210 (GRCm39) R421* probably null Het
Mmp17 A T 5: 129,671,686 (GRCm39) K79* probably null Het
Or8k16 G C 2: 85,520,395 (GRCm39) L207F probably damaging Het
Pla2r1 A G 2: 60,282,744 (GRCm39) probably null Het
Ppp1r3a A G 6: 14,755,010 (GRCm39) V79A probably damaging Het
Prkd3 G T 17: 79,264,719 (GRCm39) P633H probably damaging Het
Prss40 T A 1: 34,591,794 (GRCm39) S294C probably damaging Het
Raph1 T A 1: 60,565,154 (GRCm39) Q111L probably benign Het
Rufy3 A T 5: 88,797,725 (GRCm39) N634I possibly damaging Het
Sel1l3 A C 5: 53,265,486 (GRCm39) V1102G probably benign Het
Sh2b1 AGCTCAGCC AGCTCAGCCCCGGGGACCCGCTCAGCC 7: 126,066,750 (GRCm39) probably benign Het
Sh2b1 GG GGCACCAGCTCAGCCCCGCG 7: 126,066,762 (GRCm39) probably benign Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Sh2b1 GGGACCAGCTCAGCCACG GGGACCAGCTCAGCCACGTGGACCAGCTCAGCCACG 7: 126,066,744 (GRCm39) probably benign Het
Slc25a23 C A 17: 57,360,930 (GRCm39) G165C probably damaging Het
Spata31e1 T A 13: 49,940,175 (GRCm39) T512S possibly damaging Het
Sytl2 T A 7: 90,041,658 (GRCm39) D585E probably benign Het
Ttc14 A G 3: 33,858,856 (GRCm39) T372A possibly damaging Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Vmn2r82 T A 10: 79,214,768 (GRCm39) Y250* probably null Het
Vmn2r92 T A 17: 18,389,137 (GRCm39) S484T probably benign Het
Other mutations in Or8b39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02506:Or8b39 APN 9 37,996,741 (GRCm39) missense probably damaging 1.00
R0639:Or8b39 UTSW 9 37,996,666 (GRCm39) missense probably damaging 1.00
R0671:Or8b39 UTSW 9 37,996,423 (GRCm39) missense possibly damaging 0.91
R1957:Or8b39 UTSW 9 37,996,419 (GRCm39) missense probably damaging 1.00
R1958:Or8b39 UTSW 9 37,996,419 (GRCm39) missense probably damaging 1.00
R2126:Or8b39 UTSW 9 37,996,572 (GRCm39) missense probably benign 0.02
R5329:Or8b39 UTSW 9 37,996,422 (GRCm39) missense probably benign 0.00
R5541:Or8b39 UTSW 9 37,996,419 (GRCm39) missense probably damaging 1.00
R5681:Or8b39 UTSW 9 37,996,927 (GRCm39) missense possibly damaging 0.90
R6042:Or8b39 UTSW 9 37,996,390 (GRCm39) missense probably damaging 0.99
R6417:Or8b39 UTSW 9 37,996,890 (GRCm39) missense probably benign 0.18
R6420:Or8b39 UTSW 9 37,996,890 (GRCm39) missense probably benign 0.18
R9299:Or8b39 UTSW 9 37,996,785 (GRCm39) missense probably benign 0.38
R9409:Or8b39 UTSW 9 37,996,584 (GRCm39) missense probably damaging 1.00
R9748:Or8b39 UTSW 9 37,996,353 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- TGTGGCTCTCATGTAATAGCTG -3'
(R):5'- CTGGTAGATGGCTGCAAAAC -3'

Sequencing Primer
(F):5'- CCTTCTAGTGCATCTGTG -3'
(R):5'- GGCTGCAAAACTGTGTTTGTTAAC -3'
Posted On 2022-04-18