Incidental Mutation 'R9400:Lrrd1'
ID 711044
Institutional Source Beutler Lab
Gene Symbol Lrrd1
Ensembl Gene ENSMUSG00000040367
Gene Name leucine rich repeats and death domain containing 1
Synonyms 4932412H11Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R9400 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 3895173-3916596 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 3899677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044039] [ENSMUST00000143027] [ENSMUST00000200386]
AlphaFold Q8C0R9
Predicted Effect probably benign
Transcript: ENSMUST00000044039
SMART Domains Protein: ENSMUSP00000038675
Gene: ENSMUSG00000040367

DomainStartEndE-ValueType
low complexity region 89 101 N/A INTRINSIC
low complexity region 155 165 N/A INTRINSIC
LRR 181 203 3.18e1 SMART
LRR 204 226 7.8e1 SMART
LRR 227 249 5.26e0 SMART
LRR 250 272 3.98e1 SMART
LRR 273 294 2.33e1 SMART
LRR 296 318 2.14e1 SMART
LRR_TYP 319 342 1.45e-2 SMART
LRR 365 388 4.44e0 SMART
LRR 389 410 2.76e1 SMART
LRR 411 433 8.73e1 SMART
LRR 434 457 3.55e1 SMART
LRR 480 503 1.45e1 SMART
LRR 526 548 1.31e0 SMART
LRR 549 571 3.65e1 SMART
LRR 572 594 6.22e0 SMART
LRR 595 618 2.68e1 SMART
LRR 644 665 1.15e1 SMART
LRR 667 689 8.01e0 SMART
LRR 690 713 1.53e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143027
SMART Domains Protein: ENSMUSP00000122668
Gene: ENSMUSG00000040367

DomainStartEndE-ValueType
low complexity region 89 101 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000200386
SMART Domains Protein: ENSMUSP00000143559
Gene: ENSMUSG00000000600

DomainStartEndE-ValueType
Pfam:NUDIX_5 22 198 8.1e-85 PFAM
ANK 306 334 7.5e-4 SMART
B41 368 592 9.1e-42 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik A G 17: 9,211,118 (GRCm39) N89S probably benign Het
9930111J21Rik1 C T 11: 48,839,244 (GRCm39) E448K possibly damaging Het
Acer1 G A 17: 57,288,990 (GRCm39) T40M probably damaging Het
Adam1a T C 5: 121,657,893 (GRCm39) T467A probably benign Het
Agmat A G 4: 141,476,981 (GRCm39) D129G probably damaging Het
Ak8 T A 2: 28,650,011 (GRCm39) I346N probably benign Het
Ankrd12 A T 17: 66,291,875 (GRCm39) V1186E probably damaging Het
Ankrd27 T G 7: 35,316,282 (GRCm39) L516R probably damaging Het
Aplp2 C A 9: 31,075,855 (GRCm39) R402L possibly damaging Het
Aspm A G 1: 139,407,641 (GRCm39) Y2176C probably damaging Het
Boc T C 16: 44,319,844 (GRCm39) D380G Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Chst2 T C 9: 95,287,642 (GRCm39) S235G probably benign Het
Clca4b A G 3: 144,616,953 (GRCm39) V899A probably benign Het
Ddx1 A G 12: 13,273,703 (GRCm39) S617P probably damaging Het
Etv5 A T 16: 22,220,476 (GRCm39) F304I probably benign Het
Fmo9 T G 1: 166,505,243 (GRCm39) E50A probably benign Het
Gbp11 T C 5: 105,478,841 (GRCm39) E199G probably damaging Het
Gemin5 C T 11: 58,028,541 (GRCm39) G893D probably damaging Het
Gorab G T 1: 163,224,567 (GRCm39) P78Q probably damaging Het
Gprc5a A G 6: 135,055,558 (GRCm39) T2A probably benign Het
Gtf3c1 A G 7: 125,275,683 (GRCm39) I581T probably damaging Het
H6pd A G 4: 150,080,248 (GRCm39) F199S probably damaging Het
Hdac3 A T 18: 38,070,677 (GRCm39) V426E possibly damaging Het
Jag2 G T 12: 112,875,608 (GRCm39) Y838* probably null Het
Kat6b G T 14: 21,659,826 (GRCm39) R210L probably damaging Het
Kctd11 C A 11: 69,770,544 (GRCm39) E165* probably null Het
Knl1 T C 2: 118,931,224 (GRCm39) V1980A probably damaging Het
Lilrb4b T C 10: 51,357,319 (GRCm39) S52P probably benign Het
Lrp5 T G 19: 3,635,272 (GRCm39) M1535L probably benign Het
Lrr1 A G 12: 69,221,476 (GRCm39) D206G probably benign Het
Map3k6 C A 4: 132,968,467 (GRCm39) A23E probably damaging Het
Mgat4a T C 1: 37,502,025 (GRCm39) D241G probably damaging Het
Mpzl3 A G 9: 44,986,077 (GRCm39) Y237C possibly damaging Het
Mroh1 A G 15: 76,336,093 (GRCm39) E1489G possibly damaging Het
Myocd T C 11: 65,086,934 (GRCm39) H331R probably benign Het
Myoz1 T A 14: 20,699,504 (GRCm39) H278L probably benign Het
Or12d2 A T 17: 37,624,554 (GRCm39) C240* probably null Het
Or1e22 A T 11: 73,376,807 (GRCm39) V281E probably damaging Het
Or4c104 A G 2: 88,586,293 (GRCm39) I242T possibly damaging Het
Or5a3 C A 19: 12,400,274 (GRCm39) N200K possibly damaging Het
Or5b102 T A 19: 13,041,139 (GRCm39) Y121* probably null Het
Or5b24 T A 19: 12,912,878 (GRCm39) Y259N probably damaging Het
Otof A T 5: 30,540,863 (GRCm39) probably null Het
Pcdha1 A G 18: 37,064,760 (GRCm39) I475V probably benign Het
Pcgf1 A G 6: 83,057,066 (GRCm39) E199G possibly damaging Het
Pip C A 6: 41,828,782 (GRCm39) T109K probably benign Het
Slc12a7 A G 13: 73,932,689 (GRCm39) E59G probably benign Het
Slc38a2 T C 15: 96,591,053 (GRCm39) I237V probably benign Het
Slc6a5 T C 7: 49,595,267 (GRCm39) V543A probably benign Het
Slc9a2 T C 1: 40,758,211 (GRCm39) V250A possibly damaging Het
Smarcad1 T C 6: 65,050,214 (GRCm39) Y278H probably damaging Het
Snx7 A T 3: 117,630,863 (GRCm39) N248K probably benign Het
Spata6 T A 4: 111,577,428 (GRCm39) C9S probably benign Het
Stra6l T A 4: 45,885,293 (GRCm39) L587Q probably damaging Het
Tmem131l G T 3: 83,830,293 (GRCm39) N916K possibly damaging Het
Tmprss11c C T 5: 86,385,516 (GRCm39) V319I probably benign Het
Tpo A T 12: 30,169,441 (GRCm39) I98K possibly damaging Het
Umodl1 A G 17: 31,215,367 (GRCm39) T1064A probably damaging Het
Vldlr T C 19: 27,216,175 (GRCm39) I332T probably damaging Het
Wdr75 T A 1: 45,843,064 (GRCm39) L133Q probably damaging Het
Zdhhc21 T C 4: 82,753,687 (GRCm39) N167S probably benign Het
Zfp37 A T 4: 62,109,904 (GRCm39) C428S probably damaging Het
Other mutations in Lrrd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00235:Lrrd1 APN 5 3,900,573 (GRCm39) missense possibly damaging 0.94
IGL00329:Lrrd1 APN 5 3,900,081 (GRCm39) missense possibly damaging 0.94
IGL00674:Lrrd1 APN 5 3,899,773 (GRCm39) missense possibly damaging 0.92
IGL00691:Lrrd1 APN 5 3,913,929 (GRCm39) missense probably damaging 0.98
IGL00839:Lrrd1 APN 5 3,900,017 (GRCm39) missense probably benign 0.00
IGL00911:Lrrd1 APN 5 3,915,689 (GRCm39) missense probably benign 0.07
IGL01754:Lrrd1 APN 5 3,901,432 (GRCm39) missense probably damaging 1.00
IGL01981:Lrrd1 APN 5 3,901,267 (GRCm39) missense probably damaging 1.00
IGL02003:Lrrd1 APN 5 3,899,857 (GRCm39) missense probably damaging 0.99
IGL02223:Lrrd1 APN 5 3,900,211 (GRCm39) missense probably benign
IGL02477:Lrrd1 APN 5 3,915,770 (GRCm39) missense probably benign
IGL02609:Lrrd1 APN 5 3,908,803 (GRCm39) missense probably benign 0.26
IGL02833:Lrrd1 APN 5 3,900,709 (GRCm39) missense probably damaging 0.98
IGL02886:Lrrd1 APN 5 3,901,534 (GRCm39) missense probably benign 0.00
IGL02896:Lrrd1 APN 5 3,901,473 (GRCm39) missense probably benign 0.08
R0045:Lrrd1 UTSW 5 3,916,418 (GRCm39) missense possibly damaging 0.50
R0138:Lrrd1 UTSW 5 3,901,345 (GRCm39) missense probably benign 0.04
R0305:Lrrd1 UTSW 5 3,915,707 (GRCm39) missense probably damaging 1.00
R0346:Lrrd1 UTSW 5 3,900,215 (GRCm39) missense probably benign 0.03
R0455:Lrrd1 UTSW 5 3,916,425 (GRCm39) missense probably benign 0.21
R1717:Lrrd1 UTSW 5 3,900,580 (GRCm39) missense probably damaging 0.99
R1719:Lrrd1 UTSW 5 3,900,483 (GRCm39) splice site probably null
R1836:Lrrd1 UTSW 5 3,915,709 (GRCm39) missense probably benign 0.36
R1951:Lrrd1 UTSW 5 3,901,488 (GRCm39) missense probably damaging 1.00
R2199:Lrrd1 UTSW 5 3,916,478 (GRCm39) missense possibly damaging 0.86
R3751:Lrrd1 UTSW 5 3,900,282 (GRCm39) missense probably benign 0.37
R3752:Lrrd1 UTSW 5 3,900,282 (GRCm39) missense probably benign 0.37
R3837:Lrrd1 UTSW 5 3,900,204 (GRCm39) missense possibly damaging 0.73
R3862:Lrrd1 UTSW 5 3,901,248 (GRCm39) missense probably benign 0.00
R3863:Lrrd1 UTSW 5 3,901,248 (GRCm39) missense probably benign 0.00
R3864:Lrrd1 UTSW 5 3,901,248 (GRCm39) missense probably benign 0.00
R4816:Lrrd1 UTSW 5 3,901,126 (GRCm39) nonsense probably null
R5225:Lrrd1 UTSW 5 3,908,735 (GRCm39) missense probably benign 0.00
R5721:Lrrd1 UTSW 5 3,900,619 (GRCm39) missense probably benign 0.13
R5791:Lrrd1 UTSW 5 3,901,254 (GRCm39) missense probably benign 0.11
R6077:Lrrd1 UTSW 5 3,900,837 (GRCm39) missense probably benign 0.01
R6229:Lrrd1 UTSW 5 3,913,887 (GRCm39) missense probably damaging 1.00
R6330:Lrrd1 UTSW 5 3,900,629 (GRCm39) missense probably damaging 1.00
R6588:Lrrd1 UTSW 5 3,901,386 (GRCm39) missense probably benign 0.19
R6734:Lrrd1 UTSW 5 3,900,226 (GRCm39) missense possibly damaging 0.95
R6932:Lrrd1 UTSW 5 3,901,395 (GRCm39) missense probably benign 0.06
R7180:Lrrd1 UTSW 5 3,901,459 (GRCm39) missense probably damaging 1.00
R7771:Lrrd1 UTSW 5 3,916,476 (GRCm39) missense possibly damaging 0.84
R8356:Lrrd1 UTSW 5 3,916,509 (GRCm39) missense probably benign 0.19
R9031:Lrrd1 UTSW 5 3,900,963 (GRCm39) nonsense probably null
R9208:Lrrd1 UTSW 5 3,900,995 (GRCm39) missense probably damaging 0.97
R9344:Lrrd1 UTSW 5 3,908,819 (GRCm39) missense possibly damaging 0.59
R9381:Lrrd1 UTSW 5 3,901,074 (GRCm39) missense probably benign 0.43
R9471:Lrrd1 UTSW 5 3,913,980 (GRCm39) missense
R9549:Lrrd1 UTSW 5 3,901,473 (GRCm39) missense probably benign 0.08
R9557:Lrrd1 UTSW 5 3,901,432 (GRCm39) missense probably damaging 1.00
R9607:Lrrd1 UTSW 5 3,901,561 (GRCm39) missense probably damaging 0.99
R9725:Lrrd1 UTSW 5 3,901,147 (GRCm39) missense probably benign 0.42
R9775:Lrrd1 UTSW 5 3,899,897 (GRCm39) missense probably benign 0.03
R9778:Lrrd1 UTSW 5 3,899,982 (GRCm39) missense possibly damaging 0.77
R9785:Lrrd1 UTSW 5 3,908,708 (GRCm39) missense probably damaging 1.00
Z1176:Lrrd1 UTSW 5 3,900,025 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- AAAGGAAAATTTTCAGTCTCTCAAGA -3'
(R):5'- GACTGTTCTGTGTCCTTTGAAG -3'

Sequencing Primer
(F):5'- GATGTATGCACGCAATCCACTGG -3'
(R):5'- AGGATTTGCTTCATAAATCTGGTTG -3'
Posted On 2022-04-20