Incidental Mutation 'R9333:Mageb3'
ID 711144
Institutional Source Beutler Lab
Gene Symbol Mageb3
Ensembl Gene ENSMUSG00000074881
Gene Name MAGE family member B3
Synonyms Mage-rs3, Mage-ps1, Smage3, Mage-b3
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R9333 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 121784252-121786573 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 121784973 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 243 (V243E)
Ref Sequence ENSEMBL: ENSMUSP00000100541 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036647] [ENSMUST00000104936] [ENSMUST00000110574] [ENSMUST00000110578]
AlphaFold Q9D2H4
Predicted Effect probably benign
Transcript: ENSMUST00000036647
SMART Domains Protein: ENSMUSP00000047543
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 285 429 4.19e-71 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000104936
AA Change: V243E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100541
Gene: ENSMUSG00000074881
AA Change: V243E

DomainStartEndE-ValueType
Pfam:MAGE_N 3 93 5.9e-9 PFAM
MAGE 109 278 2.37e-105 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110574
SMART Domains Protein: ENSMUSP00000106203
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 285 429 4.19e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110578
SMART Domains Protein: ENSMUSP00000106207
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 284 428 4.19e-71 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik G T 4: 123,754,416 (GRCm39) G110V probably benign Het
Abraxas1 T C 5: 100,959,939 (GRCm39) S138G probably damaging Het
Aldoart1 C T 4: 72,770,367 (GRCm39) R147H probably benign Het
Arfgef1 C A 1: 10,222,037 (GRCm39) E1556* probably null Het
Arhgap39 C T 15: 76,619,325 (GRCm39) R753H probably damaging Het
Asb2 G A 12: 103,311,955 (GRCm39) Q56* probably null Het
Atp8b3 T C 10: 80,360,180 (GRCm39) I964V probably benign Het
Baiap3 C A 17: 25,467,676 (GRCm39) R338L possibly damaging Het
Clcn4 T A 7: 7,292,192 (GRCm39) M540L probably damaging Het
Crbn T C 6: 106,776,984 (GRCm39) H12R probably benign Het
D6Wsu163e A G 6: 126,952,096 (GRCm39) Y530C probably damaging Het
Dolpp1 T A 2: 30,287,140 (GRCm39) F191I probably damaging Het
Fam217a T C 13: 35,100,876 (GRCm39) T94A probably benign Het
Fanci T C 7: 79,067,594 (GRCm39) W347R possibly damaging Het
Fbxo39 A T 11: 72,208,349 (GRCm39) N234Y probably damaging Het
Fbxo4 A G 15: 3,998,502 (GRCm39) S319P probably benign Het
Gm14403 A G 2: 177,200,919 (GRCm39) N46S probably benign Het
Grm2 C A 9: 106,525,416 (GRCm39) R433L possibly damaging Het
Gtf2i C T 5: 134,271,840 (GRCm39) D855N probably benign Het
Hcn2 T A 10: 79,561,991 (GRCm39) M329K possibly damaging Het
Hsd3b3 T C 3: 98,649,216 (GRCm39) D369G probably benign Het
Kctd12 T C 14: 103,219,054 (GRCm39) K275E probably damaging Het
Klra4 T A 6: 130,021,080 (GRCm39) K238N probably damaging Het
Kremen2 T A 17: 23,962,775 (GRCm39) T104S probably damaging Het
Lmf2 G A 15: 89,239,577 (GRCm39) L26F probably damaging Het
Mfsd10 A G 5: 34,792,427 (GRCm39) V258A probably damaging Het
Myh10 A C 11: 68,680,980 (GRCm39) Q1007P probably benign Het
Ndufaf5 A G 2: 140,035,513 (GRCm39) E243G probably benign Het
Or2ag16 T C 7: 106,351,782 (GRCm39) D271G probably damaging Het
Orm3 T C 4: 63,274,528 (GRCm39) I31T probably damaging Het
Pgm2 C A 5: 64,263,100 (GRCm39) T249K probably benign Het
Prcp T C 7: 92,577,894 (GRCm39) Y388H probably damaging Het
Prmt3 T G 7: 49,456,308 (GRCm39) I306M probably damaging Het
Rag2 A T 2: 101,460,752 (GRCm39) D354V probably benign Het
Reep1 A G 6: 71,772,198 (GRCm39) D162G probably damaging Het
Rnpep A T 1: 135,191,862 (GRCm39) W575R probably damaging Het
Rpl28 T C 7: 4,796,079 (GRCm39) probably benign Het
Ryr1 A C 7: 28,774,214 (GRCm39) probably null Het
Spg11 G A 2: 121,932,244 (GRCm39) R533C probably damaging Het
Tcf7l2 C A 19: 55,919,928 (GRCm39) S487* probably null Het
Usp39 T C 6: 72,314,710 (GRCm39) N232S probably benign Het
Vmn2r26 C T 6: 124,003,009 (GRCm39) P140S probably benign Het
Vmn2r34 C T 7: 7,675,367 (GRCm39) V674I probably benign Het
Other mutations in Mageb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01728:Mageb3 APN 2 121,784,941 (GRCm39) missense probably damaging 0.99
R1817:Mageb3 UTSW 2 121,784,918 (GRCm39) nonsense probably null
R2111:Mageb3 UTSW 2 121,785,306 (GRCm39) splice site probably null
R2116:Mageb3 UTSW 2 121,785,033 (GRCm39) missense probably damaging 0.99
R2883:Mageb3 UTSW 2 121,784,847 (GRCm39) missense probably benign 0.16
R5214:Mageb3 UTSW 2 121,785,319 (GRCm39) missense possibly damaging 0.90
R5546:Mageb3 UTSW 2 121,784,868 (GRCm39) missense probably damaging 0.99
R7054:Mageb3 UTSW 2 121,784,973 (GRCm39) missense probably damaging 1.00
R7467:Mageb3 UTSW 2 121,784,953 (GRCm39) missense probably damaging 1.00
R9655:Mageb3 UTSW 2 121,785,649 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCCTGCCTGATCTCTAAGAGC -3'
(R):5'- CAAACTGGGTCTTTCCACTGAG -3'

Sequencing Primer
(F):5'- CTGATCTCTAAGAGCCAACTGGTAG -3'
(R):5'- TCCACTGAGGGAAGTTTGAGTAG -3'
Posted On 2022-05-16