Incidental Mutation 'R9333:Rpl28'
ID 711162
Institutional Source Beutler Lab
Gene Symbol Rpl28
Ensembl Gene ENSMUSG00000030432
Gene Name ribosomal protein L28
Synonyms D7Wsu21e
MMRRC Submission
Accession Numbers
Essential gene? Not available question?
Stock # R9333 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 4795964-4797546 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 4796079 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000032597] [ENSMUST00000078432] [ENSMUST00000168578] [ENSMUST00000205815]
AlphaFold P41105
Predicted Effect probably benign
Transcript: ENSMUST00000032597
SMART Domains Protein: ENSMUSP00000032597
Gene: ENSMUSG00000030432

DomainStartEndE-ValueType
Pfam:Ribosomal_L28e 5 120 3.3e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000078432
SMART Domains Protein: ENSMUSP00000104217
Gene: ENSMUSG00000030432

DomainStartEndE-ValueType
Pfam:Ribosomal_L28e 5 121 2.5e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126794
SMART Domains Protein: ENSMUSP00000117699
Gene: ENSMUSG00000030432

DomainStartEndE-ValueType
Pfam:Ribosomal_L28e 8 68 1.2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168578
SMART Domains Protein: ENSMUSP00000130452
Gene: ENSMUSG00000030431

DomainStartEndE-ValueType
Pfam:TMEM238 32 100 1.2e-32 PFAM
low complexity region 124 135 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000205815
Predicted Effect probably benign
Transcript: ENSMUST00000206315
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik G T 4: 123,754,416 (GRCm39) G110V probably benign Het
Abraxas1 T C 5: 100,959,939 (GRCm39) S138G probably damaging Het
Aldoart1 C T 4: 72,770,367 (GRCm39) R147H probably benign Het
Arfgef1 C A 1: 10,222,037 (GRCm39) E1556* probably null Het
Arhgap39 C T 15: 76,619,325 (GRCm39) R753H probably damaging Het
Asb2 G A 12: 103,311,955 (GRCm39) Q56* probably null Het
Atp8b3 T C 10: 80,360,180 (GRCm39) I964V probably benign Het
Baiap3 C A 17: 25,467,676 (GRCm39) R338L possibly damaging Het
Clcn4 T A 7: 7,292,192 (GRCm39) M540L probably damaging Het
Crbn T C 6: 106,776,984 (GRCm39) H12R probably benign Het
D6Wsu163e A G 6: 126,952,096 (GRCm39) Y530C probably damaging Het
Dolpp1 T A 2: 30,287,140 (GRCm39) F191I probably damaging Het
Fam217a T C 13: 35,100,876 (GRCm39) T94A probably benign Het
Fanci T C 7: 79,067,594 (GRCm39) W347R possibly damaging Het
Fbxo39 A T 11: 72,208,349 (GRCm39) N234Y probably damaging Het
Fbxo4 A G 15: 3,998,502 (GRCm39) S319P probably benign Het
Gm14403 A G 2: 177,200,919 (GRCm39) N46S probably benign Het
Grm2 C A 9: 106,525,416 (GRCm39) R433L possibly damaging Het
Gtf2i C T 5: 134,271,840 (GRCm39) D855N probably benign Het
Hcn2 T A 10: 79,561,991 (GRCm39) M329K possibly damaging Het
Hsd3b3 T C 3: 98,649,216 (GRCm39) D369G probably benign Het
Kctd12 T C 14: 103,219,054 (GRCm39) K275E probably damaging Het
Klra4 T A 6: 130,021,080 (GRCm39) K238N probably damaging Het
Kremen2 T A 17: 23,962,775 (GRCm39) T104S probably damaging Het
Lmf2 G A 15: 89,239,577 (GRCm39) L26F probably damaging Het
Mageb3 A T 2: 121,784,973 (GRCm39) V243E probably damaging Het
Mfsd10 A G 5: 34,792,427 (GRCm39) V258A probably damaging Het
Myh10 A C 11: 68,680,980 (GRCm39) Q1007P probably benign Het
Ndufaf5 A G 2: 140,035,513 (GRCm39) E243G probably benign Het
Or2ag16 T C 7: 106,351,782 (GRCm39) D271G probably damaging Het
Orm3 T C 4: 63,274,528 (GRCm39) I31T probably damaging Het
Pgm2 C A 5: 64,263,100 (GRCm39) T249K probably benign Het
Prcp T C 7: 92,577,894 (GRCm39) Y388H probably damaging Het
Prmt3 T G 7: 49,456,308 (GRCm39) I306M probably damaging Het
Rag2 A T 2: 101,460,752 (GRCm39) D354V probably benign Het
Reep1 A G 6: 71,772,198 (GRCm39) D162G probably damaging Het
Rnpep A T 1: 135,191,862 (GRCm39) W575R probably damaging Het
Ryr1 A C 7: 28,774,214 (GRCm39) probably null Het
Spg11 G A 2: 121,932,244 (GRCm39) R533C probably damaging Het
Tcf7l2 C A 19: 55,919,928 (GRCm39) S487* probably null Het
Usp39 T C 6: 72,314,710 (GRCm39) N232S probably benign Het
Vmn2r26 C T 6: 124,003,009 (GRCm39) P140S probably benign Het
Vmn2r34 C T 7: 7,675,367 (GRCm39) V674I probably benign Het
Other mutations in Rpl28
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7373:Rpl28 UTSW 7 4,796,602 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TTCAGACGAAGAGCTCCGAAG -3'
(R):5'- ACGACCATCCACTGCAGATG -3'

Sequencing Primer
(F):5'- GCTGGGTAGCCGAGTTCAG -3'
(R):5'- ACCGCGGAGACTTAGAA -3'
Posted On 2022-05-16