Incidental Mutation 'R9403:Olfr263'
ID 711357
Institutional Source Beutler Lab
Gene Symbol Olfr263
Ensembl Gene ENSMUSG00000071522
Gene Name olfactory receptor 263
Synonyms MOR256-61, GA_x6K02T2QHY8-12114828-12113875, Olfr263-ps1, Olfr42, MOR256-31, IA3, GA_x6K02T2N5E5-9379-8514, MOR256-37P
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R9403 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 21129639-21136296 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21133695 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 307 (F307L)
Ref Sequence ENSEMBL: ENSMUSP00000149892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096006] [ENSMUST00000215804]
AlphaFold Q7TQT8
Predicted Effect probably benign
Transcript: ENSMUST00000096006
AA Change: F307L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000093705
Gene: ENSMUSG00000071522
AA Change: F307L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.4e-46 PFAM
Pfam:7tm_1 41 290 4.2e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215804
AA Change: F307L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123L14Rik T G 6: 96,165,299 (GRCm38) T255P probably benign Het
4930444G20Rik C T 10: 22,067,941 (GRCm38) D47N possibly damaging Het
Angpt4 C T 2: 151,938,972 (GRCm38) T380M probably damaging Het
Apoa5 G C 9: 46,270,646 (GRCm38) R340P probably damaging Het
Cyp3a41a T A 5: 145,702,198 (GRCm38) Y320F probably damaging Het
Dmtf1 A G 5: 9,121,927 (GRCm38) L503S possibly damaging Het
Dock1 T C 7: 135,168,396 (GRCm38) V1795A probably benign Het
Dpys C G 15: 39,828,071 (GRCm38) W285S probably damaging Het
Fam187b T C 7: 30,977,090 (GRCm38) V8A Het
Fbn2 T C 18: 58,066,107 (GRCm38) E1363G probably damaging Het
Glg1 C T 8: 111,187,793 (GRCm38) R453Q probably benign Het
Gm5591 T A 7: 38,520,148 (GRCm38) M434L probably benign Het
Gm5591 T C 7: 38,522,256 (GRCm38) T130A probably damaging Het
Gpld1 G A 13: 24,979,729 (GRCm38) V502I probably benign Het
Inhba A G 13: 16,017,381 (GRCm38) H29R probably benign Het
Itga4 T A 2: 79,325,660 (GRCm38) I990N possibly damaging Het
Kcnma1 T A 14: 23,543,077 (GRCm38) I280L probably benign Het
Malrd1 T C 2: 15,614,177 (GRCm38) V284A Het
Maml2 C T 9: 13,621,673 (GRCm38) Q728* probably null Het
Mkln1 T C 6: 31,432,970 (GRCm38) L181P probably damaging Het
Mms22l T C 4: 24,580,204 (GRCm38) probably null Het
Muc16 A G 9: 18,537,764 (GRCm38) probably null Het
Mylk C A 16: 34,875,642 (GRCm38) S249* probably null Het
Naa35 G A 13: 59,601,003 (GRCm38) A150T possibly damaging Het
Naip5 T A 13: 100,219,830 (GRCm38) E1092D probably benign Het
Nup205 G A 6: 35,199,974 (GRCm38) R635H probably benign Het
Olfr723 T C 14: 49,929,449 (GRCm38) T32A probably benign Het
Padi3 T C 4: 140,810,532 (GRCm38) I26V probably benign Het
Polq T C 16: 37,061,853 (GRCm38) S1460P probably benign Het
Ptgdr A G 14: 44,853,258 (GRCm38) S348P Het
Qsox1 A G 1: 155,782,597 (GRCm38) S409P probably damaging Het
Rergl T A 6: 139,494,854 (GRCm38) Y99F possibly damaging Het
Rptn C A 3: 93,395,042 (GRCm38) H22N probably benign Het
Sh2b1 GGACCAGCTCAG GGACCAGCTCAGTCACGGTGACCAGCTCAG 7: 126,467,573 (GRCm38) probably null Het
Sh2b1 ACCAGCTCAGCCACGGGG ACCAGCTCAGCCACGGGGCCCAGCTCAGCCACGGGG 7: 126,467,575 (GRCm38) probably benign Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,467,570 (GRCm38) probably benign Het
Slc2a3 A C 6: 122,736,610 (GRCm38) I214M probably damaging Het
Slc5a7 A T 17: 54,276,641 (GRCm38) N540K probably benign Het
Slco6c1 A T 1: 97,062,523 (GRCm38) S664R possibly damaging Het
Tgm4 C A 9: 123,052,772 (GRCm38) S344R probably damaging Het
Trim61 T A 8: 65,014,576 (GRCm38) Q11L probably damaging Het
Trpm6 C A 19: 18,832,652 (GRCm38) D1137E possibly damaging Het
Txndc2 G A 17: 65,637,997 (GRCm38) T395I probably damaging Het
Txndc9 T C 1: 37,995,778 (GRCm38) E15G probably benign Het
Vcpip1 A G 1: 9,745,824 (GRCm38) I778T possibly damaging Het
Zfp383 T C 7: 29,915,259 (GRCm38) F313S possibly damaging Het
Other mutations in Olfr263
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1880:Olfr263 UTSW 13 21,133,632 (GRCm38) missense probably damaging 1.00
R2012:Olfr263 UTSW 13 21,133,489 (GRCm38) missense probably benign 0.13
R3113:Olfr263 UTSW 13 21,133,129 (GRCm38) missense probably damaging 1.00
R4210:Olfr263 UTSW 13 21,133,437 (GRCm38) missense possibly damaging 0.78
R4934:Olfr263 UTSW 13 21,133,071 (GRCm38) missense probably benign
R4952:Olfr263 UTSW 13 21,133,344 (GRCm38) missense probably benign 0.00
R5755:Olfr263 UTSW 13 21,133,525 (GRCm38) missense probably damaging 0.98
R6012:Olfr263 UTSW 13 21,132,808 (GRCm38) missense probably benign 0.01
R6077:Olfr263 UTSW 13 21,133,293 (GRCm38) missense probably benign 0.02
R6168:Olfr263 UTSW 13 21,133,229 (GRCm38) missense possibly damaging 0.53
R6325:Olfr263 UTSW 13 21,133,075 (GRCm38) missense probably damaging 0.97
R6829:Olfr263 UTSW 13 21,132,853 (GRCm38) missense possibly damaging 0.69
R7130:Olfr263 UTSW 13 21,133,246 (GRCm38) missense probably benign 0.41
R7257:Olfr263 UTSW 13 21,133,257 (GRCm38) missense probably benign 0.34
R8113:Olfr263 UTSW 13 21,133,201 (GRCm38) missense probably benign 0.00
R9348:Olfr263 UTSW 13 21,132,961 (GRCm38) missense possibly damaging 0.95
R9359:Olfr263 UTSW 13 21,133,695 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTCAACATGAAGTCAAAGGC -3'
(R):5'- TCTGCATCCACAAGAGGTCTG -3'

Sequencing Primer
(F):5'- GCAATGAATACCTGTGGATCCC -3'
(R):5'- CATCCACAAGAGGTCTGTATGTG -3'
Posted On 2022-05-16