Mutagenetix > Incidental Mutation

Incidental Mutation 'R9404:Armt1'

711417

Institutional Source

Beutler Lab

Gene Symbol

Armt1

Ensembl Gene

ENSMUSG00000061759

Gene Name

acidic residue methyltransferase 1

Synonyms

1700052N19Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.148) question?

Stock #

R9404 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

4382572-4405140 bp(+) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

AC to A at 4400848 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000114073 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095893] [ENSMUST00000118544] [ENSMUST00000152294]

AlphaFold

A6H630

Predicted Effect

probably benign
Transcript: ENSMUST00000095893

SMART Domains

Protein: ENSMUSP00000093581
Gene: ENSMUSG00000061759

Domain	Start	End	E-Value	Type
Pfam:DUF89	20	417	1.3e-125	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000118544

SMART Domains

Protein: ENSMUSP00000114073
Gene: ENSMUSG00000061759

Domain	Start	End	E-Value	Type
Pfam:DUF89	20	187	1.2e-33	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000152294

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot11	T	C	4: 106,615,509 (GRCm39)	K314R	possibly damaging	Het
Atad5	T	C	11: 80,005,064 (GRCm39)	V1167A	probably damaging	Het
Bbs12	T	C	3: 37,373,557 (GRCm39)	S2P	probably damaging	Het
Cdh11	A	T	8: 103,406,254 (GRCm39)	L73Q	probably damaging	Het
Cdk15	A	G	1: 59,328,914 (GRCm39)	E274G	possibly damaging	Het
Col27a1	T	C	4: 63,194,178 (GRCm39)	V845A	possibly damaging	Het
Cyp3a11	T	C	5: 145,799,258 (GRCm39)	T310A	probably benign	Het
Efcab5	G	A	11: 77,022,934 (GRCm39)	T593I	probably damaging	Het
Ewsr1	A	G	11: 5,022,940 (GRCm39)	M388T	unknown	Het
Fat2	A	G	11: 55,144,348 (GRCm39)		probably null	Het
Gm8225	T	A	17: 26,762,034 (GRCm39)	I75N	probably damaging	Het
Gsap	A	G	5: 21,474,919 (GRCm39)	Y526C	probably damaging	Het
Hk1	T	A	10: 62,131,859 (GRCm39)	I203F	possibly damaging	Het
Insl5	T	C	4: 102,875,535 (GRCm39)	R72G	probably benign	Het
Iqcb1	T	C	16: 36,671,632 (GRCm39)	V321A	probably damaging	Het
Iqcd	A	C	5: 120,738,601 (GRCm39)	T140P		Het
Kcnt2	T	A	1: 140,353,107 (GRCm39)	I272K	probably damaging	Het
Klhl25	A	C	7: 75,515,153 (GRCm39)	I20L	probably benign	Het
Krt1	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	15: 101,758,813 (GRCm39)		probably benign	Het
Lrba	T	C	3: 86,205,224 (GRCm39)	V356A	probably damaging	Het
Mast4	A	G	13: 102,887,933 (GRCm39)	Y1159H	probably damaging	Het
Mavs	T	A	2: 131,083,818 (GRCm39)	L105Q	probably damaging	Het
Megf6	T	A	4: 154,348,225 (GRCm39)	C902S		Het
Mmp17	A	G	5: 129,682,741 (GRCm39)	D460G	possibly damaging	Het
Myh2	G	T	11: 67,070,454 (GRCm39)	A466S	probably damaging	Het
Neb	T	C	2: 52,147,788 (GRCm39)	N2744D	probably damaging	Het
Oga	CTCGGGTC	CTC	19: 45,743,096 (GRCm39)		probably null	Het
Or13a26	T	A	7: 140,284,722 (GRCm39)	L186H	probably damaging	Het
Or2a12	T	C	6: 42,904,750 (GRCm39)	V195A	probably benign	Het
Or2aj4	C	T	16: 19,384,731 (GRCm39)	V301M	probably benign	Het
Or4a27	T	A	2: 88,559,551 (GRCm39)	M131L	probably benign	Het
Or6d13	T	G	6: 116,517,708 (GRCm39)	I98S	probably damaging	Het
Or8g55	A	T	9: 39,784,708 (GRCm39)	I46F	possibly damaging	Het
Parpbp	A	G	10: 87,950,411 (GRCm39)	V323A	possibly damaging	Het
Pax5	G	A	4: 44,645,565 (GRCm39)	P255S	possibly damaging	Het
Pcdhga2	A	G	18: 37,803,067 (GRCm39)	T304A	probably benign	Het
Pcsk1	T	G	13: 75,280,342 (GRCm39)	S722R	probably benign	Het
Pcsk9	C	A	4: 106,311,723 (GRCm39)	R218L	probably damaging	Het
Pds5a	T	A	5: 65,776,307 (GRCm39)	I96F	probably damaging	Het
Pkdrej	C	A	15: 85,703,270 (GRCm39)	V889L	probably benign	Het
Plekhh2	A	T	17: 84,878,468 (GRCm39)		probably null	Het
Pnn	A	G	12: 59,118,758 (GRCm39)	E447G	probably damaging	Het
Ppp2r3d	A	G	9: 101,025,840 (GRCm39)	L289P	probably damaging	Het
Ppp6r2	A	G	15: 89,152,753 (GRCm39)	H298R	probably benign	Het
Ptpn23	T	C	9: 110,216,025 (GRCm39)	N1277S		Het
Pus10	T	A	11: 23,661,202 (GRCm39)	F263L	possibly damaging	Het
Rexo5	A	G	7: 119,400,542 (GRCm39)	Y109C	probably damaging	Het
Rnf185	A	T	11: 3,382,615 (GRCm39)	C23*	probably null	Het
Runx1	T	C	16: 92,485,915 (GRCm39)	N140D	probably benign	Het
Sbf2	T	C	7: 110,040,702 (GRCm39)	Q375R	possibly damaging	Het
Scn9a	G	A	2: 66,357,040 (GRCm39)	T1087I	probably benign	Het
Sh2b1	TGGGGACCAGCTCAGCCACGGGGACCAGCTC	TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC	7: 126,066,742 (GRCm39)		probably benign	Het
Sh2b1	TC	TCAGCCACGGGGACCAGCCC	7: 126,066,771 (GRCm39)		probably benign	Het
Slc7a11	T	C	3: 50,335,488 (GRCm39)	H350R	possibly damaging	Het
Spaca6	T	C	17: 18,057,800 (GRCm39)	C155R	probably damaging	Het
Spire2	C	T	8: 124,090,077 (GRCm39)	R580*	probably null	Het
Srgap3	A	T	6: 112,706,616 (GRCm39)	M851K	probably benign	Het
Themis	A	G	10: 28,665,743 (GRCm39)	D602G	probably benign	Het
Tlcd4	T	C	3: 121,028,731 (GRCm39)	N52S	probably benign	Het
Trak2	T	C	1: 58,960,296 (GRCm39)	T236A	possibly damaging	Het
Trrap	T	C	5: 144,752,225 (GRCm39)	C1709R	possibly damaging	Het
Ttn	A	T	2: 76,584,500 (GRCm39)	S22203T	probably damaging	Het
Tut7	A	T	13: 59,947,701 (GRCm39)	N873K	probably benign	Het
Ube3a	A	G	7: 58,936,763 (GRCm39)	T701A	probably damaging	Het
Ufl1	T	C	4: 25,275,912 (GRCm39)	I164V	probably benign	Het
Vcpip1	T	C	1: 9,817,856 (GRCm39)	T176A	probably damaging	Het
Virma	T	A	4: 11,513,626 (GRCm39)	D493E	probably benign	Het
Vmn2r77	T	A	7: 86,451,247 (GRCm39)	W378R	probably benign	Het
Vps13b	A	T	15: 35,876,565 (GRCm39)	T2799S	probably damaging	Het
Vps8	T	C	16: 21,426,927 (GRCm39)	S1337P	probably benign	Het
Zfp235	A	T	7: 23,839,862 (GRCm39)	I94F	possibly damaging	Het
Zfp3	A	G	11: 70,663,366 (GRCm39)	K442E	probably damaging	Het
Zfp418	A	T	7: 7,185,104 (GRCm39)	I356F	possibly damaging	Het
Zfp790	G	A	7: 29,525,185 (GRCm39)	G68S	probably benign	Het

Other mutations in Armt1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00907:Armt1	APN	10	4,454,051 (GRCm38)	missense	possibly damaging	0.50
IGL01018:Armt1	APN	10	4,404,237 (GRCm39)	unclassified	probably benign
IGL01018:Armt1	APN	10	4,400,732 (GRCm39)	missense	probably benign
IGL02198:Armt1	APN	10	4,404,064 (GRCm39)	missense	possibly damaging	0.95
IGL02980:Armt1	APN	10	4,400,643 (GRCm39)	splice site	probably benign
IGL03104:Armt1	APN	10	4,389,615 (GRCm39)	missense	possibly damaging	0.94
R0620:Armt1	UTSW	10	4,382,689 (GRCm39)	missense	probably benign	0.38
R4248:Armt1	UTSW	10	4,389,687 (GRCm39)	missense	probably benign	0.00
R5709:Armt1	UTSW	10	4,384,903 (GRCm39)	missense	probably damaging	0.97
R6058:Armt1	UTSW	10	4,403,488 (GRCm39)	missense	probably damaging	1.00
R6318:Armt1	UTSW	10	4,400,859 (GRCm39)	missense	probably benign	0.01
R6410:Armt1	UTSW	10	4,403,826 (GRCm39)	missense	probably benign
R6998:Armt1	UTSW	10	4,403,937 (GRCm39)	missense	probably benign	0.03
R7242:Armt1	UTSW	10	4,403,475 (GRCm39)	missense	probably damaging	1.00
R7268:Armt1	UTSW	10	4,400,855 (GRCm39)	missense	possibly damaging	0.75
R7432:Armt1	UTSW	10	4,382,706 (GRCm39)	missense	probably benign	0.00
R7640:Armt1	UTSW	10	4,403,572 (GRCm39)	missense	probably damaging	0.97
R7715:Armt1	UTSW	10	4,400,751 (GRCm39)	missense	probably benign	0.01
R8877:Armt1	UTSW	10	4,400,864 (GRCm39)	missense	possibly damaging	0.66
R8968:Armt1	UTSW	10	4,404,150 (GRCm39)	missense	probably damaging	1.00
R8973:Armt1	UTSW	10	4,389,550 (GRCm39)	missense	probably damaging	0.99
R9096:Armt1	UTSW	10	4,384,829 (GRCm39)	missense	probably damaging	1.00
R9405:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9408:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9563:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9785:Armt1	UTSW	10	4,389,606 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACAGAAATGCCTCACCTTGC -3'
(R):5'- TGAACTGTCAGGAGCAATGAGC -3'

Sequencing Primer
(F):5'- CTTCGACGTGTTTAAGGAAAGC -3'
(R):5'- CAATGAGCTGGCATGTAAAGTTCTC -3'

Posted On

2022-05-16