|Institutional Source||Beutler Lab|
|Gene Name||FAT atypical cadherin 2|
|Synonyms||mKIAA0811, LOC245827, Fath2, EMI2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R9404 (G1)|
|Chromosomal Location||55250609-55336564 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 55253522 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000067556 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]|
|AlphaFold||no structure available at present|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fat2||
(F):5'- GCTGCAAACTCTGGGTCAAG -3'
(R):5'- CGGCTCCTGCAATGACTTAAAC -3'
(F):5'- AGGGACTTAGCATCTTCTCCAG -3'
(R):5'- TGCAATGACTTAAACCAACTGGAG -3'