Mutagenetix > Incidental Mutations

Incidental Mutation 'R9406:Lilra6'

711527

Institutional Source

Beutler Lab

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R9406 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 3914854 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 97 (R97Q)

Ref Sequence

ENSEMBL: ENSMUSP00000042636 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

probably benign
Transcript: ENSMUST00000038176
AA Change: R97Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: R97Q

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090689
AA Change: R97Q

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: R97Q

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000206077

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300002M23Rik	A	G	17: 35,568,590	Y275C	possibly damaging	Het
3632451O06Rik	C	T	14: 49,773,488	G254E	possibly damaging	Het
4932414N04Rik	A	G	2: 68,667,675	K150R	unknown	Het
Aatf	ACACACACACACACACACACACACACACACACACACACACACACACAC	ACACACACACACACACACACACACACACACACACACACACACACACACAC	11: 84,471,040		probably null	Het
Ank3	C	A	10: 69,809,181	T92K	unknown	Het
Cdca2	T	C	14: 67,700,323	S294G	unknown	Het
Cerk	A	G	15: 86,144,586	I423T	possibly damaging	Het
Cfap74	A	T	4: 155,426,169	K404*	probably null	Het
Cftr	T	C	6: 18,299,867	V1213A	probably benign	Het
Chst11	A	G	10: 83,191,047	T103A	possibly damaging	Het
Col22a1	A	G	15: 71,973,692	I407T	probably damaging	Het
Cpn2	A	G	16: 30,259,542	V447A	probably benign	Het
Crybg3	T	C	16: 59,558,476	E805G	probably benign	Het
Cstb	A	G	10: 78,427,339	H66R	probably benign	Het
Cyp2g1	T	C	7: 26,819,485		probably null	Het
Fkbp1b	G	T	12: 4,833,732	H88N	probably benign	Het
Gm4884	A	T	7: 41,043,141	D178V	probably damaging	Het
Grik5	T	C	7: 25,058,544	T371A	probably benign	Het
Hydin	G	A	8: 110,587,780	G4299S	probably null	Het
Ibtk	A	T	9: 85,721,340	Y537*	probably null	Het
Ighv8-9	A	G	12: 115,468,637	L18P	probably damaging	Het
Lbp	G	T	2: 158,317,557	K203N	probably benign	Het
Man1c1	A	G	4: 134,576,007	I392T	probably damaging	Het
Mcf2l	A	T	8: 13,009,676	H727L	probably damaging	Het
Med7	T	A	11: 46,441,038	F153L	probably benign	Het
Neurl1b	G	C	17: 26,438,846	V253L	probably benign	Het
Noc2l	T	C	4: 156,236,054	S4P	probably benign	Het
Obscn	A	C	11: 59,056,979	F4408C		Het
Olfr1318	A	G	2: 112,156,298	I116V	probably benign	Het
Olfr346	A	G	2: 36,688,284	Y94C	possibly damaging	Het
Orc2	T	C	1: 58,467,683	Q498R	probably damaging	Het
Oxsm	A	C	14: 16,242,531	D79E	probably benign	Het
Pask	G	A	1: 93,324,265	T464I	probably benign	Het
Pcdha8	A	G	18: 36,993,869	N468S	probably damaging	Het
Pcm1	T	A	8: 41,275,685	V565E	probably damaging	Het
Pcsk5	T	C	19: 17,793,733	I67V	probably benign	Het
Pde4d	A	G	13: 109,740,530	D139G	probably damaging	Het
Pdzd8	C	T	19: 59,344,813	E259K		Het
Phactr3	T	C	2: 178,284,063	L377P	probably damaging	Het
Ppargc1b	G	A	18: 61,310,980	P387S	possibly damaging	Het
Prmt7	T	G	8: 106,243,803	V426G	probably damaging	Het
Rab39	G	C	9: 53,686,615	P117A	probably damaging	Het
Rab40b	G	A	11: 121,363,526	R62*	probably null	Het
Rpf1	T	G	3: 146,508,182	H220P	probably damaging	Het
Rps6kl1	A	G	12: 85,139,506	I276T	probably benign	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,579,911		probably benign	Het
Sbf2	T	C	7: 110,441,495	Q375R	possibly damaging	Het
Sestd1	G	A	2: 77,245,077		probably benign	Het
Slc38a6	T	A	12: 73,329,993	Y140*	probably null	Het
Smpd1	C	A	7: 105,554,543	H4Q	possibly damaging	Het
Sox8	A	T	17: 25,567,660	S356R	probably damaging	Het
Tapbpl	A	G	6: 125,228,356	L209P	probably damaging	Het
Txndc11	A	G	16: 11,075,634	L744P	probably benign	Het
Ush2a	C	T	1: 188,263,449	P139L	probably benign	Het
Vmn1r54	A	T	6: 90,269,110	N2I	probably damaging	Het
Vmn2r112	C	T	17: 22,605,242	Q493*	probably null	Het
Vps16	T	C	2: 130,441,505		probably null	Het
Zfp40	A	T	17: 23,177,155	S153T	possibly damaging	Het
Zfp523	G	A	17: 28,197,866	A109T	probably benign	Het
Zfp78	A	T	7: 6,379,183	N411Y	probably benign	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3913057	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL01585:Lilra6	APN	7	3914499	missense	probably benign	0.01
IGL02195:Lilra6	APN	7	3914550	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0423:Lilra6	UTSW	7	3914775	splice site	probably benign
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3915441	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3913047	missense	probably benign	0.01
R9197:Lilra6	UTSW	7	3912717	missense	possibly damaging	0.94
R9354:Lilra6	UTSW	7	3911629	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3913167	missense	probably damaging	1.00
R9462:Lilra6	UTSW	7	3911995	missense	probably damaging	0.97
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Predicted Primers

PCR Primer
(F):5'- GAGTCAGTTAAATATCCCCAAGCC -3'
(R):5'- TCCTCAGAGTACAGCCAGAC -3'

Sequencing Primer
(F):5'- AAATATCCCCAAGCCTCATTATTCTC -3'
(R):5'- TCAGAGTACAGCCAGACTCTGTG -3'

Posted On

2022-05-16