Mutagenetix > Incidental Mutation

Incidental Mutation 'R9406:Cyp2g1'

711530

Institutional Source

Beutler Lab

Gene Symbol

Cyp2g1

Ensembl Gene

ENSMUSG00000049685

Gene Name

cytochrome P450, family 2, subfamily g, polypeptide 1

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9406 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

26808892-26821205 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 26819485 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000047150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040944]

AlphaFold

Q9WV19

Predicted Effect

probably null
Transcript: ENSMUST00000040944

SMART Domains

Protein: ENSMUSP00000047150
Gene: ENSMUSG00000049685

Domain	Start	End	E-Value	Type
low complexity region	12	23	N/A	INTRINSIC
Pfam:p450	34	491	4e-150	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300002M23Rik	A	G	17: 35,568,590	Y275C	possibly damaging	Het
3632451O06Rik	C	T	14: 49,773,488	G254E	possibly damaging	Het
4932414N04Rik	A	G	2: 68,667,675	K150R	unknown	Het
Aatf	ACACACACACACACACACACACACACACACACACACACACACACACAC	ACACACACACACACACACACACACACACACACACACACACACACACACAC	11: 84,471,040		probably null	Het
Ank3	C	A	10: 69,809,181	T92K	unknown	Het
Cdca2	T	C	14: 67,700,323	S294G	unknown	Het
Cerk	A	G	15: 86,144,586	I423T	possibly damaging	Het
Cfap74	A	T	4: 155,426,169	K404*	probably null	Het
Cftr	T	C	6: 18,299,867	V1213A	probably benign	Het
Chst11	A	G	10: 83,191,047	T103A	possibly damaging	Het
Col22a1	A	G	15: 71,973,692	I407T	probably damaging	Het
Cpn2	A	G	16: 30,259,542	V447A	probably benign	Het
Crybg3	T	C	16: 59,558,476	E805G	probably benign	Het
Cstb	A	G	10: 78,427,339	H66R	probably benign	Het
Fkbp1b	G	T	12: 4,833,732	H88N	probably benign	Het
Gm4884	A	T	7: 41,043,141	D178V	probably damaging	Het
Grik5	T	C	7: 25,058,544	T371A	probably benign	Het
Hydin	G	A	8: 110,587,780	G4299S	probably null	Het
Ibtk	A	T	9: 85,721,340	Y537*	probably null	Het
Ighv8-9	A	G	12: 115,468,637	L18P	probably damaging	Het
Lbp	G	T	2: 158,317,557	K203N	probably benign	Het
Lilra6	C	T	7: 3,914,854	R97Q	probably benign	Het
Man1c1	A	G	4: 134,576,007	I392T	probably damaging	Het
Mcf2l	A	T	8: 13,009,676	H727L	probably damaging	Het
Med7	T	A	11: 46,441,038	F153L	probably benign	Het
Neurl1b	G	C	17: 26,438,846	V253L	probably benign	Het
Noc2l	T	C	4: 156,236,054	S4P	probably benign	Het
Obscn	A	C	11: 59,056,979	F4408C		Het
Olfr1318	A	G	2: 112,156,298	I116V	probably benign	Het
Olfr346	A	G	2: 36,688,284	Y94C	possibly damaging	Het
Orc2	T	C	1: 58,467,683	Q498R	probably damaging	Het
Oxsm	A	C	14: 16,242,531	D79E	probably benign	Het
Pask	G	A	1: 93,324,265	T464I	probably benign	Het
Pcdha8	A	G	18: 36,993,869	N468S	probably damaging	Het
Pcm1	T	A	8: 41,275,685	V565E	probably damaging	Het
Pcsk5	T	C	19: 17,793,733	I67V	probably benign	Het
Pde4d	A	G	13: 109,740,530	D139G	probably damaging	Het
Pdzd8	C	T	19: 59,344,813	E259K		Het
Phactr3	T	C	2: 178,284,063	L377P	probably damaging	Het
Ppargc1b	G	A	18: 61,310,980	P387S	possibly damaging	Het
Prmt7	T	G	8: 106,243,803	V426G	probably damaging	Het
Rab39	G	C	9: 53,686,615	P117A	probably damaging	Het
Rab40b	G	A	11: 121,363,526	R62*	probably null	Het
Rpf1	T	G	3: 146,508,182	H220P	probably damaging	Het
Rps6kl1	A	G	12: 85,139,506	I276T	probably benign	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,579,911		probably benign	Het
Sbf2	T	C	7: 110,441,495	Q375R	possibly damaging	Het
Sestd1	G	A	2: 77,245,077		probably benign	Het
Slc38a6	T	A	12: 73,329,993	Y140*	probably null	Het
Smpd1	C	A	7: 105,554,543	H4Q	possibly damaging	Het
Sox8	A	T	17: 25,567,660	S356R	probably damaging	Het
Tapbpl	A	G	6: 125,228,356	L209P	probably damaging	Het
Txndc11	A	G	16: 11,075,634	L744P	probably benign	Het
Ush2a	C	T	1: 188,263,449	P139L	probably benign	Het
Vmn1r54	A	T	6: 90,269,110	N2I	probably damaging	Het
Vmn2r112	C	T	17: 22,605,242	Q493*	probably null	Het
Vps16	T	C	2: 130,441,505		probably null	Het
Zfp40	A	T	17: 23,177,155	S153T	possibly damaging	Het
Zfp523	G	A	17: 28,197,866	A109T	probably benign	Het
Zfp78	A	T	7: 6,379,183	N411Y	probably benign	Het

Other mutations in Cyp2g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01134:Cyp2g1	APN	7	26809831	missense	probably benign	0.05
IGL01137:Cyp2g1	APN	7	26814259	missense	possibly damaging	0.87
IGL02052:Cyp2g1	APN	7	26814294	splice site	probably benign
IGL02338:Cyp2g1	APN	7	26814804	splice site	probably benign
IGL02452:Cyp2g1	APN	7	26811446	missense	probably benign	0.28
IGL02523:Cyp2g1	APN	7	26819187	missense	probably damaging	1.00
IGL03165:Cyp2g1	APN	7	26809776	missense	possibly damaging	0.94
IGL03230:Cyp2g1	APN	7	26819403	missense	probably damaging	1.00
PIT4472001:Cyp2g1	UTSW	7	26814194	missense	probably benign	0.28
R0106:Cyp2g1	UTSW	7	26814182	missense	probably damaging	1.00
R0106:Cyp2g1	UTSW	7	26814182	missense	probably damaging	1.00
R0380:Cyp2g1	UTSW	7	26814295	splice site	probably benign
R0697:Cyp2g1	UTSW	7	26814727	nonsense	probably null
R0830:Cyp2g1	UTSW	7	26814791	missense	probably benign	0.00
R1660:Cyp2g1	UTSW	7	26809682	critical splice acceptor site	probably null
R2093:Cyp2g1	UTSW	7	26819433	missense	probably benign	0.35
R2131:Cyp2g1	UTSW	7	26820710	missense	probably damaging	0.99
R4606:Cyp2g1	UTSW	7	26814154	missense	possibly damaging	0.80
R5030:Cyp2g1	UTSW	7	26820801	missense	probably benign	0.06
R5574:Cyp2g1	UTSW	7	26820740	missense	possibly damaging	0.81
R5877:Cyp2g1	UTSW	7	26816640	missense	possibly damaging	0.80
R6745:Cyp2g1	UTSW	7	26814179	missense	probably damaging	1.00
R7040:Cyp2g1	UTSW	7	26820759	missense	probably damaging	0.99
R7223:Cyp2g1	UTSW	7	26814632	missense	probably damaging	0.98
R7934:Cyp2g1	UTSW	7	26819193	missense	probably damaging	1.00
R8112:Cyp2g1	UTSW	7	26819461	missense	probably benign
R8177:Cyp2g1	UTSW	7	26819153	missense	probably damaging	1.00
R8194:Cyp2g1	UTSW	7	26814734	missense	possibly damaging	0.89
R9043:Cyp2g1	UTSW	7	26809831	missense	probably benign	0.05
R9441:Cyp2g1	UTSW	7	26814635	missense	possibly damaging	0.72
X0067:Cyp2g1	UTSW	7	26820762	missense	possibly damaging	0.70

Predicted Primers

PCR Primer
(F):5'- TGTACCCCAGTGTTGTCCTG -3'
(R):5'- AGACAAGGGTCATATGGCTGAC -3'

Sequencing Primer
(F):5'- TATTGCCCAACACAGAACTCTAATAG -3'
(R):5'- AGTCAGGATCTCACGTTAGCC -3'

Posted On

2022-05-16