Incidental Mutation 'R9406:Vmn2r112'
| ID |
711561 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r112
|
| Ensembl Gene |
ENSMUSG00000094921 |
| Gene Name |
vomeronasal 2, receptor 112 |
| Synonyms |
EG628185 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R9406 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
22820129-22838114 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 22824223 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 493
(Q493*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094994
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000097381]
|
| AlphaFold |
L7N221 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000097381
AA Change: Q493*
|
| SMART Domains |
Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: Q493*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
471 |
2.8e-32 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
5.8e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
6.5e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2300002M23Rik |
A |
G |
17: 35,879,487 (GRCm39) |
Y275C |
possibly damaging |
Het |
| 4932414N04Rik |
A |
G |
2: 68,498,019 (GRCm39) |
K150R |
unknown |
Het |
| Aatf |
ACACACACACACACACACACACACACACACACACACACACACACACAC |
ACACACACACACACACACACACACACACACACACACACACACACACACAC |
11: 84,361,866 (GRCm39) |
|
probably null |
Het |
| Ank3 |
C |
A |
10: 69,645,011 (GRCm39) |
T92K |
unknown |
Het |
| Armh4 |
C |
T |
14: 50,010,945 (GRCm39) |
G254E |
possibly damaging |
Het |
| Cdca2 |
T |
C |
14: 67,937,772 (GRCm39) |
S294G |
unknown |
Het |
| Cerk |
A |
G |
15: 86,028,787 (GRCm39) |
I423T |
possibly damaging |
Het |
| Cfap74 |
A |
T |
4: 155,510,626 (GRCm39) |
K404* |
probably null |
Het |
| Cftr |
T |
C |
6: 18,299,866 (GRCm39) |
V1213A |
probably benign |
Het |
| Chst11 |
A |
G |
10: 83,026,881 (GRCm39) |
T103A |
possibly damaging |
Het |
| Col22a1 |
A |
G |
15: 71,845,541 (GRCm39) |
I407T |
probably damaging |
Het |
| Cpn2 |
A |
G |
16: 30,078,360 (GRCm39) |
V447A |
probably benign |
Het |
| Crybg3 |
T |
C |
16: 59,378,839 (GRCm39) |
E805G |
probably benign |
Het |
| Cstb |
A |
G |
10: 78,263,173 (GRCm39) |
H66R |
probably benign |
Het |
| Cyp2g1 |
T |
C |
7: 26,518,910 (GRCm39) |
|
probably null |
Het |
| Fkbp1b |
G |
T |
12: 4,883,732 (GRCm39) |
H88N |
probably benign |
Het |
| Gm4884 |
A |
T |
7: 40,692,565 (GRCm39) |
D178V |
probably damaging |
Het |
| Grik5 |
T |
C |
7: 24,757,969 (GRCm39) |
T371A |
probably benign |
Het |
| Hydin |
G |
A |
8: 111,314,412 (GRCm39) |
G4299S |
probably null |
Het |
| Ibtk |
A |
T |
9: 85,603,393 (GRCm39) |
Y537* |
probably null |
Het |
| Ighv8-9 |
A |
G |
12: 115,432,257 (GRCm39) |
L18P |
probably damaging |
Het |
| Lbp |
G |
T |
2: 158,159,477 (GRCm39) |
K203N |
probably benign |
Het |
| Lilra6 |
C |
T |
7: 3,917,853 (GRCm39) |
R97Q |
probably benign |
Het |
| Man1c1 |
A |
G |
4: 134,303,318 (GRCm39) |
I392T |
probably damaging |
Het |
| Mcf2l |
A |
T |
8: 13,059,676 (GRCm39) |
H727L |
probably damaging |
Het |
| Med7 |
T |
A |
11: 46,331,865 (GRCm39) |
F153L |
probably benign |
Het |
| Neurl1b |
G |
C |
17: 26,657,820 (GRCm39) |
V253L |
probably benign |
Het |
| Noc2l |
T |
C |
4: 156,320,511 (GRCm39) |
S4P |
probably benign |
Het |
| Obscn |
A |
C |
11: 58,947,805 (GRCm39) |
F4408C |
|
Het |
| Or1j17 |
A |
G |
2: 36,578,296 (GRCm39) |
Y94C |
possibly damaging |
Het |
| Or4f62 |
A |
G |
2: 111,986,643 (GRCm39) |
I116V |
probably benign |
Het |
| Orc2 |
T |
C |
1: 58,506,842 (GRCm39) |
Q498R |
probably damaging |
Het |
| Oxsm |
A |
C |
14: 16,242,531 (GRCm38) |
D79E |
probably benign |
Het |
| Pask |
G |
A |
1: 93,251,987 (GRCm39) |
T464I |
probably benign |
Het |
| Pcdha8 |
A |
G |
18: 37,126,922 (GRCm39) |
N468S |
probably damaging |
Het |
| Pcm1 |
T |
A |
8: 41,728,722 (GRCm39) |
V565E |
probably damaging |
Het |
| Pcsk5 |
T |
C |
19: 17,771,097 (GRCm39) |
I67V |
probably benign |
Het |
| Pde4d |
A |
G |
13: 109,877,064 (GRCm39) |
D139G |
probably damaging |
Het |
| Pdzd8 |
C |
T |
19: 59,333,245 (GRCm39) |
E259K |
|
Het |
| Phactr3 |
T |
C |
2: 177,925,856 (GRCm39) |
L377P |
probably damaging |
Het |
| Ppargc1b |
G |
A |
18: 61,444,051 (GRCm39) |
P387S |
possibly damaging |
Het |
| Prmt7 |
T |
G |
8: 106,970,435 (GRCm39) |
V426G |
probably damaging |
Het |
| Rab39 |
G |
C |
9: 53,597,915 (GRCm39) |
P117A |
probably damaging |
Het |
| Rab40b |
G |
A |
11: 121,254,352 (GRCm39) |
R62* |
probably null |
Het |
| Rpf1 |
T |
G |
3: 146,213,937 (GRCm39) |
H220P |
probably damaging |
Het |
| Rps6kl1 |
A |
G |
12: 85,186,280 (GRCm39) |
I276T |
probably benign |
Het |
| Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,118 (GRCm39) |
|
probably benign |
Het |
| Sbf2 |
T |
C |
7: 110,040,702 (GRCm39) |
Q375R |
possibly damaging |
Het |
| Sestd1 |
G |
A |
2: 77,075,421 (GRCm39) |
|
probably benign |
Het |
| Slc38a6 |
T |
A |
12: 73,376,767 (GRCm39) |
Y140* |
probably null |
Het |
| Smpd1 |
C |
A |
7: 105,203,750 (GRCm39) |
H4Q |
possibly damaging |
Het |
| Sox8 |
A |
T |
17: 25,786,634 (GRCm39) |
S356R |
probably damaging |
Het |
| Tapbpl |
A |
G |
6: 125,205,319 (GRCm39) |
L209P |
probably damaging |
Het |
| Txndc11 |
A |
G |
16: 10,893,498 (GRCm39) |
L744P |
probably benign |
Het |
| Ush2a |
C |
T |
1: 187,995,646 (GRCm39) |
P139L |
probably benign |
Het |
| Vmn1r54 |
A |
T |
6: 90,246,092 (GRCm39) |
N2I |
probably damaging |
Het |
| Vps16 |
T |
C |
2: 130,283,425 (GRCm39) |
|
probably null |
Het |
| Zfp40 |
A |
T |
17: 23,396,129 (GRCm39) |
S153T |
possibly damaging |
Het |
| Zfp523 |
G |
A |
17: 28,416,840 (GRCm39) |
A109T |
probably benign |
Het |
| Zfp78 |
A |
T |
7: 6,382,182 (GRCm39) |
N411Y |
probably benign |
Het |
|
| Other mutations in Vmn2r112 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Vmn2r112
|
APN |
17 |
22,837,917 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01021:Vmn2r112
|
APN |
17 |
22,837,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01122:Vmn2r112
|
APN |
17 |
22,821,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01360:Vmn2r112
|
APN |
17 |
22,837,603 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01536:Vmn2r112
|
APN |
17 |
22,824,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02148:Vmn2r112
|
APN |
17 |
22,838,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vmn2r112
|
APN |
17 |
22,833,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4576001:Vmn2r112
|
UTSW |
17 |
22,833,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0278:Vmn2r112
|
UTSW |
17 |
22,821,987 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0328:Vmn2r112
|
UTSW |
17 |
22,824,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0583:Vmn2r112
|
UTSW |
17 |
22,837,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0831:Vmn2r112
|
UTSW |
17 |
22,833,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1080:Vmn2r112
|
UTSW |
17 |
22,837,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1245:Vmn2r112
|
UTSW |
17 |
22,822,228 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1321:Vmn2r112
|
UTSW |
17 |
22,837,500 (GRCm39) |
nonsense |
probably null |
|
|
R1381:Vmn2r112
|
UTSW |
17 |
22,837,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1514:Vmn2r112
|
UTSW |
17 |
22,821,825 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1519:Vmn2r112
|
UTSW |
17 |
22,837,884 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1572:Vmn2r112
|
UTSW |
17 |
22,822,125 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1590:Vmn2r112
|
UTSW |
17 |
22,833,989 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1640:Vmn2r112
|
UTSW |
17 |
22,824,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2221:Vmn2r112
|
UTSW |
17 |
22,820,214 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2223:Vmn2r112
|
UTSW |
17 |
22,820,214 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2310:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2312:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2337:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2339:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2340:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2341:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2342:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2401:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2860:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2861:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2926:Vmn2r112
|
UTSW |
17 |
22,833,984 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3236:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3237:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3977:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3979:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4168:Vmn2r112
|
UTSW |
17 |
22,822,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4256:Vmn2r112
|
UTSW |
17 |
22,837,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4386:Vmn2r112
|
UTSW |
17 |
22,820,303 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4912:Vmn2r112
|
UTSW |
17 |
22,822,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4947:Vmn2r112
|
UTSW |
17 |
22,821,860 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5446:Vmn2r112
|
UTSW |
17 |
22,837,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5870:Vmn2r112
|
UTSW |
17 |
22,838,004 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6351:Vmn2r112
|
UTSW |
17 |
22,820,259 (GRCm39) |
missense |
probably benign |
|
|
R6384:Vmn2r112
|
UTSW |
17 |
22,824,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6390:Vmn2r112
|
UTSW |
17 |
22,824,230 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6401:Vmn2r112
|
UTSW |
17 |
22,822,532 (GRCm39) |
nonsense |
probably null |
|
|
R6405:Vmn2r112
|
UTSW |
17 |
22,837,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Vmn2r112
|
UTSW |
17 |
22,822,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6648:Vmn2r112
|
UTSW |
17 |
22,837,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6649:Vmn2r112
|
UTSW |
17 |
22,820,160 (GRCm39) |
missense |
probably null |
1.00 |
|
R6653:Vmn2r112
|
UTSW |
17 |
22,820,160 (GRCm39) |
missense |
probably null |
1.00 |
|
R6654:Vmn2r112
|
UTSW |
17 |
22,822,450 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6700:Vmn2r112
|
UTSW |
17 |
22,822,462 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6993:Vmn2r112
|
UTSW |
17 |
22,822,195 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Vmn2r112
|
UTSW |
17 |
22,821,507 (GRCm39) |
missense |
probably benign |
|
|
R7454:Vmn2r112
|
UTSW |
17 |
22,822,288 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7763:Vmn2r112
|
UTSW |
17 |
22,822,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8032:Vmn2r112
|
UTSW |
17 |
22,822,375 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8177:Vmn2r112
|
UTSW |
17 |
22,822,594 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8263:Vmn2r112
|
UTSW |
17 |
22,824,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8395:Vmn2r112
|
UTSW |
17 |
22,837,587 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8492:Vmn2r112
|
UTSW |
17 |
22,821,470 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8889:Vmn2r112
|
UTSW |
17 |
22,837,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8892:Vmn2r112
|
UTSW |
17 |
22,837,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9246:Vmn2r112
|
UTSW |
17 |
22,824,088 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9269:Vmn2r112
|
UTSW |
17 |
22,820,213 (GRCm39) |
missense |
probably benign |
|
|
R9273:Vmn2r112
|
UTSW |
17 |
22,837,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9288:Vmn2r112
|
UTSW |
17 |
22,822,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9352:Vmn2r112
|
UTSW |
17 |
22,822,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9432:Vmn2r112
|
UTSW |
17 |
22,821,233 (GRCm39) |
missense |
|
|
|
R9728:Vmn2r112
|
UTSW |
17 |
22,824,108 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1088:Vmn2r112
|
UTSW |
17 |
22,824,059 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTGGATTCCTCTCTGAGAAAGAC -3'
(R):5'- TCATGTTGGAAACCCTCAGTG -3'
Sequencing Primer
(F):5'- GACACAGTTCACTAATCCTGTTGGG -3'
(R):5'- GTTGGAAACCCTCAGTGAATTAC -3'
|
| Posted On |
2022-05-16 |
Incidental Mutation