Mutagenetix > Incidental Mutation

Incidental Mutation 'R9407:Celsr3'

711598

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo, Adgrc3

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9407 (G1)

Quality Score

201.009

Status

Not validated

Chromosome

Chromosomal Location

108703519-108730168 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 108723596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 2877 (D2877G)

Ref Sequence

ENSEMBL: ENSMUSP00000150759 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000194079] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000024238
AA Change: D2869G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: D2869G

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000194079
AA Change: D296G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000141789
Gene: ENSMUSG00000023473
AA Change: D296G

Domain	Start	End	E-Value	Type
Pfam:7tm_2	1	185	6.9e-45	PFAM
low complexity region	240	256	N/A	INTRINSIC
low complexity region	309	333	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000213524
AA Change: D2877G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I06Rik	T	C	14: 64,223,629 (GRCm39)	Y49C	probably damaging	Het
Abca6	A	T	11: 110,093,210 (GRCm39)	L1021*	probably null	Het
Abcc9	A	G	6: 142,574,229 (GRCm39)	S1003P	possibly damaging	Het
Aldh4a1	A	G	4: 139,372,345 (GRCm39)	I505V	probably benign	Het
Brwd1	T	C	16: 95,803,693 (GRCm39)	D2159G	possibly damaging	Het
C1s2	T	C	6: 124,602,454 (GRCm39)	I586V	probably benign	Het
Cd300e	C	A	11: 114,946,171 (GRCm39)	D97Y	probably damaging	Het
Cep41	T	C	6: 30,655,841 (GRCm39)	N328D	probably benign	Het
Cldn15	G	A	5: 137,003,765 (GRCm39)	V227M	probably damaging	Het
Clec10a	T	G	11: 70,060,155 (GRCm39)	I98S	probably damaging	Het
Cpne4	A	G	9: 104,749,963 (GRCm39)	Q89R	probably damaging	Het
Cryba2	C	A	1: 74,932,037 (GRCm39)	A4S	probably benign	Het
Csmd2	G	A	4: 128,442,613 (GRCm39)	A3222T		Het
Dapk1	C	A	13: 60,898,991 (GRCm39)	Y820*	probably null	Het
Efcab5	G	A	11: 77,022,934 (GRCm39)	T593I	probably damaging	Het
Entrep3	C	A	3: 89,094,645 (GRCm39)	A416D	possibly damaging	Het
Gar1	A	G	3: 129,620,608 (GRCm39)	Y160H	probably damaging	Het
Gm21834	T	A	17: 58,048,863 (GRCm39)	I118L	probably benign	Het
Gtf2a1l	G	A	17: 89,001,531 (GRCm39)	G129D	probably damaging	Het
Gzmb	T	A	14: 56,497,712 (GRCm39)	Y176F	probably benign	Het
Helz2	T	G	2: 180,881,975 (GRCm39)	K273Q	probably benign	Het
Ifi207	T	A	1: 173,555,234 (GRCm39)	E816V	probably damaging	Het
Insr	A	C	8: 3,235,106 (GRCm39)	D694E	probably benign	Het
Insyn2b	G	A	11: 34,352,072 (GRCm39)	R38Q	probably damaging	Het
Ipcef1	A	T	10: 6,870,036 (GRCm39)	C172*	probably null	Het
Itgal	T	G	7: 126,921,796 (GRCm39)		probably null	Het
Laptm5	A	T	4: 130,655,990 (GRCm39)	M103L		Het
Lypd4	A	T	7: 24,566,160 (GRCm39)	C55S	probably null	Het
Mccc1	A	C	3: 36,030,865 (GRCm39)	H400Q	possibly damaging	Het
Myl4	C	T	11: 104,474,887 (GRCm39)	R79W	probably damaging	Het
Myo18a	A	G	11: 77,709,596 (GRCm39)	T569A	probably benign	Het
Or14a259	G	C	7: 86,013,194 (GRCm39)	S117*	probably null	Het
Or4c117	T	A	2: 88,955,629 (GRCm39)	T149S	probably benign	Het
Or5ak24	A	G	2: 85,261,060 (GRCm39)	S38P	probably damaging	Het
Otof	T	A	5: 30,538,265 (GRCm39)	D1153V	probably damaging	Het
Pcdha12	A	T	18: 37,153,614 (GRCm39)	D111V	probably damaging	Het
Pomt2	G	T	12: 87,157,146 (GRCm39)	F724L	probably damaging	Het
Ros1	T	A	10: 51,994,491 (GRCm39)	Y1284F	probably damaging	Het
Skint6	T	C	4: 113,034,224 (GRCm39)	K301R	possibly damaging	Het
Slc30a5	T	A	13: 100,951,214 (GRCm39)	R223*	probably null	Het
Slc35a1	A	T	4: 34,675,181 (GRCm39)	V119E	probably damaging	Het
Slc6a11	A	T	6: 114,220,914 (GRCm39)	I482F	probably damaging	Het
Tektl1	T	C	10: 78,583,128 (GRCm39)	T419A	probably damaging	Het
Tgm1	A	T	14: 55,942,991 (GRCm39)	C616*	probably null	Het
Tiam2	T	A	17: 3,553,298 (GRCm39)	I1125N	probably damaging	Het
Tln2	T	C	9: 67,136,732 (GRCm39)	D1251G	probably damaging	Het
Tnfaip2	C	G	12: 111,412,161 (GRCm39)	S187R	probably benign	Het
Ush2a	A	G	1: 188,644,045 (GRCm39)	Y4469C	probably damaging	Het
Vmn1r229	G	C	17: 21,035,259 (GRCm39)	C168S	probably damaging	Het
Vmn2r53	A	G	7: 12,335,124 (GRCm39)	S179P	probably damaging	Het
Zfp474	A	C	18: 52,771,502 (GRCm39)	I52L	probably benign	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108,726,124 (GRCm39)	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108,706,391 (GRCm39)	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108,718,462 (GRCm39)	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108,719,775 (GRCm39)	missense	probably benign
IGL01420:Celsr3	APN	9	108,718,389 (GRCm39)	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108,708,907 (GRCm39)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,711,756 (GRCm39)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,714,603 (GRCm39)	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108,714,603 (GRCm39)	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108,713,141 (GRCm39)	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108,705,614 (GRCm39)	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108,704,755 (GRCm39)	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108,719,709 (GRCm39)	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108,707,159 (GRCm39)	missense	probably benign
IGL02392:Celsr3	APN	9	108,711,920 (GRCm39)	splice site	probably benign
IGL02416:Celsr3	APN	9	108,709,318 (GRCm39)	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108,717,662 (GRCm39)	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108,720,092 (GRCm39)	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108,720,774 (GRCm39)	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108,726,652 (GRCm39)	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108,723,134 (GRCm39)	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108,718,454 (GRCm39)	splice site	probably null
IGL03089:Celsr3	APN	9	108,703,806 (GRCm39)	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108,719,757 (GRCm39)	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108,713,724 (GRCm39)	splice site	probably benign
Diminishment	UTSW	9	108,719,907 (GRCm39)	intron	probably benign
little_d	UTSW	9	108,704,891 (GRCm39)	missense	probably damaging	0.98
nogal	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
F6893:Celsr3	UTSW	9	108,712,266 (GRCm39)	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108,709,507 (GRCm39)	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108,722,932 (GRCm39)	missense	probably damaging	1.00
R0110:Celsr3	UTSW	9	108,704,204 (GRCm39)	missense	possibly damaging	0.62
R0243:Celsr3	UTSW	9	108,720,923 (GRCm39)	splice site	probably benign
R0382:Celsr3	UTSW	9	108,706,417 (GRCm39)	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108,706,272 (GRCm39)	nonsense	probably null
R0510:Celsr3	UTSW	9	108,704,204 (GRCm39)	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108,704,891 (GRCm39)	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108,711,854 (GRCm39)	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108,705,017 (GRCm39)	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108,719,832 (GRCm39)	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108,723,224 (GRCm39)	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108,710,375 (GRCm39)	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108,713,069 (GRCm39)	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108,704,104 (GRCm39)	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108,726,064 (GRCm39)	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108,725,857 (GRCm39)	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108,726,083 (GRCm39)	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108,706,267 (GRCm39)	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108,720,151 (GRCm39)	nonsense	probably null
R1753:Celsr3	UTSW	9	108,709,056 (GRCm39)	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108,706,157 (GRCm39)	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108,711,825 (GRCm39)	missense	possibly damaging	0.88
R1838:Celsr3	UTSW	9	108,707,105 (GRCm39)	missense	probably benign
R1839:Celsr3	UTSW	9	108,707,105 (GRCm39)	missense	probably benign
R1874:Celsr3	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
R1875:Celsr3	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
R1953:Celsr3	UTSW	9	108,720,381 (GRCm39)	missense	probably benign	0.19
R1960:Celsr3	UTSW	9	108,723,016 (GRCm39)	missense	probably benign
R2113:Celsr3	UTSW	9	108,715,669 (GRCm39)	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108,720,423 (GRCm39)	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2373:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2374:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2375:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2844:Celsr3	UTSW	9	108,706,507 (GRCm39)	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108,709,390 (GRCm39)	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108,714,338 (GRCm39)	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108,704,909 (GRCm39)	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R4194:Celsr3	UTSW	9	108,720,501 (GRCm39)	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108,723,248 (GRCm39)	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108,707,046 (GRCm39)	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108,720,443 (GRCm39)	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108,723,262 (GRCm39)	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108,722,922 (GRCm39)	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108,704,953 (GRCm39)	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108,724,851 (GRCm39)	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108,721,140 (GRCm39)	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108,726,620 (GRCm39)	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108,714,759 (GRCm39)	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108,709,958 (GRCm39)	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108,720,357 (GRCm39)	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108,719,907 (GRCm39)	intron	probably benign
R5345:Celsr3	UTSW	9	108,709,323 (GRCm39)	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108,709,224 (GRCm39)	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108,705,781 (GRCm39)	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108,717,241 (GRCm39)	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108,721,233 (GRCm39)	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108,705,836 (GRCm39)	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108,721,743 (GRCm39)	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108,726,266 (GRCm39)	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108,714,332 (GRCm39)	missense	probably damaging	1.00
R5652:Celsr3	UTSW	9	108,715,671 (GRCm39)	missense	probably benign	0.03
R5739:Celsr3	UTSW	9	108,704,357 (GRCm39)	missense	probably benign
R5785:Celsr3	UTSW	9	108,704,996 (GRCm39)	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108,722,926 (GRCm39)	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108,708,993 (GRCm39)	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108,714,350 (GRCm39)	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108,705,554 (GRCm39)	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108,706,041 (GRCm39)	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108,712,989 (GRCm39)	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108,714,283 (GRCm39)	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108,706,327 (GRCm39)	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108,704,549 (GRCm39)	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108,706,390 (GRCm39)	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108,704,914 (GRCm39)	missense	probably benign
R7061:Celsr3	UTSW	9	108,724,793 (GRCm39)	nonsense	probably null
R7122:Celsr3	UTSW	9	108,705,766 (GRCm39)	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108,715,203 (GRCm39)	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108,720,150 (GRCm39)	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108,722,961 (GRCm39)	missense	probably benign
R7213:Celsr3	UTSW	9	108,726,239 (GRCm39)	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108,706,343 (GRCm39)	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108,720,777 (GRCm39)	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108,713,821 (GRCm39)	missense	probably benign
R7554:Celsr3	UTSW	9	108,718,408 (GRCm39)	missense	probably benign
R7615:Celsr3	UTSW	9	108,714,851 (GRCm39)	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108,712,269 (GRCm39)	nonsense	probably null
R7747:Celsr3	UTSW	9	108,707,177 (GRCm39)	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108,705,271 (GRCm39)	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108,706,840 (GRCm39)	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108,722,282 (GRCm39)	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108,706,306 (GRCm39)	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108,705,530 (GRCm39)	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108,723,612 (GRCm39)	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108,715,169 (GRCm39)	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108,725,993 (GRCm39)	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108,718,471 (GRCm39)	frame shift	probably null
R8337:Celsr3	UTSW	9	108,718,471 (GRCm39)	frame shift	probably null
R8338:Celsr3	UTSW	9	108,704,539 (GRCm39)	nonsense	probably null
R8353:Celsr3	UTSW	9	108,703,734 (GRCm39)	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108,706,256 (GRCm39)	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108,708,988 (GRCm39)	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108,706,829 (GRCm39)	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108,715,319 (GRCm39)	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108,707,062 (GRCm39)	missense	probably benign
R8728:Celsr3	UTSW	9	108,723,940 (GRCm39)	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108,717,582 (GRCm39)	missense	probably benign
R8877:Celsr3	UTSW	9	108,706,877 (GRCm39)	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108,718,501 (GRCm39)	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108,706,151 (GRCm39)	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108,704,293 (GRCm39)	missense	probably benign
R9157:Celsr3	UTSW	9	108,707,185 (GRCm39)	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108,706,595 (GRCm39)	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108,715,689 (GRCm39)	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108,726,521 (GRCm39)	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108,706,961 (GRCm39)	missense	possibly damaging	0.60
R9432:Celsr3	UTSW	9	108,726,032 (GRCm39)	missense	probably benign	0.00
R9607:Celsr3	UTSW	9	108,717,701 (GRCm39)	critical splice donor site	probably null
R9626:Celsr3	UTSW	9	108,726,521 (GRCm39)	missense	probably damaging	1.00
R9628:Celsr3	UTSW	9	108,703,559 (GRCm39)	nonsense	probably null
R9630:Celsr3	UTSW	9	108,704,296 (GRCm39)	missense	probably benign
R9645:Celsr3	UTSW	9	108,704,691 (GRCm39)	nonsense	probably null
R9683:Celsr3	UTSW	9	108,704,522 (GRCm39)	missense	probably damaging	1.00
R9794:Celsr3	UTSW	9	108,728,502 (GRCm39)	missense	probably benign	0.00
R9798:Celsr3	UTSW	9	108,705,794 (GRCm39)	missense	probably damaging	1.00
RF020:Celsr3	UTSW	9	108,726,256 (GRCm39)	missense	probably benign
X0018:Celsr3	UTSW	9	108,717,611 (GRCm39)	missense	probably benign	0.01
X0018:Celsr3	UTSW	9	108,704,977 (GRCm39)	missense	possibly damaging	0.65
X0026:Celsr3	UTSW	9	108,706,129 (GRCm39)	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108,703,676 (GRCm39)	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- CCTGATGCCCTCTGTGAAATAC -3'
(R):5'- TAGGTGCTTTCTGAGGCAGC -3'

Sequencing Primer
(F):5'- TGTGAAATACTCAGCGGCTC -3'
(R):5'- TTTCTGAGGCAGCAACCTG -3'

Posted On

2022-05-16