Incidental Mutation 'R9409:Trav13-5'
ID 711721
Institutional Source Beutler Lab
Gene Symbol Trav13-5
Ensembl Gene ENSMUSG00000087666
Gene Name T cell receptor alpha variable 13-5
Synonyms B230359F08Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R9409 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 54032912-54033420 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 54033277 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 62 (R62L)
Ref Sequence ENSEMBL: ENSMUSP00000100448 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103671]
AlphaFold A0A0B4J1K3
Predicted Effect possibly damaging
Transcript: ENSMUST00000103671
AA Change: R62L

PolyPhen 2 Score 0.670 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000100448
Gene: ENSMUSG00000087666
AA Change: R62L

DomainStartEndE-ValueType
IGv 38 108 3.01e-7 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A T 8: 73,211,888 (GRCm39) I538F possibly damaging Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Ccdc138 A G 10: 58,374,135 (GRCm39) H385R probably damaging Het
Cep43 T C 17: 8,411,088 (GRCm39) V367A probably benign Het
Cfhr1 T C 1: 139,478,704 (GRCm39) D222G probably benign Het
Cpb2 A T 14: 75,505,522 (GRCm39) I173F probably damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Ebf2 T C 14: 67,472,665 (GRCm39) S28P probably damaging Het
Eomes A T 9: 118,314,069 (GRCm39) T705S probably benign Het
Fbxo15 T A 18: 84,977,246 (GRCm39) W98R possibly damaging Het
Gm12258 T C 11: 58,745,119 (GRCm39) F17L Het
Grin2c C T 11: 115,144,106 (GRCm39) R697H probably benign Het
Ighmbp2 C A 19: 3,318,832 (GRCm39) A415S possibly damaging Het
Il6st C G 13: 112,640,872 (GRCm39) Q883E probably benign Het
Med17 T C 9: 15,176,695 (GRCm39) M511V probably benign Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Or8b39 G A 9: 37,996,584 (GRCm39) G151R probably damaging Het
Pacrg A T 17: 10,996,065 (GRCm39) I67N probably damaging Het
Pam A G 1: 97,749,585 (GRCm39) S964P probably damaging Het
Pcdh15 A G 10: 74,160,190 (GRCm39) T436A probably damaging Het
Pgap4 T A 4: 49,586,043 (GRCm39) E375V probably damaging Het
Rag1 A T 2: 101,473,192 (GRCm39) L650Q probably damaging Het
Rhobtb1 A T 10: 69,106,217 (GRCm39) T323S probably benign Het
Rhot2 T C 17: 26,060,085 (GRCm39) T299A probably benign Het
Rnf180 CGAGG CGAGGAGG 13: 105,386,781 (GRCm39) probably benign Het
Ryr2 C A 13: 11,695,973 (GRCm39) V2965F probably damaging Het
Serpina1b A T 12: 103,694,607 (GRCm39) M379K probably benign Het
Serpinb9 A G 13: 33,192,797 (GRCm39) Q118R probably benign Het
Slc16a14 G A 1: 84,907,116 (GRCm39) Q53* probably null Het
Tas2r130 T A 6: 131,607,660 (GRCm39) D45V probably damaging Het
Tie1 T C 4: 118,339,945 (GRCm39) N361D probably damaging Het
Tmtc2 G T 10: 105,159,419 (GRCm39) L560M probably damaging Het
Other mutations in Trav13-5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03173:Trav13-5 APN 14 54,033,534 (GRCm39) unclassified probably benign
R0331:Trav13-5 UTSW 14 54,033,205 (GRCm39) missense probably benign 0.01
R4798:Trav13-5 UTSW 14 54,033,408 (GRCm39) missense probably damaging 1.00
R6334:Trav13-5 UTSW 14 54,033,399 (GRCm39) missense probably damaging 0.98
R8281:Trav13-5 UTSW 14 54,032,918 (GRCm39) missense possibly damaging 0.48
Z1177:Trav13-5 UTSW 14 54,032,964 (GRCm39) critical splice donor site probably benign
Predicted Primers PCR Primer
(F):5'- ACCTTCTCAGAAGACATGGGG -3'
(R):5'- AAGGTTTGTGTACAGGCTGCAG -3'

Sequencing Primer
(F):5'- CAGGGTTCTGTGGACACTGC -3'
(R):5'- AGGTGCCTGGGGAGCAC -3'
Posted On 2022-05-16