Incidental Mutation 'R9410:Tnfrsf10b'
ID 711769
Institutional Source Beutler Lab
Gene Symbol Tnfrsf10b
Ensembl Gene ENSMUSG00000022074
Gene Name tumor necrosis factor receptor superfamily, member 10b
Synonyms Killer/Dr5, DR5, Trail Receptor, Ly98, KILLER, TRICK2A, TRAIL-R2, TRICKB, TRAILR2, TRICK2B
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R9410 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 70004921-70021860 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 70010849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Glycine at position 85 (C85G)
Ref Sequence ENSEMBL: ENSMUSP00000022663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022663]
AlphaFold Q9QZM4
Predicted Effect probably damaging
Transcript: ENSMUST00000022663
AA Change: C85G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000022663
Gene: ENSMUSG00000022074
AA Change: C85G

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
transmembrane domain 32 54 N/A INTRINSIC
TNFR 88 129 3.17e-7 SMART
TNFR 131 169 4.73e-6 SMART
transmembrane domain 182 201 N/A INTRINSIC
low complexity region 236 247 N/A INTRINSIC
DEATH 262 356 7e-18 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants exhibit enhanced innate immune responses, including increased clearance of cytomegalovirus and increased levels of IL-12, IFN-alpha and IFN-gamma after viral infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 G A 12: 118,869,703 (GRCm39) S772L probably benign Het
Ampd2 A T 3: 107,982,590 (GRCm39) V722E probably damaging Het
Appbp2 A T 11: 85,106,067 (GRCm39) F83Y probably damaging Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
B020004C17Rik A T 14: 57,254,273 (GRCm39) Y132F possibly damaging Het
Cnr1 A G 4: 33,944,973 (GRCm39) T454A possibly damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Ctla4 A T 1: 60,951,911 (GRCm39) T147S probably damaging Het
Ctsa T C 2: 164,677,101 (GRCm39) L152P probably damaging Het
Dgkh T C 14: 78,862,293 (GRCm39) T225A probably damaging Het
Dsg1a A T 18: 20,464,590 (GRCm39) I362F possibly damaging Het
Dzank1 C T 2: 144,324,050 (GRCm39) probably null Het
Ephb2 A T 4: 136,386,948 (GRCm39) C760S probably null Het
Exoc1 T A 5: 76,706,989 (GRCm39) V512E probably benign Het
Faiml C A 9: 99,111,587 (GRCm39) K157N probably benign Het
Fpr2 C T 17: 18,113,604 (GRCm39) T200I probably benign Het
Fscn3 C T 6: 28,430,432 (GRCm39) R201* probably null Het
Hcrtr1 A T 4: 130,029,514 (GRCm39) L189Q probably damaging Het
Igkv4-62 T C 6: 69,376,832 (GRCm39) T84A probably benign Het
Krtap2-4 C A 11: 99,505,437 (GRCm39) R58L possibly damaging Het
Meis1 C T 11: 18,833,987 (GRCm39) probably null Het
Mfsd2b T A 12: 4,915,747 (GRCm39) I422F probably damaging Het
Mre11a G A 9: 14,716,716 (GRCm39) V304M probably damaging Het
Myo5a A G 9: 75,023,496 (GRCm39) E19G probably damaging Het
Ndufa10 A T 1: 92,367,614 (GRCm39) Y339N probably damaging Het
Odad1 T C 7: 45,597,821 (GRCm39) V577A probably benign Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Pcdh15 CAGAGA CAGA 10: 74,481,663 (GRCm39) probably null Het
Pcdh18 G A 3: 49,699,615 (GRCm39) P949L probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Perm1 TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT 4: 156,302,525 (GRCm39) probably benign Het
Plin4 A G 17: 56,413,995 (GRCm39) V210A probably benign Het
Rnf150 T C 8: 83,762,722 (GRCm39) M319T possibly damaging Het
Rnf180 CGAGG CGAGGAGG 13: 105,386,781 (GRCm39) probably benign Het
Ruvbl2 G A 7: 45,071,618 (GRCm39) Q422* probably null Het
Shroom1 C T 11: 53,354,217 (GRCm39) R46C probably damaging Het
Slc22a2 T C 17: 12,805,732 (GRCm39) F161S probably damaging Het
Src T A 2: 157,311,676 (GRCm39) M468K probably damaging Het
Stag3 T C 5: 138,297,601 (GRCm39) F606L possibly damaging Het
Stau1 T C 2: 166,797,038 (GRCm39) T120A probably benign Het
Sulf2 A C 2: 165,936,444 (GRCm39) L174R Het
Sumf1 A C 6: 108,150,363 (GRCm39) F156C probably damaging Het
Tenm2 T A 11: 36,032,396 (GRCm39) D708V probably damaging Het
Tmprss12 A C 15: 100,190,622 (GRCm39) I331L possibly damaging Het
Trav10d C A 14: 53,048,845 (GRCm39) Q79K probably benign Het
Vmn1r236 T A 17: 21,507,756 (GRCm39) Y291* probably null Het
Vmn2r115 T C 17: 23,578,915 (GRCm39) I796T possibly damaging Het
Zfp189 T A 4: 49,529,942 (GRCm39) H348Q possibly damaging Het
Zfp563 T A 17: 33,321,320 (GRCm39) L40Q probably damaging Het
Other mutations in Tnfrsf10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02525:Tnfrsf10b APN 14 70,019,825 (GRCm39) missense probably damaging 1.00
R0650:Tnfrsf10b UTSW 14 70,013,625 (GRCm39) missense probably damaging 0.98
R2102:Tnfrsf10b UTSW 14 70,013,546 (GRCm39) missense probably benign 0.42
R3870:Tnfrsf10b UTSW 14 70,010,905 (GRCm39) missense probably benign 0.03
R4840:Tnfrsf10b UTSW 14 70,013,608 (GRCm39) missense probably damaging 0.98
R6111:Tnfrsf10b UTSW 14 70,020,007 (GRCm39) missense possibly damaging 0.53
R6351:Tnfrsf10b UTSW 14 70,010,850 (GRCm39) missense probably damaging 1.00
R7853:Tnfrsf10b UTSW 14 70,005,239 (GRCm39) missense unknown
R8857:Tnfrsf10b UTSW 14 70,012,543 (GRCm39) missense probably benign
R9001:Tnfrsf10b UTSW 14 70,015,250 (GRCm39) missense possibly damaging 0.90
R9447:Tnfrsf10b UTSW 14 70,013,608 (GRCm39) missense probably damaging 0.98
R9507:Tnfrsf10b UTSW 14 70,015,221 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TCTGACAAGTTACCGACTTCATTG -3'
(R):5'- GGCTGGAACTGAAGTTTTCCAG -3'

Sequencing Primer
(F):5'- CTGGCCTACATGATAAGTTCTAGGC -3'
(R):5'- GCTGGAACTGAAGTTTTCCAGTTCAC -3'
Posted On 2022-05-16