Incidental Mutation 'R9410:Zfp563'
ID 711776
Institutional Source Beutler Lab
Gene Symbol Zfp563
Ensembl Gene ENSMUSG00000067424
Gene Name zinc finger protein 563
Synonyms zinc finger protein, Zfp413
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R9410 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 33308284-33329679 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 33321320 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 40 (L40Q)
Ref Sequence ENSEMBL: ENSMUSP00000118809 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000131722] [ENSMUST00000140829]
AlphaFold B8JJZ9
Predicted Effect probably damaging
Transcript: ENSMUST00000131722
AA Change: L40Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000118809
Gene: ENSMUSG00000067424
AA Change: L40Q

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
ZnF_C2H2 197 219 9.88e-5 SMART
ZnF_C2H2 225 247 3.16e-3 SMART
ZnF_C2H2 253 275 5.81e-2 SMART
ZnF_C2H2 281 303 2.4e-3 SMART
ZnF_C2H2 309 331 1.82e-3 SMART
ZnF_C2H2 337 359 1.72e-4 SMART
ZnF_C2H2 365 387 4.54e-4 SMART
ZnF_C2H2 393 415 7.78e-3 SMART
ZnF_C2H2 421 443 3.63e-3 SMART
Predicted Effect
SMART Domains Protein: ENSMUSP00000121678
Gene: ENSMUSG00000067424
AA Change: L40Q

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
Pfam:zf-C2H2_4 197 209 9.4e-2 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000119142
Gene: ENSMUSG00000067424
AA Change: L80Q

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
KRAB 45 102 5.45e-16 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 G A 12: 118,869,703 (GRCm39) S772L probably benign Het
Ampd2 A T 3: 107,982,590 (GRCm39) V722E probably damaging Het
Appbp2 A T 11: 85,106,067 (GRCm39) F83Y probably damaging Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
B020004C17Rik A T 14: 57,254,273 (GRCm39) Y132F possibly damaging Het
Cnr1 A G 4: 33,944,973 (GRCm39) T454A possibly damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Ctla4 A T 1: 60,951,911 (GRCm39) T147S probably damaging Het
Ctsa T C 2: 164,677,101 (GRCm39) L152P probably damaging Het
Dgkh T C 14: 78,862,293 (GRCm39) T225A probably damaging Het
Dsg1a A T 18: 20,464,590 (GRCm39) I362F possibly damaging Het
Dzank1 C T 2: 144,324,050 (GRCm39) probably null Het
Ephb2 A T 4: 136,386,948 (GRCm39) C760S probably null Het
Exoc1 T A 5: 76,706,989 (GRCm39) V512E probably benign Het
Faiml C A 9: 99,111,587 (GRCm39) K157N probably benign Het
Fpr2 C T 17: 18,113,604 (GRCm39) T200I probably benign Het
Fscn3 C T 6: 28,430,432 (GRCm39) R201* probably null Het
Hcrtr1 A T 4: 130,029,514 (GRCm39) L189Q probably damaging Het
Igkv4-62 T C 6: 69,376,832 (GRCm39) T84A probably benign Het
Krtap2-4 C A 11: 99,505,437 (GRCm39) R58L possibly damaging Het
Meis1 C T 11: 18,833,987 (GRCm39) probably null Het
Mfsd2b T A 12: 4,915,747 (GRCm39) I422F probably damaging Het
Mre11a G A 9: 14,716,716 (GRCm39) V304M probably damaging Het
Myo5a A G 9: 75,023,496 (GRCm39) E19G probably damaging Het
Ndufa10 A T 1: 92,367,614 (GRCm39) Y339N probably damaging Het
Odad1 T C 7: 45,597,821 (GRCm39) V577A probably benign Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Pcdh15 CAGAGA CAGA 10: 74,481,663 (GRCm39) probably null Het
Pcdh18 G A 3: 49,699,615 (GRCm39) P949L probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Perm1 TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT 4: 156,302,525 (GRCm39) probably benign Het
Plin4 A G 17: 56,413,995 (GRCm39) V210A probably benign Het
Rnf150 T C 8: 83,762,722 (GRCm39) M319T possibly damaging Het
Rnf180 CGAGG CGAGGAGG 13: 105,386,781 (GRCm39) probably benign Het
Ruvbl2 G A 7: 45,071,618 (GRCm39) Q422* probably null Het
Shroom1 C T 11: 53,354,217 (GRCm39) R46C probably damaging Het
Slc22a2 T C 17: 12,805,732 (GRCm39) F161S probably damaging Het
Src T A 2: 157,311,676 (GRCm39) M468K probably damaging Het
Stag3 T C 5: 138,297,601 (GRCm39) F606L possibly damaging Het
Stau1 T C 2: 166,797,038 (GRCm39) T120A probably benign Het
Sulf2 A C 2: 165,936,444 (GRCm39) L174R Het
Sumf1 A C 6: 108,150,363 (GRCm39) F156C probably damaging Het
Tenm2 T A 11: 36,032,396 (GRCm39) D708V probably damaging Het
Tmprss12 A C 15: 100,190,622 (GRCm39) I331L possibly damaging Het
Tnfrsf10b T G 14: 70,010,849 (GRCm39) C85G probably damaging Het
Trav10d C A 14: 53,048,845 (GRCm39) Q79K probably benign Het
Vmn1r236 T A 17: 21,507,756 (GRCm39) Y291* probably null Het
Vmn2r115 T C 17: 23,578,915 (GRCm39) I796T possibly damaging Het
Zfp189 T A 4: 49,529,942 (GRCm39) H348Q possibly damaging Het
Other mutations in Zfp563
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01629:Zfp563 APN 17 33,323,600 (GRCm39) missense probably damaging 1.00
IGL01981:Zfp563 APN 17 33,324,383 (GRCm39) missense probably benign 0.16
IGL02407:Zfp563 APN 17 33,323,795 (GRCm39) missense probably benign 0.00
IGL02662:Zfp563 APN 17 33,321,253 (GRCm39) missense probably damaging 1.00
IGL03220:Zfp563 APN 17 33,323,661 (GRCm39) missense probably benign 0.44
R0241:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0241:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0537:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0552:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R1544:Zfp563 UTSW 17 33,324,187 (GRCm39) missense probably benign 0.01
R3763:Zfp563 UTSW 17 33,323,902 (GRCm39) nonsense probably null
R3979:Zfp563 UTSW 17 33,324,701 (GRCm39) missense probably benign 0.03
R4938:Zfp563 UTSW 17 33,324,683 (GRCm39) missense probably damaging 1.00
R5280:Zfp563 UTSW 17 33,323,812 (GRCm39) missense probably damaging 0.99
R5383:Zfp563 UTSW 17 33,323,681 (GRCm39) missense probably benign
R5485:Zfp563 UTSW 17 33,308,540 (GRCm39) unclassified probably benign
R5524:Zfp563 UTSW 17 33,321,515 (GRCm39) critical splice acceptor site probably null
R5567:Zfp563 UTSW 17 33,308,431 (GRCm39) unclassified probably benign
R5736:Zfp563 UTSW 17 33,323,960 (GRCm39) missense possibly damaging 0.91
R5758:Zfp563 UTSW 17 33,323,894 (GRCm39) missense probably damaging 1.00
R6034:Zfp563 UTSW 17 33,323,935 (GRCm39) missense probably damaging 0.96
R6034:Zfp563 UTSW 17 33,323,935 (GRCm39) missense probably damaging 0.96
R6532:Zfp563 UTSW 17 33,324,672 (GRCm39) missense probably benign 0.21
R9241:Zfp563 UTSW 17 33,321,520 (GRCm39) missense probably benign 0.10
R9360:Zfp563 UTSW 17 33,324,428 (GRCm39) missense probably benign 0.38
R9453:Zfp563 UTSW 17 33,308,565 (GRCm39) missense
RF007:Zfp563 UTSW 17 33,323,999 (GRCm39) missense probably benign
X0023:Zfp563 UTSW 17 33,324,695 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATACCCTGTGAACTGCTTGGAG -3'
(R):5'- TGTCCTAAAATGCAGAGCCAG -3'

Sequencing Primer
(F):5'- GAGAAGGTATCTACTTTACAGCGCTG -3'
(R):5'- AATGCAGAGCCAGAAAAATTATTATG -3'
Posted On 2022-05-16