Incidental Mutation 'R9411:Msra'
ID 711825
Institutional Source Beutler Lab
Gene Symbol Msra
Ensembl Gene ENSMUSG00000054733
Gene Name methionine sulfoxide reductase A
Synonyms 2310045J23Rik, 6530413P12Rik, MSR-A
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R9411 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 64360074-64693352 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64471331 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 126 (I126T)
Ref Sequence ENSEMBL: ENSMUSP00000065754 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067927] [ENSMUST00000210363] [ENSMUST00000210428]
AlphaFold Q9D6Y7
PDB Structure Solution structure of murine myristoylated msrA [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000067927
AA Change: I126T

PolyPhen 2 Score 0.252 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000065754
Gene: ENSMUSG00000054733
AA Change: I126T

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
Pfam:PMSR 65 219 2.4e-68 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210363
AA Change: I62T

PolyPhen 2 Score 0.252 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000210428
AA Change: I84T

PolyPhen 2 Score 0.056 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Mice homozygous for disruptions in this allele display an increased sensitivity to oxidative stress, reductions in related enzyme levels, and reduced life spans. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 G A 13: 91,919,919 (GRCm39) A285T probably damaging Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Atg7 T A 6: 114,690,289 (GRCm39) M650K probably benign Het
B020011L13Rik G A 1: 117,729,246 (GRCm39) G251E probably benign Het
Bhlha9 T C 11: 76,564,018 (GRCm39) V215A probably benign Het
Bmal1 C A 7: 112,907,837 (GRCm39) S513* probably null Het
C2cd3 T C 7: 100,065,704 (GRCm39) V452A Het
Cd55 G A 1: 130,368,114 (GRCm39) H370Y probably benign Het
Col6a1 A G 10: 76,547,487 (GRCm39) V662A unknown Het
Crocc A G 4: 140,749,577 (GRCm39) probably null Het
Cspg4b T A 13: 113,504,767 (GRCm39) N1965K Het
Dnah1 C T 14: 31,018,256 (GRCm39) V1421M probably damaging Het
Eid3 T G 10: 82,703,652 (GRCm39) I371S probably damaging Het
Flnc G A 6: 29,441,484 (GRCm39) R422Q probably benign Het
Fshr T C 17: 89,293,148 (GRCm39) Y510C probably damaging Het
Garem1 C T 18: 21,369,057 (GRCm39) probably null Het
Gcn1 C T 5: 115,733,098 (GRCm39) T1045M possibly damaging Het
Ggt6 T A 11: 72,326,560 (GRCm39) L39H probably damaging Het
Glrb T C 3: 80,767,610 (GRCm39) probably null Het
Gpr171 T A 3: 59,005,311 (GRCm39) K155* probably null Het
Has2 T A 15: 56,531,306 (GRCm39) T470S possibly damaging Het
Ighv1-34 C T 12: 114,815,070 (GRCm39) V31M probably damaging Het
Kdm2a A T 19: 4,412,835 (GRCm39) N50K probably damaging Het
Mfsd9 C T 1: 40,829,692 (GRCm39) V30M probably damaging Het
Nkd2 G A 13: 73,969,330 (GRCm39) L379F probably benign Het
Nr2f2 A C 7: 70,007,525 (GRCm39) V319G Het
Ntng2 A T 2: 29,138,048 (GRCm39) L2Q probably damaging Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Pcnt T C 10: 76,258,896 (GRCm39) E523G probably damaging Het
Pllp C T 8: 95,402,868 (GRCm39) A158T probably benign Het
Plxna4 A G 6: 32,159,682 (GRCm39) S1431P probably damaging Het
Pramel16 A T 4: 143,676,215 (GRCm39) F296L probably damaging Het
Pramel31 A G 4: 144,089,997 (GRCm39) I346V probably benign Het
Prpf40a T C 2: 53,029,200 (GRCm39) D951G unknown Het
Retn G A 8: 3,707,378 (GRCm39) A113T probably benign Het
Rexo1 G T 10: 80,397,248 (GRCm39) R3S Het
Rras T A 7: 44,669,979 (GRCm39) I137N possibly damaging Het
Rsf1 A AAGGCGACGG 7: 97,229,111 (GRCm39) probably null Het
Sntb2 A G 8: 107,737,931 (GRCm39) D493G probably damaging Het
Socs5 T C 17: 87,442,521 (GRCm39) I487T possibly damaging Het
Spryd3 A G 15: 102,027,843 (GRCm39) Y235H probably damaging Het
Suco T A 1: 161,666,356 (GRCm39) I515F probably damaging Het
Syn2 T C 6: 115,231,152 (GRCm39) V269A possibly damaging Het
Tmbim6 T C 15: 99,304,501 (GRCm39) L186P probably damaging Het
Tmem234 T C 4: 129,495,988 (GRCm39) Y57H probably damaging Het
Tnik C A 3: 28,684,754 (GRCm39) P861T probably damaging Het
Tns1 A G 1: 73,992,662 (GRCm39) L45P probably damaging Het
Veph1 T A 3: 65,995,238 (GRCm39) D671V possibly damaging Het
Vwc2l A T 1: 70,767,980 (GRCm39) I15F probably benign Het
Zdbf2 A T 1: 63,343,288 (GRCm39) N556Y probably damaging Het
Zfp202 T A 9: 40,118,878 (GRCm39) V97D probably damaging Het
Zfp800 T C 6: 28,243,430 (GRCm39) I512V possibly damaging Het
Zkscan2 T C 7: 123,084,405 (GRCm39) D573G probably damaging Het
Other mutations in Msra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00898:Msra APN 14 64,360,774 (GRCm39) missense probably damaging 0.99
IGL01301:Msra APN 14 64,447,884 (GRCm39) missense probably damaging 1.00
IGL02500:Msra APN 14 64,522,637 (GRCm39) splice site probably benign
IGL03227:Msra APN 14 64,551,192 (GRCm39) missense probably benign 0.06
ANU18:Msra UTSW 14 64,447,884 (GRCm39) missense probably damaging 1.00
R0485:Msra UTSW 14 64,678,210 (GRCm39) missense possibly damaging 0.64
R0632:Msra UTSW 14 64,447,981 (GRCm39) missense probably benign 0.04
R1557:Msra UTSW 14 64,360,775 (GRCm39) missense possibly damaging 0.75
R1940:Msra UTSW 14 64,522,505 (GRCm39) splice site probably benign
R2133:Msra UTSW 14 64,471,377 (GRCm39) missense probably damaging 1.00
R2135:Msra UTSW 14 64,360,657 (GRCm39) missense probably damaging 1.00
R6119:Msra UTSW 14 64,678,183 (GRCm39) missense probably damaging 1.00
R6602:Msra UTSW 14 64,360,788 (GRCm39) missense probably benign 0.01
R7233:Msra UTSW 14 64,360,714 (GRCm39) missense probably damaging 1.00
R7249:Msra UTSW 14 64,678,212 (GRCm39) missense probably benign 0.17
R8047:Msra UTSW 14 64,522,612 (GRCm39) missense probably damaging 1.00
R9271:Msra UTSW 14 64,471,269 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GCAATCATATTCTTGAGCTCCTG -3'
(R):5'- ATAACCGGGGACTGAGACTG -3'

Sequencing Primer
(F):5'- CCTGTGTGATTTCAAGGTTCATC -3'
(R):5'- GAAATCCAATTACACTTGTACCCTTC -3'
Posted On 2022-05-16