Incidental Mutation 'R9412:Vmn2r9'
| ID |
711842 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r9
|
| Ensembl Gene |
ENSMUSG00000091624 |
| Gene Name |
vomeronasal 2, receptor 9 |
| Synonyms |
EG435864 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R9412 (G1)
|
| Quality Score |
136.008 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
108990813-109000376 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 108991484 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 626
(I626F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170419]
|
| AlphaFold |
K7N6Z8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170419
AA Change: I626F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: I626F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
412 |
8.1e-29 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
2.3e-16 |
PFAM |
|
Pfam:7tm_3
|
592 |
829 |
3.4e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700029H14Rik |
T |
A |
8: 13,604,695 (GRCm39) |
T203S |
possibly damaging |
Het |
| 2700049A03Rik |
G |
A |
12: 71,235,457 (GRCm39) |
E1136K |
possibly damaging |
Het |
| Abca6 |
C |
A |
11: 110,103,059 (GRCm39) |
R844L |
probably damaging |
Het |
| Abcb9 |
C |
T |
5: 124,221,753 (GRCm39) |
R207Q |
probably benign |
Het |
| Abcd4 |
T |
C |
12: 84,655,581 (GRCm39) |
R343G |
probably damaging |
Het |
| Arhgap45 |
T |
A |
10: 79,855,564 (GRCm39) |
M1K |
probably null |
Het |
| Art3 |
A |
G |
5: 92,541,013 (GRCm39) |
Y252C |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,525,230 (GRCm39) |
M475T |
probably benign |
Het |
| Atxn2 |
C |
T |
5: 121,940,201 (GRCm39) |
P992L |
possibly damaging |
Het |
| Dclk3 |
G |
A |
9: 111,311,819 (GRCm39) |
|
probably null |
Het |
| Ddx21 |
T |
C |
10: 62,429,881 (GRCm39) |
T288A |
possibly damaging |
Het |
| Fat3 |
T |
C |
9: 15,908,703 (GRCm39) |
D2433G |
probably damaging |
Het |
| Flnc |
G |
A |
6: 29,441,484 (GRCm39) |
R422Q |
probably benign |
Het |
| Fmnl2 |
G |
T |
2: 53,007,016 (GRCm39) |
R776L |
unknown |
Het |
| Fndc1 |
T |
A |
17: 7,991,198 (GRCm39) |
T833S |
unknown |
Het |
| Igf1r |
T |
A |
7: 67,857,001 (GRCm39) |
Y988N |
probably damaging |
Het |
| Ints2 |
T |
C |
11: 86,117,589 (GRCm39) |
Y711C |
probably damaging |
Het |
| Irx5 |
A |
G |
8: 93,086,351 (GRCm39) |
K145E |
probably damaging |
Het |
| Kdm5a |
A |
G |
6: 120,365,991 (GRCm39) |
Y377C |
probably damaging |
Het |
| Lrp1 |
T |
A |
10: 127,409,287 (GRCm39) |
T1611S |
probably damaging |
Het |
| Lrrc28 |
T |
A |
7: 67,181,512 (GRCm39) |
E241V |
probably damaging |
Het |
| Med23 |
T |
C |
10: 24,778,019 (GRCm39) |
F789S |
probably damaging |
Het |
| Ncapd3 |
C |
T |
9: 26,967,451 (GRCm39) |
Q596* |
probably null |
Het |
| Nrde2 |
C |
A |
12: 100,096,681 (GRCm39) |
E1040* |
probably null |
Het |
| Or2n1d |
A |
T |
17: 38,646,320 (GRCm39) |
T91S |
possibly damaging |
Het |
| Pcdh15 |
CAGAGA |
CAGA |
10: 74,481,663 (GRCm39) |
|
probably null |
Het |
| Pcm1 |
T |
G |
8: 41,740,788 (GRCm39) |
N972K |
probably damaging |
Het |
| Peg10 |
C |
CTCT |
6: 4,756,453 (GRCm39) |
|
probably benign |
Het |
| Pla2g4a |
T |
C |
1: 149,755,772 (GRCm39) |
T222A |
probably damaging |
Het |
| Ptchd3 |
A |
T |
11: 121,732,779 (GRCm39) |
K556N |
possibly damaging |
Het |
| Relch |
A |
G |
1: 105,662,288 (GRCm39) |
T936A |
probably benign |
Het |
| Scap |
T |
C |
9: 110,207,673 (GRCm39) |
C461R |
possibly damaging |
Het |
| Scgb1b10 |
T |
A |
7: 31,800,627 (GRCm39) |
L72* |
probably null |
Het |
| Serpinb6c |
C |
A |
13: 34,081,371 (GRCm39) |
A93S |
probably benign |
Het |
| Serpinb9c |
C |
A |
13: 33,334,231 (GRCm39) |
L298F |
probably damaging |
Het |
| Slf2 |
A |
T |
19: 44,930,460 (GRCm39) |
E512D |
probably benign |
Het |
| Snapc3 |
C |
T |
4: 83,354,570 (GRCm39) |
H194Y |
probably benign |
Het |
| Suox |
T |
A |
10: 128,507,758 (GRCm39) |
D90V |
possibly damaging |
Het |
| Supt20 |
TCAGCAGCAGCAGCAGCAGCAGCA |
TCAGCAGCAGCAGCAGCAGCA |
3: 54,635,069 (GRCm39) |
|
probably benign |
Het |
| Tert |
C |
T |
13: 73,797,046 (GRCm39) |
R1095W |
probably benign |
Het |
| Tut4 |
A |
T |
4: 108,414,561 (GRCm39) |
H46L |
|
Het |
| Unc13c |
T |
C |
9: 73,839,772 (GRCm39) |
I360V |
probably benign |
Het |
| Uqcc1 |
A |
G |
2: 155,693,329 (GRCm39) |
C235R |
probably benign |
Het |
| Vmn2r90 |
T |
G |
17: 17,954,213 (GRCm39) |
C792W |
probably damaging |
Het |
| Zfp57 |
C |
T |
17: 37,320,814 (GRCm39) |
P223S |
probably benign |
Het |
| Zfp787 |
T |
C |
7: 6,135,946 (GRCm39) |
T102A |
probably damaging |
Het |
|
| Other mutations in Vmn2r9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00920:Vmn2r9
|
APN |
5 |
108,995,890 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00972:Vmn2r9
|
APN |
5 |
108,996,903 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01102:Vmn2r9
|
APN |
5 |
108,990,811 (GRCm39) |
splice site |
probably null |
|
|
IGL01892:Vmn2r9
|
APN |
5 |
108,995,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02086:Vmn2r9
|
APN |
5 |
108,995,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02119:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02120:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02123:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02131:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02132:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02171:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02186:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02346:Vmn2r9
|
APN |
5 |
108,990,850 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02508:Vmn2r9
|
APN |
5 |
108,996,067 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02815:Vmn2r9
|
APN |
5 |
108,990,856 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL03077:Vmn2r9
|
APN |
5 |
108,996,173 (GRCm39) |
splice site |
probably benign |
|
|
IGL03269:Vmn2r9
|
APN |
5 |
108,995,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Vmn2r9
|
APN |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r9
|
UTSW |
5 |
108,990,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0328:Vmn2r9
|
UTSW |
5 |
108,995,405 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0382:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Vmn2r9
|
UTSW |
5 |
108,996,154 (GRCm39) |
nonsense |
probably null |
|
|
R0975:Vmn2r9
|
UTSW |
5 |
108,991,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Vmn2r9
|
UTSW |
5 |
108,995,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Vmn2r9
|
UTSW |
5 |
108,996,850 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1704:Vmn2r9
|
UTSW |
5 |
108,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Vmn2r9
|
UTSW |
5 |
108,995,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1991:Vmn2r9
|
UTSW |
5 |
108,994,305 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2410:Vmn2r9
|
UTSW |
5 |
108,996,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3419:Vmn2r9
|
UTSW |
5 |
108,994,299 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3852:Vmn2r9
|
UTSW |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3873:Vmn2r9
|
UTSW |
5 |
108,995,701 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3905:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3908:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3921:Vmn2r9
|
UTSW |
5 |
108,996,921 (GRCm39) |
missense |
probably benign |
|
|
R4156:Vmn2r9
|
UTSW |
5 |
108,995,743 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4477:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4478:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4544:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4546:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4627:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Vmn2r9
|
UTSW |
5 |
108,994,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5361:Vmn2r9
|
UTSW |
5 |
108,995,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Vmn2r9
|
UTSW |
5 |
108,995,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6054:Vmn2r9
|
UTSW |
5 |
108,996,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6106:Vmn2r9
|
UTSW |
5 |
108,992,902 (GRCm39) |
missense |
probably benign |
|
|
R6125:Vmn2r9
|
UTSW |
5 |
108,990,836 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6137:Vmn2r9
|
UTSW |
5 |
108,996,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r9
|
UTSW |
5 |
108,996,912 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7579:Vmn2r9
|
UTSW |
5 |
108,992,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8683:Vmn2r9
|
UTSW |
5 |
108,996,873 (GRCm39) |
missense |
probably benign |
|
|
R8964:Vmn2r9
|
UTSW |
5 |
108,996,031 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9022:Vmn2r9
|
UTSW |
5 |
108,992,923 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9118:Vmn2r9
|
UTSW |
5 |
108,990,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9125:Vmn2r9
|
UTSW |
5 |
108,996,047 (GRCm39) |
missense |
|
|
|
R9240:Vmn2r9
|
UTSW |
5 |
108,996,099 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9327:Vmn2r9
|
UTSW |
5 |
108,996,841 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9499:Vmn2r9
|
UTSW |
5 |
108,995,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Vmn2r9
|
UTSW |
5 |
108,995,908 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9790:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9791:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCTGGAGTAGTGAGCTTG -3'
(R):5'- GAACAGTGTGTGAGTTGTACAG -3'
Sequencing Primer
(F):5'- GCTTGAAAGCCATGAGCAC -3'
(R):5'- GAGTTGTACAGGTGATAAATATGCC -3'
|
| Posted On |
2022-05-16 |
Incidental Mutation