Incidental Mutation 'R9413:Or2n1d'
ID 711910
Institutional Source Beutler Lab
Gene Symbol Or2n1d
Ensembl Gene ENSMUSG00000096840
Gene Name olfactory receptor family 2 subfamily N member 1D
Synonyms Olfr136, MOR256-7, GA_x6K02T2PSCP-2779375-2780313
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R9413 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38646050-38646988 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38646320 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 91 (T91S)
Ref Sequence ENSEMBL: ENSMUSP00000146828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077203] [ENSMUST00000208525] [ENSMUST00000208539] [ENSMUST00000214035] [ENSMUST00000216963]
AlphaFold Q8VG72
Predicted Effect possibly damaging
Transcript: ENSMUST00000077203
AA Change: T91S

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000076443
Gene: ENSMUSG00000096840
AA Change: T91S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-48 PFAM
Pfam:7tm_1 41 290 7.1e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208525
AA Change: T91S

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000208539
AA Change: T91S

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214035
AA Change: T91S

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216963
AA Change: T91S

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (35/36)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A T 7: 120,126,422 (GRCm39) T1194S probably benign Het
Akr7a5 A T 4: 139,038,059 (GRCm39) probably benign Het
Ap3b2 G T 7: 81,127,757 (GRCm39) P140T possibly damaging Het
Ap3s1 T C 18: 46,887,531 (GRCm39) probably null Het
Arrdc2 C T 8: 71,288,892 (GRCm39) R381H probably damaging Het
Atg13 T C 2: 91,511,970 (GRCm39) D286G probably benign Het
C1qtnf4 T C 2: 90,720,648 (GRCm39) F307S probably damaging Het
Cdk5rap1 A T 2: 154,207,880 (GRCm39) probably null Het
Chsy3 C T 18: 59,309,170 (GRCm39) A141V possibly damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
D5Ertd579e A G 5: 36,772,278 (GRCm39) S706P probably damaging Het
Ell2 A G 13: 75,917,705 (GRCm39) D545G Het
Ephb6 T C 6: 41,591,509 (GRCm39) L222P Het
Flnc G A 6: 29,441,484 (GRCm39) R422Q probably benign Het
Gm6619 A T 6: 131,468,370 (GRCm39) D167V unknown Het
Gucy2c T C 6: 136,700,771 (GRCm39) D581G possibly damaging Het
Hectd1 G A 12: 51,792,880 (GRCm39) R2471* probably null Het
Kif1a A T 1: 92,949,019 (GRCm39) M1501K probably benign Het
Mycbpap A G 11: 94,392,321 (GRCm39) V390A probably damaging Het
Pex3 A G 10: 13,410,454 (GRCm39) Y236H probably damaging Het
Pglyrp3 G T 3: 91,930,106 (GRCm39) A91S probably damaging Het
Ppp1ca T C 19: 4,244,897 (GRCm39) S292P probably damaging Het
Prkci T C 3: 31,097,915 (GRCm39) V455A probably damaging Het
Prrx1 A G 1: 163,140,182 (GRCm39) V8A probably benign Het
Psd4 C T 2: 24,287,472 (GRCm39) T468I probably benign Het
Rnf213 A G 11: 119,357,059 (GRCm39) E4203G Het
Snrnp27 T C 6: 86,653,255 (GRCm39) D121G possibly damaging Het
Spag6 A T 2: 18,739,029 (GRCm39) M320L probably benign Het
Spata16 T A 3: 26,978,486 (GRCm39) M484K possibly damaging Het
Trim69 G A 2: 122,009,083 (GRCm39) W381* probably null Het
Tubgcp3 A C 8: 12,674,885 (GRCm39) I745S probably damaging Het
Ubxn2b A G 4: 6,204,607 (GRCm39) D156G probably damaging Het
Vmn2r103 A G 17: 20,032,158 (GRCm39) N644S possibly damaging Het
Other mutations in Or2n1d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01712:Or2n1d APN 17 38,646,848 (GRCm39) missense probably benign 0.00
IGL01787:Or2n1d APN 17 38,646,470 (GRCm39) missense probably damaging 0.98
IGL02480:Or2n1d APN 17 38,646,314 (GRCm39) missense probably benign 0.32
IGL02603:Or2n1d APN 17 38,646,404 (GRCm39) missense probably damaging 1.00
IGL03122:Or2n1d APN 17 38,646,192 (GRCm39) missense probably benign 0.01
BB009:Or2n1d UTSW 17 38,646,146 (GRCm39) missense probably benign 0.01
BB019:Or2n1d UTSW 17 38,646,146 (GRCm39) missense probably benign 0.01
R0295:Or2n1d UTSW 17 38,646,182 (GRCm39) missense probably damaging 1.00
R0684:Or2n1d UTSW 17 38,646,735 (GRCm39) missense probably benign 0.11
R1874:Or2n1d UTSW 17 38,646,860 (GRCm39) missense probably damaging 1.00
R3436:Or2n1d UTSW 17 38,646,323 (GRCm39) missense probably damaging 1.00
R3437:Or2n1d UTSW 17 38,646,323 (GRCm39) missense probably damaging 1.00
R4714:Or2n1d UTSW 17 38,646,731 (GRCm39) missense possibly damaging 0.65
R4715:Or2n1d UTSW 17 38,646,731 (GRCm39) missense possibly damaging 0.65
R4716:Or2n1d UTSW 17 38,646,731 (GRCm39) missense possibly damaging 0.65
R4878:Or2n1d UTSW 17 38,646,518 (GRCm39) missense probably benign
R5296:Or2n1d UTSW 17 38,646,347 (GRCm39) nonsense probably null
R5370:Or2n1d UTSW 17 38,646,335 (GRCm39) nonsense probably null
R5413:Or2n1d UTSW 17 38,646,515 (GRCm39) missense probably benign 0.03
R5988:Or2n1d UTSW 17 38,646,911 (GRCm39) missense probably damaging 1.00
R6156:Or2n1d UTSW 17 38,646,064 (GRCm39) missense probably damaging 0.99
R6550:Or2n1d UTSW 17 38,646,896 (GRCm39) missense possibly damaging 0.65
R7395:Or2n1d UTSW 17 38,646,755 (GRCm39) nonsense probably null
R7417:Or2n1d UTSW 17 38,646,183 (GRCm39) missense probably damaging 1.00
R7746:Or2n1d UTSW 17 38,646,285 (GRCm39) missense probably benign 0.16
R7747:Or2n1d UTSW 17 38,646,285 (GRCm39) missense probably benign 0.16
R7821:Or2n1d UTSW 17 38,646,855 (GRCm39) missense probably benign 0.13
R7932:Or2n1d UTSW 17 38,646,146 (GRCm39) missense probably benign 0.01
R8409:Or2n1d UTSW 17 38,646,197 (GRCm39) missense probably benign 0.09
R8911:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R8912:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R8913:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R8914:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R8968:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9006:Or2n1d UTSW 17 38,646,723 (GRCm39) missense possibly damaging 0.84
R9044:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9110:Or2n1d UTSW 17 38,646,434 (GRCm39) missense probably damaging 1.00
R9155:Or2n1d UTSW 17 38,646,224 (GRCm39) missense probably damaging 0.99
R9279:Or2n1d UTSW 17 38,646,414 (GRCm39) missense probably damaging 0.99
R9289:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9295:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9317:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9318:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9348:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9409:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9410:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9411:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9412:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9512:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9522:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
R9524:Or2n1d UTSW 17 38,646,540 (GRCm39) nonsense probably null
R9547:Or2n1d UTSW 17 38,646,341 (GRCm39) missense possibly damaging 0.80
R9580:Or2n1d UTSW 17 38,646,320 (GRCm39) missense possibly damaging 0.94
V5088:Or2n1d UTSW 17 38,646,050 (GRCm39) start codon destroyed probably null 0.99
Z1176:Or2n1d UTSW 17 38,646,243 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGCTTTGCTAACCATCCTTG -3'
(R):5'- GCAAAGATCACGCCAGTCAG -3'

Sequencing Primer
(F):5'- ACTCTTCTGATAACATATCCCATGG -3'
(R):5'- CGCCAGTCAGCCACATAATAG -3'
Posted On 2022-05-16