Mutagenetix > Incidental Mutation

Incidental Mutation 'R9414:Tenm4'

711940

Institutional Source

Beutler Lab

Gene Symbol

Tenm4

Ensembl Gene

ENSMUSG00000048078

Gene Name

teneurin transmembrane protein 4

Synonyms

l7Rn3, Doc4, Ten-m4, ELM2, l(7)-3Rn, Odz4

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9414 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

95820453-96560300 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 96545367 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 2498 (E2498G)

Ref Sequence

ENSEMBL: ENSMUSP00000102783 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000107162
AA Change: E2490G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000102780
Gene: ENSMUSG00000048078
AA Change: E2490G

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	410	5.6e-195	PFAM
transmembrane domain	411	433	N/A	INTRINSIC
EGF_like	637	665	3.43e1	SMART
EGF	668	696	2.29e1	SMART
EGF	701	730	1.88e-1	SMART
EGF	733	762	1.13e1	SMART
EGF	767	797	2.39e1	SMART
EGF	800	828	4.32e-1	SMART
EGF	831	859	6.02e0	SMART
EGF	862	894	9.93e-1	SMART
low complexity region	900	914	N/A	INTRINSIC
Pfam:RHS_repeat	2327	2380	5.5e-7	PFAM
Pfam:Tox-GHH	2740	2818	5.2e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000107165
AA Change: E2498G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000102783
Gene: ENSMUSG00000048078
AA Change: E2498G

Domain	Start	End	E-Value	Type
Pfam:Ten_N	36	402	1.1e-171	PFAM
transmembrane domain	403	425	N/A	INTRINSIC
EGF_like	629	657	3.43e1	SMART
EGF	660	688	2.29e1	SMART
EGF	693	722	1.88e-1	SMART
EGF	725	754	1.13e1	SMART
EGF	759	789	2.39e1	SMART
EGF	792	820	4.32e-1	SMART
EGF	823	851	6.02e0	SMART
EGF	863	895	9.93e-1	SMART
low complexity region	901	915	N/A	INTRINSIC
Pfam:RHS_repeat	2335	2368	1.6e-7	PFAM
Pfam:Tox-GHH	2749	2826	1.8e-32	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000107166
AA Change: E2461G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000102784
Gene: ENSMUSG00000048078
AA Change: E2461G

Domain	Start	End	E-Value	Type
Pfam:Ten_N	35	193	1.4e-83	PFAM
Pfam:Ten_N	187	365	5e-78	PFAM
transmembrane domain	366	388	N/A	INTRINSIC
EGF_like	592	620	3.43e1	SMART
EGF	623	651	2.29e1	SMART
EGF	656	685	1.88e-1	SMART
EGF	688	717	1.13e1	SMART
EGF	722	752	2.39e1	SMART
EGF	755	783	4.32e-1	SMART
EGF	786	814	6.02e0	SMART
EGF	826	858	9.93e-1	SMART
low complexity region	864	878	N/A	INTRINSIC
Pfam:RHS_repeat	2298	2351	3.8e-7	PFAM
Pfam:Tox-GHH	2711	2789	3.9e-34	PFAM

Meta Mutation Damage Score

0.0582

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.7%

Validation Efficiency

98% (59/60)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	T	11: 110,035,100 (GRCm39)	I689K	probably damaging	Het
Agtpbp1	G	T	13: 59,609,902 (GRCm39)	T1076K	probably damaging	Het
Ammecr1l	A	G	18: 31,904,962 (GRCm39)	T68A	probably benign	Het
Arvcf	A	G	16: 18,215,580 (GRCm39)	E264G	probably damaging	Het
Cacna1b	C	T	2: 24,538,514 (GRCm39)	D1542N	probably damaging	Het
Cacna2d2	A	G	9: 107,392,395 (GRCm39)	T512A	probably damaging	Het
Crebbp	A	G	16: 3,925,356 (GRCm39)	C1213R	probably damaging	Het
Cybrd1	G	T	2: 70,948,567 (GRCm39)	R35L	probably damaging	Het
Dcaf1	G	A	9: 106,757,158 (GRCm39)	W1412*	probably null	Het
Eif4e	T	A	3: 138,253,495 (GRCm39)	D67E	probably benign	Het
Epb41	G	A	4: 131,702,162 (GRCm39)	T491I	probably damaging	Het
Fez1	G	A	9: 36,779,247 (GRCm39)	S308N	probably benign	Het
Fgfr3	A	G	5: 33,887,298 (GRCm39)	S206G	possibly damaging	Het
Flcn	A	T	11: 59,684,998 (GRCm39)	N484K	possibly damaging	Het
Gdap2	T	C	3: 100,090,071 (GRCm39)		probably null	Het
Gfpt1	T	A	6: 87,062,265 (GRCm39)	D541E	probably benign	Het
Gm5089	A	G	14: 122,673,604 (GRCm39)	F39S	unknown	Het
Gm7694	C	T	1: 170,130,173 (GRCm39)	G75D	probably benign	Het
Gpr15	A	G	16: 58,538,516 (GRCm39)	L191S	probably benign	Het
Hmcn1	T	G	1: 150,545,187 (GRCm39)	T2807P	probably damaging	Het
Iqgap2	T	C	13: 95,783,349 (GRCm39)	T1276A		Het
Itgae	G	T	11: 73,002,629 (GRCm39)	A129S	possibly damaging	Het
Kcns1	T	C	2: 164,010,378 (GRCm39)	E127G	probably damaging	Het
Kmt2b	T	C	7: 30,282,307 (GRCm39)	E1118G	probably damaging	Het
Lair1	T	C	7: 4,013,819 (GRCm39)	I143V	probably benign	Het
Lcmt2	T	C	2: 120,970,621 (GRCm39)	D154G	possibly damaging	Het
Ly9	T	C	1: 171,427,275 (GRCm39)	T427A	probably damaging	Het
Man2c1	A	G	9: 57,044,030 (GRCm39)	T281A	possibly damaging	Het
Map4k2	T	C	19: 6,394,515 (GRCm39)	F332L	probably benign	Het
Meak7	A	T	8: 120,495,081 (GRCm39)	S226T	probably benign	Het
Mmp10	A	T	9: 7,502,489 (GRCm39)	D32V	probably benign	Het
Mroh2a	C	T	1: 88,179,096 (GRCm39)	R1110W	probably benign	Het
Naip2	T	A	13: 100,298,243 (GRCm39)	S598C	probably damaging	Het
Npnt	T	C	3: 132,612,116 (GRCm39)	N300S	probably benign	Het
Or13a20	C	A	7: 140,232,263 (GRCm39)	R124S	probably damaging	Het
Or5b95	T	C	19: 12,657,712 (GRCm39)	V80A	probably benign	Het
Or5k15	G	A	16: 58,710,565 (GRCm39)	T6I	probably benign	Het
Pacsin1	T	C	17: 27,926,985 (GRCm39)	V387A	probably damaging	Het
Pald1	G	T	10: 61,178,932 (GRCm39)	A489E	probably benign	Het
Pcnx1	G	T	12: 81,964,978 (GRCm39)	G382W	probably damaging	Het
Pde6b	T	A	5: 108,567,592 (GRCm39)	M294K	possibly damaging	Het
Phf20	T	C	2: 156,136,167 (GRCm39)	V662A	probably benign	Het
Plcg1	T	C	2: 160,603,276 (GRCm39)	I1149T	possibly damaging	Het
Prdx2	T	C	8: 85,697,196 (GRCm39)	S79P	probably damaging	Het
Rab19	T	C	6: 39,360,855 (GRCm39)	M1T	probably null	Het
Retn	T	G	8: 3,706,908 (GRCm39)	F44C	probably damaging	Het
Rp1	A	T	1: 4,313,841 (GRCm39)	W507R	unknown	Het
Rsf1	A	C	7: 97,313,765 (GRCm39)		probably null	Het
Ryr3	C	T	2: 112,501,011 (GRCm39)	E3561K	possibly damaging	Het
Scaf1	T	A	7: 44,652,716 (GRCm39)	Y1220F	unknown	Het
Sowahc	A	G	10: 59,058,491 (GRCm39)	K209R	probably benign	Het
Supt20	T	A	3: 54,610,504 (GRCm39)	I103N	probably damaging	Het
Tet1	T	C	10: 62,674,935 (GRCm39)	N1047S	probably benign	Het
Thap1	CAGCATCTGCTCGGAGCA	CAGCA	8: 26,650,884 (GRCm39)		probably null	Het
Tub	T	A	7: 108,626,265 (GRCm39)	I267N	probably damaging	Het
Uggt1	T	C	1: 36,223,507 (GRCm39)	E594G	probably benign	Het
Vmn2r104	T	A	17: 20,250,250 (GRCm39)	I674F	probably damaging	Het
Zbed6	T	C	1: 133,585,015 (GRCm39)	D774G	probably damaging	Het
Zcchc4	T	C	5: 52,953,964 (GRCm39)	S215P	probably benign	Het
Zfc3h1	T	G	10: 115,249,916 (GRCm39)	S1177A	possibly damaging	Het
Zfp646	G	A	7: 127,481,050 (GRCm39)	A1076T	probably damaging	Het
Zfp735	T	A	11: 73,602,023 (GRCm39)	Y322*	probably null	Het

Other mutations in Tenm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Tenm4	APN	7	96,517,216 (GRCm39)	missense	probably benign	0.00
IGL00468:Tenm4	APN	7	96,523,679 (GRCm39)	missense	probably damaging	0.98
IGL00519:Tenm4	APN	7	96,454,345 (GRCm39)	splice site	probably benign
IGL00979:Tenm4	APN	7	96,378,598 (GRCm39)	missense	probably damaging	0.96
IGL01401:Tenm4	APN	7	96,523,474 (GRCm39)	missense	probably damaging	1.00
IGL01459:Tenm4	APN	7	96,378,592 (GRCm39)	missense	probably damaging	1.00
IGL01519:Tenm4	APN	7	96,544,384 (GRCm39)	missense	probably damaging	1.00
IGL01545:Tenm4	APN	7	96,523,510 (GRCm39)	missense	probably benign	0.00
IGL01579:Tenm4	APN	7	96,512,709 (GRCm39)	missense	probably benign	0.00
IGL01587:Tenm4	APN	7	96,512,709 (GRCm39)	missense	probably benign	0.00
IGL01625:Tenm4	APN	7	96,534,565 (GRCm39)	missense	probably damaging	1.00
IGL01655:Tenm4	APN	7	96,202,931 (GRCm39)	missense	probably damaging	1.00
IGL01683:Tenm4	APN	7	96,534,611 (GRCm39)	missense	possibly damaging	0.84
IGL01728:Tenm4	APN	7	96,545,271 (GRCm39)	missense	probably damaging	1.00
IGL01732:Tenm4	APN	7	96,544,716 (GRCm39)	missense	probably damaging	1.00
IGL01924:Tenm4	APN	7	96,544,419 (GRCm39)	missense	probably damaging	1.00
IGL01966:Tenm4	APN	7	96,202,757 (GRCm39)	missense	probably damaging	1.00
IGL02177:Tenm4	APN	7	96,544,869 (GRCm39)	missense	probably benign	0.40
IGL02207:Tenm4	APN	7	96,523,323 (GRCm39)	missense	possibly damaging	0.85
IGL02269:Tenm4	APN	7	96,473,029 (GRCm39)	missense	probably damaging	1.00
IGL02274:Tenm4	APN	7	96,503,941 (GRCm39)	missense	probably damaging	1.00
IGL02375:Tenm4	APN	7	96,353,344 (GRCm39)	missense	possibly damaging	0.52
IGL02415:Tenm4	APN	7	96,523,281 (GRCm39)	missense	probably damaging	0.98
IGL02472:Tenm4	APN	7	96,423,383 (GRCm39)	unclassified	probably benign
IGL02656:Tenm4	APN	7	96,534,640 (GRCm39)	missense	probably damaging	1.00
IGL02678:Tenm4	APN	7	96,545,426 (GRCm39)	missense	probably damaging	1.00
IGL02829:Tenm4	APN	7	96,544,205 (GRCm39)	nonsense	probably null
IGL02863:Tenm4	APN	7	96,522,913 (GRCm39)	missense	probably damaging	1.00
IGL03145:Tenm4	APN	7	96,492,175 (GRCm39)	missense	probably damaging	0.98
IGL03153:Tenm4	APN	7	96,522,969 (GRCm39)	missense	probably damaging	1.00
principium	UTSW	7	96,446,688 (GRCm39)	missense	probably damaging	0.98
toccata	UTSW	7	96,552,196 (GRCm39)	critical splice donor site	probably null
P0026:Tenm4	UTSW	7	96,523,734 (GRCm39)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,542,133 (GRCm39)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,542,133 (GRCm39)	missense	probably damaging	1.00
R0140:Tenm4	UTSW	7	96,545,259 (GRCm39)	missense	possibly damaging	0.78
R0164:Tenm4	UTSW	7	96,378,547 (GRCm39)	splice site	probably benign
R0277:Tenm4	UTSW	7	96,344,157 (GRCm39)	missense	possibly damaging	0.54
R0323:Tenm4	UTSW	7	96,344,157 (GRCm39)	missense	possibly damaging	0.54
R0362:Tenm4	UTSW	7	96,421,242 (GRCm39)	nonsense	probably null
R0381:Tenm4	UTSW	7	96,555,088 (GRCm39)	missense	probably damaging	1.00
R0420:Tenm4	UTSW	7	96,522,973 (GRCm39)	missense	possibly damaging	0.85
R0426:Tenm4	UTSW	7	96,427,058 (GRCm39)	missense	probably damaging	1.00
R0513:Tenm4	UTSW	7	96,544,830 (GRCm39)	missense	probably benign	0.35
R0624:Tenm4	UTSW	7	96,423,227 (GRCm39)	missense	probably damaging	1.00
R0837:Tenm4	UTSW	7	96,545,482 (GRCm39)	splice site	probably benign
R1037:Tenm4	UTSW	7	96,446,688 (GRCm39)	missense	probably damaging	0.98
R1172:Tenm4	UTSW	7	96,497,251 (GRCm39)	missense	probably damaging	1.00
R1422:Tenm4	UTSW	7	96,199,258 (GRCm39)	missense	probably damaging	0.99
R1427:Tenm4	UTSW	7	96,492,255 (GRCm39)	missense	probably benign	0.42
R1462:Tenm4	UTSW	7	96,353,360 (GRCm39)	missense	probably damaging	1.00
R1462:Tenm4	UTSW	7	96,353,360 (GRCm39)	missense	probably damaging	1.00
R1597:Tenm4	UTSW	7	96,552,196 (GRCm39)	critical splice donor site	probably null
R1701:Tenm4	UTSW	7	96,552,096 (GRCm39)	missense	probably damaging	1.00
R1707:Tenm4	UTSW	7	96,537,892 (GRCm39)	missense	probably damaging	1.00
R1809:Tenm4	UTSW	7	96,522,987 (GRCm39)	missense	probably benign	0.17
R1812:Tenm4	UTSW	7	96,545,147 (GRCm39)	missense	probably damaging	1.00
R1895:Tenm4	UTSW	7	96,385,015 (GRCm39)	missense	probably damaging	1.00
R1933:Tenm4	UTSW	7	96,544,533 (GRCm39)	missense	probably damaging	1.00
R1946:Tenm4	UTSW	7	96,385,015 (GRCm39)	missense	probably damaging	1.00
R2108:Tenm4	UTSW	7	96,555,497 (GRCm39)	missense	probably damaging	1.00
R2151:Tenm4	UTSW	7	96,552,054 (GRCm39)	missense	probably damaging	1.00
R2247:Tenm4	UTSW	7	96,555,216 (GRCm39)	missense	probably benign	0.03
R2329:Tenm4	UTSW	7	96,545,069 (GRCm39)	missense	probably benign	0.00
R2893:Tenm4	UTSW	7	96,544,197 (GRCm39)	missense	probably damaging	1.00
R2990:Tenm4	UTSW	7	96,542,332 (GRCm39)	splice site	probably null
R3409:Tenm4	UTSW	7	96,544,367 (GRCm39)	missense	probably damaging	1.00
R3410:Tenm4	UTSW	7	96,501,737 (GRCm39)	missense	probably damaging	0.99
R3411:Tenm4	UTSW	7	96,501,737 (GRCm39)	missense	probably damaging	0.99
R3440:Tenm4	UTSW	7	96,202,723 (GRCm39)	missense	probably benign	0.00
R3441:Tenm4	UTSW	7	96,202,723 (GRCm39)	missense	probably benign	0.00
R3719:Tenm4	UTSW	7	96,512,770 (GRCm39)	missense	possibly damaging	0.92
R3772:Tenm4	UTSW	7	96,344,087 (GRCm39)	missense	probably damaging	1.00
R3773:Tenm4	UTSW	7	96,344,087 (GRCm39)	missense	probably damaging	1.00
R4093:Tenm4	UTSW	7	96,544,979 (GRCm39)	missense	probably damaging	1.00
R4439:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4441:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4510:Tenm4	UTSW	7	96,544,070 (GRCm39)	missense	probably benign
R4511:Tenm4	UTSW	7	96,544,070 (GRCm39)	missense	probably benign
R4543:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4645:Tenm4	UTSW	7	96,544,949 (GRCm39)	missense	probably damaging	1.00
R4701:Tenm4	UTSW	7	96,544,556 (GRCm39)	missense	probably damaging	1.00
R4707:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4714:Tenm4	UTSW	7	96,544,131 (GRCm39)	missense	probably damaging	1.00
R4742:Tenm4	UTSW	7	96,446,691 (GRCm39)	missense	probably damaging	0.99
R4784:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4785:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4801:Tenm4	UTSW	7	96,555,452 (GRCm39)	missense	probably damaging	0.97
R4802:Tenm4	UTSW	7	96,555,452 (GRCm39)	missense	probably damaging	0.97
R4880:Tenm4	UTSW	7	96,555,025 (GRCm39)	splice site	probably null
R5036:Tenm4	UTSW	7	96,501,768 (GRCm39)	missense	probably damaging	1.00
R5036:Tenm4	UTSW	7	96,343,997 (GRCm39)	missense	probably damaging	1.00
R5050:Tenm4	UTSW	7	96,544,995 (GRCm39)	missense	probably damaging	1.00
R5103:Tenm4	UTSW	7	96,492,164 (GRCm39)	missense	probably damaging	1.00
R5106:Tenm4	UTSW	7	96,492,356 (GRCm39)	missense	probably damaging	0.99
R5118:Tenm4	UTSW	7	96,542,293 (GRCm39)	missense	probably damaging	1.00
R5272:Tenm4	UTSW	7	96,523,410 (GRCm39)	missense	probably damaging	0.98
R5282:Tenm4	UTSW	7	96,486,538 (GRCm39)	missense	possibly damaging	0.90
R5403:Tenm4	UTSW	7	96,538,034 (GRCm39)	missense	probably damaging	1.00
R5404:Tenm4	UTSW	7	96,543,887 (GRCm39)	missense	probably damaging	1.00
R5567:Tenm4	UTSW	7	96,545,416 (GRCm39)	nonsense	probably null
R5590:Tenm4	UTSW	7	96,446,608 (GRCm39)	missense	possibly damaging	0.93
R5590:Tenm4	UTSW	7	96,446,607 (GRCm39)	missense	possibly damaging	0.73
R5597:Tenm4	UTSW	7	96,202,724 (GRCm39)	missense	probably benign	0.00
R5782:Tenm4	UTSW	7	96,542,246 (GRCm39)	missense	probably benign	0.00
R5861:Tenm4	UTSW	7	96,492,424 (GRCm39)	intron	probably benign
R5890:Tenm4	UTSW	7	96,552,067 (GRCm39)	missense	probably damaging	1.00
R5930:Tenm4	UTSW	7	96,503,926 (GRCm39)	missense	probably damaging	1.00
R5940:Tenm4	UTSW	7	96,495,102 (GRCm39)	missense	probably damaging	1.00
R6012:Tenm4	UTSW	7	96,171,640 (GRCm39)	intron	probably benign
R6060:Tenm4	UTSW	7	96,522,918 (GRCm39)	missense	probably damaging	1.00
R6104:Tenm4	UTSW	7	96,486,496 (GRCm39)	missense	probably damaging	0.97
R6283:Tenm4	UTSW	7	96,523,701 (GRCm39)	missense	probably benign	0.33
R6333:Tenm4	UTSW	7	96,423,331 (GRCm39)	missense	probably damaging	1.00
R6522:Tenm4	UTSW	7	96,492,251 (GRCm39)	missense	possibly damaging	0.88
R6616:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6746:Tenm4	UTSW	7	96,542,067 (GRCm39)	missense	probably damaging	1.00
R6751:Tenm4	UTSW	7	96,494,919 (GRCm39)	missense	possibly damaging	0.95
R6806:Tenm4	UTSW	7	96,461,166 (GRCm39)	missense	possibly damaging	0.95
R6807:Tenm4	UTSW	7	96,544,478 (GRCm39)	missense	probably damaging	1.00
R6807:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6809:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6810:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6811:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6853:Tenm4	UTSW	7	96,486,502 (GRCm39)	missense	possibly damaging	0.94
R6886:Tenm4	UTSW	7	96,446,599 (GRCm39)	missense	possibly damaging	0.85
R6920:Tenm4	UTSW	7	96,544,757 (GRCm39)	missense	probably damaging	1.00
R6937:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6939:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7011:Tenm4	UTSW	7	96,545,342 (GRCm39)	nonsense	probably null
R7033:Tenm4	UTSW	7	96,544,430 (GRCm39)	nonsense	probably null
R7040:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7083:Tenm4	UTSW	7	96,544,556 (GRCm39)	missense	probably damaging	1.00
R7238:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7239:Tenm4	UTSW	7	96,385,020 (GRCm39)	missense	possibly damaging	0.47
R7239:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7337:Tenm4	UTSW	7	96,523,333 (GRCm39)	missense	probably benign	0.44
R7400:Tenm4	UTSW	7	96,344,010 (GRCm39)	missense	probably damaging	0.97
R7407:Tenm4	UTSW	7	96,423,194 (GRCm39)	missense	possibly damaging	0.89
R7449:Tenm4	UTSW	7	96,523,420 (GRCm39)	missense	possibly damaging	0.65
R7473:Tenm4	UTSW	7	96,423,353 (GRCm39)	missense	probably damaging	1.00
R7477:Tenm4	UTSW	7	96,495,015 (GRCm39)	missense	probably damaging	0.99
R7489:Tenm4	UTSW	7	96,486,521 (GRCm39)	missense	possibly damaging	0.90
R7498:Tenm4	UTSW	7	96,497,224 (GRCm39)	missense	probably damaging	1.00
R7562:Tenm4	UTSW	7	96,538,021 (GRCm39)	missense	probably damaging	1.00
R7615:Tenm4	UTSW	7	96,495,133 (GRCm39)	missense	probably damaging	1.00
R7624:Tenm4	UTSW	7	96,545,192 (GRCm39)	missense	possibly damaging	0.95
R7626:Tenm4	UTSW	7	96,542,221 (GRCm39)	missense	probably damaging	1.00
R7690:Tenm4	UTSW	7	96,512,740 (GRCm39)	missense	probably benign	0.00
R7692:Tenm4	UTSW	7	96,544,610 (GRCm39)	missense	probably damaging	1.00
R7748:Tenm4	UTSW	7	96,543,909 (GRCm39)	missense	probably damaging	1.00
R7763:Tenm4	UTSW	7	96,544,899 (GRCm39)	missense	probably benign	0.38
R7792:Tenm4	UTSW	7	96,423,221 (GRCm39)	missense	possibly damaging	0.54
R7855:Tenm4	UTSW	7	96,523,081 (GRCm39)	missense	probably damaging	1.00
R7868:Tenm4	UTSW	7	96,555,587 (GRCm39)	missense	possibly damaging	0.79
R7878:Tenm4	UTSW	7	96,501,564 (GRCm39)	missense	probably damaging	1.00
R7997:Tenm4	UTSW	7	96,523,512 (GRCm39)	missense	probably benign	0.44
R8017:Tenm4	UTSW	7	96,353,248 (GRCm39)	missense	probably damaging	1.00
R8019:Tenm4	UTSW	7	96,353,248 (GRCm39)	missense	probably damaging	1.00
R8054:Tenm4	UTSW	7	96,378,553 (GRCm39)	splice site	probably benign
R8061:Tenm4	UTSW	7	96,501,663 (GRCm39)	missense	probably damaging	1.00
R8108:Tenm4	UTSW	7	96,503,935 (GRCm39)	missense	probably benign	0.39
R8140:Tenm4	UTSW	7	96,544,383 (GRCm39)	missense	probably damaging	1.00
R8214:Tenm4	UTSW	7	96,544,614 (GRCm39)	missense	probably damaging	1.00
R8258:Tenm4	UTSW	7	96,517,198 (GRCm39)	missense	probably damaging	1.00
R8259:Tenm4	UTSW	7	96,517,198 (GRCm39)	missense	probably damaging	1.00
R8364:Tenm4	UTSW	7	96,421,313 (GRCm39)	critical splice donor site	probably null
R8542:Tenm4	UTSW	7	96,461,139 (GRCm39)	missense	probably damaging	0.99
R8669:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8670:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8683:Tenm4	UTSW	7	96,552,064 (GRCm39)	missense	probably damaging	0.99
R8691:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8692:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8714:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8716:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8735:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8736:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8737:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8738:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8738:Tenm4	UTSW	7	96,523,047 (GRCm39)	missense	probably damaging	1.00
R8739:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8776:Tenm4	UTSW	7	96,544,239 (GRCm39)	missense	probably damaging	1.00
R8776-TAIL:Tenm4	UTSW	7	96,544,239 (GRCm39)	missense	probably damaging	1.00
R8777:Tenm4	UTSW	7	96,545,244 (GRCm39)	missense	probably damaging	1.00
R8777-TAIL:Tenm4	UTSW	7	96,545,244 (GRCm39)	missense	probably damaging	1.00
R8817:Tenm4	UTSW	7	96,523,335 (GRCm39)	missense	probably benign	0.01
R8851:Tenm4	UTSW	7	96,501,710 (GRCm39)	missense	probably damaging	1.00
R8913:Tenm4	UTSW	7	96,351,952 (GRCm39)	splice site	probably benign
R8977:Tenm4	UTSW	7	96,461,177 (GRCm39)	missense	probably damaging	1.00
R9100:Tenm4	UTSW	7	96,495,061 (GRCm39)	missense	probably damaging	1.00
R9136:Tenm4	UTSW	7	96,473,125 (GRCm39)	missense	possibly damaging	0.69
R9163:Tenm4	UTSW	7	96,473,080 (GRCm39)	missense	probably damaging	1.00
R9188:Tenm4	UTSW	7	96,421,234 (GRCm39)	missense	probably damaging	1.00
R9195:Tenm4	UTSW	7	96,542,126 (GRCm39)	missense	probably damaging	1.00
R9217:Tenm4	UTSW	7	96,534,646 (GRCm39)	missense	probably damaging	1.00
R9344:Tenm4	UTSW	7	96,545,352 (GRCm39)	missense	probably damaging	1.00
R9466:Tenm4	UTSW	7	96,199,252 (GRCm39)	missense	possibly damaging	0.79
R9559:Tenm4	UTSW	7	96,473,056 (GRCm39)	missense	probably benign
R9626:Tenm4	UTSW	7	96,545,345 (GRCm39)	missense	probably damaging	1.00
R9673:Tenm4	UTSW	7	96,517,196 (GRCm39)	missense	probably damaging	1.00
R9676:Tenm4	UTSW	7	96,544,638 (GRCm39)	missense	probably damaging	1.00
R9678:Tenm4	UTSW	7	96,386,619 (GRCm39)	missense	possibly damaging	0.94
R9775:Tenm4	UTSW	7	96,555,761 (GRCm39)	missense	possibly damaging	0.92
R9790:Tenm4	UTSW	7	96,538,046 (GRCm39)	missense	probably damaging	1.00
R9791:Tenm4	UTSW	7	96,538,046 (GRCm39)	missense	probably damaging	1.00
R9803:Tenm4	UTSW	7	96,202,685 (GRCm39)	missense	probably damaging	1.00
X0021:Tenm4	UTSW	7	96,523,116 (GRCm39)	nonsense	probably null
X0026:Tenm4	UTSW	7	96,517,294 (GRCm39)	missense	probably damaging	0.98
X0066:Tenm4	UTSW	7	96,544,001 (GRCm39)	missense	probably damaging	1.00
X0066:Tenm4	UTSW	7	96,497,237 (GRCm39)	missense	probably damaging	1.00
Z1176:Tenm4	UTSW	7	96,555,121 (GRCm39)	missense	probably benign	0.00
Z1177:Tenm4	UTSW	7	96,512,792 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- CTTGTGACAACATCGGGACC -3'
(R):5'- GACCCCATACCAGTTTTCTCAAGG -3'

Sequencing Primer
(F):5'- CTGGCTTGATGATTAAGCAGATCC -3'
(R):5'- CCAGTTTTCTCAAGGAGCAATGG -3'

Posted On

2022-05-16