Incidental Mutation 'R9414:Vmn2r104'
ID 711971
Institutional Source Beutler Lab
Gene Symbol Vmn2r104
Ensembl Gene ENSMUSG00000090315
Gene Name vomeronasal 2, receptor 104
Synonyms V2r7
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R9414 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 20249687-20268467 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20250250 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 674 (I674F)
Ref Sequence ENSEMBL: ENSMUSP00000129895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168050]
AlphaFold E9Q2J5
Predicted Effect probably damaging
Transcript: ENSMUST00000168050
AA Change: I674F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: I674F

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 85 457 4e-38 PFAM
Pfam:NCD3G 512 565 2.1e-20 PFAM
Pfam:7tm_3 598 833 1.7e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.7%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A T 11: 110,035,100 (GRCm39) I689K probably damaging Het
Agtpbp1 G T 13: 59,609,902 (GRCm39) T1076K probably damaging Het
Ammecr1l A G 18: 31,904,962 (GRCm39) T68A probably benign Het
Arvcf A G 16: 18,215,580 (GRCm39) E264G probably damaging Het
Cacna1b C T 2: 24,538,514 (GRCm39) D1542N probably damaging Het
Cacna2d2 A G 9: 107,392,395 (GRCm39) T512A probably damaging Het
Crebbp A G 16: 3,925,356 (GRCm39) C1213R probably damaging Het
Cybrd1 G T 2: 70,948,567 (GRCm39) R35L probably damaging Het
Dcaf1 G A 9: 106,757,158 (GRCm39) W1412* probably null Het
Eif4e T A 3: 138,253,495 (GRCm39) D67E probably benign Het
Epb41 G A 4: 131,702,162 (GRCm39) T491I probably damaging Het
Fez1 G A 9: 36,779,247 (GRCm39) S308N probably benign Het
Fgfr3 A G 5: 33,887,298 (GRCm39) S206G possibly damaging Het
Flcn A T 11: 59,684,998 (GRCm39) N484K possibly damaging Het
Gdap2 T C 3: 100,090,071 (GRCm39) probably null Het
Gfpt1 T A 6: 87,062,265 (GRCm39) D541E probably benign Het
Gm5089 A G 14: 122,673,604 (GRCm39) F39S unknown Het
Gm7694 C T 1: 170,130,173 (GRCm39) G75D probably benign Het
Gpr15 A G 16: 58,538,516 (GRCm39) L191S probably benign Het
Hmcn1 T G 1: 150,545,187 (GRCm39) T2807P probably damaging Het
Iqgap2 T C 13: 95,783,349 (GRCm39) T1276A Het
Itgae G T 11: 73,002,629 (GRCm39) A129S possibly damaging Het
Kcns1 T C 2: 164,010,378 (GRCm39) E127G probably damaging Het
Kmt2b T C 7: 30,282,307 (GRCm39) E1118G probably damaging Het
Lair1 T C 7: 4,013,819 (GRCm39) I143V probably benign Het
Lcmt2 T C 2: 120,970,621 (GRCm39) D154G possibly damaging Het
Ly9 T C 1: 171,427,275 (GRCm39) T427A probably damaging Het
Man2c1 A G 9: 57,044,030 (GRCm39) T281A possibly damaging Het
Map4k2 T C 19: 6,394,515 (GRCm39) F332L probably benign Het
Meak7 A T 8: 120,495,081 (GRCm39) S226T probably benign Het
Mmp10 A T 9: 7,502,489 (GRCm39) D32V probably benign Het
Mroh2a C T 1: 88,179,096 (GRCm39) R1110W probably benign Het
Naip2 T A 13: 100,298,243 (GRCm39) S598C probably damaging Het
Npnt T C 3: 132,612,116 (GRCm39) N300S probably benign Het
Or13a20 C A 7: 140,232,263 (GRCm39) R124S probably damaging Het
Or5b95 T C 19: 12,657,712 (GRCm39) V80A probably benign Het
Or5k15 G A 16: 58,710,565 (GRCm39) T6I probably benign Het
Pacsin1 T C 17: 27,926,985 (GRCm39) V387A probably damaging Het
Pald1 G T 10: 61,178,932 (GRCm39) A489E probably benign Het
Pcnx1 G T 12: 81,964,978 (GRCm39) G382W probably damaging Het
Pde6b T A 5: 108,567,592 (GRCm39) M294K possibly damaging Het
Phf20 T C 2: 156,136,167 (GRCm39) V662A probably benign Het
Plcg1 T C 2: 160,603,276 (GRCm39) I1149T possibly damaging Het
Prdx2 T C 8: 85,697,196 (GRCm39) S79P probably damaging Het
Rab19 T C 6: 39,360,855 (GRCm39) M1T probably null Het
Retn T G 8: 3,706,908 (GRCm39) F44C probably damaging Het
Rp1 A T 1: 4,313,841 (GRCm39) W507R unknown Het
Rsf1 A C 7: 97,313,765 (GRCm39) probably null Het
Ryr3 C T 2: 112,501,011 (GRCm39) E3561K possibly damaging Het
Scaf1 T A 7: 44,652,716 (GRCm39) Y1220F unknown Het
Sowahc A G 10: 59,058,491 (GRCm39) K209R probably benign Het
Supt20 T A 3: 54,610,504 (GRCm39) I103N probably damaging Het
Tenm4 A G 7: 96,545,367 (GRCm39) E2498G probably benign Het
Tet1 T C 10: 62,674,935 (GRCm39) N1047S probably benign Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Tub T A 7: 108,626,265 (GRCm39) I267N probably damaging Het
Uggt1 T C 1: 36,223,507 (GRCm39) E594G probably benign Het
Zbed6 T C 1: 133,585,015 (GRCm39) D774G probably damaging Het
Zcchc4 T C 5: 52,953,964 (GRCm39) S215P probably benign Het
Zfc3h1 T G 10: 115,249,916 (GRCm39) S1177A possibly damaging Het
Zfp646 G A 7: 127,481,050 (GRCm39) A1076T probably damaging Het
Zfp735 T A 11: 73,602,023 (GRCm39) Y322* probably null Het
Other mutations in Vmn2r104
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Vmn2r104 APN 17 20,258,501 (GRCm39) missense probably damaging 0.98
IGL01098:Vmn2r104 APN 17 20,268,358 (GRCm39) missense probably benign 0.27
IGL01333:Vmn2r104 APN 17 20,263,055 (GRCm39) missense probably benign 0.17
IGL01527:Vmn2r104 APN 17 20,263,158 (GRCm39) missense possibly damaging 0.82
IGL01773:Vmn2r104 APN 17 20,260,930 (GRCm39) missense probably benign 0.10
IGL01939:Vmn2r104 APN 17 20,250,187 (GRCm39) missense probably damaging 0.99
IGL02121:Vmn2r104 APN 17 20,262,056 (GRCm39) nonsense probably null
IGL02305:Vmn2r104 APN 17 20,263,118 (GRCm39) missense probably benign 0.09
IGL02374:Vmn2r104 APN 17 20,263,048 (GRCm39) missense probably benign 0.34
IGL03260:Vmn2r104 APN 17 20,263,083 (GRCm39) missense probably benign 0.05
IGL03366:Vmn2r104 APN 17 20,249,866 (GRCm39) missense probably damaging 1.00
R0091:Vmn2r104 UTSW 17 20,262,075 (GRCm39) missense possibly damaging 0.79
R0125:Vmn2r104 UTSW 17 20,250,069 (GRCm39) missense probably damaging 0.98
R0257:Vmn2r104 UTSW 17 20,249,889 (GRCm39) missense probably damaging 1.00
R0381:Vmn2r104 UTSW 17 20,268,264 (GRCm39) nonsense probably null
R0709:Vmn2r104 UTSW 17 20,263,166 (GRCm39) missense probably damaging 1.00
R0786:Vmn2r104 UTSW 17 20,262,987 (GRCm39) missense probably benign
R1575:Vmn2r104 UTSW 17 20,262,477 (GRCm39) missense probably damaging 1.00
R1827:Vmn2r104 UTSW 17 20,262,497 (GRCm39) missense probably damaging 0.97
R1932:Vmn2r104 UTSW 17 20,261,031 (GRCm39) missense probably damaging 1.00
R1956:Vmn2r104 UTSW 17 20,262,313 (GRCm39) missense probably damaging 0.98
R2203:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2205:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2859:Vmn2r104 UTSW 17 20,268,455 (GRCm39) missense possibly damaging 0.82
R3701:Vmn2r104 UTSW 17 20,249,818 (GRCm39) missense probably damaging 1.00
R3834:Vmn2r104 UTSW 17 20,250,183 (GRCm39) missense probably benign 0.02
R4151:Vmn2r104 UTSW 17 20,250,147 (GRCm39) missense probably damaging 1.00
R4470:Vmn2r104 UTSW 17 20,262,503 (GRCm39) missense probably damaging 1.00
R4625:Vmn2r104 UTSW 17 20,268,443 (GRCm39) missense probably benign 0.00
R4754:Vmn2r104 UTSW 17 20,261,030 (GRCm39) nonsense probably null
R4911:Vmn2r104 UTSW 17 20,250,288 (GRCm39) missense probably benign 0.00
R5270:Vmn2r104 UTSW 17 20,258,528 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r104 UTSW 17 20,262,146 (GRCm39) missense probably benign 0.07
R5311:Vmn2r104 UTSW 17 20,250,163 (GRCm39) missense probably damaging 1.00
R5370:Vmn2r104 UTSW 17 20,250,450 (GRCm39) missense probably damaging 0.97
R5461:Vmn2r104 UTSW 17 20,250,343 (GRCm39) missense probably damaging 1.00
R5683:Vmn2r104 UTSW 17 20,260,981 (GRCm39) nonsense probably null
R5795:Vmn2r104 UTSW 17 20,250,544 (GRCm39) missense possibly damaging 0.89
R5795:Vmn2r104 UTSW 17 20,250,372 (GRCm39) missense probably benign 0.02
R5970:Vmn2r104 UTSW 17 20,249,733 (GRCm39) missense probably benign 0.01
R5983:Vmn2r104 UTSW 17 20,261,970 (GRCm39) missense probably damaging 1.00
R5992:Vmn2r104 UTSW 17 20,249,747 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r104 UTSW 17 20,258,573 (GRCm39) missense possibly damaging 0.69
R6156:Vmn2r104 UTSW 17 20,261,909 (GRCm39) missense probably damaging 1.00
R6182:Vmn2r104 UTSW 17 20,250,507 (GRCm39) missense probably benign 0.16
R6245:Vmn2r104 UTSW 17 20,261,829 (GRCm39) missense possibly damaging 0.69
R6333:Vmn2r104 UTSW 17 20,249,848 (GRCm39) missense probably benign 0.30
R6573:Vmn2r104 UTSW 17 20,262,487 (GRCm39) missense probably damaging 1.00
R7101:Vmn2r104 UTSW 17 20,250,358 (GRCm39) missense possibly damaging 0.65
R7123:Vmn2r104 UTSW 17 20,261,088 (GRCm39) missense probably benign 0.12
R7485:Vmn2r104 UTSW 17 20,249,737 (GRCm39) missense probably benign 0.01
R7514:Vmn2r104 UTSW 17 20,249,791 (GRCm39) missense probably damaging 1.00
R7634:Vmn2r104 UTSW 17 20,261,971 (GRCm39) missense possibly damaging 0.48
R7958:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8031:Vmn2r104 UTSW 17 20,263,048 (GRCm39) missense probably benign 0.34
R8094:Vmn2r104 UTSW 17 20,250,483 (GRCm39) missense possibly damaging 0.77
R8191:Vmn2r104 UTSW 17 20,250,465 (GRCm39) missense possibly damaging 0.89
R8308:Vmn2r104 UTSW 17 20,261,040 (GRCm39) missense possibly damaging 0.55
R8691:Vmn2r104 UTSW 17 20,262,110 (GRCm39) missense probably damaging 0.98
R8795:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8900:Vmn2r104 UTSW 17 20,261,924 (GRCm39) missense probably damaging 0.99
R8913:Vmn2r104 UTSW 17 20,249,968 (GRCm39) missense probably damaging 1.00
R9180:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9199:Vmn2r104 UTSW 17 20,262,097 (GRCm39) missense probably damaging 0.99
R9282:Vmn2r104 UTSW 17 20,261,098 (GRCm39) missense probably damaging 1.00
R9303:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9305:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9322:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9325:Vmn2r104 UTSW 17 20,268,433 (GRCm39) missense possibly damaging 0.95
R9785:Vmn2r104 UTSW 17 20,268,409 (GRCm39) missense probably benign
RF007:Vmn2r104 UTSW 17 20,268,302 (GRCm39) missense probably benign 0.36
Z1177:Vmn2r104 UTSW 17 20,250,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAGCTGAGCCCTTGTTGC -3'
(R):5'- AGACACTCCTATTGTCAAGGCC -3'

Sequencing Primer
(F):5'- CTGAGCCCTTGTTGCACAAAAGG -3'
(R):5'- CTCCTATTGTCAAGGCCAATAATCGG -3'
Posted On 2022-05-16