Incidental Mutation 'R9415:Or1e32'
ID 712009
Institutional Source Beutler Lab
Gene Symbol Or1e32
Ensembl Gene ENSMUSG00000061984
Gene Name olfactory receptor family 1 subfamily E member 32
Synonyms GA_x6K02T2P1NL-3966976-3966038, Olfr392, MOR135-9
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9415 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 73704968-73707703 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73705143 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 255 (I255T)
Ref Sequence ENSEMBL: ENSMUSP00000123649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000118463] [ENSMUST00000144724]
AlphaFold Q7TRX6
Predicted Effect probably damaging
Transcript: ENSMUST00000118463
AA Change: I255T

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113118
Gene: ENSMUSG00000061984
AA Change: I255T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-58 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.6e-6 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000144724
AA Change: I255T

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000123649
Gene: ENSMUSG00000061984
AA Change: I255T

DomainStartEndE-ValueType
Pfam:7tm_1 41 116 2e-12 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc1 A G 2: 128,476,598 (GRCm39) M1340T probably benign Het
Arhgef15 A G 11: 68,842,233 (GRCm39) L457P probably damaging Het
Arih2 A T 9: 108,486,986 (GRCm39) C317S probably damaging Het
Asb14 A T 14: 26,633,793 (GRCm39) T333S probably damaging Het
Atp13a4 T C 16: 29,227,821 (GRCm39) N1012S Het
Capn9 C A 8: 125,332,449 (GRCm39) D429E probably benign Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Cntrob C T 11: 69,193,741 (GRCm39) R803Q possibly damaging Het
Dnah8 A G 17: 31,029,297 (GRCm39) I4089V probably benign Het
Fam162b A G 10: 51,466,155 (GRCm39) probably null Het
Fhod3 A G 18: 25,102,244 (GRCm39) D180G probably damaging Het
Gtf3c4 A G 2: 28,723,966 (GRCm39) S589P possibly damaging Het
Jcad T C 18: 4,673,912 (GRCm39) L558P probably damaging Het
Kmt2d A G 15: 98,737,586 (GRCm39) I5170T unknown Het
Lamb3 T C 1: 193,008,319 (GRCm39) F251L probably benign Het
Lpxn T A 19: 12,802,336 (GRCm39) D220E probably benign Het
Mex3a T A 3: 88,444,480 (GRCm39) F519I probably damaging Het
Mfap1a T C 2: 121,337,001 (GRCm39) M8V probably benign Het
Mical3 T A 6: 120,934,712 (GRCm39) D1789V probably damaging Het
Mpdz G A 4: 81,235,905 (GRCm39) Q1211* probably null Het
Myd88 A G 9: 119,167,070 (GRCm39) probably null Het
Myof T A 19: 37,941,412 (GRCm39) K799N probably damaging Het
Naip2 T A 13: 100,298,243 (GRCm39) S598C probably damaging Het
Ndst4 C T 3: 125,518,385 (GRCm39) S354L probably benign Het
Ntn4 A G 10: 93,480,488 (GRCm39) T71A probably benign Het
Omd A C 13: 49,745,837 (GRCm39) M416L probably benign Het
Oog1 G C 12: 87,655,086 (GRCm39) L411F probably damaging Het
Or10a3m T A 7: 108,313,042 (GRCm39) W161R probably damaging Het
Or56a5 T G 7: 104,793,498 (GRCm39) M7L probably benign Het
Or7e171-ps1 A G 9: 19,853,200 (GRCm39) W179R probably benign Het
Pde4dip T C 3: 97,660,468 (GRCm39) Q670R possibly damaging Het
Pex13 C A 11: 23,601,034 (GRCm39) G272V probably damaging Het
Pfkl A T 10: 77,824,081 (GRCm39) V769D probably damaging Het
Pkn3 A G 2: 29,968,332 (GRCm39) Y10C probably benign Het
Pomgnt1 A G 4: 116,013,378 (GRCm39) H500R probably damaging Het
Rasef T C 4: 73,645,882 (GRCm39) T496A probably benign Het
Rgs6 A G 12: 83,184,166 (GRCm39) S459G probably benign Het
Serpinb6b A T 13: 33,159,002 (GRCm39) M187L Het
Shcbp1l A G 1: 153,321,627 (GRCm39) I408M possibly damaging Het
Slc25a45 T C 19: 5,934,967 (GRCm39) V272A probably damaging Het
Tlr4 T C 4: 66,746,160 (GRCm39) probably null Het
Unc80 A T 1: 66,550,064 (GRCm39) N774I Het
Urb2 T A 8: 124,756,613 (GRCm39) S773R possibly damaging Het
Vmn1r35 A T 6: 66,656,115 (GRCm39) V185E probably damaging Het
Vps13d A C 4: 144,796,527 (GRCm39) V3691G Het
Wdtc1 A G 4: 133,022,684 (GRCm39) V554A possibly damaging Het
Xrn1 A T 9: 95,851,527 (GRCm39) M182L probably damaging Het
Zfp747 T C 7: 126,973,198 (GRCm39) H324R possibly damaging Het
Other mutations in Or1e32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Or1e32 APN 11 73,705,612 (GRCm39) missense probably damaging 0.97
IGL02976:Or1e32 APN 11 73,705,143 (GRCm39) missense probably damaging 0.98
IGL03344:Or1e32 APN 11 73,705,003 (GRCm39) missense probably benign 0.21
BB007:Or1e32 UTSW 11 73,705,926 (GRCm39) start gained probably benign
BB017:Or1e32 UTSW 11 73,705,926 (GRCm39) start gained probably benign
R0196:Or1e32 UTSW 11 73,705,731 (GRCm39) missense probably damaging 0.99
R0347:Or1e32 UTSW 11 73,705,137 (GRCm39) missense probably damaging 0.98
R0594:Or1e32 UTSW 11 73,705,443 (GRCm39) missense probably benign 0.12
R0940:Or1e32 UTSW 11 73,705,050 (GRCm39) missense probably damaging 1.00
R1233:Or1e32 UTSW 11 73,705,176 (GRCm39) missense probably damaging 1.00
R1300:Or1e32 UTSW 11 73,705,072 (GRCm39) missense probably benign 0.13
R1490:Or1e32 UTSW 11 73,705,197 (GRCm39) missense possibly damaging 0.95
R3111:Or1e32 UTSW 11 73,705,012 (GRCm39) missense probably benign
R4827:Or1e32 UTSW 11 73,705,547 (GRCm39) nonsense probably null
R4852:Or1e32 UTSW 11 73,705,074 (GRCm39) missense probably benign 0.11
R4992:Or1e32 UTSW 11 73,705,146 (GRCm39) missense probably damaging 1.00
R6193:Or1e32 UTSW 11 73,705,650 (GRCm39) missense probably benign
R7201:Or1e32 UTSW 11 73,705,167 (GRCm39) missense probably benign 0.19
R7310:Or1e32 UTSW 11 73,705,112 (GRCm39) missense probably damaging 0.98
R7930:Or1e32 UTSW 11 73,705,926 (GRCm39) start gained probably benign
R8471:Or1e32 UTSW 11 73,705,309 (GRCm39) missense probably benign 0.00
R8722:Or1e32 UTSW 11 73,705,882 (GRCm39) missense probably benign 0.03
R8866:Or1e32 UTSW 11 73,705,237 (GRCm39) missense probably damaging 1.00
X0021:Or1e32 UTSW 11 73,705,131 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCCAAGTGCTACCATTACAGAG -3'
(R):5'- TGAAGTTGTCCTGCTCAGAC -3'

Sequencing Primer
(F):5'- GTGCTACCATTACAGAGAGATTTTC -3'
(R):5'- CCTGCTCAGACACTTTTGTTAATGAG -3'
Posted On 2022-05-16