Incidental Mutation 'R9417:Zranb1'
ID 712111
Institutional Source Beutler Lab
Gene Symbol Zranb1
Ensembl Gene ENSMUSG00000030967
Gene Name zinc finger, RAN-binding domain containing 1
Synonyms 9330160G10Rik, D7Wsu87e
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.915) question?
Stock # R9417 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 132532905-132588127 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 132585466 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 638 (G638D)
Ref Sequence ENSEMBL: ENSMUSP00000033265 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033265] [ENSMUST00000033269] [ENSMUST00000106157] [ENSMUST00000124096] [ENSMUST00000165457] [ENSMUST00000166439] [ENSMUST00000169570] [ENSMUST00000210507] [ENSMUST00000215716]
AlphaFold Q7M760
Predicted Effect probably damaging
Transcript: ENSMUST00000033265
AA Change: G638D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000033265
Gene: ENSMUSG00000030967
AA Change: G638D

DomainStartEndE-ValueType
ZnF_RBZ 6 30 9.14e-5 SMART
ZnF_RBZ 86 110 6.56e-6 SMART
ZnF_RBZ 151 175 1.69e-8 SMART
low complexity region 180 195 N/A INTRINSIC
Pfam:OTU 438 586 9.8e-35 PFAM
low complexity region 698 708 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000033269
SMART Domains Protein: ENSMUSP00000033269
Gene: ENSMUSG00000030970

DomainStartEndE-ValueType
Pfam:2-Hacid_dh 36 358 2.9e-31 PFAM
Pfam:2-Hacid_dh_C 139 323 1.7e-57 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106157
AA Change: G638D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101763
Gene: ENSMUSG00000030967
AA Change: G638D

DomainStartEndE-ValueType
ZnF_RBZ 6 30 9.14e-5 SMART
ZnF_RBZ 86 110 6.56e-6 SMART
ZnF_RBZ 151 175 1.69e-8 SMART
low complexity region 180 195 N/A INTRINSIC
Pfam:OTU 438 586 1.5e-40 PFAM
low complexity region 698 708 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165457
Predicted Effect probably benign
Transcript: ENSMUST00000166439
SMART Domains Protein: ENSMUSP00000127448
Gene: ENSMUSG00000030970

DomainStartEndE-ValueType
Pfam:2-Hacid_dh 11 333 2.4e-31 PFAM
Pfam:2-Hacid_dh_C 114 298 1.5e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169570
SMART Domains Protein: ENSMUSP00000130294
Gene: ENSMUSG00000030970

DomainStartEndE-ValueType
Pfam:2-Hacid_dh 579 901 2.8e-31 PFAM
Pfam:2-Hacid_dh_C 682 866 5.6e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210507
Predicted Effect probably damaging
Transcript: ENSMUST00000215716
AA Change: G664D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased CD4+ T cells and decreased susceptibility to experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik A G 4: 88,786,202 (GRCm39) Y139H unknown Het
Akr1b10 T C 6: 34,371,027 (GRCm39) V259A probably benign Het
Aldh5a1 A T 13: 25,095,673 (GRCm39) N481K probably damaging Het
Ankrd26 A T 6: 118,504,725 (GRCm39) M728K possibly damaging Het
Asic1 A G 15: 99,590,405 (GRCm39) M52V probably benign Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Het
Cacna2d2 C A 9: 107,392,689 (GRCm39) Y544* probably null Het
Cdcp3 A G 7: 130,852,218 (GRCm39) D818G possibly damaging Het
Chd4 A G 6: 125,097,688 (GRCm39) N1403S probably damaging Het
Cldn4 G T 5: 134,975,174 (GRCm39) N142K probably benign Het
Cracd GCGCGAGGCCGAGAGGCAGGAGGAGGAAGCAAGACAACGCGAGGCCGAGAGGCAGG GCGCGAGGCCGAGAGGCAGG 5: 77,004,801 (GRCm39) probably benign Het
Dll1 T C 17: 15,593,710 (GRCm39) Y219C probably damaging Het
Dnah2 T A 11: 69,326,990 (GRCm39) I3539F probably damaging Het
Egfr T A 11: 16,825,067 (GRCm39) L469* probably null Het
Elmo1 A G 13: 20,756,573 (GRCm39) N554D possibly damaging Het
Fam234a A C 17: 26,435,225 (GRCm39) F306L probably benign Het
Fbl G A 7: 27,874,052 (GRCm39) G45D unknown Het
Fbxw10 C A 11: 62,753,522 (GRCm39) C505* probably null Het
Ftcd G A 10: 76,417,153 (GRCm39) G221S probably damaging Het
Gad1 A G 2: 70,417,716 (GRCm39) D305G possibly damaging Het
Gdpd4 A G 7: 97,607,074 (GRCm39) D16G probably benign Het
Gsdmc3 T A 15: 63,738,663 (GRCm39) D133V possibly damaging Het
Hpdl T C 4: 116,677,817 (GRCm39) T215A possibly damaging Het
Ift56 T C 6: 38,386,386 (GRCm39) F369S probably damaging Het
Igsf10 A T 3: 59,236,526 (GRCm39) N1218K possibly damaging Het
Isg20 C T 7: 78,569,605 (GRCm39) P192L probably benign Het
Itga7 C T 10: 128,793,543 (GRCm39) T126M unknown Het
Krr1 A G 10: 111,813,026 (GRCm39) I134V probably benign Het
Krt71 T A 15: 101,646,731 (GRCm39) T326S probably benign Het
Lamb1 T A 12: 31,337,983 (GRCm39) V480E probably damaging Het
Mmp19 T A 10: 128,630,523 (GRCm39) L102Q possibly damaging Het
Mtor T A 4: 148,622,776 (GRCm39) L1952* probably null Het
Myo15a T A 11: 60,378,243 (GRCm39) V215E Het
Nfs1 T A 2: 155,965,851 (GRCm39) K77* probably null Het
Or52s1 A T 7: 102,861,156 (GRCm39) I30F possibly damaging Het
Or9a4 T A 6: 40,549,096 (GRCm39) Y259N Het
Pcdhga4 T C 18: 37,820,560 (GRCm39) F703S probably damaging Het
Pdzd7 A G 19: 45,034,022 (GRCm39) S21P probably damaging Het
Pitrm1 A T 13: 6,617,394 (GRCm39) I583F possibly damaging Het
Ppox A G 1: 171,107,855 (GRCm39) L77P unknown Het
Ppp1r37 G T 7: 19,269,658 (GRCm39) R114S probably damaging Het
Ppp4r3b T C 11: 29,144,598 (GRCm39) V316A probably benign Het
Ptprd A G 4: 75,865,335 (GRCm39) I1214T probably damaging Het
Rasal3 A G 17: 32,615,441 (GRCm39) F466L probably benign Het
Ric8b A T 10: 84,761,447 (GRCm39) D41V probably benign Het
Rin2 T C 2: 145,686,713 (GRCm39) S81P probably benign Het
Sft2d1 T A 17: 8,542,139 (GRCm39) C128S probably damaging Het
Skint1 T C 4: 111,878,509 (GRCm39) V147A probably benign Het
Slc9c1 T C 16: 45,413,848 (GRCm39) V992A probably benign Het
Sst A G 16: 23,708,487 (GRCm39) S115P probably damaging Het
Sv2b G T 7: 74,769,772 (GRCm39) S590Y probably damaging Het
Syne1 C T 10: 5,082,021 (GRCm39) V868I probably benign Het
Tex35 T C 1: 156,934,789 (GRCm39) I42V possibly damaging Het
Tlr2 T C 3: 83,744,892 (GRCm39) N397S probably damaging Het
Tmem202 A G 9: 59,431,999 (GRCm39) probably null Het
Usp20 A G 2: 30,873,030 (GRCm39) probably null Het
Usp32 C T 11: 84,885,369 (GRCm39) R1226Q probably damaging Het
Usp47 C T 7: 111,688,801 (GRCm39) A736V possibly damaging Het
Vmn2r-ps117 T A 17: 19,044,037 (GRCm39) L371* probably null Het
Wwp1 T A 4: 19,662,215 (GRCm39) N127Y possibly damaging Het
Yae1d1 A T 13: 18,167,770 (GRCm39) V41D probably damaging Het
Zbtb8b T C 4: 129,326,517 (GRCm39) D216G probably benign Het
Zfp462 T C 4: 55,016,988 (GRCm39) S903P probably benign Het
Other mutations in Zranb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00499:Zranb1 APN 7 132,584,233 (GRCm39) splice site probably benign
IGL00843:Zranb1 APN 7 132,551,622 (GRCm39) missense probably benign 0.26
IGL01727:Zranb1 APN 7 132,568,349 (GRCm39) missense probably damaging 1.00
IGL02087:Zranb1 APN 7 132,575,146 (GRCm39) splice site probably benign
IGL02676:Zranb1 APN 7 132,568,410 (GRCm39) missense probably benign 0.16
IGL03081:Zranb1 APN 7 132,552,126 (GRCm39) missense probably damaging 0.99
IGL03095:Zranb1 APN 7 132,551,635 (GRCm39) nonsense probably null
IGL03186:Zranb1 APN 7 132,551,932 (GRCm39) missense possibly damaging 0.68
PIT4151001:Zranb1 UTSW 7 132,551,723 (GRCm39) missense probably benign
R0207:Zranb1 UTSW 7 132,552,114 (GRCm39) missense probably damaging 1.00
R0470:Zranb1 UTSW 7 132,584,500 (GRCm39) missense probably damaging 1.00
R0854:Zranb1 UTSW 7 132,551,577 (GRCm39) missense possibly damaging 0.78
R1318:Zranb1 UTSW 7 132,568,281 (GRCm39) nonsense probably null
R1389:Zranb1 UTSW 7 132,573,062 (GRCm39) missense probably damaging 1.00
R1480:Zranb1 UTSW 7 132,551,745 (GRCm39) missense probably benign 0.39
R1656:Zranb1 UTSW 7 132,551,496 (GRCm39) missense probably benign 0.31
R1956:Zranb1 UTSW 7 132,584,458 (GRCm39) missense probably damaging 1.00
R1958:Zranb1 UTSW 7 132,584,458 (GRCm39) missense probably damaging 1.00
R2010:Zranb1 UTSW 7 132,568,425 (GRCm39) critical splice donor site probably null
R2289:Zranb1 UTSW 7 132,551,768 (GRCm39) missense probably damaging 1.00
R3831:Zranb1 UTSW 7 132,584,505 (GRCm39) missense probably damaging 0.98
R4128:Zranb1 UTSW 7 132,568,281 (GRCm39) nonsense probably null
R4745:Zranb1 UTSW 7 132,574,443 (GRCm39) missense probably damaging 0.97
R5121:Zranb1 UTSW 7 132,551,916 (GRCm39) missense probably benign 0.06
R5262:Zranb1 UTSW 7 132,584,556 (GRCm39) small insertion probably benign
R5263:Zranb1 UTSW 7 132,584,556 (GRCm39) small insertion probably benign
R5264:Zranb1 UTSW 7 132,584,556 (GRCm39) small insertion probably benign
R5522:Zranb1 UTSW 7 132,585,678 (GRCm39) makesense probably null
R6252:Zranb1 UTSW 7 132,585,633 (GRCm39) missense probably benign 0.00
R6519:Zranb1 UTSW 7 132,551,857 (GRCm39) nonsense probably null
R6671:Zranb1 UTSW 7 132,573,042 (GRCm39) missense probably damaging 1.00
R6827:Zranb1 UTSW 7 132,551,474 (GRCm39) missense probably benign 0.17
R6928:Zranb1 UTSW 7 132,568,323 (GRCm39) missense possibly damaging 0.65
R7313:Zranb1 UTSW 7 132,584,481 (GRCm39) missense probably damaging 1.00
R7583:Zranb1 UTSW 7 132,585,625 (GRCm39) missense probably benign 0.00
R8181:Zranb1 UTSW 7 132,585,508 (GRCm39) missense probably damaging 1.00
R8236:Zranb1 UTSW 7 132,551,393 (GRCm39) missense probably damaging 0.99
R8463:Zranb1 UTSW 7 132,551,810 (GRCm39) missense possibly damaging 0.68
R9006:Zranb1 UTSW 7 132,572,909 (GRCm39) splice site probably benign
R9103:Zranb1 UTSW 7 132,584,167 (GRCm39) missense probably damaging 0.96
R9134:Zranb1 UTSW 7 132,551,886 (GRCm39) missense probably benign 0.00
R9229:Zranb1 UTSW 7 132,583,117 (GRCm39) missense probably damaging 0.98
R9244:Zranb1 UTSW 7 132,585,640 (GRCm39) missense probably damaging 1.00
R9596:Zranb1 UTSW 7 132,552,146 (GRCm39) missense probably benign 0.32
R9708:Zranb1 UTSW 7 132,584,600 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACGTCTGAAGCTGAGACCTTTC -3'
(R):5'- TACAAGGCCGGATCTGTCTG -3'

Sequencing Primer
(F):5'- CTTAGACCCTTTTGTGAAGAAGGC -3'
(R):5'- ATCTGTCTGTAGCGGTCAAGCC -3'
Posted On 2022-05-16