Incidental Mutation 'R9424:Car3'
ID 712478
Institutional Source Beutler Lab
Gene Symbol Car3
Ensembl Gene ENSMUSG00000027559
Gene Name carbonic anhydrase 3
Synonyms Car-3
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9424 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 14928598-14937441 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 14929450 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 59 (I59F)
Ref Sequence ENSEMBL: ENSMUSP00000029076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029076]
AlphaFold P16015
Predicted Effect
SMART Domains Protein: ENSMUSP00000029076
Gene: ENSMUSG00000027559
AA Change: I59F

DomainStartEndE-ValueType
Carb_anhydrase 5 259 2.72e-135 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit a normal life span and a normal response to hyperoxic challenge. Mutant muscles display shorter half-relaxation times for both single and tetanic twitches but show normal fatigability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T A 15: 81,947,843 (GRCm39) I580N probably benign Het
Adam9 C A 8: 25,445,953 (GRCm39) V814F probably benign Het
Aipl1 C T 11: 71,928,253 (GRCm39) G11D probably damaging Het
Ak2 A G 4: 128,896,195 (GRCm39) E120G possibly damaging Het
Akap9 C A 5: 4,012,223 (GRCm39) Y975* probably null Het
Akap9 C T 5: 4,012,224 (GRCm39) Q976* probably null Het
Bpnt1 T C 1: 185,070,335 (GRCm39) M9T possibly damaging Het
C4bp C A 1: 130,584,912 (GRCm39) L41F probably damaging Het
Card11 T C 5: 140,894,395 (GRCm39) D78G probably damaging Het
Ccdc125 A G 13: 100,820,876 (GRCm39) D199G possibly damaging Het
Ccdc88c T C 12: 100,911,749 (GRCm39) D695G possibly damaging Het
Cd48 T A 1: 171,532,432 (GRCm39) I237N possibly damaging Het
Cep295 T C 9: 15,244,499 (GRCm39) E1319G probably damaging Het
Col6a4 C A 9: 105,945,271 (GRCm39) A948S probably benign Het
Dcp1b T A 6: 119,196,993 (GRCm39) Y563* probably null Het
Dcp2 C T 18: 44,538,361 (GRCm39) R173C probably damaging Het
Ddx59 T A 1: 136,344,681 (GRCm39) Y117* probably null Het
Dennd2a A T 6: 39,485,294 (GRCm39) Y328* probably null Het
Dhx30 A G 9: 109,916,712 (GRCm39) L601P probably damaging Het
Dip2c A G 13: 9,709,431 (GRCm39) T1424A probably damaging Het
Dlg2 A G 7: 92,080,325 (GRCm39) N733S probably damaging Het
Dnah5 C T 15: 28,272,286 (GRCm39) T1030M probably benign Het
Fgd5 A T 6: 91,956,017 (GRCm39) R3* probably null Het
Gbf1 A T 19: 46,248,122 (GRCm39) T300S probably benign Het
Gm5591 A T 7: 38,219,721 (GRCm39) L384Q probably damaging Het
Grm5 C T 7: 87,765,484 (GRCm39) A904V probably benign Het
Havcr1 T A 11: 46,669,391 (GRCm39) V290E probably benign Het
Hspb7 A G 4: 141,149,241 (GRCm39) D49G possibly damaging Het
Itpr2 A T 6: 146,212,505 (GRCm39) I1537N probably damaging Het
Kalrn T C 16: 33,809,188 (GRCm39) T2567A probably benign Het
Kat8 T C 7: 127,524,100 (GRCm39) L380S probably benign Het
Krt1c T A 15: 101,719,792 (GRCm39) Y626F unknown Het
Lrrk2 T A 15: 91,636,388 (GRCm39) L1454* probably null Het
Mgat4a C A 1: 37,529,436 (GRCm39) V148F probably damaging Het
Mtg1 T A 7: 139,727,212 (GRCm39) Y238* probably null Het
Neb T A 2: 52,041,410 (GRCm39) Q6807L probably benign Het
Nlrp9a C A 7: 26,260,178 (GRCm39) F644L probably benign Het
Pcdhb15 A G 18: 37,607,263 (GRCm39) N165S Het
Pcdhb5 C A 18: 37,454,120 (GRCm39) Q167K probably damaging Het
Per1 T A 11: 68,998,855 (GRCm39) M1142K probably damaging Het
Piezo1 A G 8: 123,218,079 (GRCm39) V1220A Het
Pkd1l1 T C 11: 8,820,091 (GRCm39) T1713A Het
Plec C A 15: 76,115,377 (GRCm39) A66S probably benign Het
Ppfia4 C A 1: 134,247,044 (GRCm39) V559F possibly damaging Het
Ppil6 T C 10: 41,379,024 (GRCm39) S224P probably damaging Het
Ppp2r2d T A 7: 138,475,978 (GRCm39) M262K possibly damaging Het
Prl7d1 A T 13: 27,894,185 (GRCm39) M127K probably benign Het
Rassf9 T A 10: 102,381,577 (GRCm39) C320S probably benign Het
Rbm19 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 5: 120,278,345 (GRCm39) probably benign Het
Rin3 T A 12: 102,335,589 (GRCm39) L420* probably null Het
Serpina3i A G 12: 104,234,730 (GRCm39) T354A probably benign Het
Serpinb9b A G 13: 33,213,544 (GRCm39) S34G probably damaging Het
Slc19a2 T C 1: 164,076,895 (GRCm39) V25A probably damaging Het
Slc1a2 G A 2: 102,591,394 (GRCm39) E375K probably damaging Het
Slfn9 T A 11: 82,878,211 (GRCm39) Y306F possibly damaging Het
Sparcl1 A T 5: 104,241,030 (GRCm39) D131E possibly damaging Het
Srl A T 16: 4,301,031 (GRCm39) L680Q probably damaging Het
Sufu G A 19: 46,474,320 (GRCm39) W465* probably null Het
Szt2 A G 4: 118,248,151 (GRCm39) L691P probably damaging Het
Tbc1d4 A T 14: 101,703,096 (GRCm39) I783N probably damaging Het
Tmem191 C T 16: 17,094,526 (GRCm39) R62* probably null Het
Tmem217 C A 17: 29,745,690 (GRCm39) M13I possibly damaging Het
Triobp T C 15: 78,844,266 (GRCm39) S161P probably damaging Het
Trp53bp2 T C 1: 182,273,864 (GRCm39) V503A possibly damaging Het
Tspoap1 G A 11: 87,652,082 (GRCm39) probably benign Het
Ttn T C 2: 76,582,347 (GRCm39) T22849A probably damaging Het
Ugt2b37 A T 5: 87,402,217 (GRCm39) M138K probably damaging Het
Uimc1 A T 13: 55,223,646 (GRCm39) F209I possibly damaging Het
Vipr1 G A 9: 121,471,993 (GRCm39) probably null Het
Wdr91 A T 6: 34,861,302 (GRCm39) N633K possibly damaging Het
Zfp618 T C 4: 63,051,282 (GRCm39) S688P probably benign Het
Other mutations in Car3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Car3 APN 3 14,933,439 (GRCm39) missense probably benign 0.03
IGL02423:Car3 APN 3 14,931,911 (GRCm39) missense probably damaging 1.00
R0624:Car3 UTSW 3 14,931,864 (GRCm39) missense probably benign 0.16
R1775:Car3 UTSW 3 14,929,492 (GRCm39) missense probably benign 0.01
R4861:Car3 UTSW 3 14,931,956 (GRCm39) missense probably damaging 0.99
R4861:Car3 UTSW 3 14,931,956 (GRCm39) missense probably damaging 0.99
R5856:Car3 UTSW 3 14,936,701 (GRCm39) missense probably damaging 1.00
R6273:Car3 UTSW 3 14,936,677 (GRCm39) missense probably benign 0.14
R7481:Car3 UTSW 3 14,928,632 (GRCm39) start codon destroyed probably benign 0.41
R7666:Car3 UTSW 3 14,935,124 (GRCm39) missense probably benign
R8922:Car3 UTSW 3 14,931,952 (GRCm39) missense
R9355:Car3 UTSW 3 14,928,664 (GRCm39) missense
Z1177:Car3 UTSW 3 14,936,696 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- GGCTTCTGTACACTTTGCTG -3'
(R):5'- TTCAGGGATAAACTTCTCCCGC -3'

Sequencing Primer
(F):5'- GTTCACTAAATAGAGGCCTTGAGCTG -3'
(R):5'- GGGATAAACTTCTCCCGCTTCCC -3'
Posted On 2022-05-16