Incidental Mutation 'R9425:Agtrap'
ID 712552
Institutional Source Beutler Lab
Gene Symbol Agtrap
Ensembl Gene ENSMUSG00000029007
Gene Name angiotensin II, type I receptor-associated protein
Synonyms Atrap, 3300002E14Rik, D4Wsu124e
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R9425 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 148161518-148172488 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 148165019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 136 (I136T)
Ref Sequence ENSEMBL: ENSMUSP00000030865 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030865]
AlphaFold Q9WVK0
Predicted Effect probably damaging
Transcript: ENSMUST00000030865
AA Change: I136T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030865
Gene: ENSMUSG00000029007
AA Change: I136T

DomainStartEndE-ValueType
AGTRAP 1 161 1.91e-121 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased mean systemic and systolic blood pressure, hypervolemia, decreased urine pH, and polyuria following administration of acetazolamide. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 G C 3: 121,926,344 (GRCm39) S1260T probably damaging Het
Adgra2 A G 8: 27,576,094 (GRCm39) I41V probably benign Het
Adgrf1 A G 17: 43,621,274 (GRCm39) I504V possibly damaging Het
Arhgef7 C T 8: 11,867,736 (GRCm39) T601I probably damaging Het
Asb7 T C 7: 66,328,987 (GRCm39) I18V possibly damaging Het
C1rl T C 6: 124,485,322 (GRCm39) V231A probably benign Het
Cachd1 A T 4: 100,832,057 (GRCm39) T740S probably benign Het
Ccdc146 T A 5: 21,508,135 (GRCm39) I638F probably damaging Het
Ccser2 T C 14: 36,601,163 (GRCm39) N407S probably benign Het
Clec7a G A 6: 129,442,514 (GRCm39) S126L probably damaging Het
Copb1 C T 7: 113,848,182 (GRCm39) G118R probably damaging Het
Cpne3 A T 4: 19,525,148 (GRCm39) M449K probably damaging Het
Cttnbp2 A T 6: 18,423,880 (GRCm39) C815S probably damaging Het
Cyp27b1 T C 10: 126,886,006 (GRCm39) L253P probably damaging Het
Cyp3a44 C A 5: 145,740,548 (GRCm39) G31* probably null Het
Dcp2 C T 18: 44,538,361 (GRCm39) R173C probably damaging Het
Dmgdh A T 13: 93,880,813 (GRCm39) I748L probably benign Het
Drc1 T A 5: 30,502,938 (GRCm39) W154R probably benign Het
E330034G19Rik T A 14: 24,358,387 (GRCm39) probably null Het
Gbp7 T A 3: 142,248,718 (GRCm39) V327E probably damaging Het
Gm11564 G A 11: 99,706,065 (GRCm39) P122S unknown Het
Grid2ip C A 5: 143,367,435 (GRCm39) S615R Het
Kcp T A 6: 29,489,151 (GRCm39) Q1045L probably benign Het
Lgals3bp T A 11: 118,284,751 (GRCm39) E276V probably damaging Het
Lrit1 T C 14: 36,784,208 (GRCm39) V512A possibly damaging Het
Mecom T A 3: 30,039,597 (GRCm39) H154L probably benign Het
Mmp14 C A 14: 54,677,804 (GRCm39) T475K probably damaging Het
Mmp1a T G 9: 7,476,210 (GRCm39) F436V probably damaging Het
Notch4 A G 17: 34,795,801 (GRCm39) S830G probably benign Het
Oas1b T C 5: 120,955,693 (GRCm39) L158P probably benign Het
Odf4 A G 11: 68,813,810 (GRCm39) V126A probably benign Het
Olfml2a A G 2: 38,847,721 (GRCm39) T427A probably damaging Het
Or2b28 A G 13: 21,531,473 (GRCm39) Y125C probably damaging Het
Or4c102 C A 2: 88,422,877 (GRCm39) T243K probably damaging Het
Or5b121 C T 19: 13,507,222 (GRCm39) L106F probably damaging Het
Or6d12 G A 6: 116,493,574 (GRCm39) E279K possibly damaging Het
Or8b42 A G 9: 38,342,286 (GRCm39) K236R possibly damaging Het
Panx3 G A 9: 37,572,393 (GRCm39) H386Y probably benign Het
Papss1 C A 3: 131,270,708 (GRCm39) C8* probably null Het
Papss2 G T 19: 32,615,750 (GRCm39) V161L possibly damaging Het
Pcdh18 G T 3: 49,709,051 (GRCm39) H755N possibly damaging Het
Pilrb2 G C 5: 137,866,964 (GRCm39) H180D probably benign Het
Pla2g4f T C 2: 120,133,264 (GRCm39) D645G possibly damaging Het
Pnlip A T 19: 58,669,290 (GRCm39) K430* probably null Het
Ralbp1 C A 17: 66,171,506 (GRCm39) A156S possibly damaging Het
Rnf4 C T 5: 34,508,641 (GRCm39) R168C probably benign Het
Slc17a5 C T 9: 78,484,457 (GRCm39) G127E probably damaging Het
Slc22a27 A T 19: 7,874,156 (GRCm39) N306K probably damaging Het
Slc5a9 G A 4: 111,734,803 (GRCm39) R664C probably damaging Het
Slco1b2 T A 6: 141,603,249 (GRCm39) I210K possibly damaging Het
Snx16 C T 3: 10,499,520 (GRCm39) R170H probably damaging Het
Speer4e1 T C 5: 14,987,136 (GRCm39) I90V possibly damaging Het
Stxbp5l T C 16: 36,994,706 (GRCm39) D733G possibly damaging Het
Tbc1d24 A G 17: 24,404,382 (GRCm39) V254A probably benign Het
Tmf1 A G 6: 97,149,293 (GRCm39) F485L probably benign Het
Tnks G A 8: 35,340,819 (GRCm39) L396F probably damaging Het
Trabd T C 15: 88,969,496 (GRCm39) C230R probably damaging Het
Trp53rkb C T 2: 166,637,542 (GRCm39) A166V probably benign Het
Upf1 A T 8: 70,792,003 (GRCm39) D418E probably benign Het
Ust A C 10: 8,205,873 (GRCm39) S137A probably damaging Het
Zfp513 T A 5: 31,357,695 (GRCm39) H228L possibly damaging Het
Zfp827 C A 8: 79,905,588 (GRCm39) A855E probably damaging Het
Other mutations in Agtrap
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1381:Agtrap UTSW 4 148,168,422 (GRCm39) missense probably damaging 1.00
R1913:Agtrap UTSW 4 148,168,434 (GRCm39) missense probably damaging 1.00
R5237:Agtrap UTSW 4 148,166,817 (GRCm39) missense probably benign 0.00
R6768:Agtrap UTSW 4 148,166,067 (GRCm39) missense probably benign 0.06
R7348:Agtrap UTSW 4 148,165,054 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACCTCTGTGATAGGGAATGGC -3'
(R):5'- CACCCATCAGATGCTAGGATTG -3'

Sequencing Primer
(F):5'- CGGATGCCCCACTGTAGGTC -3'
(R):5'- CCCATCAGATGCTAGGATTGAGTGG -3'
Posted On 2022-05-16