Incidental Mutation 'R9426:Strn3'
ID 712640
Institutional Source Beutler Lab
Gene Symbol Strn3
Ensembl Gene ENSMUSG00000020954
Gene Name striatin, calmodulin binding protein 3
Synonyms SG2NA
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9426 (G1)
Quality Score 225.009
Status Not validated
Chromosome 12
Chromosomal Location 51656415-51738680 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 51694873 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 297 (T297A)
Ref Sequence ENSEMBL: ENSMUSP00000013130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013130] [ENSMUST00000169503]
AlphaFold Q9ERG2
Predicted Effect probably damaging
Transcript: ENSMUST00000013130
AA Change: T297A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000013130
Gene: ENSMUSG00000020954
AA Change: T297A

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
low complexity region 31 55 N/A INTRINSIC
Pfam:Striatin 64 194 1.3e-50 PFAM
low complexity region 252 263 N/A INTRINSIC
low complexity region 349 367 N/A INTRINSIC
low complexity region 429 446 N/A INTRINSIC
WD40 468 507 7.05e-9 SMART
WD40 521 560 2.42e-7 SMART
WD40 574 613 1.62e-8 SMART
WD40 617 659 8.25e0 SMART
WD40 670 708 2.65e1 SMART
WD40 711 750 2.32e-9 SMART
WD40 753 796 4.95e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169503
AA Change: T297A

PolyPhen 2 Score 0.395 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000130184
Gene: ENSMUSG00000020954
AA Change: T297A

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
low complexity region 31 55 N/A INTRINSIC
Pfam:Striatin 64 198 3.2e-51 PFAM
low complexity region 252 263 N/A INTRINSIC
low complexity region 345 362 N/A INTRINSIC
WD40 384 423 7.05e-9 SMART
WD40 437 476 2.42e-7 SMART
WD40 490 529 1.62e-8 SMART
WD40 533 575 8.25e0 SMART
WD40 586 624 2.65e1 SMART
WD40 627 666 2.32e-9 SMART
WD40 669 712 4.95e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 A G 10: 79,851,264 (GRCm39) D2159G possibly damaging Het
Adamts8 A G 9: 30,864,721 (GRCm39) Y404C possibly damaging Het
Adprhl1 A G 8: 13,274,034 (GRCm39) F908S possibly damaging Het
Arhgef16 A C 4: 154,366,300 (GRCm39) L489R probably damaging Het
Asmt G A X: 169,110,199 (GRCm39) G236E probably damaging Het
Ces2e A G 8: 105,656,220 (GRCm39) Y177C probably damaging Het
Cfap43 A G 19: 47,814,237 (GRCm39) I199T probably damaging Het
Chac1 T A 2: 119,183,914 (GRCm39) F172Y possibly damaging Het
Cldnd2 A T 7: 43,092,688 (GRCm39) I160F possibly damaging Het
Col15a1 G C 4: 47,288,200 (GRCm39) probably benign Het
Coq10b C G 1: 55,106,719 (GRCm39) L175V possibly damaging Het
Cpne6 T C 14: 55,751,176 (GRCm39) probably null Het
Dnai4 A T 4: 102,906,743 (GRCm39) I690N probably damaging Het
Eif2b3 C A 4: 116,923,578 (GRCm39) Y264* probably null Het
Fcgbpl1 A T 7: 27,843,281 (GRCm39) H723L possibly damaging Het
Fhod1 C T 8: 106,056,490 (GRCm39) R1100Q probably benign Het
Hao1 T A 2: 134,347,555 (GRCm39) H250L probably benign Het
Has3 A G 8: 107,600,823 (GRCm39) Y95C probably damaging Het
Hoxc10 A T 15: 102,879,289 (GRCm39) K270* probably null Het
Kcnq5 A G 1: 21,473,118 (GRCm39) F710L probably benign Het
Knl1 C T 2: 118,899,979 (GRCm39) T560I possibly damaging Het
Ltbp1 C T 17: 75,598,309 (GRCm39) R597W possibly damaging Het
Nfib T G 4: 82,416,529 (GRCm39) T170P probably damaging Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Optn T A 2: 5,059,485 (GRCm39) E11V possibly damaging Het
Or4d2b A T 11: 87,780,056 (GRCm39) L222Q probably damaging Het
Phf3 A T 1: 30,870,625 (GRCm39) L141* probably null Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Pramel39-ps G T 5: 94,451,001 (GRCm39) P375H probably damaging Het
Prkcg C T 7: 3,375,975 (GRCm39) S540F probably damaging Het
Ptbp1 T A 10: 79,694,897 (GRCm39) I75N probably damaging Het
R3hdm1 T C 1: 128,164,212 (GRCm39) L1042P probably damaging Het
Scmh1 T C 4: 120,362,556 (GRCm39) V264A probably benign Het
Sec23a A G 12: 59,053,890 (GRCm39) V36A probably benign Het
Senp2 A G 16: 21,828,491 (GRCm39) S34G probably damaging Het
Serpina3a A G 12: 104,087,649 (GRCm39) N191D probably benign Het
Slc4a11 C T 2: 130,533,664 (GRCm39) A100T probably damaging Het
Smchd1 C T 17: 71,672,125 (GRCm39) S1643N probably benign Het
Snrk T A 9: 121,986,326 (GRCm39) Y232N probably damaging Het
Spata31h1 T A 10: 82,126,610 (GRCm39) K2133N probably damaging Het
Spmip3 T A 1: 177,570,834 (GRCm39) L56* probably null Het
St6galnac6 T C 2: 32,505,094 (GRCm39) I202T probably damaging Het
Stab2 T C 10: 86,704,911 (GRCm39) K1819R probably damaging Het
Sult1b1 T A 5: 87,665,280 (GRCm39) E218V probably damaging Het
Tcp10c T C 17: 13,584,463 (GRCm39) S275P probably benign Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Urb2 T G 8: 124,755,285 (GRCm39) L331V probably damaging Het
Zfp592 A T 7: 80,674,205 (GRCm39) T390S probably damaging Het
Other mutations in Strn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Strn3 APN 12 51,707,979 (GRCm39) missense possibly damaging 0.63
IGL00690:Strn3 APN 12 51,657,221 (GRCm39) missense possibly damaging 0.96
IGL00886:Strn3 APN 12 51,656,933 (GRCm39) missense probably damaging 1.00
IGL01967:Strn3 APN 12 51,699,596 (GRCm39) missense probably damaging 1.00
IGL02507:Strn3 APN 12 51,708,410 (GRCm39) nonsense probably null
IGL03139:Strn3 APN 12 51,699,633 (GRCm39) splice site probably benign
IGL03282:Strn3 APN 12 51,673,992 (GRCm39) missense probably benign 0.00
PIT4519001:Strn3 UTSW 12 51,680,491 (GRCm39) missense probably benign 0.00
R0106:Strn3 UTSW 12 51,668,571 (GRCm39) missense probably benign 0.01
R0106:Strn3 UTSW 12 51,668,571 (GRCm39) missense probably benign 0.01
R0336:Strn3 UTSW 12 51,708,391 (GRCm39) critical splice donor site probably null
R0492:Strn3 UTSW 12 51,657,187 (GRCm39) missense probably damaging 1.00
R0512:Strn3 UTSW 12 51,673,966 (GRCm39) missense possibly damaging 0.94
R0610:Strn3 UTSW 12 51,657,231 (GRCm39) critical splice acceptor site probably null
R0707:Strn3 UTSW 12 51,657,187 (GRCm39) missense probably damaging 1.00
R0834:Strn3 UTSW 12 51,673,879 (GRCm39) splice site probably benign
R1562:Strn3 UTSW 12 51,680,401 (GRCm39) missense probably benign
R1599:Strn3 UTSW 12 51,699,549 (GRCm39) missense possibly damaging 0.78
R1663:Strn3 UTSW 12 51,699,609 (GRCm39) missense probably damaging 1.00
R1807:Strn3 UTSW 12 51,673,986 (GRCm39) missense probably benign 0.10
R2263:Strn3 UTSW 12 51,690,006 (GRCm39) splice site probably null
R2443:Strn3 UTSW 12 51,674,618 (GRCm39) missense probably damaging 1.00
R3623:Strn3 UTSW 12 51,707,999 (GRCm39) missense possibly damaging 0.87
R3624:Strn3 UTSW 12 51,707,999 (GRCm39) missense possibly damaging 0.87
R4154:Strn3 UTSW 12 51,673,914 (GRCm39) missense probably damaging 1.00
R4223:Strn3 UTSW 12 51,674,638 (GRCm39) missense probably damaging 1.00
R4400:Strn3 UTSW 12 51,694,883 (GRCm39) missense possibly damaging 0.85
R4564:Strn3 UTSW 12 51,680,404 (GRCm39) missense probably benign 0.00
R4585:Strn3 UTSW 12 51,696,953 (GRCm39) missense probably benign 0.02
R4755:Strn3 UTSW 12 51,656,999 (GRCm39) missense possibly damaging 0.70
R4794:Strn3 UTSW 12 51,696,954 (GRCm39) missense probably benign 0.38
R5288:Strn3 UTSW 12 51,694,803 (GRCm39) missense probably damaging 1.00
R5308:Strn3 UTSW 12 51,676,168 (GRCm39) missense probably damaging 0.99
R5765:Strn3 UTSW 12 51,680,410 (GRCm39) missense probably benign
R5893:Strn3 UTSW 12 51,690,006 (GRCm39) splice site probably null
R5945:Strn3 UTSW 12 51,676,279 (GRCm39) missense probably benign 0.00
R6244:Strn3 UTSW 12 51,656,890 (GRCm39) missense probably damaging 0.98
R6523:Strn3 UTSW 12 51,689,881 (GRCm39) splice site probably null
R7437:Strn3 UTSW 12 51,656,946 (GRCm39) missense probably damaging 1.00
R7545:Strn3 UTSW 12 51,674,543 (GRCm39) missense probably damaging 0.98
R8299:Strn3 UTSW 12 51,694,890 (GRCm39) missense probably damaging 1.00
R8337:Strn3 UTSW 12 51,707,955 (GRCm39) missense probably damaging 1.00
R9141:Strn3 UTSW 12 51,694,873 (GRCm39) missense probably damaging 1.00
R9501:Strn3 UTSW 12 51,696,956 (GRCm39) missense probably damaging 0.99
R9503:Strn3 UTSW 12 51,656,894 (GRCm39) missense possibly damaging 0.68
R9518:Strn3 UTSW 12 51,696,956 (GRCm39) missense probably damaging 0.99
R9563:Strn3 UTSW 12 51,674,300 (GRCm39) missense possibly damaging 0.92
R9630:Strn3 UTSW 12 51,657,013 (GRCm39) missense probably damaging 1.00
R9696:Strn3 UTSW 12 51,676,286 (GRCm39) missense probably damaging 1.00
X0024:Strn3 UTSW 12 51,699,492 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTTACCTGCTACCATACACACAGAG -3'
(R):5'- AGCACCTCATCACTTGTGTC -3'

Sequencing Primer
(F):5'- TACACACAGAGCCCACACAGG -3'
(R):5'- CTCATCACTTGTGTCAGATGTTACAG -3'
Posted On 2022-05-16