Incidental Mutation 'R9427:Pira12'
ID 712675
Institutional Source Beutler Lab
Gene Symbol Pira12
Ensembl Gene ENSMUSG00000074417
Gene Name paired-Ig-like receptor A12
Synonyms Gm14548
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # R9427 (G1)
Quality Score 193.009
Status Not validated
Chromosome 7
Chromosomal Location 3887241-3901119 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) T to G at 3897284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000070073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070639] [ENSMUST00000070639] [ENSMUST00000070639]
AlphaFold E9Q1Z6
Predicted Effect probably null
Transcript: ENSMUST00000070639
SMART Domains Protein: ENSMUSP00000070073
Gene: ENSMUSG00000074417

DomainStartEndE-ValueType
IG 34 118 6.41e-2 SMART
IG 129 315 8.59e-3 SMART
IG_like 237 302 1.91e-1 SMART
IG 328 415 3.36e0 SMART
IG_like 435 502 3.11e0 SMART
IG 529 618 8.59e-3 SMART
low complexity region 627 636 N/A INTRINSIC
low complexity region 654 663 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000070639
SMART Domains Protein: ENSMUSP00000070073
Gene: ENSMUSG00000074417

DomainStartEndE-ValueType
IG 34 118 6.41e-2 SMART
IG 129 315 8.59e-3 SMART
IG_like 237 302 1.91e-1 SMART
IG 328 415 3.36e0 SMART
IG_like 435 502 3.11e0 SMART
IG 529 618 8.59e-3 SMART
low complexity region 627 636 N/A INTRINSIC
low complexity region 654 663 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000070639
SMART Domains Protein: ENSMUSP00000070073
Gene: ENSMUSG00000074417

DomainStartEndE-ValueType
IG 34 118 6.41e-2 SMART
IG 129 315 8.59e-3 SMART
IG_like 237 302 1.91e-1 SMART
IG 328 415 3.36e0 SMART
IG_like 435 502 3.11e0 SMART
IG 529 618 8.59e-3 SMART
low complexity region 627 636 N/A INTRINSIC
low complexity region 654 663 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 T C 2: 103,531,244 (GRCm39) L458P probably damaging Het
Adgrl2 T C 3: 148,526,068 (GRCm39) N130S Het
Adgrv1 T C 13: 81,732,234 (GRCm39) S161G probably benign Het
Aldh1l1 A G 6: 90,536,903 (GRCm39) D153G probably benign Het
Arhgap20 G A 9: 51,754,991 (GRCm39) S444N probably damaging Het
Bpifc A G 10: 85,812,129 (GRCm39) F360L probably benign Het
Cacna1s A T 1: 136,012,090 (GRCm39) I511F probably benign Het
Chdh G A 14: 29,758,806 (GRCm39) V584I probably benign Het
Col12a1 T C 9: 79,589,445 (GRCm39) R1037G probably benign Het
Col15a1 G C 4: 47,288,200 (GRCm39) probably benign Het
Col6a5 T C 9: 105,816,992 (GRCm39) N440D unknown Het
Dsel A T 1: 111,787,425 (GRCm39) Y1037N probably damaging Het
Eloa A G 4: 135,748,935 (GRCm39) M1T probably null Het
Elp2 C G 18: 24,755,560 (GRCm39) P436A probably damaging Het
Etv5 A C 16: 22,218,112 (GRCm39) S328A probably damaging Het
Fat3 A T 9: 16,288,691 (GRCm39) Y277* probably null Het
Fbxo38 A T 18: 62,644,160 (GRCm39) H899Q probably benign Het
Fstl5 T C 3: 76,229,583 (GRCm39) V128A Het
Gm3371 T C 14: 44,641,066 (GRCm39) E166G Het
Herc6 T C 6: 57,636,722 (GRCm39) S813P probably damaging Het
Ifnlr1 G A 4: 135,426,142 (GRCm39) G75D probably damaging Het
Kbtbd2 A T 6: 56,756,132 (GRCm39) C535S probably damaging Het
Lgr5 A C 10: 115,288,913 (GRCm39) L577W probably damaging Het
Limk1 A T 5: 134,686,358 (GRCm39) D590E probably benign Het
Lnpep A T 17: 17,795,609 (GRCm39) S301T probably benign Het
Lrch1 A C 14: 75,032,787 (GRCm39) V521G probably benign Het
Lrrc71 T C 3: 87,650,368 (GRCm39) H235R probably benign Het
Mttp A G 3: 137,820,962 (GRCm39) S282P probably benign Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Or2t1 G A 14: 14,328,456 (GRCm38) G115D probably damaging Het
Or55b10 T A 7: 102,143,206 (GRCm39) T259S probably benign Het
Or5a3 T C 19: 12,399,889 (GRCm39) V72A Het
Or5m13 T C 2: 85,748,704 (GRCm39) V145A probably benign Het
Or7a41 C T 10: 78,871,395 (GRCm39) T255I probably damaging Het
Or7c70 A G 10: 78,682,906 (GRCm39) V281A probably damaging Het
Ppfia3 T C 7: 45,008,213 (GRCm39) Q219R possibly damaging Het
Prdm5 T A 6: 65,771,321 (GRCm39) M44K possibly damaging Het
Psmc5 T C 11: 106,153,303 (GRCm39) I315T probably damaging Het
Ptprd T A 4: 76,051,440 (GRCm39) E27V probably benign Het
Rft1 T A 14: 30,411,781 (GRCm39) I443N probably damaging Het
Rsf1 G GACGGCGGCC 7: 97,229,116 (GRCm39) probably benign Het
Slco1a5 A G 6: 142,214,001 (GRCm39) M40T probably damaging Het
Svep1 T C 4: 58,069,804 (GRCm39) T2661A possibly damaging Het
Tigit T C 16: 43,482,515 (GRCm39) D73G probably benign Het
Tmem237 G A 1: 59,159,213 (GRCm39) probably benign Het
Trim42 T C 9: 97,247,874 (GRCm39) D274G probably damaging Het
Trmt61a C A 12: 111,647,490 (GRCm39) L196I probably damaging Het
Tspan8 T C 10: 115,669,213 (GRCm39) C83R probably damaging Het
Ttc7 CCTGCTGCTGCTGCTGCTG CCTGCTGCTGCTGCTG 17: 87,678,147 (GRCm39) probably benign Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Unc80 G A 1: 66,594,158 (GRCm39) G1179E probably damaging Het
Vmn2r2 A G 3: 64,041,945 (GRCm39) S257P probably damaging Het
Xpo6 G T 7: 125,748,418 (GRCm39) Y404* probably null Het
Other mutations in Pira12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00541:Pira12 APN 7 3,900,385 (GRCm39) splice site probably benign
IGL01358:Pira12 APN 7 3,898,686 (GRCm39) missense probably benign 0.41
IGL01868:Pira12 APN 7 3,900,174 (GRCm39) nonsense probably null
IGL02421:Pira12 APN 7 3,899,994 (GRCm39) missense possibly damaging 0.87
IGL02544:Pira12 APN 7 3,900,185 (GRCm39) missense probably damaging 0.96
IGL02960:Pira12 APN 7 3,900,078 (GRCm39) missense possibly damaging 0.88
IGL02973:Pira12 APN 7 3,900,239 (GRCm39) missense probably damaging 1.00
PIT4495001:Pira12 UTSW 7 3,900,457 (GRCm39) missense probably damaging 1.00
R0761:Pira12 UTSW 7 3,896,978 (GRCm39) critical splice donor site probably null
R1917:Pira12 UTSW 7 3,900,637 (GRCm39) missense probably damaging 1.00
R1920:Pira12 UTSW 7 3,900,871 (GRCm39) missense probably damaging 0.98
R2219:Pira12 UTSW 7 3,900,488 (GRCm39) missense probably benign 0.10
R2220:Pira12 UTSW 7 3,900,488 (GRCm39) missense probably benign 0.10
R4991:Pira12 UTSW 7 3,898,571 (GRCm39) missense probably benign 0.37
R5271:Pira12 UTSW 7 3,900,566 (GRCm39) nonsense probably null
R5909:Pira12 UTSW 7 3,900,621 (GRCm39) missense probably damaging 1.00
R6008:Pira12 UTSW 7 3,897,599 (GRCm39) missense probably damaging 1.00
R6193:Pira12 UTSW 7 3,901,049 (GRCm39) critical splice donor site probably null
R6218:Pira12 UTSW 7 3,897,031 (GRCm39) missense possibly damaging 0.65
R6219:Pira12 UTSW 7 3,897,640 (GRCm39) missense probably damaging 1.00
R6650:Pira12 UTSW 7 3,898,632 (GRCm39) missense probably benign 0.15
R6879:Pira12 UTSW 7 3,899,961 (GRCm39) missense probably benign 0.40
R6987:Pira12 UTSW 7 3,900,660 (GRCm39) missense probably damaging 0.99
R7082:Pira12 UTSW 7 3,898,510 (GRCm39) missense probably damaging 1.00
R7087:Pira12 UTSW 7 3,900,218 (GRCm39) missense probably benign 0.08
R7144:Pira12 UTSW 7 3,900,615 (GRCm39) missense probably damaging 1.00
R7298:Pira12 UTSW 7 3,898,264 (GRCm39) missense possibly damaging 0.92
R7359:Pira12 UTSW 7 3,901,103 (GRCm39) start gained probably benign
R7751:Pira12 UTSW 7 3,898,603 (GRCm39) missense probably damaging 1.00
R7810:Pira12 UTSW 7 3,897,204 (GRCm39) missense probably damaging 1.00
R8344:Pira12 UTSW 7 3,899,954 (GRCm39) missense possibly damaging 0.93
R8428:Pira12 UTSW 7 3,898,257 (GRCm39) missense probably benign 0.02
R8875:Pira12 UTSW 7 3,897,256 (GRCm39) missense probably damaging 0.98
R8943:Pira12 UTSW 7 3,898,365 (GRCm39) missense probably benign 0.11
R9045:Pira12 UTSW 7 3,897,547 (GRCm39) missense possibly damaging 0.92
R9125:Pira12 UTSW 7 3,900,021 (GRCm39) missense possibly damaging 0.62
R9129:Pira12 UTSW 7 3,898,500 (GRCm39) critical splice donor site probably null
R9224:Pira12 UTSW 7 3,900,234 (GRCm39) missense probably benign 0.13
R9777:Pira12 UTSW 7 3,897,612 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGCTGATCATGGGACTTTG -3'
(R):5'- ATCAGGAACCTAGCCTCTGC -3'

Sequencing Primer
(F):5'- CTGATCATGGGACTTTGATTTTAGTC -3'
(R):5'- CTCTGCTCAGGCTCTAATGGG -3'
Posted On 2022-05-16