Mutagenetix > Incidental Mutation

Incidental Mutation 'R9428:Ptprc'

712709

Institutional Source

Beutler Lab

Gene Symbol

Ptprc

Ensembl Gene

ENSMUSG00000026395

Gene Name

protein tyrosine phosphatase receptor type C

Synonyms

Ly-5, T200, CD45, B220, Lyt-4

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9428 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

137990599-138103446 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 138041485 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 76 (T76S)

Ref Sequence

ENSEMBL: ENSMUSP00000138800 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182283] [ENSMUST00000182755] [ENSMUST00000183301] [ENSMUST00000193650] [ENSMUST00000195533]

AlphaFold

P06800

Predicted Effect

probably benign
Transcript: ENSMUST00000182283
AA Change: T76S

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395
AA Change: T76S

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182755
AA Change: T52S

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395
AA Change: T52S

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395
AA Change: T215S

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000193650

SMART Domains

Protein: ENSMUSP00000141524
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	8.4e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000195533
AA Change: T125S

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000142052
Gene: ENSMUSG00000026395
AA Change: T125S

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	7.4e-11	PFAM
low complexity region	68	115	N/A	INTRINSIC
Pfam:CD45	121	180	2.1e-22	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acte1	G	T	7: 143,434,902 (GRCm39)		probably null	Het
Agmo	A	G	12: 37,455,330 (GRCm39)	I281M	probably benign	Het
Ahdc1	C	T	4: 132,791,773 (GRCm39)	P1005S	possibly damaging	Het
Akap12	T	A	10: 4,303,409 (GRCm39)	V178D	probably damaging	Het
Arc	A	G	15: 74,543,063 (GRCm39)	S387P	probably benign	Het
Arhgap11a	C	T	2: 113,667,279 (GRCm39)	V423I	probably benign	Het
Arhgap44	A	G	11: 64,899,168 (GRCm39)	S670P	probably damaging	Het
C4b	G	A	17: 34,949,885 (GRCm39)	T1433M	possibly damaging	Het
C4bp	A	T	1: 130,581,094 (GRCm39)	F138L	probably benign	Het
Carmil1	A	T	13: 24,295,834 (GRCm39)	C393*	probably null	Het
Cblif	A	G	19: 11,735,102 (GRCm39)	T241A	probably benign	Het
Celsr1	A	T	15: 85,815,549 (GRCm39)	V1822E	possibly damaging	Het
Chgb	C	G	2: 132,635,154 (GRCm39)	S365R	probably damaging	Het
Cnih3	T	C	1: 181,180,857 (GRCm39)		probably benign	Het
Dcaf1	T	A	9: 106,735,528 (GRCm39)	D825E	possibly damaging	Het
Dlx3	T	C	11: 95,011,430 (GRCm39)	Y95H	probably benign	Het
Dmbt1	A	T	7: 130,668,208 (GRCm39)	E488V	unknown	Het
Espnl	A	G	1: 91,273,595 (GRCm39)	Y985C	probably damaging	Het
Frmpd2	T	C	14: 33,272,010 (GRCm39)	V1048A	probably damaging	Het
Fxn	A	T	19: 24,249,787 (GRCm39)	L100Q	probably damaging	Het
Gapvd1	T	A	2: 34,607,318 (GRCm39)	D560V	probably damaging	Het
Gm4924	T	A	10: 82,213,490 (GRCm39)	H429Q	unknown	Het
Gpr158	T	C	2: 21,787,972 (GRCm39)	F538L	probably benign	Het
Itpr1	T	A	6: 108,378,308 (GRCm39)	M1278K	possibly damaging	Het
Ivd	T	A	2: 118,708,369 (GRCm39)	V361E	probably damaging	Het
Kcnh6	T	C	11: 105,899,821 (GRCm39)	L30P	probably damaging	Het
Lipo4	C	T	19: 33,495,074 (GRCm39)	V35I	probably benign	Het
Lmo7	A	G	14: 102,155,076 (GRCm39)	D1200G	probably damaging	Het
Med1	T	A	11: 98,080,049 (GRCm39)	R31*	probably null	Het
Mill2	A	T	7: 18,573,950 (GRCm39)	R12*	probably null	Het
Mphosph8	A	G	14: 56,934,114 (GRCm39)		probably null	Het
Mtfr2	T	A	10: 20,233,039 (GRCm39)	S203T	possibly damaging	Het
Muc5ac	A	C	7: 141,362,559 (GRCm39)	T1957P	unknown	Het
Mxi1	C	A	19: 53,299,213 (GRCm39)	P28Q	probably benign	Het
Mycbpap	T	C	11: 94,393,995 (GRCm39)	D367G	probably damaging	Het
Nav3	T	C	10: 109,605,176 (GRCm39)	T966A	probably benign	Het
Nbea	AC	A	3: 55,998,393 (GRCm39)		probably null	Het
Ndst2	A	T	14: 20,775,470 (GRCm39)	F673L	possibly damaging	Het
Ndst3	T	A	3: 123,340,518 (GRCm39)	I767F	probably benign	Het
Nell1	A	T	7: 50,503,683 (GRCm39)	D696V	probably damaging	Het
Nol9	A	T	4: 152,124,109 (GRCm39)	T100S	probably benign	Het
Nr4a1	T	C	15: 101,168,245 (GRCm39)	S94P	probably damaging	Het
Nrdc	T	C	4: 108,858,121 (GRCm39)	I31T	probably damaging	Het
Oas2	T	A	5: 120,887,576 (GRCm39)	D88V	probably damaging	Het
Or8w1	T	C	2: 87,465,774 (GRCm39)	I106V	probably benign	Het
Pex6	A	G	17: 47,022,991 (GRCm39)	H189R	probably benign	Het
Pgap1	A	G	1: 54,575,206 (GRCm39)	S239P	probably damaging	Het
Pheta1	C	T	5: 121,991,147 (GRCm39)	P170S	possibly damaging	Het
Plec	A	G	15: 76,067,721 (GRCm39)		probably null	Het
Plekhg5	T	C	4: 152,192,780 (GRCm39)	V582A	probably benign	Het
Plekhh2	G	T	17: 84,873,841 (GRCm39)	E375D	probably benign	Het
Pramel55	G	T	5: 95,949,545 (GRCm39)	R97S	probably damaging	Het
Prp2rt	A	G	13: 97,235,724 (GRCm39)	S8P	probably benign	Het
Psmd4	G	A	3: 94,940,767 (GRCm39)	T332I	probably benign	Het
Rab44	A	T	17: 29,358,315 (GRCm39)	I168L		Het
Ros1	T	C	10: 51,958,061 (GRCm39)	T1872A	probably benign	Het
Scgb1b24	A	T	7: 33,443,493 (GRCm39)	K51*	probably null	Het
Scube2	A	T	7: 109,428,345 (GRCm39)	D509E	probably benign	Het
Sgo2b	A	T	8: 64,393,067 (GRCm39)	S123R	probably damaging	Het
Smc3	G	C	19: 53,617,150 (GRCm39)	R521P	possibly damaging	Het
Socs4	G	A	14: 47,528,034 (GRCm39)	R323H	probably damaging	Het
Socs5	T	A	17: 87,441,067 (GRCm39)	D2E	probably benign	Het
Sra1	A	G	18: 36,810,299 (GRCm39)	V121A	probably damaging	Het
Stimate	T	C	14: 30,594,645 (GRCm39)	S253P	probably benign	Het
Tanc1	T	C	2: 59,601,548 (GRCm39)	L143P	probably damaging	Het
Tcerg1l	A	T	7: 137,811,490 (GRCm39)	F568Y	probably damaging	Het
Trpm7	T	C	2: 126,671,140 (GRCm39)	E614G	probably damaging	Het
Tuba4a	G	T	1: 75,192,686 (GRCm39)	H337Q		Het
Tubgcp6	G	A	15: 88,985,100 (GRCm39)	H1663Y	probably damaging	Het
Ush2a	A	G	1: 188,175,316 (GRCm39)	Y1138C	probably damaging	Het
Vmn1r18	A	T	6: 57,367,535 (GRCm39)	N6K	possibly damaging	Het
Vmn1r213	G	A	13: 23,195,944 (GRCm39)	A176T		Het
Vmn1r215	A	T	13: 23,260,749 (GRCm39)	H263L	probably benign	Het
Vmn2r51	CGGCCAATAGAAGAAACTTTTACCTTCAAGCAGTGAGAACTGGC	CGGC	7: 9,833,712 (GRCm39)		probably benign	Het
Wdhd1	A	C	14: 47,489,427 (GRCm39)	L702*	probably null	Het
Zc3h12a	T	C	4: 125,020,558 (GRCm39)	E95G	probably benign	Het

Other mutations in Ptprc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
lochy	APN	1	138,011,528 (GRCm39)	splice site	probably benign
IGL00486:Ptprc	APN	1	138,043,359 (GRCm39)	missense	probably damaging	0.97
IGL00771:Ptprc	APN	1	138,041,415 (GRCm39)	missense	probably benign	0.00
IGL00833:Ptprc	APN	1	138,006,230 (GRCm39)	missense	possibly damaging	0.55
IGL00919:Ptprc	APN	1	138,041,380 (GRCm39)	missense	probably damaging	1.00
IGL01020:Ptprc	APN	1	138,047,911 (GRCm39)	critical splice acceptor site	probably null	0.00
IGL01024:Ptprc	APN	1	138,008,650 (GRCm39)	missense	probably damaging	1.00
IGL01302:Ptprc	APN	1	138,027,369 (GRCm39)	missense	possibly damaging	0.82
IGL01548:Ptprc	APN	1	138,027,219 (GRCm39)	critical splice donor site	probably null	0.00
IGL01620:Ptprc	APN	1	137,996,148 (GRCm39)	missense	possibly damaging	0.88
IGL01775:Ptprc	APN	1	137,992,497 (GRCm39)	missense	probably damaging	1.00
IGL01820:Ptprc	APN	1	137,993,936 (GRCm39)	missense	probably damaging	1.00
IGL02340:Ptprc	APN	1	137,998,957 (GRCm39)	missense	probably damaging	1.00
IGL02943:Ptprc	APN	1	138,027,251 (GRCm39)	missense	probably damaging	0.99
IGL03169:Ptprc	APN	1	138,041,357 (GRCm39)	missense	probably benign	0.15
IGL03308:Ptprc	APN	1	138,054,058 (GRCm39)	missense	possibly damaging	0.70
IGL03404:Ptprc	APN	1	138,020,739 (GRCm39)	missense	probably damaging	1.00
belittle	UTSW	1	138,137,493 (GRCm38)	intron	probably benign
Benighted	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
bletchley	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
Blush	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
bruise	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
chor_muang	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
crystal	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
Dumpling	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
fluorescent	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
fuchsia	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
Gentian	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
guotie	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
guotie2	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
Guotie3	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
Gyoza	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
Half_measure	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
jirisan	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
mauve	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
Perverse	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
petechiae	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
ultra	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
violaceous	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R0013:Ptprc	UTSW	1	138,041,297 (GRCm39)	splice site	probably null
R0189:Ptprc	UTSW	1	138,010,453 (GRCm39)	missense	probably benign	0.10
R0390:Ptprc	UTSW	1	138,050,313 (GRCm39)	missense	possibly damaging	0.71
R0504:Ptprc	UTSW	1	138,016,435 (GRCm39)	missense	probably damaging	1.00
R0602:Ptprc	UTSW	1	138,017,223 (GRCm39)	splice site	probably benign
R0627:Ptprc	UTSW	1	137,996,058 (GRCm39)	missense	probably damaging	0.99
R0632:Ptprc	UTSW	1	138,001,348 (GRCm39)	missense	probably benign	0.01
R0751:Ptprc	UTSW	1	138,020,668 (GRCm39)	missense	probably damaging	1.00
R0839:Ptprc	UTSW	1	138,028,870 (GRCm39)	missense	possibly damaging	0.47
R0942:Ptprc	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
R0943:Ptprc	UTSW	1	138,038,902 (GRCm39)	missense	probably damaging	0.96
R1159:Ptprc	UTSW	1	138,000,057 (GRCm39)	missense	probably damaging	1.00
R1442:Ptprc	UTSW	1	138,000,050 (GRCm39)	missense	probably damaging	1.00
R1489:Ptprc	UTSW	1	138,047,824 (GRCm39)	missense	possibly damaging	0.91
R1728:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1728:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1728:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1728:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1728:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1729:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1729:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1729:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1730:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1730:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1730:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1730:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1730:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1739:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1739:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1739:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1739:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1739:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1762:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1762:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1762:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1762:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1762:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1783:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1783:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1783:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1784:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1784:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1784:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1785:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1785:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1785:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1785:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1785:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1862:Ptprc	UTSW	1	138,039,965 (GRCm39)	missense	probably benign	0.13
R2145:Ptprc	UTSW	1	138,001,419 (GRCm39)	missense	probably damaging	1.00
R2290:Ptprc	UTSW	1	138,038,926 (GRCm39)	missense	probably benign	0.00
R2403:Ptprc	UTSW	1	138,016,270 (GRCm39)	missense	probably damaging	1.00
R2439:Ptprc	UTSW	1	137,993,890 (GRCm39)	missense	possibly damaging	0.67
R2887:Ptprc	UTSW	1	138,007,916 (GRCm39)	missense	probably damaging	1.00
R2906:Ptprc	UTSW	1	137,992,272 (GRCm39)	missense	possibly damaging	0.93
R3774:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3775:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3776:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3834:Ptprc	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
R4019:Ptprc	UTSW	1	138,006,254 (GRCm39)	missense	probably damaging	1.00
R4377:Ptprc	UTSW	1	137,995,663 (GRCm39)	missense	probably benign	0.04
R4580:Ptprc	UTSW	1	137,998,989 (GRCm39)	missense	probably benign	0.09
R4923:Ptprc	UTSW	1	138,006,236 (GRCm39)	missense	possibly damaging	0.93
R4925:Ptprc	UTSW	1	138,027,235 (GRCm39)	missense	probably benign	0.04
R4937:Ptprc	UTSW	1	138,017,238 (GRCm39)	missense	probably damaging	1.00
R4970:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5112:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5145:Ptprc	UTSW	1	138,017,304 (GRCm39)	missense	probably benign	0.07
R5158:Ptprc	UTSW	1	138,102,822 (GRCm39)	missense	possibly damaging	0.75
R5223:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R5593:Ptprc	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
R5689:Ptprc	UTSW	1	138,045,515 (GRCm39)	missense	probably benign	0.01
R5885:Ptprc	UTSW	1	138,016,246 (GRCm39)	missense	probably damaging	1.00
R6010:Ptprc	UTSW	1	138,028,794 (GRCm39)	missense	probably benign	0.09
R6026:Ptprc	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
R6047:Ptprc	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
R6173:Ptprc	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
R6328:Ptprc	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
R6383:Ptprc	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
R6436:Ptprc	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R6492:Ptprc	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
R6520:Ptprc	UTSW	1	138,007,881 (GRCm39)	nonsense	probably null
R6805:Ptprc	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
R6830:Ptprc	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
R6847:Ptprc	UTSW	1	138,016,283 (GRCm39)	missense	probably damaging	0.99
R6960:Ptprc	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
R6995:Ptprc	UTSW	1	138,016,482 (GRCm39)	missense	probably damaging	1.00
R7009:Ptprc	UTSW	1	137,992,291 (GRCm39)	missense	probably damaging	0.97
R7041:Ptprc	UTSW	1	138,054,047 (GRCm39)	missense	probably benign	0.04
R7055:Ptprc	UTSW	1	138,017,309 (GRCm39)	missense	probably damaging	1.00
R7098:Ptprc	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
R7164:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7188:Ptprc	UTSW	1	137,998,918 (GRCm39)	missense	probably damaging	1.00
R7191:Ptprc	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
R7204:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7316:Ptprc	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
R7644:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01
R7948:Ptprc	UTSW	1	137,992,314 (GRCm39)	missense	probably benign	0.45
R8029:Ptprc	UTSW	1	138,006,197 (GRCm39)	missense	probably damaging	1.00
R8677:Ptprc	UTSW	1	138,011,335 (GRCm39)	missense	probably damaging	1.00
R8704:Ptprc	UTSW	1	138,043,362 (GRCm39)	missense	probably benign	0.34
R8824:Ptprc	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
R8921:Ptprc	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
R8998:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R8999:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R9154:Ptprc	UTSW	1	138,016,302 (GRCm39)	missense	probably damaging	1.00
R9388:Ptprc	UTSW	1	138,011,380 (GRCm39)	missense	possibly damaging	0.87
R9467:Ptprc	UTSW	1	137,993,960 (GRCm39)	missense	probably damaging	1.00
R9468:Ptprc	UTSW	1	138,044,754 (GRCm39)	missense	probably benign	0.01
R9479:Ptprc	UTSW	1	138,001,388 (GRCm39)	missense	probably benign	0.38
R9526:Ptprc	UTSW	1	137,996,111 (GRCm39)	missense	probably benign	0.02
R9632:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9710:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9714:Ptprc	UTSW	1	138,008,687 (GRCm39)	missense	probably damaging	1.00
R9777:Ptprc	UTSW	1	138,047,901 (GRCm39)	missense
Z1177:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CCCAGATAGAGAGAAATTGACATTC -3'
(R):5'- TACTTCTGCTTGCTGAGTACTG -3'

Sequencing Primer
(F):5'- ATTGACATTCACCTGGTGGTAC -3'
(R):5'- CATTCTCGATGATGATTGTACT -3'

Posted On

2022-05-16