Incidental Mutation 'R9430:Trpm1'
| ID |
712880 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, melastatin, 4732499L03Rik, LTRPC1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9430 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
63803583-63919523 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 63873446 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 567
(L567P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000082318
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000177102]
[ENSMUST00000205348]
[ENSMUST00000205731]
[ENSMUST00000205994]
[ENSMUST00000206263]
[ENSMUST00000206277]
[ENSMUST00000206314]
[ENSMUST00000206706]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085222
AA Change: L567P
PolyPhen 2
Score 0.375 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: L567P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177102
AA Change: L451P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000134947
Gene: ENSMUSG00000030523
AA Change: L451P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
Blast:ANK
|
389 |
417 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205348
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205731
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205994
AA Change: L75P
PolyPhen 2
Score 0.143 (Sensitivity: 0.92; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206263
AA Change: L451P
PolyPhen 2
Score 0.375 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206277
AA Change: L567P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206706
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Als2 |
A |
C |
1: 59,231,198 (GRCm39) |
N804K |
probably benign |
Het |
| Arid5b |
C |
A |
10: 68,022,087 (GRCm39) |
|
probably null |
Het |
| Brd2 |
T |
C |
17: 34,331,610 (GRCm39) |
D779G |
unknown |
Het |
| Brox |
A |
T |
1: 183,069,353 (GRCm39) |
V118E |
probably damaging |
Het |
| Ccdc137 |
A |
T |
11: 120,349,530 (GRCm39) |
E76V |
probably damaging |
Het |
| Ccdc150 |
A |
G |
1: 54,320,930 (GRCm39) |
K327E |
probably damaging |
Het |
| Ccdc171 |
A |
G |
4: 83,522,362 (GRCm39) |
E342G |
probably damaging |
Het |
| Cd109 |
G |
A |
9: 78,574,698 (GRCm39) |
|
probably null |
Het |
| Cep85 |
C |
A |
4: 133,894,665 (GRCm39) |
R47L |
probably damaging |
Het |
| Cgrrf1 |
T |
A |
14: 47,091,331 (GRCm39) |
V285E |
probably damaging |
Het |
| Ctu1 |
T |
C |
7: 43,326,042 (GRCm39) |
S234P |
probably damaging |
Het |
| Dnah3 |
G |
A |
7: 119,628,205 (GRCm39) |
T1484I |
probably damaging |
Het |
| Dusp16 |
G |
T |
6: 134,737,829 (GRCm39) |
Q70K |
probably damaging |
Het |
| Eri3 |
T |
G |
4: 117,439,868 (GRCm39) |
Y187* |
probably null |
Het |
| Evi2a |
T |
A |
11: 79,418,523 (GRCm39) |
Y29F |
possibly damaging |
Het |
| Ext2 |
A |
G |
2: 93,592,999 (GRCm39) |
S402P |
possibly damaging |
Het |
| Fam76a |
T |
A |
4: 132,645,055 (GRCm39) |
Q60L |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 16,287,381 (GRCm39) |
N714S |
probably damaging |
Het |
| Fbxw24 |
T |
A |
9: 109,439,038 (GRCm39) |
N179I |
probably damaging |
Het |
| Fras1 |
A |
G |
5: 96,929,251 (GRCm39) |
N3885S |
probably benign |
Het |
| Grip2 |
A |
T |
6: 91,784,265 (GRCm39) |
V12E |
probably benign |
Het |
| Gse1 |
A |
T |
8: 121,299,049 (GRCm39) |
Y766F |
unknown |
Het |
| Herc1 |
C |
T |
9: 66,325,785 (GRCm39) |
Q1420* |
probably null |
Het |
| Htr1f |
T |
A |
16: 64,746,831 (GRCm39) |
I154F |
probably damaging |
Het |
| Hus1b |
G |
T |
13: 31,131,587 (GRCm39) |
A24E |
probably damaging |
Het |
| Igkv17-127 |
A |
G |
6: 67,838,441 (GRCm39) |
I51V |
probably damaging |
Het |
| Ilk |
G |
T |
7: 105,390,072 (GRCm39) |
R149L |
probably benign |
Het |
| Inpp5b |
T |
A |
4: 124,636,340 (GRCm39) |
V5E |
possibly damaging |
Het |
| Jak2 |
A |
T |
19: 29,265,367 (GRCm39) |
S465C |
possibly damaging |
Het |
| Kif23 |
T |
C |
9: 61,834,722 (GRCm39) |
T394A |
probably damaging |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
| Lama4 |
A |
G |
10: 38,921,802 (GRCm39) |
D441G |
probably null |
Het |
| Ldhd |
A |
G |
8: 112,356,680 (GRCm39) |
L27P |
possibly damaging |
Het |
| Lingo1 |
A |
G |
9: 56,527,512 (GRCm39) |
I365T |
probably benign |
Het |
| Lyz2 |
C |
A |
10: 117,118,077 (GRCm39) |
C24F |
possibly damaging |
Het |
| Map1b |
T |
A |
13: 99,570,616 (GRCm39) |
T702S |
unknown |
Het |
| Map4 |
T |
A |
9: 109,863,760 (GRCm39) |
D328E |
probably benign |
Het |
| Matn1 |
C |
T |
4: 130,673,278 (GRCm39) |
T82M |
probably damaging |
Het |
| Mfrp |
T |
C |
9: 44,014,570 (GRCm39) |
V239A |
probably damaging |
Het |
| Misp |
G |
T |
10: 79,661,675 (GRCm39) |
V31F |
probably benign |
Het |
| Muc5ac |
C |
T |
7: 141,362,569 (GRCm39) |
T1960I |
unknown |
Het |
| Myh2 |
T |
A |
11: 67,070,359 (GRCm39) |
M434K |
probably benign |
Het |
| Myh3 |
T |
A |
11: 66,982,726 (GRCm39) |
I815N |
possibly damaging |
Het |
| Myo18a |
A |
G |
11: 77,709,410 (GRCm39) |
M507V |
possibly damaging |
Het |
| Nbas |
T |
A |
12: 13,371,654 (GRCm39) |
S385T |
probably benign |
Het |
| Nepro |
G |
A |
16: 44,552,460 (GRCm39) |
R319K |
possibly damaging |
Het |
| Nlrc3 |
A |
T |
16: 3,783,396 (GRCm39) |
C53S |
probably benign |
Het |
| Nudt17 |
A |
G |
3: 96,614,224 (GRCm39) |
|
probably null |
Het |
| Nwd2 |
T |
G |
5: 63,964,665 (GRCm39) |
C1416W |
probably damaging |
Het |
| Ocln |
A |
C |
13: 100,676,356 (GRCm39) |
F46V |
possibly damaging |
Het |
| Or52n3 |
A |
T |
7: 104,530,204 (GRCm39) |
N97Y |
possibly damaging |
Het |
| Or5be3 |
A |
T |
2: 86,864,253 (GRCm39) |
V104D |
probably damaging |
Het |
| Osbpl5 |
T |
C |
7: 143,263,526 (GRCm39) |
K119R |
probably benign |
Het |
| Paf1 |
T |
G |
7: 28,096,331 (GRCm39) |
F315V |
possibly damaging |
Het |
| Parp4 |
T |
A |
14: 56,866,673 (GRCm39) |
V1079D |
probably damaging |
Het |
| Pcgf6 |
C |
T |
19: 47,039,219 (GRCm39) |
A14T |
unknown |
Het |
| Plcxd1 |
A |
G |
5: 110,251,368 (GRCm39) |
T315A |
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,758,544 (GRCm39) |
V384A |
probably benign |
Het |
| Polm |
G |
A |
11: 5,784,749 (GRCm39) |
T236I |
probably damaging |
Het |
| Prl7d1 |
T |
C |
13: 27,898,360 (GRCm39) |
T50A |
possibly damaging |
Het |
| Reln |
T |
C |
5: 22,120,105 (GRCm39) |
D2849G |
probably damaging |
Het |
| Sec16b |
C |
T |
1: 157,394,894 (GRCm39) |
R1045C |
probably damaging |
Het |
| Six4 |
A |
G |
12: 73,150,719 (GRCm39) |
S609P |
possibly damaging |
Het |
| Slc25a31 |
A |
T |
3: 40,679,297 (GRCm39) |
|
probably null |
Het |
| Slc4a2 |
A |
G |
5: 24,636,317 (GRCm39) |
N230S |
probably benign |
Het |
| Sorcs1 |
T |
C |
19: 50,199,208 (GRCm39) |
Y785C |
probably damaging |
Het |
| Styxl1 |
A |
G |
5: 135,784,259 (GRCm39) |
|
probably null |
Het |
| Synm |
C |
T |
7: 67,383,181 (GRCm39) |
V1494M |
possibly damaging |
Het |
| Taf7l2 |
A |
T |
10: 115,949,282 (GRCm39) |
D81E |
probably damaging |
Het |
| Tamm41 |
A |
G |
6: 114,993,063 (GRCm39) |
M230T |
probably benign |
Het |
| Tbc1d12 |
T |
G |
19: 38,884,490 (GRCm39) |
M347R |
probably damaging |
Het |
| Thap1 |
CAGCATCTGCTCGGAGCA |
CAGCA |
8: 26,650,884 (GRCm39) |
|
probably null |
Het |
| Tm4sf1 |
A |
C |
3: 57,197,214 (GRCm39) |
S164A |
probably damaging |
Het |
| Trim67 |
A |
G |
8: 125,552,956 (GRCm39) |
H686R |
probably damaging |
Het |
| Tsfm |
A |
G |
10: 126,858,771 (GRCm39) |
L198P |
probably damaging |
Het |
| Ttc6 |
A |
T |
12: 57,733,193 (GRCm39) |
D1112V |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,601,922 (GRCm39) |
V18580A |
probably benign |
Het |
| Ubr1 |
C |
A |
2: 120,734,506 (GRCm39) |
Q1131H |
possibly damaging |
Het |
| Uhrf2 |
C |
T |
19: 30,016,659 (GRCm39) |
R117C |
probably benign |
Het |
| Vmn2r70 |
A |
G |
7: 85,215,240 (GRCm39) |
V98A |
probably benign |
Het |
| Zfp799 |
T |
C |
17: 33,039,186 (GRCm39) |
E360G |
probably damaging |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
63,893,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
63,897,215 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
63,885,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
63,893,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
63,860,578 (GRCm39) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
63,884,767 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
63,854,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
63,893,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
63,918,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
63,876,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
63,884,742 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
63,858,723 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
63,860,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
63,867,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
63,895,690 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
63,868,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
63,890,175 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
63,918,862 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
63,848,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
63,868,881 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
63,868,908 (GRCm39) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
63,918,309 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
63,848,998 (GRCm39) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
63,918,339 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
63,897,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
63,893,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
63,894,590 (GRCm39) |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
63,870,002 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
63,852,801 (GRCm39) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
63,867,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
63,873,565 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
63,890,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
63,885,569 (GRCm39) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
63,884,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
63,876,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
63,880,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
63,917,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
63,858,182 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
63,858,780 (GRCm39) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
63,890,303 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
63,884,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
63,859,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
63,918,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
63,884,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
63,849,061 (GRCm39) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
63,867,475 (GRCm39) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
63,867,451 (GRCm39) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
63,851,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
63,858,660 (GRCm39) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
63,852,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
63,893,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
63,858,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
63,894,580 (GRCm39) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
63,885,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
63,887,441 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
63,918,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
63,858,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
63,870,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
63,858,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
63,918,710 (GRCm39) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
63,873,547 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
63,876,553 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
63,918,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
63,917,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
63,918,226 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
63,848,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
63,918,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
63,803,781 (GRCm39) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
63,890,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
63,893,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
63,876,462 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
63,885,593 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
63,918,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
63,854,333 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
63,868,854 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
63,859,729 (GRCm39) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
63,918,549 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
63,858,723 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
63,890,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
63,858,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
63,854,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
63,897,939 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
63,851,689 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
63,858,718 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
63,849,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
63,851,699 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
63,918,541 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
63,897,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
63,874,356 (GRCm39) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
63,851,756 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
63,918,628 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
63,858,089 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
63,848,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
63,890,319 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
63,884,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
63,873,623 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
63,918,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9537:Trpm1
|
UTSW |
7 |
63,803,616 (GRCm39) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
63,858,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
63,898,041 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
63,918,658 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
63,854,342 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
63,852,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
63,867,439 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGATCACTCTATCTGGCCAC -3'
(R):5'- ACCACATGTTACTCTGGGAGG -3'
Sequencing Primer
(F):5'- CACAGGTGTGCCATGGACTCTATAG -3'
(R):5'- CATGTTACTCTGGGAGGCACAG -3'
|
| Posted On |
2022-05-16 |
Incidental Mutation