Incidental Mutation 'R9432:Vmn1r176'
ID 713016
Institutional Source Beutler Lab
Gene Symbol Vmn1r176
Ensembl Gene ENSMUSG00000096859
Gene Name vomeronasal 1 receptor 176
Synonyms Gm5998
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R9432 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 23534237-23535151 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23534743 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 137 (Y137N)
Ref Sequence ENSEMBL: ENSMUSP00000132168 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171073] [ENSMUST00000226319] [ENSMUST00000226767] [ENSMUST00000227129] [ENSMUST00000227661] [ENSMUST00000228280] [ENSMUST00000228793]
AlphaFold G3UW31
Predicted Effect probably damaging
Transcript: ENSMUST00000171073
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000132168
Gene: ENSMUSG00000096859
AA Change: Y137N

DomainStartEndE-ValueType
Pfam:7tm_1 5 288 5.4e-6 PFAM
Pfam:TAS2R 8 295 1.8e-13 PFAM
Pfam:V1R 41 295 1.7e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226319
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000226767
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227129
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227661
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228280
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228793
AA Change: Y137N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik T C 5: 109,884,917 (GRCm39) R314G unknown Het
Abca13 G A 11: 9,244,559 (GRCm39) V2141M probably benign Het
Abcc10 G A 17: 46,634,710 (GRCm39) A431V possibly damaging Het
Acod1 A G 14: 103,292,414 (GRCm39) R313G probably damaging Het
Adam3 G T 8: 25,193,928 (GRCm39) S361R probably damaging Het
Ahcyl2 C T 6: 29,768,874 (GRCm39) T113M possibly damaging Het
Ano8 C A 8: 71,933,561 (GRCm39) R577L unknown Het
Arhgef7 T A 8: 11,869,646 (GRCm39) S653R probably damaging Het
Atp10a G A 7: 58,469,418 (GRCm39) V1090I possibly damaging Het
Birc6 A G 17: 74,966,216 (GRCm39) M4048V probably benign Het
C3 G A 17: 57,530,950 (GRCm39) P384S probably damaging Het
Camkk1 A T 11: 72,928,757 (GRCm39) E432V probably damaging Het
Celsr3 T A 9: 108,726,032 (GRCm39) V3087D probably benign Het
Ckap4 A G 10: 84,363,543 (GRCm39) S507P probably damaging Het
Coq6 G A 12: 84,420,464 (GRCm39) M471I probably benign Het
Csmd2 C A 4: 128,171,004 (GRCm39) H332Q Het
Cxcr1 T A 1: 74,231,231 (GRCm39) N264Y probably damaging Het
Dchs2 C A 3: 83,036,032 (GRCm39) R260S possibly damaging Het
Elmod2 C A 8: 84,057,761 (GRCm39) A41S possibly damaging Het
Emilin2 G A 17: 71,581,781 (GRCm39) T315I probably benign Het
Eml1 A G 12: 108,482,842 (GRCm39) N487S probably benign Het
Epn1 G T 7: 5,096,369 (GRCm39) R221L probably benign Het
Faah A G 4: 115,874,772 (GRCm39) V28A probably benign Het
Fbl G A 7: 27,876,689 (GRCm39) R230H probably benign Het
Fsip2 C T 2: 82,805,907 (GRCm39) S742F probably damaging Het
Gm5460 A G 14: 33,767,769 (GRCm39) D184G possibly damaging Het
Gpatch2l T C 12: 86,307,408 (GRCm39) V262A probably damaging Het
Grin2c A T 11: 115,142,052 (GRCm39) L789* probably null Het
H1f0 C T 15: 78,912,947 (GRCm39) P9L probably damaging Het
Hectd4 A G 5: 121,460,864 (GRCm39) T948A probably benign Het
Herc2 G A 7: 55,780,932 (GRCm39) G1199D probably damaging Het
Hoxb7 G T 11: 96,177,617 (GRCm39) A22S possibly damaging Het
Ifih1 T A 2: 62,439,618 (GRCm39) I519F probably damaging Het
Ifit1bl1 T A 19: 34,571,498 (GRCm39) I320F possibly damaging Het
Iqgap2 T C 13: 95,774,261 (GRCm39) T1320A probably benign Het
Kat2a A G 11: 100,602,178 (GRCm39) V192A probably damaging Het
Kat6b A C 14: 21,672,077 (GRCm39) H329P probably damaging Het
Klhl29 A G 12: 5,260,056 (GRCm39) L54P probably benign Het
Kntc1 A T 5: 123,925,112 (GRCm39) I1142F possibly damaging Het
Lipo3 A G 19: 33,533,864 (GRCm39) Y323H probably damaging Het
Lmtk3 G A 7: 45,441,994 (GRCm39) V351I probably damaging Het
Lrrc8b T C 5: 105,633,888 (GRCm39) S787P probably benign Het
Magi1 A G 6: 93,660,058 (GRCm39) I1179T probably damaging Het
Mapk11 T C 15: 89,028,631 (GRCm39) D269G probably benign Het
Mfsd13a T G 19: 46,354,868 (GRCm39) I15R probably benign Het
Myo1h G A 5: 114,499,366 (GRCm39) V143I possibly damaging Het
Naaladl1 T C 19: 6,156,917 (GRCm39) I187T possibly damaging Het
Nos1 G A 5: 118,034,871 (GRCm39) V416M probably damaging Het
Or14a256 G A 7: 86,265,065 (GRCm39) R263C possibly damaging Het
Or14j8 A G 17: 38,263,559 (GRCm39) S119P probably damaging Het
Or8k30 T G 2: 86,338,914 (GRCm39) I37S probably benign Het
Pcdh15 A G 10: 74,460,170 (GRCm39) T1373A probably damaging Het
Pcdh18 T G 3: 49,699,667 (GRCm39) M932L probably damaging Het
Pcdhb15 T A 18: 37,608,683 (GRCm39) H638Q probably benign Het
Pcdhb19 A G 18: 37,630,628 (GRCm39) E141G possibly damaging Het
Pds5b T G 5: 150,693,256 (GRCm39) L656R probably damaging Het
Plcl1 T C 1: 55,445,587 (GRCm39) L14P probably benign Het
Pzp A T 6: 128,499,128 (GRCm39) I173N Het
Rnf123 C T 9: 107,937,008 (GRCm39) R849H probably damaging Het
Sfrp5 T C 19: 42,188,225 (GRCm39) D198G probably damaging Het
Sftpb G C 6: 72,283,843 (GRCm39) A147P probably benign Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Slc30a6 A G 17: 74,719,699 (GRCm39) T220A possibly damaging Het
Slc5a3 T A 16: 91,874,615 (GRCm39) V224D probably benign Het
Smad5 T A 13: 56,875,417 (GRCm39) Y202N probably benign Het
Smok2b A G 17: 13,453,881 (GRCm39) I14V probably damaging Het
Tas2r108 T A 6: 40,471,121 (GRCm39) I199K probably damaging Het
Tcea2 A G 2: 181,322,227 (GRCm39) I10V probably damaging Het
Tfg G A 16: 56,524,868 (GRCm39) R113* probably null Het
Tubb4a A T 17: 57,388,034 (GRCm39) L331I probably benign Het
Ugt2b37 A G 5: 87,402,046 (GRCm39) V195A probably damaging Het
Umad1 A G 6: 8,401,096 (GRCm39) H55R unknown Het
Vmn1r44 T A 6: 89,870,473 (GRCm39) M73K possibly damaging Het
Vmn2r112 A G 17: 22,821,233 (GRCm39) T69A Het
Vmn2r59 A T 7: 41,696,254 (GRCm39) Y163N probably damaging Het
Vps13c T A 9: 67,830,137 (GRCm39) D1514E probably benign Het
Vsir A G 10: 60,193,732 (GRCm39) D65G possibly damaging Het
Ypel3 A T 7: 126,379,262 (GRCm39) M112L probably benign Het
Zfp26 T A 9: 20,347,830 (GRCm39) K911N probably damaging Het
Zfp362 C T 4: 128,670,980 (GRCm39) R346Q probably damaging Het
Zfp595 A T 13: 67,465,407 (GRCm39) Y288* probably null Het
Zfyve28 G T 5: 34,400,633 (GRCm39) Q22K possibly damaging Het
Zswim4 T G 8: 84,963,539 (GRCm39) D32A probably damaging Het
Other mutations in Vmn1r176
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01100:Vmn1r176 APN 7 23,535,049 (GRCm39) missense probably benign 0.04
IGL03004:Vmn1r176 APN 7 23,534,702 (GRCm39) missense probably damaging 1.00
PIT4151001:Vmn1r176 UTSW 7 23,534,808 (GRCm39) missense probably damaging 1.00
R0195:Vmn1r176 UTSW 7 23,535,010 (GRCm39) missense probably benign 0.10
R1186:Vmn1r176 UTSW 7 23,535,051 (GRCm39) missense probably damaging 1.00
R1531:Vmn1r176 UTSW 7 23,534,536 (GRCm39) missense possibly damaging 0.95
R1680:Vmn1r176 UTSW 7 23,534,806 (GRCm39) missense probably damaging 0.99
R1770:Vmn1r176 UTSW 7 23,534,946 (GRCm39) missense probably benign 0.06
R1803:Vmn1r176 UTSW 7 23,534,609 (GRCm39) missense probably damaging 1.00
R1970:Vmn1r176 UTSW 7 23,534,373 (GRCm39) missense probably benign 0.01
R2092:Vmn1r176 UTSW 7 23,534,578 (GRCm39) missense probably damaging 1.00
R3498:Vmn1r176 UTSW 7 23,534,667 (GRCm39) missense probably benign 0.12
R4832:Vmn1r176 UTSW 7 23,534,463 (GRCm39) missense possibly damaging 0.67
R5712:Vmn1r176 UTSW 7 23,534,925 (GRCm39) missense probably benign 0.00
R6965:Vmn1r176 UTSW 7 23,535,099 (GRCm39) missense possibly damaging 0.78
R7105:Vmn1r176 UTSW 7 23,534,748 (GRCm39) nonsense probably null
R7839:Vmn1r176 UTSW 7 23,534,394 (GRCm39) missense possibly damaging 0.91
R8262:Vmn1r176 UTSW 7 23,534,878 (GRCm39) missense probably benign 0.29
R8870:Vmn1r176 UTSW 7 23,534,480 (GRCm39) missense probably damaging 1.00
R9147:Vmn1r176 UTSW 7 23,534,785 (GRCm39) missense probably benign 0.12
Z1088:Vmn1r176 UTSW 7 23,534,598 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCATCATGGGCAAATGACAAG -3'
(R):5'- GCTTTGGGCAATACCTTGATTCTC -3'

Sequencing Primer
(F):5'- AGATGCGCATGCCTATACTG -3'
(R):5'- AGAGTTTTTATTCCAAGGGAGTTCC -3'
Posted On 2022-05-16