Incidental Mutation 'R9432:Vmn2r59'
| ID |
713018 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r59
|
| Ensembl Gene |
ENSMUSG00000092032 |
| Gene Name |
vomeronasal 2, receptor 59 |
| Synonyms |
EG628444 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R9432 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 41696254 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 163
(Y163N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
| AlphaFold |
E9PUT5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168489
AA Change: Y163N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: Y163N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
T |
C |
5: 109,884,917 (GRCm39) |
R314G |
unknown |
Het |
| Abca13 |
G |
A |
11: 9,244,559 (GRCm39) |
V2141M |
probably benign |
Het |
| Abcc10 |
G |
A |
17: 46,634,710 (GRCm39) |
A431V |
possibly damaging |
Het |
| Acod1 |
A |
G |
14: 103,292,414 (GRCm39) |
R313G |
probably damaging |
Het |
| Adam3 |
G |
T |
8: 25,193,928 (GRCm39) |
S361R |
probably damaging |
Het |
| Ahcyl2 |
C |
T |
6: 29,768,874 (GRCm39) |
T113M |
possibly damaging |
Het |
| Ano8 |
C |
A |
8: 71,933,561 (GRCm39) |
R577L |
unknown |
Het |
| Arhgef7 |
T |
A |
8: 11,869,646 (GRCm39) |
S653R |
probably damaging |
Het |
| Atp10a |
G |
A |
7: 58,469,418 (GRCm39) |
V1090I |
possibly damaging |
Het |
| Birc6 |
A |
G |
17: 74,966,216 (GRCm39) |
M4048V |
probably benign |
Het |
| C3 |
G |
A |
17: 57,530,950 (GRCm39) |
P384S |
probably damaging |
Het |
| Camkk1 |
A |
T |
11: 72,928,757 (GRCm39) |
E432V |
probably damaging |
Het |
| Celsr3 |
T |
A |
9: 108,726,032 (GRCm39) |
V3087D |
probably benign |
Het |
| Ckap4 |
A |
G |
10: 84,363,543 (GRCm39) |
S507P |
probably damaging |
Het |
| Coq6 |
G |
A |
12: 84,420,464 (GRCm39) |
M471I |
probably benign |
Het |
| Csmd2 |
C |
A |
4: 128,171,004 (GRCm39) |
H332Q |
|
Het |
| Cxcr1 |
T |
A |
1: 74,231,231 (GRCm39) |
N264Y |
probably damaging |
Het |
| Dchs2 |
C |
A |
3: 83,036,032 (GRCm39) |
R260S |
possibly damaging |
Het |
| Elmod2 |
C |
A |
8: 84,057,761 (GRCm39) |
A41S |
possibly damaging |
Het |
| Emilin2 |
G |
A |
17: 71,581,781 (GRCm39) |
T315I |
probably benign |
Het |
| Eml1 |
A |
G |
12: 108,482,842 (GRCm39) |
N487S |
probably benign |
Het |
| Epn1 |
G |
T |
7: 5,096,369 (GRCm39) |
R221L |
probably benign |
Het |
| Faah |
A |
G |
4: 115,874,772 (GRCm39) |
V28A |
probably benign |
Het |
| Fbl |
G |
A |
7: 27,876,689 (GRCm39) |
R230H |
probably benign |
Het |
| Fsip2 |
C |
T |
2: 82,805,907 (GRCm39) |
S742F |
probably damaging |
Het |
| Gm5460 |
A |
G |
14: 33,767,769 (GRCm39) |
D184G |
possibly damaging |
Het |
| Gpatch2l |
T |
C |
12: 86,307,408 (GRCm39) |
V262A |
probably damaging |
Het |
| Grin2c |
A |
T |
11: 115,142,052 (GRCm39) |
L789* |
probably null |
Het |
| H1f0 |
C |
T |
15: 78,912,947 (GRCm39) |
P9L |
probably damaging |
Het |
| Hectd4 |
A |
G |
5: 121,460,864 (GRCm39) |
T948A |
probably benign |
Het |
| Herc2 |
G |
A |
7: 55,780,932 (GRCm39) |
G1199D |
probably damaging |
Het |
| Hoxb7 |
G |
T |
11: 96,177,617 (GRCm39) |
A22S |
possibly damaging |
Het |
| Ifih1 |
T |
A |
2: 62,439,618 (GRCm39) |
I519F |
probably damaging |
Het |
| Ifit1bl1 |
T |
A |
19: 34,571,498 (GRCm39) |
I320F |
possibly damaging |
Het |
| Iqgap2 |
T |
C |
13: 95,774,261 (GRCm39) |
T1320A |
probably benign |
Het |
| Kat2a |
A |
G |
11: 100,602,178 (GRCm39) |
V192A |
probably damaging |
Het |
| Kat6b |
A |
C |
14: 21,672,077 (GRCm39) |
H329P |
probably damaging |
Het |
| Klhl29 |
A |
G |
12: 5,260,056 (GRCm39) |
L54P |
probably benign |
Het |
| Kntc1 |
A |
T |
5: 123,925,112 (GRCm39) |
I1142F |
possibly damaging |
Het |
| Lipo3 |
A |
G |
19: 33,533,864 (GRCm39) |
Y323H |
probably damaging |
Het |
| Lmtk3 |
G |
A |
7: 45,441,994 (GRCm39) |
V351I |
probably damaging |
Het |
| Lrrc8b |
T |
C |
5: 105,633,888 (GRCm39) |
S787P |
probably benign |
Het |
| Magi1 |
A |
G |
6: 93,660,058 (GRCm39) |
I1179T |
probably damaging |
Het |
| Mapk11 |
T |
C |
15: 89,028,631 (GRCm39) |
D269G |
probably benign |
Het |
| Mfsd13a |
T |
G |
19: 46,354,868 (GRCm39) |
I15R |
probably benign |
Het |
| Myo1h |
G |
A |
5: 114,499,366 (GRCm39) |
V143I |
possibly damaging |
Het |
| Naaladl1 |
T |
C |
19: 6,156,917 (GRCm39) |
I187T |
possibly damaging |
Het |
| Nos1 |
G |
A |
5: 118,034,871 (GRCm39) |
V416M |
probably damaging |
Het |
| Or14a256 |
G |
A |
7: 86,265,065 (GRCm39) |
R263C |
possibly damaging |
Het |
| Or14j8 |
A |
G |
17: 38,263,559 (GRCm39) |
S119P |
probably damaging |
Het |
| Or8k30 |
T |
G |
2: 86,338,914 (GRCm39) |
I37S |
probably benign |
Het |
| Pcdh15 |
A |
G |
10: 74,460,170 (GRCm39) |
T1373A |
probably damaging |
Het |
| Pcdh18 |
T |
G |
3: 49,699,667 (GRCm39) |
M932L |
probably damaging |
Het |
| Pcdhb15 |
T |
A |
18: 37,608,683 (GRCm39) |
H638Q |
probably benign |
Het |
| Pcdhb19 |
A |
G |
18: 37,630,628 (GRCm39) |
E141G |
possibly damaging |
Het |
| Pds5b |
T |
G |
5: 150,693,256 (GRCm39) |
L656R |
probably damaging |
Het |
| Plcl1 |
T |
C |
1: 55,445,587 (GRCm39) |
L14P |
probably benign |
Het |
| Pzp |
A |
T |
6: 128,499,128 (GRCm39) |
I173N |
|
Het |
| Rnf123 |
C |
T |
9: 107,937,008 (GRCm39) |
R849H |
probably damaging |
Het |
| Sfrp5 |
T |
C |
19: 42,188,225 (GRCm39) |
D198G |
probably damaging |
Het |
| Sftpb |
G |
C |
6: 72,283,843 (GRCm39) |
A147P |
probably benign |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Slc30a6 |
A |
G |
17: 74,719,699 (GRCm39) |
T220A |
possibly damaging |
Het |
| Slc5a3 |
T |
A |
16: 91,874,615 (GRCm39) |
V224D |
probably benign |
Het |
| Smad5 |
T |
A |
13: 56,875,417 (GRCm39) |
Y202N |
probably benign |
Het |
| Smok2b |
A |
G |
17: 13,453,881 (GRCm39) |
I14V |
probably damaging |
Het |
| Tas2r108 |
T |
A |
6: 40,471,121 (GRCm39) |
I199K |
probably damaging |
Het |
| Tcea2 |
A |
G |
2: 181,322,227 (GRCm39) |
I10V |
probably damaging |
Het |
| Tfg |
G |
A |
16: 56,524,868 (GRCm39) |
R113* |
probably null |
Het |
| Tubb4a |
A |
T |
17: 57,388,034 (GRCm39) |
L331I |
probably benign |
Het |
| Ugt2b37 |
A |
G |
5: 87,402,046 (GRCm39) |
V195A |
probably damaging |
Het |
| Umad1 |
A |
G |
6: 8,401,096 (GRCm39) |
H55R |
unknown |
Het |
| Vmn1r176 |
A |
T |
7: 23,534,743 (GRCm39) |
Y137N |
probably damaging |
Het |
| Vmn1r44 |
T |
A |
6: 89,870,473 (GRCm39) |
M73K |
possibly damaging |
Het |
| Vmn2r112 |
A |
G |
17: 22,821,233 (GRCm39) |
T69A |
|
Het |
| Vps13c |
T |
A |
9: 67,830,137 (GRCm39) |
D1514E |
probably benign |
Het |
| Vsir |
A |
G |
10: 60,193,732 (GRCm39) |
D65G |
possibly damaging |
Het |
| Ypel3 |
A |
T |
7: 126,379,262 (GRCm39) |
M112L |
probably benign |
Het |
| Zfp26 |
T |
A |
9: 20,347,830 (GRCm39) |
K911N |
probably damaging |
Het |
| Zfp362 |
C |
T |
4: 128,670,980 (GRCm39) |
R346Q |
probably damaging |
Het |
| Zfp595 |
A |
T |
13: 67,465,407 (GRCm39) |
Y288* |
probably null |
Het |
| Zfyve28 |
G |
T |
5: 34,400,633 (GRCm39) |
Q22K |
possibly damaging |
Het |
| Zswim4 |
T |
G |
8: 84,963,539 (GRCm39) |
D32A |
probably damaging |
Het |
|
| Other mutations in Vmn2r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
|
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
|
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATAGCTGGTCTTACCCACC -3'
(R):5'- GGAACCCTGATCTTCTACCCAATAC -3'
Sequencing Primer
(F):5'- ATAGCTGGTCTTACCCACCTCTAC -3'
(R):5'- CTTTATTTGGCACACAGGG -3'
|
| Posted On |
2022-05-16 |
Incidental Mutation