Incidental Mutation 'R9435:Or8g33'
ID 713233
Institutional Source Beutler Lab
Gene Symbol Or8g33
Ensembl Gene ENSMUSG00000058856
Gene Name olfactory receptor family 8 subfamily G member 33
Synonyms GA_x6K02T2PVTD-33124064-33123120, MOR171-21, Olfr952
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R9435 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39337389-39338444 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39337506 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 287 (L287P)
Ref Sequence ENSEMBL: ENSMUSP00000073558 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073895]
AlphaFold Q8VFD7
Predicted Effect probably benign
Transcript: ENSMUST00000073895
AA Change: L287P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000073558
Gene: ENSMUSG00000058856
AA Change: L287P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.5e-42 PFAM
Pfam:7tm_1 41 294 3.2e-18 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,382,562 (GRCm39) D1134E probably benign Het
Abca5 C T 11: 110,182,911 (GRCm39) probably null Het
Acp2 A G 2: 91,036,409 (GRCm39) T169A probably damaging Het
Agtpbp1 A T 13: 59,622,429 (GRCm39) N932K probably benign Het
Aldh5a1 G A 13: 25,121,293 (GRCm39) R87C probably damaging Het
Bpifa1 G T 2: 153,985,843 (GRCm39) A53S unknown Het
Cacna2d2 T C 9: 107,396,384 (GRCm39) I667T probably benign Het
Catsperg1 T A 7: 28,889,751 (GRCm39) T784S probably benign Het
Ccdc93 C T 1: 121,369,584 (GRCm39) Q109* probably null Het
Cd46 C G 1: 194,767,720 (GRCm39) D114H probably damaging Het
Cd82 A T 2: 93,267,740 (GRCm39) L19Q probably damaging Het
Celsr1 T C 15: 85,806,535 (GRCm39) probably benign Het
Cnksr1 A G 4: 133,961,885 (GRCm39) I180T possibly damaging Het
Drg2 T C 11: 60,358,966 (GRCm39) V362A probably benign Het
Eef2 T A 10: 81,014,994 (GRCm39) M231K probably benign Het
Egr2 T C 10: 67,375,628 (GRCm39) Y75H probably damaging Het
Exoc6 A C 19: 37,585,545 (GRCm39) Q473H probably benign Het
Focad T A 4: 88,267,076 (GRCm39) M1029K unknown Het
Fpr-rs4 T A 17: 18,242,391 (GRCm39) S133T probably benign Het
Gbf1 T C 19: 46,268,432 (GRCm39) V1322A probably benign Het
Gm572 T C 4: 148,752,966 (GRCm39) S282P possibly damaging Het
Gm7579 GGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGATGCAAGGGAGGCTGTGGCTCCTGTGGGGG GGCTGTGGCTCCTGTGGGGGCTGCAAGGGAAGCTGTGGCTCCTGTGGGGGATGCAAGGGAGGCTGTGGCTCCTGTGGGGG 7: 141,765,782 (GRCm39) probably benign Het
Golph3l T C 3: 95,496,369 (GRCm39) V31A probably benign Het
Iars2 A T 1: 185,034,913 (GRCm39) V610D probably damaging Het
Igsf6 T A 7: 120,666,472 (GRCm39) I203F probably damaging Het
Ildr2 A G 1: 166,136,691 (GRCm39) Y510C probably damaging Het
Iqcf4 C A 9: 106,445,652 (GRCm39) R165L possibly damaging Het
Itgb1bp1 T G 12: 21,320,943 (GRCm39) I183L possibly damaging Het
Itgb4 A C 11: 115,895,855 (GRCm39) S1414R probably benign Het
Kbtbd7 G T 14: 79,664,944 (GRCm39) A259S probably benign Het
Kif14 T A 1: 136,401,174 (GRCm39) D508E possibly damaging Het
Klc2 A T 19: 5,159,662 (GRCm39) D484E possibly damaging Het
Lamc2 T C 1: 153,013,072 (GRCm39) S630G probably benign Het
Myl6b G A 10: 128,331,066 (GRCm39) T125M possibly damaging Het
Nbea T A 3: 55,943,309 (GRCm39) K655N possibly damaging Het
Nkx3-2 T C 5: 41,919,493 (GRCm39) D165G probably benign Het
Npy A T 6: 49,804,481 (GRCm39) R67S probably damaging Het
Nrg3 A T 14: 39,194,556 (GRCm39) C68S possibly damaging Het
Nup160 C T 2: 90,560,138 (GRCm39) P1288S probably damaging Het
Or52e15 T C 7: 104,645,946 (GRCm39) H55R probably benign Het
Pam T A 1: 97,822,144 (GRCm39) I287L probably benign Het
Phf10 T C 17: 15,165,387 (GRCm39) R490G probably benign Het
Prim2 T C 1: 33,523,876 (GRCm39) Y345C probably damaging Het
Ptchd3 C T 11: 121,721,646 (GRCm39) A173V probably benign Het
Rab8b G A 9: 66,755,912 (GRCm39) R167W probably damaging Het
S100a3 A G 3: 90,509,502 (GRCm39) E49G probably benign Het
Slc41a1 T A 1: 131,766,896 (GRCm39) V138E probably damaging Het
Slit1 C A 19: 41,591,764 (GRCm39) probably null Het
Sntg1 T A 1: 8,433,814 (GRCm39) H479L probably damaging Het
Stam T A 2: 14,120,801 (GRCm39) C72S probably damaging Het
Sval2 G T 6: 41,840,795 (GRCm39) A93S probably benign Het
Tas2r103 T A 6: 133,013,686 (GRCm39) K127* probably null Het
Trank1 C T 9: 111,193,890 (GRCm39) T638M probably benign Het
Utrn T A 10: 12,519,173 (GRCm39) I2260F probably damaging Het
Zfp268 G C 4: 145,349,045 (GRCm39) E161Q Het
Zfp280d T C 9: 72,226,599 (GRCm39) probably null Het
Other mutations in Or8g33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00976:Or8g33 APN 9 39,337,953 (GRCm39) missense probably benign 0.02
IGL01368:Or8g33 APN 9 39,337,476 (GRCm39) missense probably damaging 1.00
IGL01866:Or8g33 APN 9 39,338,025 (GRCm39) missense probably damaging 0.99
IGL01939:Or8g33 APN 9 39,337,634 (GRCm39) missense probably damaging 1.00
IGL03048:Or8g33 UTSW 9 39,338,065 (GRCm39) missense probably benign 0.00
R0069:Or8g33 UTSW 9 39,338,188 (GRCm39) missense probably damaging 0.98
R1460:Or8g33 UTSW 9 39,337,503 (GRCm39) missense probably benign 0.43
R1478:Or8g33 UTSW 9 39,337,888 (GRCm39) missense possibly damaging 0.91
R1737:Or8g33 UTSW 9 39,338,254 (GRCm39) missense probably damaging 0.99
R2112:Or8g33 UTSW 9 39,337,966 (GRCm39) missense probably benign 0.26
R2169:Or8g33 UTSW 9 39,337,654 (GRCm39) missense possibly damaging 0.95
R2225:Or8g33 UTSW 9 39,337,915 (GRCm39) missense probably benign 0.00
R3731:Or8g33 UTSW 9 39,338,365 (GRCm39) start codon destroyed probably benign 0.23
R3777:Or8g33 UTSW 9 39,337,901 (GRCm39) missense possibly damaging 0.75
R3802:Or8g33 UTSW 9 39,337,582 (GRCm39) missense probably damaging 1.00
R4600:Or8g33 UTSW 9 39,337,731 (GRCm39) missense probably benign 0.27
R4887:Or8g33 UTSW 9 39,337,531 (GRCm39) missense possibly damaging 0.80
R5215:Or8g33 UTSW 9 39,337,919 (GRCm39) nonsense probably null
R5813:Or8g33 UTSW 9 39,338,032 (GRCm39) missense probably damaging 1.00
R6140:Or8g33 UTSW 9 39,337,543 (GRCm39) missense possibly damaging 0.91
R6180:Or8g33 UTSW 9 39,338,008 (GRCm39) missense probably damaging 1.00
R6383:Or8g33 UTSW 9 39,337,530 (GRCm39) missense probably damaging 1.00
R6416:Or8g33 UTSW 9 39,338,187 (GRCm39) missense probably damaging 0.98
R6808:Or8g33 UTSW 9 39,337,836 (GRCm39) missense probably damaging 0.99
R7099:Or8g33 UTSW 9 39,337,599 (GRCm39) missense probably benign 0.01
R7826:Or8g33 UTSW 9 39,337,423 (GRCm39) makesense probably null
R8309:Or8g33 UTSW 9 39,337,966 (GRCm39) missense probably benign 0.40
R8870:Or8g33 UTSW 9 39,337,548 (GRCm39) missense probably damaging 0.97
R8879:Or8g33 UTSW 9 39,337,515 (GRCm39) missense possibly damaging 0.86
R9084:Or8g33 UTSW 9 39,337,521 (GRCm39) missense probably damaging 1.00
R9209:Or8g33 UTSW 9 39,337,635 (GRCm39) missense probably damaging 0.99
R9583:Or8g33 UTSW 9 39,337,851 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- GATATGCGTCTGAGAGTCCTC -3'
(R):5'- TTGCACATTAAATCCTCTGGGG -3'

Sequencing Primer
(F):5'- CGTCTGAGAGTCCTCTTATATTTTG -3'
(R):5'- CATTAAATCCTCTGGGGGCAGAGTC -3'
Posted On 2022-05-16