Incidental Mutation 'R9436:Vmn2r26'
| ID |
713280 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R9436 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
124024758-124062035 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 124025867 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 79
(Y79H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032238
AA Change: Y79H
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: Y79H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
A |
G |
19: 31,932,575 (GRCm38) |
T340A |
probably benign |
Het |
| Adamts2 |
G |
T |
11: 50,803,680 (GRCm38) |
R1098L |
probably benign |
Het |
| Add1 |
A |
T |
5: 34,605,929 (GRCm38) |
R154* |
probably null |
Het |
| Alpk1 |
A |
G |
3: 127,685,275 (GRCm38) |
V41A |
|
Het |
| Anapc1 |
T |
C |
2: 128,676,125 (GRCm38) |
T270A |
probably benign |
Het |
| Ankhd1 |
C |
A |
18: 36,560,988 (GRCm38) |
A84D |
probably benign |
Het |
| Ankhd1 |
T |
A |
18: 36,641,601 (GRCm38) |
C1412S |
probably benign |
Het |
| Ccdc93 |
C |
T |
1: 121,441,855 (GRCm38) |
Q109* |
probably null |
Het |
| Chrm5 |
T |
C |
2: 112,479,479 (GRCm38) |
R431G |
possibly damaging |
Het |
| Dnah14 |
A |
C |
1: 181,680,783 (GRCm38) |
E1842A |
probably damaging |
Het |
| Dync1h1 |
T |
C |
12: 110,616,541 (GRCm38) |
L386P |
probably damaging |
Het |
| Efcab1 |
T |
A |
16: 14,917,677 (GRCm38) |
C84* |
probably null |
Het |
| Eme1 |
G |
A |
11: 94,647,681 (GRCm38) |
Q393* |
probably null |
Het |
| Gm7714 |
A |
G |
5: 88,282,398 (GRCm38) |
D51G |
possibly damaging |
Het |
| Hinfp |
A |
T |
9: 44,297,979 (GRCm38) |
Y308N |
probably damaging |
Het |
| Hnrnph3 |
T |
A |
10: 63,018,848 (GRCm38) |
R55* |
probably null |
Het |
| Ifi44 |
T |
C |
3: 151,749,249 (GRCm38) |
D113G |
probably benign |
Het |
| Katnal1 |
A |
T |
5: 148,878,951 (GRCm38) |
L392H |
probably damaging |
Het |
| Kcnk12 |
C |
A |
17: 87,797,452 (GRCm38) |
M1I |
probably null |
Het |
| Krt17 |
T |
A |
11: 100,257,499 (GRCm38) |
D372V |
probably damaging |
Het |
| Mkl2 |
T |
A |
16: 13,405,287 (GRCm38) |
Y796* |
probably null |
Het |
| Myo3a |
T |
A |
2: 22,407,424 (GRCm38) |
Y751* |
probably null |
Het |
| Ndrg3 |
C |
A |
2: 156,940,356 (GRCm38) |
|
probably null |
Het |
| Nfkbib |
C |
A |
7: 28,766,375 (GRCm38) |
W16C |
probably damaging |
Het |
| Nlrp14 |
T |
C |
7: 107,181,899 (GRCm38) |
V101A |
probably benign |
Het |
| Npy5r |
A |
G |
8: 66,680,831 (GRCm38) |
S437P |
probably damaging |
Het |
| Olfr790 |
T |
C |
10: 129,501,100 (GRCm38) |
F64S |
probably damaging |
Het |
| Pcdhga3 |
G |
A |
18: 37,675,091 (GRCm38) |
R199H |
probably damaging |
Het |
| Pi4ka |
T |
A |
16: 17,307,806 (GRCm38) |
H1155L |
|
Het |
| Rbp3 |
A |
G |
14: 33,955,277 (GRCm38) |
D394G |
possibly damaging |
Het |
| Rnmt |
T |
A |
18: 68,309,339 (GRCm38) |
V180E |
probably damaging |
Het |
| Rpl3l |
A |
T |
17: 24,728,326 (GRCm38) |
K5* |
probably null |
Het |
| Rps6ka1 |
A |
T |
4: 133,848,652 (GRCm38) |
V652E |
probably damaging |
Het |
| Slc7a1 |
A |
T |
5: 148,333,920 (GRCm38) |
W579R |
probably damaging |
Het |
| Smyd4 |
T |
A |
11: 75,402,191 (GRCm38) |
L649Q |
probably damaging |
Het |
| Snx19 |
A |
G |
9: 30,463,306 (GRCm38) |
R954G |
possibly damaging |
Het |
| Sp4 |
T |
C |
12: 118,238,265 (GRCm38) |
E744G |
possibly damaging |
Het |
| Spag16 |
C |
T |
1: 69,853,380 (GRCm38) |
L107F |
probably damaging |
Het |
| Stk36 |
A |
G |
1: 74,611,113 (GRCm38) |
D268G |
probably benign |
Het |
| Tat |
G |
T |
8: 109,991,860 (GRCm38) |
G85W |
probably damaging |
Het |
| Tchp |
G |
T |
5: 114,709,385 (GRCm38) |
E88D |
probably benign |
Het |
| Tmem132b |
A |
G |
5: 125,698,569 (GRCm38) |
N369S |
possibly damaging |
Het |
| Tmf1 |
T |
C |
6: 97,176,656 (GRCm38) |
D152G |
probably benign |
Het |
| Ttc7 |
T |
C |
17: 87,292,892 (GRCm38) |
Y145H |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,941,919 (GRCm38) |
I2592M |
unknown |
Het |
| Unc80 |
T |
G |
1: 66,693,805 (GRCm38) |
|
probably null |
Het |
| Whamm |
G |
T |
7: 81,571,315 (GRCm38) |
|
probably benign |
Het |
| Zfp184 |
A |
G |
13: 21,949,728 (GRCm38) |
I48M |
probably benign |
Het |
| Zfp974 |
A |
T |
7: 27,911,669 (GRCm38) |
F210L |
probably benign |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,061,607 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,061,756 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,053,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,050,673 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,061,625 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,061,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,026,141 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,026,132 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,039,795 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,050,819 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,039,899 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,062,033 (GRCm38) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,053,981 (GRCm38) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,061,170 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,061,644 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,053,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,050,708 (GRCm38) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,039,747 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,061,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,061,410 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,024,771 (GRCm38) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,053,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,061,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,061,237 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,039,749 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,061,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,025,979 (GRCm38) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,050,738 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,061,191 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,061,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,053,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,026,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,061,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,061,326 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,050,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,039,449 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,025,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,061,674 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,039,871 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,039,560 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,061,485 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,061,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,026,080 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,061,691 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,039,098 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,039,782 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,061,296 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,039,768 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,061,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,025,955 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,039,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,039,647 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,039,362 (GRCm38) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,061,535 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,061,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,039,799 (GRCm38) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,024,955 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,061,928 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,026,036 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,024,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,062,024 (GRCm38) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,026,050 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,039,374 (GRCm38) |
missense |
probably benign |
|
|
R9515:Vmn2r26
|
UTSW |
6 |
124,061,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,039,489 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCTTTATATGCCTTAGATTGCTG -3'
(R):5'- CTCGGGAGATCTGAATGGATATTGATG -3'
Sequencing Primer
(F):5'- atttgagagggagcactg -3'
(R):5'- GATGTTGAAATGCCTCCTATCACTG -3'
|
| Posted On |
2022-05-16 |
Incidental Mutation