Incidental Mutation 'R9438:Grm7'
ID 713365
Institutional Source Beutler Lab
Gene Symbol Grm7
Ensembl Gene ENSMUSG00000056755
Gene Name glutamate receptor, metabotropic 7
Synonyms 6330570A01Rik, Gpr1g, mGlu7a receptor, mGluR7, E130018M02Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9438 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 110622542-111544191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111231077 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 500 (D500V)
Ref Sequence ENSEMBL: ENSMUSP00000133957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071076] [ENSMUST00000172951] [ENSMUST00000174018]
AlphaFold Q68ED2
Predicted Effect possibly damaging
Transcript: ENSMUST00000071076
AA Change: D500V

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000064404
Gene: ENSMUSG00000056755
AA Change: D500V

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 3e-108 PFAM
Pfam:Peripla_BP_6 144 371 3e-11 PFAM
Pfam:NCD3G 519 569 1.2e-13 PFAM
Pfam:7tm_3 602 847 5.1e-59 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000172951
AA Change: D500V

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000133957
Gene: ENSMUSG00000056755
AA Change: D500V

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 1.7e-103 PFAM
Pfam:Peripla_BP_6 144 487 1e-12 PFAM
Pfam:NCD3G 519 569 1.2e-17 PFAM
Pfam:7tm_3 600 848 1.4e-87 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174018
SMART Domains Protein: ENSMUSP00000134635
Gene: ENSMUSG00000056755

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 176 4.9e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
PHENOTYPE: Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp2 G A 2: 91,033,339 (GRCm39) M20I probably benign Het
Adgra1 C T 7: 139,432,525 (GRCm39) P121L probably benign Het
Arhgap39 C A 15: 76,636,118 (GRCm39) R39L probably damaging Het
Atp1b3 A T 9: 96,215,631 (GRCm39) N261K possibly damaging Het
Atp8b3 C T 10: 80,361,409 (GRCm39) A838T probably damaging Het
Cacng8 G A 7: 3,463,919 (GRCm39) S357N unknown Het
Calhm5 T C 10: 33,972,049 (GRCm39) M129V probably benign Het
Ccdc93 C T 1: 121,369,584 (GRCm39) Q109* probably null Het
Cdk19 T A 10: 40,352,176 (GRCm39) D319E probably damaging Het
Chd6 A G 2: 160,799,078 (GRCm39) S2336P probably benign Het
Cntn1 G A 15: 92,144,024 (GRCm39) probably null Het
Cts6 G A 13: 61,350,069 (GRCm39) T4I probably benign Het
Ddt A T 10: 75,607,332 (GRCm39) I98N probably damaging Het
Diaph1 A C 18: 38,026,443 (GRCm39) V465G unknown Het
Dnah2 G T 11: 69,364,220 (GRCm39) D2064E probably damaging Het
Dnmt1 T C 9: 20,827,190 (GRCm39) N969D probably benign Het
Dot1l T A 10: 80,627,120 (GRCm39) V1447E probably benign Het
Efs T A 14: 55,156,868 (GRCm39) D389V Het
Gbp11 T A 5: 105,474,471 (GRCm39) K402* probably null Het
Hecw1 T C 13: 14,481,414 (GRCm39) M439V probably benign Het
Ice1 A G 13: 70,754,434 (GRCm39) S551P probably benign Het
Igsf9b T C 9: 27,243,839 (GRCm39) S779P probably benign Het
Itpr2 T C 6: 146,068,166 (GRCm39) N2437S probably benign Het
Kbtbd12 G A 6: 88,591,040 (GRCm39) Q391* probably null Het
Kcnma1 T C 14: 23,417,653 (GRCm39) I859V probably benign Het
Klri1 A C 6: 129,675,879 (GRCm39) D130E probably benign Het
Krt9 A G 11: 100,079,824 (GRCm39) Y523H unknown Het
Ldhc G T 7: 46,515,857 (GRCm39) V51F possibly damaging Het
Macf1 G T 4: 123,279,366 (GRCm39) D5890E probably benign Het
Map4k4 A G 1: 40,045,952 (GRCm39) S613G probably damaging Het
Mrpl55 A G 11: 59,096,581 (GRCm39) D118G probably damaging Het
Muc16 T C 9: 18,559,028 (GRCm39) T2422A unknown Het
Nfkbib T A 7: 28,459,654 (GRCm39) D219V probably damaging Het
Nsd2 A G 5: 34,000,632 (GRCm39) K50E probably damaging Het
Nudcd1 C T 15: 44,269,321 (GRCm39) R113H probably benign Het
Or5p55 A T 7: 107,567,000 (GRCm39) Y132F probably damaging Het
Or7e170 C T 9: 19,795,083 (GRCm39) E173K probably benign Het
Or7g19 T A 9: 18,856,326 (GRCm39) C127* probably null Het
Papln A T 12: 83,818,606 (GRCm39) T63S probably benign Het
Pax4 T C 6: 28,446,185 (GRCm39) I103V possibly damaging Het
Pitpnm2 G A 5: 124,269,342 (GRCm39) H427Y probably damaging Het
Plk5 T A 10: 80,193,867 (GRCm39) V52E probably damaging Het
Prr23a4 G A 9: 98,785,833 (GRCm39) S166N probably benign Het
Rab44 A G 17: 29,364,226 (GRCm39) H600R unknown Het
Rbbp6 G A 7: 122,599,456 (GRCm39) V1256I Het
Rexo1 T A 10: 80,378,848 (GRCm39) T1063S possibly damaging Het
Rp1l1 A G 14: 64,265,574 (GRCm39) R387G possibly damaging Het
Rufy3 T C 5: 88,796,124 (GRCm39) S603P probably benign Het
Setd1b A G 5: 123,285,944 (GRCm39) H330R unknown Het
Strc A T 2: 121,198,647 (GRCm39) W1415R probably damaging Het
Tcstv5 A G 13: 120,411,363 (GRCm39) L81P probably benign Het
Terf2 C A 8: 107,803,504 (GRCm39) A359S probably benign Het
Tmod1 A G 4: 46,093,958 (GRCm39) N223S probably damaging Het
Tram2 T A 1: 21,075,834 (GRCm39) I195F possibly damaging Het
Trap1 T C 16: 3,883,131 (GRCm39) Q148R probably benign Het
Tsks C T 7: 44,607,095 (GRCm39) R143* probably null Het
Ttc14 T A 3: 33,858,861 (GRCm39) H373Q probably damaging Het
Ttn T C 2: 76,747,748 (GRCm39) K4434E probably benign Het
Usp7 T C 16: 8,522,833 (GRCm39) D347G probably benign Het
Vps13d T C 4: 144,858,314 (GRCm39) E2170G Het
Xrn1 T C 9: 95,893,287 (GRCm39) I1001T probably benign Het
Other mutations in Grm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Grm7 APN 6 111,223,145 (GRCm39) missense probably benign 0.14
IGL02058:Grm7 APN 6 111,335,278 (GRCm39) missense probably damaging 1.00
IGL02650:Grm7 APN 6 111,335,919 (GRCm39) missense probably damaging 1.00
IGL02892:Grm7 APN 6 111,230,981 (GRCm39) missense probably damaging 0.99
IGL03074:Grm7 APN 6 111,472,604 (GRCm39) splice site probably null
IGL03185:Grm7 APN 6 110,623,183 (GRCm39) missense possibly damaging 0.84
Appropriated UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
Consumed UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
Devoured UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
Ravaged UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
shaky UTSW 6 111,472,752 (GRCm39) nonsense probably null
PIT4651001:Grm7 UTSW 6 110,623,050 (GRCm39) missense probably benign
R0539:Grm7 UTSW 6 111,336,055 (GRCm39) splice site probably benign
R0622:Grm7 UTSW 6 111,335,457 (GRCm39) missense probably damaging 1.00
R1356:Grm7 UTSW 6 111,335,985 (GRCm39) missense probably damaging 1.00
R1762:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1783:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1785:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1816:Grm7 UTSW 6 111,472,752 (GRCm39) nonsense probably null
R1823:Grm7 UTSW 6 111,184,730 (GRCm39) missense probably benign 0.17
R1864:Grm7 UTSW 6 111,057,384 (GRCm39) missense probably benign 0.03
R1894:Grm7 UTSW 6 111,335,568 (GRCm39) missense probably benign
R1987:Grm7 UTSW 6 110,891,472 (GRCm39) missense probably damaging 1.00
R1993:Grm7 UTSW 6 111,184,769 (GRCm39) missense probably benign 0.13
R2138:Grm7 UTSW 6 110,623,098 (GRCm39) missense probably damaging 1.00
R2214:Grm7 UTSW 6 111,335,958 (GRCm39) missense probably damaging 1.00
R2289:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2296:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2339:Grm7 UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
R2847:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2849:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2879:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2884:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2921:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R2923:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R3014:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3015:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3703:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3713:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3963:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4009:Grm7 UTSW 6 111,472,683 (GRCm39) missense probably damaging 1.00
R4091:Grm7 UTSW 6 110,891,301 (GRCm39) missense probably damaging 1.00
R4131:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4132:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4161:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 0.99
R4329:Grm7 UTSW 6 110,891,325 (GRCm39) missense probably damaging 1.00
R4357:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4359:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4379:Grm7 UTSW 6 111,223,335 (GRCm39) missense probably benign 0.05
R4379:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4380:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4514:Grm7 UTSW 6 111,335,265 (GRCm39) missense possibly damaging 0.81
R4518:Grm7 UTSW 6 110,891,507 (GRCm39) splice site probably null
R4647:Grm7 UTSW 6 110,891,344 (GRCm39) nonsense probably null
R4714:Grm7 UTSW 6 111,057,383 (GRCm39) missense possibly damaging 0.52
R4775:Grm7 UTSW 6 110,891,332 (GRCm39) missense probably damaging 1.00
R4957:Grm7 UTSW 6 111,335,824 (GRCm39) missense probably damaging 1.00
R5056:Grm7 UTSW 6 111,057,404 (GRCm39) missense probably damaging 0.99
R5062:Grm7 UTSW 6 110,623,097 (GRCm39) missense probably damaging 1.00
R5256:Grm7 UTSW 6 111,335,182 (GRCm39) missense probably benign 0.01
R5431:Grm7 UTSW 6 111,335,387 (GRCm39) missense probably benign
R6026:Grm7 UTSW 6 111,478,500 (GRCm39) nonsense probably null
R6174:Grm7 UTSW 6 111,223,258 (GRCm39) missense probably benign
R6305:Grm7 UTSW 6 111,335,626 (GRCm39) missense probably damaging 1.00
R6318:Grm7 UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
R6440:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 1.00
R6519:Grm7 UTSW 6 111,184,713 (GRCm39) missense probably benign 0.00
R6531:Grm7 UTSW 6 111,335,386 (GRCm39) missense probably benign 0.29
R6888:Grm7 UTSW 6 111,335,314 (GRCm39) missense possibly damaging 0.79
R6949:Grm7 UTSW 6 111,472,690 (GRCm39) missense probably damaging 1.00
R6949:Grm7 UTSW 6 110,623,265 (GRCm39) missense probably benign 0.03
R6989:Grm7 UTSW 6 111,184,766 (GRCm39) missense probably damaging 1.00
R7076:Grm7 UTSW 6 111,335,113 (GRCm39) missense probably benign 0.04
R7203:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7208:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7217:Grm7 UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
R7257:Grm7 UTSW 6 110,623,079 (GRCm39) missense probably damaging 1.00
R7297:Grm7 UTSW 6 110,622,974 (GRCm39) missense probably benign 0.16
R7470:Grm7 UTSW 6 111,478,476 (GRCm39) missense
R7567:Grm7 UTSW 6 111,335,722 (GRCm39) missense probably damaging 0.96
R7806:Grm7 UTSW 6 111,223,314 (GRCm39) nonsense probably null
R8018:Grm7 UTSW 6 111,184,737 (GRCm39) missense probably benign 0.01
R8076:Grm7 UTSW 6 111,543,000 (GRCm39) missense probably damaging 1.00
R8409:Grm7 UTSW 6 110,891,297 (GRCm39) missense probably benign 0.02
R8420:Grm7 UTSW 6 111,057,315 (GRCm39) missense probably benign
R8523:Grm7 UTSW 6 111,223,280 (GRCm39) missense possibly damaging 0.76
R8816:Grm7 UTSW 6 111,230,966 (GRCm39) missense possibly damaging 0.46
R8958:Grm7 UTSW 6 111,472,783 (GRCm39) missense probably damaging 0.96
R9135:Grm7 UTSW 6 111,472,729 (GRCm39) missense probably benign 0.39
R9207:Grm7 UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
R9210:Grm7 UTSW 6 110,622,869 (GRCm39) missense probably benign 0.01
R9448:Grm7 UTSW 6 111,335,193 (GRCm39) missense probably benign 0.01
Z1176:Grm7 UTSW 6 111,335,451 (GRCm39) missense probably damaging 1.00
Z1176:Grm7 UTSW 6 111,335,110 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCTACCATGAGCTGAAGAGGATAC -3'
(R):5'- CCAGTGCACACAATTCTGTC -3'

Sequencing Primer
(F):5'- TTCAGGTAGTGCTGGAAC -3'
(R):5'- GACCAAATTGCATGCGTG -3'
Posted On 2022-05-16