Incidental Mutation 'R9439:Olfr92'
ID 713461
Institutional Source Beutler Lab
Gene Symbol Olfr92
Ensembl Gene ENSMUSG00000096477
Gene Name olfactory receptor 92
Synonyms MOR256-29, GA_x6K02T2PSCP-1552066-1551128
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R9439 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37110512-37120088 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37111313 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 223 (V223A)
Ref Sequence ENSEMBL: ENSMUSP00000150998 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168659] [ENSMUST00000214994] [ENSMUST00000216341]
AlphaFold L7N475
Predicted Effect probably damaging
Transcript: ENSMUST00000168659
AA Change: V223A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128393
Gene: ENSMUSG00000096477
AA Change: V223A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 23 304 5.1e-7 PFAM
Pfam:7tm_4 29 306 3.4e-50 PFAM
Pfam:7tm_1 39 288 1.1e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214994
AA Change: V223A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216341
AA Change: V223A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A T 3: 138,066,287 E412D probably benign Het
Aak1 T A 6: 86,956,292 V415D probably damaging Het
Ache A C 5: 137,290,923 D297A probably damaging Het
Armc9 T C 1: 86,156,965 I4T possibly damaging Het
Atp8b2 T A 3: 89,944,185 Y925F Het
Avpr1b T C 1: 131,600,291 L184P probably damaging Het
Cabin1 G A 10: 75,745,235 P419L probably damaging Het
Ccdc88c T C 12: 100,918,338 S1578G probably benign Het
Ccnd2 A T 6: 127,150,654 C40* probably null Het
Col6a3 A T 1: 90,816,433 I471N probably damaging Het
Cp A G 3: 19,992,507 probably null Het
Cyfip2 C T 11: 46,200,841 R1084Q probably damaging Het
D11Wsu47e C T 11: 113,692,403 Q519* probably null Het
Diaph1 A G 18: 37,896,359 probably null Het
Dnah6 T C 6: 73,035,347 N3713S possibly damaging Het
Dot1l G T 10: 80,785,604 R633L possibly damaging Het
Ehmt1 A T 2: 24,825,018 M809K probably damaging Het
Fcgbp C A 7: 28,104,011 A1680E possibly damaging Het
Flt1 A G 5: 147,578,397 F1072L probably damaging Het
Gm19410 G T 8: 35,781,656 A549S probably damaging Het
Gnat1 A T 9: 107,676,312 I249N Het
Gp2 T C 7: 119,454,210 Y176C probably damaging Het
Gpc2 G T 5: 138,278,986 Q60K probably benign Het
Gpsm2 T A 3: 108,703,081 E21V probably damaging Het
Igkv4-80 T A 6: 69,016,809 M33L probably benign Het
Il20ra C A 10: 19,743,003 H66Q probably benign Het
Kap C T 6: 133,851,987 D61N probably benign Het
Magi3 C T 3: 104,015,157 A1415T probably benign Het
Mpp7 A T 18: 7,461,692 Y60* probably null Het
Neil1 T A 9: 57,143,814 R294* probably null Het
Nkx6-3 A G 8: 23,153,762 S60G probably benign Het
Noc2l T A 4: 156,241,673 S406T possibly damaging Het
Olfr113 A G 17: 37,574,934 I163T probably benign Het
Olfr279 T C 15: 98,498,366 V298A possibly damaging Het
Olfr325 T C 11: 58,581,278 C145R probably benign Het
Olfr510 T C 7: 108,667,419 M1T probably null Het
Olfr616 T G 7: 103,564,842 I146L probably benign Het
Paqr4 A G 17: 23,739,965 F21L probably damaging Het
Pcdha9 A G 18: 36,998,474 T199A probably benign Het
Pcdhgb7 T C 18: 37,751,864 L29P probably benign Het
Pfkl G A 10: 77,995,338 A323V probably damaging Het
Pik3r4 C A 9: 105,650,842 P465T probably damaging Het
Pitpnm2 A G 5: 124,136,126 S307P probably damaging Het
Pitpnm2 A G 5: 124,140,596 Y191H probably damaging Het
Plod3 G A 5: 136,994,182 V613I probably benign Het
Prr23a2 C T 9: 98,856,868 T93I probably damaging Het
Ptk6 T A 2: 181,198,413 M267L possibly damaging Het
Rabl6 C T 2: 25,602,420 probably null Het
Ralgapa2 T C 2: 146,412,138 H787R probably benign Het
Rfx8 T G 1: 39,685,509 M231L probably benign Het
Rnf126 A T 10: 79,761,631 I149N probably damaging Het
Smpd4 A G 16: 17,641,587 I625V probably benign Het
Tcf7l1 A G 6: 72,788,757 S66P probably damaging Het
Tsc22d1 G A 14: 76,506,459 V1007M probably damaging Het
Tspoap1 C T 11: 87,774,709 R758C probably damaging Het
Vmn1r210 A C 13: 22,827,227 H296Q possibly damaging Het
Zfp532 G A 18: 65,685,643 V857I probably benign Het
Zfyve9 T C 4: 108,644,341 T593A probably benign Het
Other mutations in Olfr92
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Olfr92 APN 17 37111809 missense probably damaging 1.00
IGL02850:Olfr92 APN 17 37111973 missense probably benign 0.35
IGL03209:Olfr92 APN 17 37111521 missense probably benign 0.04
R0579:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R0580:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R0582:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R0615:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R0669:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R0674:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R0675:Olfr92 UTSW 17 37111455 missense probably benign 0.00
R2424:Olfr92 UTSW 17 37111516 missense probably benign 0.02
R3714:Olfr92 UTSW 17 37111335 missense probably damaging 1.00
R4393:Olfr92 UTSW 17 37114084 intron probably benign
R5811:Olfr92 UTSW 17 37111757 missense probably benign 0.00
R6615:Olfr92 UTSW 17 37111602 missense probably damaging 1.00
R6853:Olfr92 UTSW 17 37111508 missense probably benign 0.02
R6876:Olfr92 UTSW 17 37111206 missense probably damaging 1.00
R7665:Olfr92 UTSW 17 37111391 missense probably benign 0.20
R8087:Olfr92 UTSW 17 37111548 missense probably benign
R9224:Olfr92 UTSW 17 37111875 missense possibly damaging 0.53
R9541:Olfr92 UTSW 17 37111932 missense probably benign 0.00
R9559:Olfr92 UTSW 17 37111617 missense possibly damaging 0.84
Z1177:Olfr92 UTSW 17 37111430 missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- AGCAGCTTCCAGAATGCTC -3'
(R):5'- TTGTTCCCACAGGCAGATAGAC -3'

Sequencing Primer
(F):5'- CCTTGTTCCTCAGGGTGTATACAAG -3'
(R):5'- CAGGCAGATAGACAACTTTCTGTGTG -3'
Posted On 2022-05-16