Mutagenetix > Incidental Mutation

Incidental Mutation 'R8931:Or7g19'

713475

Institutional Source

Beutler Lab

Gene Symbol

Or7g19

Ensembl Gene

ENSMUSG00000095957

Gene Name

olfactory receptor family 7 subfamily G member 19

Synonyms

GA_x6K02T2PVTD-12687800-12688738, Olfr832, MOR153-1

MMRRC Submission

068775-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.227) question?

Stock #

R8931 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

18855946-18856884 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 18855920 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151834 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060601] [ENSMUST00000218385]

AlphaFold

Q7TRG9

Predicted Effect

probably benign
Transcript: ENSMUST00000060601

SMART Domains

Protein: ENSMUSP00000056724
Gene: ENSMUSG00000095957

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4.1e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	305	3.1e-6	PFAM
Pfam:7tm_1	41	290	1.4e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218385

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (58/58)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acat3	G	C	17: 13,147,405 (GRCm39)	P204R	probably damaging	Het
Aldh3b1	A	G	19: 3,968,803 (GRCm39)	I250T	possibly damaging	Het
Ankrd11	C	T	8: 123,622,718 (GRCm39)	R378K	probably damaging	Het
Arap1	G	A	7: 101,057,324 (GRCm39)	R1355Q	possibly damaging	Het
Arhgef19	T	C	4: 140,976,603 (GRCm39)	V455A	probably damaging	Het
BC051019	T	C	7: 109,315,286 (GRCm39)	E323G	probably damaging	Het
Bzw2	T	C	12: 36,184,943 (GRCm39)	N2S	possibly damaging	Het
Calm3	G	C	7: 16,651,398 (GRCm39)	F66L	probably damaging	Het
Carmil1	T	A	13: 24,338,704 (GRCm39)	T191S	probably benign	Het
Cemip2	T	A	19: 21,770,323 (GRCm39)	S104T	probably benign	Het
Cep170	A	T	1: 176,597,377 (GRCm39)	C389S	probably benign	Het
Clhc1	C	T	11: 29,510,533 (GRCm39)	Q195*	probably null	Het
Cttnbp2	A	G	6: 18,434,808 (GRCm39)	L350P	probably benign	Het
Cyp7a1	T	C	4: 6,271,238 (GRCm39)	E306G	possibly damaging	Het
Ddx25	T	C	9: 35,465,864 (GRCm39)	N119S	possibly damaging	Het
Ephx2	G	T	14: 66,322,441 (GRCm39)		probably benign	Het
Ern2	C	T	7: 121,769,363 (GRCm39)	A888T	probably benign	Het
Fbln2	A	T	6: 91,246,072 (GRCm39)	I973F	probably damaging	Het
Fbn1	T	C	2: 125,202,095 (GRCm39)	I1259M	probably damaging	Het
Glis1	A	G	4: 107,421,060 (GRCm39)	H92R	probably benign	Het
Gm13283	A	C	4: 88,679,516 (GRCm39)	D169A	probably benign	Het
Gpr61	A	G	3: 108,057,470 (GRCm39)	L397P	probably benign	Het
H4c11	T	A	13: 21,919,369 (GRCm39)	I35N	probably damaging	Het
Hip1	A	T	5: 135,460,297 (GRCm39)		probably benign	Het
Hmgcs2	C	T	3: 98,203,557 (GRCm39)	A222V	probably damaging	Het
Ifna2	G	A	4: 88,601,712 (GRCm39)	T102I	probably benign	Het
Kat6b	T	C	14: 21,674,995 (GRCm39)	S387P	probably damaging	Het
Ldlr	G	A	9: 21,643,108 (GRCm39)	V45M	probably damaging	Het
Mc3r	A	T	2: 172,091,515 (GRCm39)	I246F	possibly damaging	Het
Mug1	G	C	6: 121,861,296 (GRCm39)	A1306P	probably benign	Het
Myo15a	A	G	11: 60,368,020 (GRCm39)	E260G	probably benign	Het
Naa16	A	G	14: 79,582,395 (GRCm39)	Y565H	probably damaging	Het
Ndufaf7	A	G	17: 79,244,950 (GRCm39)	Y23C	possibly damaging	Het
Nop58	G	A	1: 59,731,549 (GRCm39)		probably null	Het
Or6c33	A	T	10: 129,853,769 (GRCm39)	T180S	possibly damaging	Het
Or6c88	A	T	10: 129,406,550 (GRCm39)	T9S	probably benign	Het
Pcdh8	G	A	14: 80,006,971 (GRCm39)	Q531*	probably null	Het
Pik3c2g	A	G	6: 139,821,093 (GRCm39)	T297A	probably benign	Het
Poc1b	T	C	10: 99,028,861 (GRCm39)		probably null	Het
Prb1c	G	A	6: 132,338,897 (GRCm39)	P107L		Het
Prokr2	A	G	2: 132,215,996 (GRCm39)	V155A	possibly damaging	Het
Rce1	C	T	19: 4,674,094 (GRCm39)		probably benign	Het
Rnf148	A	T	6: 23,654,704 (GRCm39)	N97K	possibly damaging	Het
Setbp1	A	G	18: 78,899,723 (GRCm39)	S1315P	probably benign	Het
Sgcz	A	G	8: 38,107,140 (GRCm39)	V124A	probably damaging	Het
Slc25a2	C	A	18: 37,771,089 (GRCm39)	G147C	probably damaging	Het
Slc28a2b	C	A	2: 122,348,983 (GRCm39)	P303Q		Het
Sod2	T	C	17: 13,227,193 (GRCm39)	L49P	probably damaging	Het
Tbc1d12	T	C	19: 38,854,098 (GRCm39)	V260A	probably benign	Het
Tcte2	C	A	17: 13,933,410 (GRCm39)		probably benign	Het
Tenm3	T	C	8: 48,688,637 (GRCm39)	T2317A	probably damaging	Het
Tfcp2	T	C	15: 100,402,298 (GRCm39)	I500V	possibly damaging	Het
Trav14-3	C	A	14: 54,001,112 (GRCm39)	Q108K	probably damaging	Het
Trbv14	T	C	6: 41,112,364 (GRCm39)	Y54H	probably damaging	Het
Trpm3	T	A	19: 22,744,034 (GRCm39)	V337E	probably damaging	Het
Tsbp1	T	C	17: 34,659,328 (GRCm39)		probably benign	Het
Uox	A	T	3: 146,318,047 (GRCm39)	I14F	probably damaging	Het
Wdfy3	A	G	5: 102,065,421 (GRCm39)	V1249A	probably benign	Het
Zfp511	T	C	7: 139,617,194 (GRCm39)	Y97H	probably damaging	Het
Zfp536	G	T	7: 37,268,721 (GRCm39)	Q232K	probably benign	Het
Zng1	T	G	19: 24,932,780 (GRCm39)	K84N	probably damaging	Het

Other mutations in Or7g19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03018:Or7g19	APN	9	18,856,177 (GRCm39)	missense	probably damaging	0.98
IGL03172:Or7g19	APN	9	18,856,757 (GRCm39)	missense	probably benign	0.01
R0537:Or7g19	UTSW	9	18,856,444 (GRCm39)	missense	probably damaging	1.00
R1923:Or7g19	UTSW	9	18,856,781 (GRCm39)	missense	probably benign	0.21
R2226:Or7g19	UTSW	9	18,856,177 (GRCm39)	missense	probably damaging	0.98
R2234:Or7g19	UTSW	9	18,856,112 (GRCm39)	missense	probably damaging	1.00
R2402:Or7g19	UTSW	9	18,856,496 (GRCm39)	missense	probably damaging	0.98
R4060:Or7g19	UTSW	9	18,856,346 (GRCm39)	missense	probably benign	0.09
R4537:Or7g19	UTSW	9	18,856,526 (GRCm39)	missense	possibly damaging	0.85
R4715:Or7g19	UTSW	9	18,856,742 (GRCm39)	missense	probably benign	0.01
R5557:Or7g19	UTSW	9	18,856,466 (GRCm39)	missense	possibly damaging	0.94
R6001:Or7g19	UTSW	9	18,856,340 (GRCm39)	missense	probably damaging	1.00
R6172:Or7g19	UTSW	9	18,856,042 (GRCm39)	missense	probably benign	0.00
R6415:Or7g19	UTSW	9	18,856,415 (GRCm39)	missense	probably damaging	1.00
R6594:Or7g19	UTSW	9	18,856,127 (GRCm39)	missense	probably damaging	0.98
R6874:Or7g19	UTSW	9	18,856,777 (GRCm39)	missense	possibly damaging	0.95
R7801:Or7g19	UTSW	9	18,856,555 (GRCm39)	missense	probably damaging	0.97
R7818:Or7g19	UTSW	9	18,856,305 (GRCm39)	nonsense	probably null
R7880:Or7g19	UTSW	9	18,856,024 (GRCm39)	missense	probably benign	0.06
R7890:Or7g19	UTSW	9	18,856,799 (GRCm39)	missense	probably benign	0.10
R8352:Or7g19	UTSW	9	18,856,459 (GRCm39)	missense	possibly damaging	0.51
R8452:Or7g19	UTSW	9	18,856,459 (GRCm39)	missense	possibly damaging	0.51
R8776:Or7g19	UTSW	9	18,856,286 (GRCm39)	missense	possibly damaging	0.93
R8776-TAIL:Or7g19	UTSW	9	18,856,286 (GRCm39)	missense	possibly damaging	0.93
R9438:Or7g19	UTSW	9	18,856,326 (GRCm39)	nonsense	probably null
Z1088:Or7g19	UTSW	9	18,856,717 (GRCm39)	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- GGTTGACTACAAAGCAAGACAGTATC -3'
(R):5'- ATTGTGGCCAGTATTATGAGAAGG -3'

Sequencing Primer
(F):5'- TTCTAGGCCAGCCAAGGTCTATAG -3'
(R):5'- GGTTTCCAAACAGTGTGATCAG -3'

Posted On

2022-05-19