Incidental Mutation 'R8976:Vmn2r10'
| ID |
713558 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r10
|
| Ensembl Gene |
ENSMUSG00000067010 |
| Gene Name |
vomeronasal 2, receptor 10 |
| Synonyms |
VR16, V2r16 |
| MMRRC Submission |
068810-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R8976 (G1)
|
| Quality Score |
49.0072 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109145479 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 543
(N543Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
| AlphaFold |
K7N621 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000079163
AA Change: N543Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: N543Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
| SMART Domains |
Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6329 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
98% (60/61) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgef11 |
A |
G |
3: 87,635,321 (GRCm39) |
I906V |
probably benign |
Het |
| Atad2b |
T |
A |
12: 4,967,923 (GRCm39) |
|
probably null |
Het |
| Atr |
T |
A |
9: 95,772,819 (GRCm39) |
D1243E |
probably benign |
Het |
| Baiap2l1 |
A |
T |
5: 144,223,117 (GRCm39) |
H73Q |
probably benign |
Het |
| Bdp1 |
C |
A |
13: 100,197,407 (GRCm39) |
G993* |
probably null |
Het |
| Cacna2d4 |
A |
T |
6: 119,315,118 (GRCm39) |
I883F |
possibly damaging |
Het |
| Cep250 |
C |
T |
2: 155,812,042 (GRCm39) |
A446V |
unknown |
Het |
| Crem |
A |
G |
18: 3,268,088 (GRCm39) |
V80A |
possibly damaging |
Het |
| Cyp2j9 |
T |
C |
4: 96,479,399 (GRCm39) |
K62E |
probably benign |
Het |
| Dnah17 |
T |
A |
11: 117,917,666 (GRCm39) |
I4132F |
probably damaging |
Het |
| Dnm3 |
G |
A |
1: 162,135,505 (GRCm39) |
P423S |
probably damaging |
Het |
| Dop1b |
G |
T |
16: 93,558,969 (GRCm39) |
V572L |
probably benign |
Het |
| F12 |
T |
A |
13: 55,569,777 (GRCm39) |
|
probably benign |
Het |
| F2 |
A |
G |
2: 91,466,738 (GRCm39) |
S2P |
probably benign |
Het |
| Fam171a2 |
T |
C |
11: 102,329,451 (GRCm39) |
E436G |
possibly damaging |
Het |
| Fat1 |
T |
C |
8: 45,484,332 (GRCm39) |
V3190A |
probably benign |
Het |
| Flnb |
A |
T |
14: 7,901,882 (GRCm38) |
|
probably null |
Het |
| Frs3 |
A |
T |
17: 48,009,546 (GRCm39) |
D9V |
probably benign |
Het |
| Galnt17 |
T |
G |
5: 130,935,543 (GRCm39) |
E380A |
probably benign |
Het |
| Glrb |
A |
C |
3: 80,758,363 (GRCm39) |
V350G |
probably damaging |
Het |
| Helz2 |
T |
A |
2: 180,876,486 (GRCm39) |
K1336M |
possibly damaging |
Het |
| Ifnlr1 |
T |
A |
4: 135,428,650 (GRCm39) |
V159E |
probably damaging |
Het |
| Igf2r |
T |
C |
17: 12,945,659 (GRCm39) |
E310G |
probably damaging |
Het |
| Il2rb |
C |
T |
15: 78,370,681 (GRCm39) |
D145N |
probably benign |
Het |
| Iqcb1 |
A |
G |
16: 36,692,005 (GRCm39) |
I535V |
probably benign |
Het |
| Keap1 |
A |
C |
9: 21,142,663 (GRCm39) |
L531V |
probably damaging |
Het |
| Lrrc8d |
T |
A |
5: 105,960,957 (GRCm39) |
W456R |
probably damaging |
Het |
| Med12l |
T |
A |
3: 59,183,329 (GRCm39) |
H1910Q |
probably damaging |
Het |
| Mybphl |
G |
A |
3: 108,272,334 (GRCm39) |
E8K |
probably damaging |
Het |
| Odad3 |
T |
A |
9: 21,903,334 (GRCm39) |
|
probably benign |
Het |
| Olig2 |
A |
G |
16: 91,023,363 (GRCm39) |
S26G |
probably benign |
Het |
| Or10a4 |
T |
C |
7: 106,697,466 (GRCm39) |
S265P |
possibly damaging |
Het |
| Or5p73 |
T |
A |
7: 108,064,630 (GRCm39) |
I33N |
possibly damaging |
Het |
| Or6f2 |
T |
C |
7: 139,756,885 (GRCm39) |
V284A |
probably damaging |
Het |
| Or7a38 |
T |
C |
10: 78,753,418 (GRCm39) |
I248T |
possibly damaging |
Het |
| Or7g22 |
T |
A |
9: 19,049,141 (GRCm39) |
M284K |
probably damaging |
Het |
| Pcdhb22 |
G |
A |
18: 37,651,396 (GRCm39) |
|
probably benign |
Het |
| Plekha8 |
A |
T |
6: 54,607,521 (GRCm39) |
E376V |
probably damaging |
Het |
| Polr2a |
A |
G |
11: 69,638,037 (GRCm39) |
V144A |
possibly damaging |
Het |
| Pramel34 |
T |
A |
5: 93,785,977 (GRCm39) |
N101I |
probably damaging |
Het |
| Prr18 |
T |
C |
17: 8,560,047 (GRCm39) |
S68P |
probably damaging |
Het |
| Ptprk |
G |
A |
10: 28,461,669 (GRCm39) |
R1153H |
probably damaging |
Het |
| Pus1 |
A |
G |
5: 110,922,789 (GRCm39) |
F293L |
possibly damaging |
Het |
| Shank3 |
A |
G |
15: 89,442,381 (GRCm39) |
E1758G |
probably damaging |
Het |
| Ska3 |
A |
T |
14: 58,057,851 (GRCm39) |
I167N |
probably damaging |
Het |
| Ski |
A |
G |
4: 155,242,411 (GRCm39) |
S663P |
probably damaging |
Het |
| Slc49a3 |
A |
C |
5: 108,589,897 (GRCm39) |
S502A |
probably benign |
Het |
| Spa17 |
C |
T |
9: 37,523,254 (GRCm39) |
R11Q |
possibly damaging |
Het |
| Spag5 |
T |
C |
11: 78,195,413 (GRCm39) |
V240A |
probably benign |
Het |
| Srl |
A |
T |
16: 4,300,894 (GRCm39) |
Y726N |
probably damaging |
Het |
| Ssbp4 |
A |
T |
8: 71,052,336 (GRCm39) |
|
probably null |
Het |
| Surf1 |
A |
T |
2: 26,805,767 (GRCm39) |
C48S |
probably benign |
Het |
| Tigd3 |
G |
A |
19: 5,941,853 (GRCm39) |
P426S |
probably benign |
Het |
| Tmem176b |
A |
G |
6: 48,812,600 (GRCm39) |
S122P |
probably damaging |
Het |
| Trim23 |
G |
T |
13: 104,328,545 (GRCm39) |
L355F |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,545,110 (GRCm39) |
T32664M |
probably damaging |
Het |
| Ulk3 |
T |
A |
9: 57,502,220 (GRCm39) |
|
probably benign |
Het |
| Unc80 |
A |
G |
1: 66,511,169 (GRCm39) |
H59R |
possibly damaging |
Het |
| Vmn1r19 |
A |
G |
6: 57,381,719 (GRCm39) |
I91V |
probably benign |
Het |
| Zbtb14 |
G |
A |
17: 69,694,752 (GRCm39) |
R150H |
possibly damaging |
Het |
| Zfp831 |
T |
C |
2: 174,487,079 (GRCm39) |
Y585H |
possibly damaging |
Het |
|
| Other mutations in Vmn2r10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
|
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGTATGACCCACTTGATATTTTC -3'
(R):5'- CATTCAGTGCATTGCATGGTAATAC -3'
Sequencing Primer
(F):5'- GAAAATATTGCTAGTTATTTGCTGGG -3'
(R):5'- CAGAGGAATATTTATAGCCACATCTG -3'
|
| Posted On |
2022-06-15 |
Incidental Mutation