Mutagenetix > Incidental Mutation

Incidental Mutation 'R9440:Vmn1r5'

713586

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r5

Ensembl Gene

ENSMUSG00000090346

Gene Name

vomeronasal 1 receptor 5

Synonyms

V1rc19

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R9440 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

56947320-56963335 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 56962415 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 30 (I30T)

Ref Sequence

ENSEMBL: ENSMUSP00000131092 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164307] [ENSMUST00000226130] [ENSMUST00000228276]

AlphaFold

B2RQT2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164307
AA Change: I30T

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000131092
Gene: ENSMUSG00000090346
AA Change: I30T

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	9.7e-53	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226130
AA Change: I30T

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228276
AA Change: I30T

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	G	A	17: 24,499,452 (GRCm39)	T1359M	probably benign	Het
Acacb	T	A	5: 114,384,085 (GRCm39)	C2205S	possibly damaging	Het
Akap3	A	G	6: 126,841,591 (GRCm39)	E70G	probably benign	Het
Aldh1a3	C	A	7: 66,068,992 (GRCm39)		probably null	Het
Asb4	A	G	6: 5,429,817 (GRCm39)	I352M	probably benign	Het
Bach1	C	G	16: 87,516,603 (GRCm39)	S381R	probably benign	Het
BC034090	A	G	1: 155,101,961 (GRCm39)	L101P	probably benign	Het
Bms1	A	T	6: 118,382,217 (GRCm39)	D440E	probably benign	Het
Bpifb6	A	T	2: 153,747,914 (GRCm39)	D191V	probably benign	Het
Cfap298	A	T	16: 90,726,832 (GRCm39)	V116E	probably benign	Het
Cfd	T	C	10: 79,726,816 (GRCm39)		probably null	Het
Cnot3	G	A	7: 3,656,560 (GRCm39)	E252K	probably damaging	Het
Col6a3	T	C	1: 90,707,068 (GRCm39)	D2622G	unknown	Het
Crybg2	T	C	4: 133,801,602 (GRCm39)	S612P	probably benign	Het
Cyp4b1	T	C	4: 115,493,581 (GRCm39)	K167R	probably damaging	Het
Gbp3	T	C	3: 142,272,335 (GRCm39)	V279A	possibly damaging	Het
Gipc2	T	C	3: 151,833,706 (GRCm39)	T192A	possibly damaging	Het
Gm3285	T	C	10: 77,697,911 (GRCm39)	V20A		Het
Gorasp2	T	C	2: 70,541,469 (GRCm39)		probably null	Het
Gpr179	A	G	11: 97,229,315 (GRCm39)	S947P	probably benign	Het
Klra5	C	A	6: 129,883,686 (GRCm39)	W147L	possibly damaging	Het
Lrch4	G	A	5: 137,636,051 (GRCm39)	R368Q	probably damaging	Het
Mamdc4	A	G	2: 25,455,600 (GRCm39)	V876A	probably benign	Het
Marf1	A	C	16: 13,938,196 (GRCm39)	D1433E	probably benign	Het
Mcm4	A	T	16: 15,453,175 (GRCm39)	C171*	probably null	Het
Micall1	C	T	15: 79,011,159 (GRCm39)	P510S		Het
Morc3	A	G	16: 93,649,975 (GRCm39)		probably null	Het
Mrpl28	G	T	17: 26,345,266 (GRCm39)	V229F	possibly damaging	Het
Mrps33	A	T	6: 39,782,364 (GRCm39)	Y52*	probably null	Het
Mybphl	T	C	3: 108,282,202 (GRCm39)	I144T	probably benign	Het
Myom1	A	G	17: 71,433,329 (GRCm39)	M1657V	probably benign	Het
Ogfr	AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG	AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG	2: 180,236,850 (GRCm39)		probably benign	Het
Or5p67	A	G	7: 107,922,037 (GRCm39)	I282T	probably benign	Het
Peg10	T	TCCG	6: 4,756,451 (GRCm39)		probably benign	Het
Plxna1	T	C	6: 89,318,912 (GRCm39)	K637R	probably benign	Het
Prob1	G	T	18: 35,786,218 (GRCm39)	L679I	possibly damaging	Het
Sgms2	C	A	3: 131,118,718 (GRCm39)	C255F	probably damaging	Het
Slc17a9	T	C	2: 180,383,090 (GRCm39)	C399R	probably benign	Het
Smc4	T	A	3: 68,915,455 (GRCm39)		probably null	Het
St14	A	G	9: 31,007,845 (GRCm39)	L578P	probably damaging	Het
Tcaf3	A	T	6: 42,573,906 (GRCm39)	L102*	probably null	Het
Tex15	A	G	8: 34,072,273 (GRCm39)	T2607A	possibly damaging	Het
Trav15-2-dv6-2	T	A	14: 53,886,932 (GRCm39)		probably benign	Het
Trip4	T	C	9: 65,760,234 (GRCm39)		probably null	Het
Ttf1	A	G	2: 28,955,709 (GRCm39)	I358V	probably benign	Het
Uroc1	C	A	6: 90,322,353 (GRCm39)	S292R	possibly damaging	Het
Vps33a	A	T	5: 123,703,047 (GRCm39)	I192N	probably damaging	Het
Vps50	A	G	6: 3,516,724 (GRCm39)	I69V	probably benign	Het
Wdr97	T	C	15: 76,245,064 (GRCm39)	S1176P		Het
Xirp1	G	A	9: 119,847,203 (GRCm39)	T560M	probably damaging	Het
Zfp512	A	T	5: 31,628,359 (GRCm39)	T266S	possibly damaging	Het

Other mutations in Vmn1r5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01674:Vmn1r5	APN	6	56,962,911 (GRCm39)	missense	probably damaging	0.98
IGL02027:Vmn1r5	APN	6	56,962,640 (GRCm39)	missense	probably damaging	0.97
IGL03133:Vmn1r5	APN	6	56,962,600 (GRCm39)	missense	probably benign	0.10
IGL03412:Vmn1r5	APN	6	56,962,918 (GRCm39)	missense	possibly damaging	0.90
R0316:Vmn1r5	UTSW	6	56,962,784 (GRCm39)	missense	probably benign	0.27
R0378:Vmn1r5	UTSW	6	56,962,570 (GRCm39)	missense	probably benign	0.00
R0946:Vmn1r5	UTSW	6	56,963,150 (GRCm39)	missense	possibly damaging	0.64
R1511:Vmn1r5	UTSW	6	56,962,771 (GRCm39)	missense	probably benign	0.02
R1553:Vmn1r5	UTSW	6	56,962,483 (GRCm39)	missense	probably benign	0.00
R1823:Vmn1r5	UTSW	6	56,962,580 (GRCm39)	missense	probably damaging	0.98
R3980:Vmn1r5	UTSW	6	56,962,636 (GRCm39)	missense	probably damaging	1.00
R4473:Vmn1r5	UTSW	6	56,962,633 (GRCm39)	missense	probably benign	0.01
R4742:Vmn1r5	UTSW	6	56,963,236 (GRCm39)	nonsense	probably null
R5321:Vmn1r5	UTSW	6	56,962,592 (GRCm39)	missense	probably damaging	1.00
R5364:Vmn1r5	UTSW	6	56,962,583 (GRCm39)	missense	probably damaging	0.98
R6102:Vmn1r5	UTSW	6	56,963,099 (GRCm39)	missense	probably damaging	0.96
R6581:Vmn1r5	UTSW	6	56,962,366 (GRCm39)	missense	probably benign
R6885:Vmn1r5	UTSW	6	56,963,042 (GRCm39)	missense	possibly damaging	0.89
R7297:Vmn1r5	UTSW	6	56,963,204 (GRCm39)	missense	possibly damaging	0.94
R8063:Vmn1r5	UTSW	6	56,962,583 (GRCm39)	missense	probably damaging	0.98
R8766:Vmn1r5	UTSW	6	56,963,100 (GRCm39)	missense	possibly damaging	0.76
R8968:Vmn1r5	UTSW	6	56,963,182 (GRCm39)	nonsense	probably null
R9460:Vmn1r5	UTSW	6	56,962,829 (GRCm39)	missense
Z1176:Vmn1r5	UTSW	6	56,962,933 (GRCm39)	missense	possibly damaging	0.75

Predicted Primers

PCR Primer
(F):5'- AGAGCCACTGAGTATTCTGTAC -3'
(R):5'- AGAGGCTTCTCATCACCCTG -3'

Sequencing Primer
(F):5'- GCCACTGAGTATTCTGTACAGATATG -3'
(R):5'- CACCCTGCTTATGTAAAAAGTTGCC -3'

Posted On

2022-06-15