Incidental Mutation 'R9441:Lgals12'
ID 713670
Institutional Source Beutler Lab
Gene Symbol Lgals12
Ensembl Gene ENSMUSG00000024972
Gene Name lectin, galactose binding, soluble 12
Synonyms galectin-12, galectin-related inhibitor of proliferation, GRIP1
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9441 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 7574025-7584558 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7581356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 117 (L117P)
Ref Sequence ENSEMBL: ENSMUSP00000097318 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079902] [ENSMUST00000099729] [ENSMUST00000159983]
AlphaFold Q91VD1
Predicted Effect probably damaging
Transcript: ENSMUST00000079902
AA Change: L117P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000078824
Gene: ENSMUSG00000024972
AA Change: L117P

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 181 301 3.6e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000099729
AA Change: L117P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097318
Gene: ENSMUSG00000024972
AA Change: L117P

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000159983
AA Change: L117P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124610
Gene: ENSMUSG00000024972
AA Change: L117P

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik C A 9: 55,917,776 (GRCm39) G20V unknown Het
Adam22 T C 5: 8,161,974 (GRCm39) T733A possibly damaging Het
Adam28 T A 14: 68,874,943 (GRCm39) N245Y probably damaging Het
Aldh9a1 C G 1: 167,177,919 (GRCm39) R39G probably benign Het
Armc3 A C 2: 19,253,426 (GRCm39) E189A possibly damaging Het
Atg9a C T 1: 75,163,086 (GRCm39) C338Y possibly damaging Het
Card6 TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG 15: 5,128,173 (GRCm39) probably benign Het
Cars1 G A 7: 143,123,185 (GRCm39) T560I probably benign Het
Casp8ap2 A G 4: 32,645,873 (GRCm39) K1649E probably benign Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Cd84 G A 1: 171,713,994 (GRCm39) probably null Het
Ces2g G T 8: 105,690,623 (GRCm39) A135S possibly damaging Het
Cfh T C 1: 140,030,149 (GRCm39) D926G probably benign Het
Chrm2 A G 6: 36,500,955 (GRCm39) T271A probably benign Het
Col6a3 G T 1: 90,705,249 (GRCm39) Y2824* probably null Het
Cth T A 3: 157,616,575 (GRCm39) R196S probably damaging Het
Cyp2g1 T C 7: 26,514,060 (GRCm39) M222T possibly damaging Het
Depdc5 T A 5: 33,095,042 (GRCm39) M773K probably benign Het
Dmbx1 G A 4: 115,780,884 (GRCm39) P39L probably damaging Het
Dst G C 1: 34,238,432 (GRCm39) W1697C probably damaging Het
Eno1 C T 4: 150,321,208 (GRCm39) probably benign Het
Erc2 G T 14: 27,802,114 (GRCm39) V761L possibly damaging Het
Frem1 A T 4: 82,924,083 (GRCm39) I292N probably damaging Het
Ftdc2 G A 16: 58,458,884 (GRCm39) probably benign Het
Hip1 G T 5: 135,460,571 (GRCm39) L530M possibly damaging Het
Kcna2 A G 3: 107,012,268 (GRCm39) Q283R probably benign Het
Kndc1 G A 7: 139,501,392 (GRCm39) D894N probably damaging Het
Lats1 G T 10: 7,578,681 (GRCm39) G602W probably damaging Het
Mfsd4b1 A T 10: 39,878,680 (GRCm39) L406I possibly damaging Het
Msln A T 17: 25,969,731 (GRCm39) M333K probably benign Het
Mup2 A G 4: 60,139,740 (GRCm39) V16A probably benign Het
Mybpc2 T C 7: 44,166,330 (GRCm39) E220G probably null Het
Myh6 A G 14: 55,197,771 (GRCm39) Y456H probably benign Het
Nlrp1a A G 11: 71,013,934 (GRCm39) S439P probably damaging Het
Nyap1 T C 5: 137,733,194 (GRCm39) E613G probably benign Het
Or10b1 G A 10: 78,355,609 (GRCm39) V56M probably benign Het
Parp8 C T 13: 117,029,562 (GRCm39) V554M probably damaging Het
Phpt1 A T 2: 25,464,750 (GRCm39) D34E probably benign Het
Ppip5k2 G A 1: 97,672,921 (GRCm39) S463L probably benign Het
Prss28 A G 17: 25,530,215 (GRCm39) Q173R probably benign Het
Rtel1 T A 2: 180,988,860 (GRCm39) W441R possibly damaging Het
Serbp1 T C 6: 67,244,025 (GRCm39) probably benign Het
Skint5 T C 4: 113,347,848 (GRCm39) K1319E unknown Het
Slc35a4 G A 18: 36,816,111 (GRCm39) G314S probably damaging Het
Slc8a1 A G 17: 81,956,498 (GRCm39) I180T probably damaging Het
Spire1 G A 18: 67,652,462 (GRCm39) P205L probably benign Het
Tat G T 8: 110,720,547 (GRCm39) G168W probably damaging Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Trh C T 6: 92,219,939 (GRCm39) G126R probably benign Het
Ugcg G A 4: 59,207,843 (GRCm39) G61R probably damaging Het
Uggt1 T C 1: 36,260,306 (GRCm39) T170A probably benign Het
Unc5b G A 10: 60,608,028 (GRCm39) P702S probably damaging Het
Usp8 A G 2: 126,562,073 (GRCm39) D89G possibly damaging Het
Vmn2r1 T A 3: 64,012,674 (GRCm39) I845K probably damaging Het
Vnn3 A G 10: 23,740,498 (GRCm39) N267S possibly damaging Het
Xkr9 A G 1: 13,771,587 (GRCm39) R368G possibly damaging Het
Other mutations in Lgals12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02442:Lgals12 APN 19 7,584,019 (GRCm39) splice site probably benign
IGL02630:Lgals12 APN 19 7,578,607 (GRCm39) splice site probably benign
IGL02700:Lgals12 APN 19 7,575,455 (GRCm39) missense probably benign 0.01
R0129:Lgals12 UTSW 19 7,580,403 (GRCm39) missense probably damaging 0.99
R1398:Lgals12 UTSW 19 7,581,322 (GRCm39) splice site probably benign
R1421:Lgals12 UTSW 19 7,584,079 (GRCm39) missense probably benign 0.08
R1548:Lgals12 UTSW 19 7,581,677 (GRCm39) missense probably benign 0.12
R1697:Lgals12 UTSW 19 7,581,530 (GRCm39) missense possibly damaging 0.91
R2075:Lgals12 UTSW 19 7,576,210 (GRCm39) missense possibly damaging 0.81
R2192:Lgals12 UTSW 19 7,578,606 (GRCm39) splice site probably null
R2253:Lgals12 UTSW 19 7,584,130 (GRCm39) start gained probably benign
R4256:Lgals12 UTSW 19 7,584,081 (GRCm39) missense possibly damaging 0.93
R4738:Lgals12 UTSW 19 7,581,464 (GRCm39) missense probably benign 0.01
R5495:Lgals12 UTSW 19 7,581,495 (GRCm39) missense probably damaging 1.00
R5810:Lgals12 UTSW 19 7,584,085 (GRCm39) missense probably benign 0.00
R6139:Lgals12 UTSW 19 7,581,742 (GRCm39) missense probably benign 0.07
R7414:Lgals12 UTSW 19 7,581,335 (GRCm39) missense probably damaging 1.00
R8755:Lgals12 UTSW 19 7,581,345 (GRCm39) missense possibly damaging 0.95
R8920:Lgals12 UTSW 19 7,576,166 (GRCm39) missense possibly damaging 0.55
R9334:Lgals12 UTSW 19 7,578,086 (GRCm39) missense probably benign 0.01
X0067:Lgals12 UTSW 19 7,581,329 (GRCm39) splice site probably null
Z1177:Lgals12 UTSW 19 7,575,445 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CCTACTAGATCCAGGGACTTTTGC -3'
(R):5'- AACTCCCCTACCAGGTTTCAG -3'

Sequencing Primer
(F):5'- GCAGTTTCCTATTGCTATACAGG -3'
(R):5'- ACCAGGTTTCAGGTGGACTTCC -3'
Posted On 2022-06-15