Mutagenetix > Incidental Mutation

Incidental Mutation 'R9442:Vmn1r180'

713683

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

V1rd16, LOC232962

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R9442 (G1)

Quality Score

92.0077

Status

Validated

Chromosome

Chromosomal Location

23651812-23652781 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 23651620 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

probably benign
Transcript: ENSMUST00000173816

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.3%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700122O11Rik	T	A	17: 48,347,580 (GRCm39)	K241N	possibly damaging	Het
Adam5	A	T	8: 25,296,510 (GRCm39)	S312R	probably damaging	Het
Atg9a	C	T	1: 75,163,086 (GRCm39)	C338Y	possibly damaging	Het
Cage1	T	C	13: 38,196,447 (GRCm39)	E749G	possibly damaging	Het
Catspere2	C	A	1: 177,931,275 (GRCm39)	T398K	unknown	Het
Ccdc88b	T	C	19: 6,833,213 (GRCm39)	E278G	probably damaging	Het
Ccndbp1	T	C	2: 120,839,013 (GRCm39)	V8A	probably benign	Het
Cenpt	T	C	8: 106,575,418 (GRCm39)	D228G	probably benign	Het
Cfap57	A	G	4: 118,463,731 (GRCm39)		probably null	Het
Cyp4a32	T	A	4: 115,468,422 (GRCm39)	N301K	probably benign	Het
Epha6	T	C	16: 60,025,850 (GRCm39)	T531A	probably benign	Het
Gmeb1	A	T	4: 131,962,156 (GRCm39)	C168S	probably damaging	Het
H2-DMa	G	A	17: 34,357,132 (GRCm39)	R210H	possibly damaging	Het
Ighv1-7	T	G	12: 114,502,198 (GRCm39)	T90P	probably damaging	Het
Kalrn	A	C	16: 33,916,249 (GRCm39)	M1R	probably null	Het
Kcnrg	CACAACAA	CACAA	14: 61,845,009 (GRCm39)		probably benign	Het
Krtap14	T	C	16: 88,622,865 (GRCm39)	D38G	possibly damaging	Het
Lrrc8e	A	G	8: 4,283,964 (GRCm39)	N63S	probably benign	Het
Map4k2	T	A	19: 6,392,814 (GRCm39)	L152Q	probably damaging	Het
Mcf2l	A	G	8: 13,023,048 (GRCm39)	D78G	possibly damaging	Het
Ms4a6c	T	C	19: 11,449,851 (GRCm39)	V81A	probably benign	Het
Mtnr1b	T	C	9: 15,785,660 (GRCm39)	T33A	probably benign	Het
Muc16	T	A	9: 18,566,624 (GRCm39)	Q1965L	unknown	Het
Nfatc2	A	C	2: 168,328,898 (GRCm39)		probably benign	Het
Nlrp9b	C	T	7: 19,779,707 (GRCm39)	T790I	possibly damaging	Het
Nol4	A	T	18: 22,902,899 (GRCm39)	C371S	probably damaging	Het
Ntn1	A	C	11: 68,148,485 (GRCm39)		probably benign	Het
Or14j3	A	G	17: 37,900,633 (GRCm39)	S204P	possibly damaging	Het
Orc1	T	C	4: 108,469,357 (GRCm39)	V727A	probably benign	Het
Phf20l1	C	T	15: 66,484,888 (GRCm39)	Q318*	probably null	Het
Psg18	A	T	7: 18,083,185 (GRCm39)	Y323*	probably null	Het
Ptk2b	T	C	14: 66,409,189 (GRCm39)	Y529C	probably damaging	Het
Rrm1	A	G	7: 102,108,598 (GRCm39)	Y374C	probably damaging	Het
Selp	T	A	1: 163,964,765 (GRCm39)	F476I	probably damaging	Het
Sema3b	A	G	9: 107,478,957 (GRCm39)		probably null	Het
Setdb2	T	G	14: 59,639,849 (GRCm39)	T665P	probably damaging	Het
Sorbs3	T	C	14: 70,424,387 (GRCm39)	Y515C	probably damaging	Het
St13	G	A	15: 81,272,575 (GRCm39)	P90S	possibly damaging	Het
Stag1	T	A	9: 100,836,306 (GRCm39)	I1197N	probably damaging	Het
Svs3a	A	G	2: 164,132,179 (GRCm39)	Y250C	probably damaging	Het
Ticam1	T	C	17: 56,577,428 (GRCm39)	I556V	probably benign	Het
Xirp2	T	A	2: 67,342,235 (GRCm39)	L1492*	probably null	Het
Zfp438	A	G	18: 5,214,379 (GRCm39)	V193A	probably benign	Het
Zfp729b	A	G	13: 67,739,337 (GRCm39)	V976A	probably benign	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Vmn1r180	APN	7	23,651,948 (GRCm39)	missense	probably benign	0.36
IGL01309:Vmn1r180	APN	7	23,652,424 (GRCm39)	missense	probably damaging	1.00
IGL01793:Vmn1r180	APN	7	23,652,668 (GRCm39)	missense	probably benign	0.00
IGL02653:Vmn1r180	APN	7	23,652,500 (GRCm39)	missense	probably damaging	1.00
IGL03277:Vmn1r180	APN	7	23,652,710 (GRCm39)	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23,652,077 (GRCm39)	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23,652,572 (GRCm39)	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23,652,395 (GRCm39)	missense	possibly damaging	0.84
R1702:Vmn1r180	UTSW	7	23,652,394 (GRCm39)	missense	possibly damaging	0.52
R2122:Vmn1r180	UTSW	7	23,652,566 (GRCm39)	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23,652,298 (GRCm39)	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23,652,635 (GRCm39)	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23,651,891 (GRCm39)	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23,652,685 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn1r180	UTSW	7	23,652,415 (GRCm39)	missense	probably damaging	1.00
R8991:Vmn1r180	UTSW	7	23,652,076 (GRCm39)	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- GGAATCTCTAACTTGTTACTGATTACG -3'
(R):5'- AACTTTACCTGACCCTGGGG -3'

Sequencing Primer
(F):5'- ACATGCCTTTGCAGTCTT -3'
(R):5'- CCCTGGGGTAATGATTAGGTTGAAC -3'

Posted On

2022-06-15