Incidental Mutation 'R9442:Or14j3'
ID 713706
Institutional Source Beutler Lab
Gene Symbol Or14j3
Ensembl Gene ENSMUSG00000062629
Gene Name olfactory receptor family 14 subfamily J member 3
Synonyms MOR218-10, GA_x6K02T2PSCP-2049802-2048870, Olfr114
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R9442 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 37900304-37901242 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37900633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 204 (S204P)
Ref Sequence ENSEMBL: ENSMUSP00000151201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076914] [ENSMUST00000214871] [ENSMUST00000216249]
AlphaFold Q923Q8
Predicted Effect possibly damaging
Transcript: ENSMUST00000076914
AA Change: S204P

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000076181
Gene: ENSMUSG00000062629
AA Change: S204P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2e-43 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.7e-6 PFAM
Pfam:7tm_1 41 290 3e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214871
AA Change: S204P

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216249
AA Change: S204P

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik T A 17: 48,347,580 (GRCm39) K241N possibly damaging Het
Adam5 A T 8: 25,296,510 (GRCm39) S312R probably damaging Het
Atg9a C T 1: 75,163,086 (GRCm39) C338Y possibly damaging Het
Cage1 T C 13: 38,196,447 (GRCm39) E749G possibly damaging Het
Catspere2 C A 1: 177,931,275 (GRCm39) T398K unknown Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Ccndbp1 T C 2: 120,839,013 (GRCm39) V8A probably benign Het
Cenpt T C 8: 106,575,418 (GRCm39) D228G probably benign Het
Cfap57 A G 4: 118,463,731 (GRCm39) probably null Het
Cyp4a32 T A 4: 115,468,422 (GRCm39) N301K probably benign Het
Epha6 T C 16: 60,025,850 (GRCm39) T531A probably benign Het
Gmeb1 A T 4: 131,962,156 (GRCm39) C168S probably damaging Het
H2-DMa G A 17: 34,357,132 (GRCm39) R210H possibly damaging Het
Ighv1-7 T G 12: 114,502,198 (GRCm39) T90P probably damaging Het
Kalrn A C 16: 33,916,249 (GRCm39) M1R probably null Het
Kcnrg CACAACAA CACAA 14: 61,845,009 (GRCm39) probably benign Het
Krtap14 T C 16: 88,622,865 (GRCm39) D38G possibly damaging Het
Lrrc8e A G 8: 4,283,964 (GRCm39) N63S probably benign Het
Map4k2 T A 19: 6,392,814 (GRCm39) L152Q probably damaging Het
Mcf2l A G 8: 13,023,048 (GRCm39) D78G possibly damaging Het
Ms4a6c T C 19: 11,449,851 (GRCm39) V81A probably benign Het
Mtnr1b T C 9: 15,785,660 (GRCm39) T33A probably benign Het
Muc16 T A 9: 18,566,624 (GRCm39) Q1965L unknown Het
Nfatc2 A C 2: 168,328,898 (GRCm39) probably benign Het
Nlrp9b C T 7: 19,779,707 (GRCm39) T790I possibly damaging Het
Nol4 A T 18: 22,902,899 (GRCm39) C371S probably damaging Het
Ntn1 A C 11: 68,148,485 (GRCm39) probably benign Het
Orc1 T C 4: 108,469,357 (GRCm39) V727A probably benign Het
Phf20l1 C T 15: 66,484,888 (GRCm39) Q318* probably null Het
Psg18 A T 7: 18,083,185 (GRCm39) Y323* probably null Het
Ptk2b T C 14: 66,409,189 (GRCm39) Y529C probably damaging Het
Rrm1 A G 7: 102,108,598 (GRCm39) Y374C probably damaging Het
Selp T A 1: 163,964,765 (GRCm39) F476I probably damaging Het
Sema3b A G 9: 107,478,957 (GRCm39) probably null Het
Setdb2 T G 14: 59,639,849 (GRCm39) T665P probably damaging Het
Sorbs3 T C 14: 70,424,387 (GRCm39) Y515C probably damaging Het
St13 G A 15: 81,272,575 (GRCm39) P90S possibly damaging Het
Stag1 T A 9: 100,836,306 (GRCm39) I1197N probably damaging Het
Svs3a A G 2: 164,132,179 (GRCm39) Y250C probably damaging Het
Ticam1 T C 17: 56,577,428 (GRCm39) I556V probably benign Het
Vmn1r180 A G 7: 23,651,620 (GRCm39) probably benign Het
Xirp2 T A 2: 67,342,235 (GRCm39) L1492* probably null Het
Zfp438 A G 18: 5,214,379 (GRCm39) V193A probably benign Het
Zfp729b A G 13: 67,739,337 (GRCm39) V976A probably benign Het
Other mutations in Or14j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01534:Or14j3 APN 17 37,900,963 (GRCm39) missense possibly damaging 0.93
IGL01624:Or14j3 APN 17 37,900,816 (GRCm39) missense probably benign 0.00
IGL02026:Or14j3 APN 17 37,900,298 (GRCm39) utr 3 prime probably benign
IGL02608:Or14j3 APN 17 37,901,110 (GRCm39) missense probably damaging 1.00
IGL02632:Or14j3 APN 17 37,901,232 (GRCm39) missense probably benign 0.00
IGL02990:Or14j3 APN 17 37,900,559 (GRCm39) missense probably benign 0.00
R0114:Or14j3 UTSW 17 37,900,306 (GRCm39) makesense probably null
R1156:Or14j3 UTSW 17 37,900,408 (GRCm39) missense possibly damaging 0.93
R1366:Or14j3 UTSW 17 37,900,655 (GRCm39) missense probably benign 0.03
R3413:Or14j3 UTSW 17 37,900,587 (GRCm39) missense probably benign 0.00
R3701:Or14j3 UTSW 17 37,900,717 (GRCm39) nonsense probably null
R6122:Or14j3 UTSW 17 37,900,817 (GRCm39) missense probably benign 0.12
R6639:Or14j3 UTSW 17 37,900,822 (GRCm39) missense probably damaging 1.00
R7066:Or14j3 UTSW 17 37,901,034 (GRCm39) missense probably damaging 1.00
R7316:Or14j3 UTSW 17 37,901,026 (GRCm39) missense probably damaging 0.99
R8340:Or14j3 UTSW 17 37,901,034 (GRCm39) missense probably damaging 1.00
R8483:Or14j3 UTSW 17 37,900,866 (GRCm39) missense possibly damaging 0.52
R8555:Or14j3 UTSW 17 37,900,540 (GRCm39) missense possibly damaging 0.95
R9617:Or14j3 UTSW 17 37,901,053 (GRCm39) nonsense probably null
R9718:Or14j3 UTSW 17 37,900,914 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTAAAGCAGTTGGAAAGTCTGAGG -3'
(R):5'- TCCCAGAAAGTGTAGGTGGG -3'

Sequencing Primer
(F):5'- CTGAGGTTGGGTTTAGATATGCAAAG -3'
(R):5'- AAAGTGTAGGTGGGCTGTGAC -3'
Posted On 2022-06-15