Incidental Mutation 'R9443:Zfp369'
ID 713767
Institutional Source Beutler Lab
Gene Symbol Zfp369
Ensembl Gene ENSMUSG00000021514
Gene Name zinc finger protein 369
Synonyms B930030B22Rik, NRIF2, D230020H11Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R9443 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 65426628-65452035 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 65444347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 497 (S497P)
Ref Sequence ENSEMBL: ENSMUSP00000119114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000126879] [ENSMUST00000130799]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000126879
AA Change: S497P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000119114
Gene: ENSMUSG00000021514
AA Change: S497P

DomainStartEndE-ValueType
KRAB 35 95 7.13e-20 SMART
SCAN 178 289 2.57e-39 SMART
KRAB 300 367 1.63e-14 SMART
low complexity region 440 452 N/A INTRINSIC
ZnF_C2H2 701 723 5.42e-2 SMART
ZnF_C2H2 729 751 4.79e-3 SMART
ZnF_C2H2 757 779 1.47e-3 SMART
ZnF_C2H2 785 807 2.43e-4 SMART
ZnF_C2H2 813 835 6.88e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000130799
SMART Domains Protein: ENSMUSP00000116221
Gene: ENSMUSG00000021514

DomainStartEndE-ValueType
KRAB 35 95 7.13e-20 SMART
SCAN 178 289 2.57e-39 SMART
KRAB 300 354 3.54e-15 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad1 T C 3: 37,146,140 (GRCm39) Y503H probably benign Het
Adck1 T C 12: 88,338,550 (GRCm39) probably null Het
Afap1l1 T C 18: 61,879,859 (GRCm39) D337G probably damaging Het
Afg1l G A 10: 42,189,587 (GRCm39) T448M probably damaging Het
Aqp6 T C 15: 99,499,409 (GRCm39) S41P Het
Atad5 T G 11: 80,023,388 (GRCm39) V1500G probably benign Het
B3galt9 C T 2: 34,728,623 (GRCm39) Q141* probably null Het
Btbd18 T A 2: 84,497,524 (GRCm39) D387E probably benign Het
Catsperd A G 17: 56,969,720 (GRCm39) N605D possibly damaging Het
Ccdc24 C T 4: 117,728,355 (GRCm39) V102I probably benign Het
Cenpe T A 3: 134,976,609 (GRCm39) D2405E probably damaging Het
Cfap46 T C 7: 139,195,023 (GRCm39) D2249G Het
Chrm1 A T 19: 8,655,550 (GRCm39) Y85F possibly damaging Het
Clstn3 C T 6: 124,428,358 (GRCm39) G465S probably damaging Het
Col7a1 G A 9: 108,785,059 (GRCm39) G262D unknown Het
Copg2 T C 6: 30,750,578 (GRCm39) T736A probably benign Het
Coro2b T C 9: 62,333,080 (GRCm39) E435G probably benign Het
Cp A T 3: 20,033,083 (GRCm39) I637F possibly damaging Het
Cpne7 T C 8: 123,853,411 (GRCm39) F239L probably damaging Het
Cstdc2 C T 2: 148,689,878 (GRCm39) E92K probably damaging Het
Cul2 T A 18: 3,434,041 (GRCm39) Y679* probably null Het
Dhx8 T C 11: 101,655,740 (GRCm39) Y1158H probably damaging Het
Eda G T X: 99,019,775 (GRCm39) R130L unknown Het
Elp6 T A 9: 110,150,004 (GRCm39) V265D probably damaging Het
Eomes A G 9: 118,313,640 (GRCm39) T562A Het
Fam187b A T 7: 30,677,067 (GRCm39) E192V probably damaging Het
Foxi1 T C 11: 34,155,671 (GRCm39) T320A probably benign Het
Gga1 C T 15: 78,765,247 (GRCm39) T18I possibly damaging Het
Grik4 T A 9: 42,571,037 (GRCm39) M223L probably benign Het
Hdac7 T C 15: 97,700,352 (GRCm39) N594S probably benign Het
Ifnar1 C T 16: 91,292,367 (GRCm39) P207L probably benign Het
Itpr3 T G 17: 27,324,523 (GRCm39) F1235C probably damaging Het
Klhdc4 A G 8: 122,523,765 (GRCm39) S484P possibly damaging Het
Kmt2c A G 5: 25,515,045 (GRCm39) S2933P probably damaging Het
Lama5 T A 2: 179,843,522 (GRCm39) H475L probably benign Het
Ly6g6f A G 17: 35,299,826 (GRCm39) L292P possibly damaging Het
Macf1 T A 4: 123,365,668 (GRCm39) Q3031L probably benign Het
Mbd5 T G 2: 49,146,712 (GRCm39) S307R probably damaging Het
Mertk T C 2: 128,604,029 (GRCm39) F388L probably benign Het
Mmp11 A G 10: 75,762,733 (GRCm39) F240S probably damaging Het
Mroh1 T A 15: 76,318,964 (GRCm39) F949I probably damaging Het
Mroh2b T C 15: 4,973,821 (GRCm39) L1113P probably damaging Het
Ndufv1 C A 19: 4,057,614 (GRCm39) A454S probably benign Het
Or13e8 A G 4: 43,696,591 (GRCm39) L194P probably damaging Het
Or56b2j T C 7: 104,352,821 (GRCm39) S16P probably benign Het
Or5d46 T A 2: 88,170,364 (GRCm39) W152R probably damaging Het
Osbpl1a C A 18: 13,031,244 (GRCm39) D329Y probably benign Het
Pcdh1 C A 18: 38,330,633 (GRCm39) R929L probably damaging Het
Phactr2 C T 10: 13,122,841 (GRCm39) R427K probably benign Het
Pip5k1c T C 10: 81,153,184 (GRCm39) Y670H probably damaging Het
Plbd1 T A 6: 136,611,555 (GRCm39) N241Y probably damaging Het
Pmvk C A 3: 89,374,956 (GRCm39) Q139K probably benign Het
Pramel30 T A 4: 144,059,678 (GRCm39) I463N possibly damaging Het
Rab3gap2 T A 1: 184,967,523 (GRCm39) C136S probably damaging Het
Rcor3 A G 1: 191,786,050 (GRCm39) V396A probably damaging Het
Rgs20 C A 1: 4,982,629 (GRCm39) E147* probably null Het
Rnf167 G T 11: 70,540,777 (GRCm39) L170F probably damaging Het
Scn9a T C 2: 66,395,553 (GRCm39) T164A probably damaging Het
Skic3 A G 13: 76,266,288 (GRCm39) Q210R probably benign Het
Slc52a3 A T 2: 151,846,299 (GRCm39) I87F probably benign Het
Sntn A T 14: 13,682,364 (GRCm38) M146L Het
Svep1 C T 4: 58,179,697 (GRCm39) R182H possibly damaging Het
Taar7f A G 10: 23,926,311 (GRCm39) I302V probably benign Het
Tm4sf20 T C 1: 82,746,090 (GRCm39) I17V probably benign Het
Traf1 T C 2: 34,836,748 (GRCm39) T270A probably benign Het
Trpm5 C T 7: 142,638,860 (GRCm39) E304K probably benign Het
Ttll8 T C 15: 88,809,863 (GRCm39) D311G possibly damaging Het
Unc79 T A 12: 103,037,035 (GRCm39) F608I probably damaging Het
Vmn2r11 A T 5: 109,195,159 (GRCm39) C722* probably null Het
Wdr7 A G 18: 63,853,407 (GRCm39) T36A probably damaging Het
Ybx2 C T 11: 69,831,188 (GRCm39) P261L Het
Zfp101 C T 17: 33,601,418 (GRCm39) V113I probably benign Het
Zfp260 T C 7: 29,804,249 (GRCm39) S50P probably benign Het
Zfp319 A T 8: 96,054,922 (GRCm39) F427Y probably benign Het
Other mutations in Zfp369
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Zfp369 APN 13 65,445,074 (GRCm39) missense probably benign 0.41
IGL01393:Zfp369 APN 13 65,442,288 (GRCm39) missense possibly damaging 0.85
IGL02277:Zfp369 APN 13 65,432,746 (GRCm39) missense probably damaging 1.00
IGL02986:Zfp369 APN 13 65,428,095 (GRCm39) missense probably damaging 1.00
IGL02992:Zfp369 APN 13 65,442,265 (GRCm39) missense possibly damaging 0.50
IGL03170:Zfp369 APN 13 65,442,224 (GRCm39) missense probably damaging 0.99
IGL03351:Zfp369 APN 13 65,443,967 (GRCm39) missense possibly damaging 0.95
R0136:Zfp369 UTSW 13 65,445,016 (GRCm39) missense probably benign 0.08
R0600:Zfp369 UTSW 13 65,444,248 (GRCm39) missense probably damaging 0.97
R0646:Zfp369 UTSW 13 65,445,362 (GRCm39) missense probably damaging 1.00
R1190:Zfp369 UTSW 13 65,440,107 (GRCm39) missense probably damaging 0.99
R1191:Zfp369 UTSW 13 65,439,776 (GRCm39) nonsense probably null
R1528:Zfp369 UTSW 13 65,439,979 (GRCm39) missense probably damaging 1.00
R1934:Zfp369 UTSW 13 65,444,965 (GRCm39) missense probably damaging 1.00
R2168:Zfp369 UTSW 13 65,444,762 (GRCm39) missense probably benign 0.01
R4386:Zfp369 UTSW 13 65,444,806 (GRCm39) missense probably benign 0.00
R4928:Zfp369 UTSW 13 65,444,614 (GRCm39) missense possibly damaging 0.91
R5127:Zfp369 UTSW 13 65,426,847 (GRCm39) start gained probably benign
R5549:Zfp369 UTSW 13 65,445,194 (GRCm39) missense probably damaging 1.00
R5740:Zfp369 UTSW 13 65,444,581 (GRCm39) missense probably benign
R5743:Zfp369 UTSW 13 65,443,494 (GRCm39) missense probably benign 0.02
R5840:Zfp369 UTSW 13 65,445,092 (GRCm39) missense possibly damaging 0.46
R6351:Zfp369 UTSW 13 65,444,044 (GRCm39) missense possibly damaging 0.83
R7248:Zfp369 UTSW 13 65,443,931 (GRCm39) missense probably damaging 0.98
R7288:Zfp369 UTSW 13 65,432,832 (GRCm39) critical splice donor site probably null
R7314:Zfp369 UTSW 13 65,439,918 (GRCm39) missense probably damaging 0.97
R7470:Zfp369 UTSW 13 65,439,960 (GRCm39) missense probably benign 0.12
R7508:Zfp369 UTSW 13 65,427,087 (GRCm39) missense unknown
R7796:Zfp369 UTSW 13 65,444,029 (GRCm39) missense probably benign
R7886:Zfp369 UTSW 13 65,439,868 (GRCm39) missense possibly damaging 0.95
R8425:Zfp369 UTSW 13 65,444,489 (GRCm39) missense possibly damaging 0.96
R8671:Zfp369 UTSW 13 65,444,095 (GRCm39) missense possibly damaging 0.92
R8868:Zfp369 UTSW 13 65,445,082 (GRCm39) missense possibly damaging 0.60
R8918:Zfp369 UTSW 13 65,443,529 (GRCm39) nonsense probably null
R8921:Zfp369 UTSW 13 65,444,044 (GRCm39) missense possibly damaging 0.92
R9201:Zfp369 UTSW 13 65,444,396 (GRCm39) missense probably benign 0.07
R9236:Zfp369 UTSW 13 65,445,010 (GRCm39) missense probably benign 0.08
Z1177:Zfp369 UTSW 13 65,439,974 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTTGTATTGACAAAAGCCAGTGCTC -3'
(R):5'- CCAGCTTTATGCCATTCAGGG -3'

Sequencing Primer
(F):5'- GCCAGTGCTCACTCAATGAAGTTC -3'
(R):5'- CATTCAGGGCCTTTCTGGTGAATC -3'
Posted On 2022-06-15