Incidental Mutation 'R9444:Dop1b'
ID 713845
Institutional Source Beutler Lab
Gene Symbol Dop1b
Ensembl Gene ENSMUSG00000022946
Gene Name DOP1 leucine zipper like protein B
Synonyms Dopey2, 0610038M01Rik, 2610510B01Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9444 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 93508795-93607476 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93607127 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 2260 (D2260E)
Ref Sequence ENSEMBL: ENSMUSP00000044437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045004] [ENSMUST00000227156]
AlphaFold Q3UHQ6
Predicted Effect probably benign
Transcript: ENSMUST00000045004
AA Change: D2260E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000044437
Gene: ENSMUSG00000022946
AA Change: D2260E

DomainStartEndE-ValueType
Pfam:Dopey_N 11 308 3.9e-104 PFAM
low complexity region 651 666 N/A INTRINSIC
low complexity region 709 719 N/A INTRINSIC
low complexity region 747 759 N/A INTRINSIC
low complexity region 1186 1199 N/A INTRINSIC
low complexity region 1436 1451 N/A INTRINSIC
low complexity region 1893 1908 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000226215
Predicted Effect probably benign
Transcript: ENSMUST00000227156
AA Change: D2143E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,854,724 (GRCm39) D106G probably damaging Het
Acacb T C 5: 114,384,020 (GRCm39) I2183T probably damaging Het
Adam17 A C 12: 21,375,536 (GRCm39) L761R probably benign Het
Apobr A G 7: 126,185,140 (GRCm39) D217G probably benign Het
Arhgap12 A T 18: 6,052,909 (GRCm39) Y434* probably null Het
Brwd1 T C 16: 95,855,180 (GRCm39) D416G possibly damaging Het
C1qtnf2 T C 11: 43,376,661 (GRCm39) I11T probably damaging Het
C1qtnf6 C T 15: 78,411,544 (GRCm39) C44Y probably damaging Het
Cacna1d A C 14: 29,829,741 (GRCm39) probably null Het
Card11 T A 5: 140,894,393 (GRCm39) I79F probably damaging Het
Chuk T C 19: 44,075,385 (GRCm39) D490G Het
Cilp2 T C 8: 70,335,546 (GRCm39) D484G probably damaging Het
Col8a1 C A 16: 57,448,455 (GRCm39) G352* probably null Het
Csmd1 A G 8: 16,208,250 (GRCm39) F1235S probably benign Het
Drd2 T C 9: 49,318,347 (GRCm39) F430L probably damaging Het
Fbxl17 A T 17: 63,778,455 (GRCm39) I485K probably damaging Het
Frem2 A G 3: 53,560,265 (GRCm39) V1414A probably benign Het
Galnt13 C A 2: 55,002,928 (GRCm39) S578R probably benign Het
Gfra2 T A 14: 71,203,751 (GRCm39) M300K possibly damaging Het
Gm12695 C T 4: 96,612,195 (GRCm39) A523T probably damaging Het
Gm19965 T C 1: 116,732,393 (GRCm39) S79P Het
Hsf1 T C 15: 76,384,769 (GRCm39) S487P probably damaging Het
Ifnar1 C T 16: 91,292,367 (GRCm39) P207L probably benign Het
Jag1 A C 2: 136,936,397 (GRCm39) W366G probably damaging Het
Larp4 T C 15: 99,909,807 (GRCm39) S638P probably benign Het
Lipm A G 19: 34,098,690 (GRCm39) D388G probably damaging Het
Lrp1b T A 2: 41,013,730 (GRCm39) Y1925F Het
Lrrc37 G A 11: 103,508,846 (GRCm39) Q1041* probably null Het
Mchr1 T C 15: 81,121,919 (GRCm39) V223A possibly damaging Het
Mfrp T A 9: 44,017,440 (GRCm39) I505N probably damaging Het
Msc T C 1: 14,825,714 (GRCm39) K87E probably damaging Het
Myo7a A G 7: 97,742,698 (GRCm39) F433L possibly damaging Het
Ncapg2 G A 12: 116,370,863 (GRCm39) R4H probably damaging Het
Ntrk3 G A 7: 78,110,805 (GRCm39) L299F probably damaging Het
Nup210 T A 6: 91,048,885 (GRCm39) Y457F probably benign Het
Or4k15c T C 14: 50,321,869 (GRCm39) K90E Het
Or4k48 T C 2: 111,476,132 (GRCm39) D70G probably damaging Het
Or5h18 T C 16: 58,848,018 (GRCm39) D84G probably benign Het
Or5t18 T A 2: 86,636,486 (GRCm39) I286F Het
Or8g32 A G 9: 39,305,365 (GRCm39) N90D probably benign Het
Ovgp1 CCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCATCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGGGTTTCTAAGATCACCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCA CCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGGGTTTCTAAGATCACCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCA 3: 105,893,841 (GRCm39) probably benign Het
Pcdh15 A G 10: 74,478,176 (GRCm39) Y217C probably damaging Het
Pde6h T G 6: 136,936,359 (GRCm39) F34C probably damaging Het
Pkhd1l1 A G 15: 44,418,053 (GRCm39) E2903G probably benign Het
Pnp T C 14: 51,188,052 (GRCm39) V113A probably damaging Het
Prss35 A G 9: 86,638,157 (GRCm39) D309G probably damaging Het
Pzp T C 6: 128,487,362 (GRCm39) R501G Het
Rfx8 A T 1: 39,709,476 (GRCm39) V517D probably damaging Het
Rnf213 A G 11: 119,325,623 (GRCm39) Y1509C Het
Rtp4 T C 16: 23,431,836 (GRCm39) Y123H probably benign Het
Sema3e A G 5: 14,302,625 (GRCm39) I717V possibly damaging Het
Stap2 A T 17: 56,307,907 (GRCm39) V150E possibly damaging Het
Stard9 C A 2: 120,495,414 (GRCm39) N96K probably damaging Het
Stoml2 T C 4: 43,030,442 (GRCm39) T93A probably damaging Het
Suclg2 T C 6: 95,543,474 (GRCm39) D319G probably damaging Het
Tcf12 C T 9: 72,018,040 (GRCm39) D19N probably damaging Het
Tcp10c T A 17: 13,581,503 (GRCm39) probably null Het
Tll1 T C 8: 64,469,123 (GRCm39) Y1000C probably damaging Het
Trappc10 G T 10: 78,033,612 (GRCm39) T985N probably benign Het
Trpc7 T A 13: 56,923,968 (GRCm39) K794M possibly damaging Het
Unc5c G T 3: 141,507,209 (GRCm39) probably null Het
Upf2 T A 2: 6,023,755 (GRCm39) C702S unknown Het
Wdhd1 A G 14: 47,488,324 (GRCm39) F728L possibly damaging Het
Other mutations in Dop1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Dop1b APN 16 93,596,914 (GRCm39) unclassified probably benign
IGL00492:Dop1b APN 16 93,577,670 (GRCm39) missense probably benign 0.00
IGL00753:Dop1b APN 16 93,566,512 (GRCm39) missense probably benign
IGL00832:Dop1b APN 16 93,560,289 (GRCm39) missense probably benign 0.01
IGL00939:Dop1b APN 16 93,570,971 (GRCm39) missense possibly damaging 0.83
IGL01019:Dop1b APN 16 93,607,117 (GRCm39) missense probably benign 0.32
IGL01288:Dop1b APN 16 93,536,181 (GRCm39) missense possibly damaging 0.78
IGL01505:Dop1b APN 16 93,554,004 (GRCm39) missense possibly damaging 0.87
IGL01535:Dop1b APN 16 93,566,846 (GRCm39) nonsense probably null
IGL01696:Dop1b APN 16 93,567,128 (GRCm39) missense probably benign 0.00
IGL02077:Dop1b APN 16 93,577,648 (GRCm39) missense probably damaging 0.96
IGL02163:Dop1b APN 16 93,559,315 (GRCm39) missense possibly damaging 0.48
IGL02234:Dop1b APN 16 93,549,039 (GRCm39) missense probably benign
IGL02302:Dop1b APN 16 93,607,005 (GRCm39) missense probably benign 0.08
IGL02485:Dop1b APN 16 93,567,710 (GRCm39) missense probably damaging 1.00
IGL02563:Dop1b APN 16 93,574,293 (GRCm39) missense probably damaging 0.99
IGL02733:Dop1b APN 16 93,536,079 (GRCm39) missense possibly damaging 0.80
IGL02792:Dop1b APN 16 93,598,460 (GRCm39) missense possibly damaging 0.75
IGL02941:Dop1b APN 16 93,552,361 (GRCm39) missense probably benign 0.09
IGL03143:Dop1b APN 16 93,556,543 (GRCm39) missense probably benign
PIT4519001:Dop1b UTSW 16 93,558,942 (GRCm39) missense probably benign
R0320:Dop1b UTSW 16 93,607,035 (GRCm39) missense probably benign 0.02
R0499:Dop1b UTSW 16 93,567,325 (GRCm39) missense probably benign 0.00
R0501:Dop1b UTSW 16 93,549,750 (GRCm39) missense probably benign 0.00
R0534:Dop1b UTSW 16 93,559,393 (GRCm39) missense probably benign 0.04
R0583:Dop1b UTSW 16 93,552,374 (GRCm39) missense probably benign 0.30
R0626:Dop1b UTSW 16 93,560,844 (GRCm39) missense probably damaging 1.00
R0724:Dop1b UTSW 16 93,559,213 (GRCm39) missense probably benign 0.01
R0907:Dop1b UTSW 16 93,598,481 (GRCm39) missense probably damaging 1.00
R1263:Dop1b UTSW 16 93,574,274 (GRCm39) missense probably benign
R1378:Dop1b UTSW 16 93,567,280 (GRCm39) missense probably benign
R1572:Dop1b UTSW 16 93,567,041 (GRCm39) missense probably damaging 1.00
R1604:Dop1b UTSW 16 93,559,458 (GRCm39) missense probably benign
R1642:Dop1b UTSW 16 93,559,203 (GRCm39) missense probably benign 0.00
R1668:Dop1b UTSW 16 93,562,404 (GRCm39) missense probably damaging 1.00
R1669:Dop1b UTSW 16 93,566,548 (GRCm39) missense probably damaging 1.00
R1702:Dop1b UTSW 16 93,544,509 (GRCm39) missense possibly damaging 0.47
R1711:Dop1b UTSW 16 93,596,814 (GRCm39) missense probably damaging 1.00
R1917:Dop1b UTSW 16 93,513,150 (GRCm39) missense probably damaging 1.00
R1968:Dop1b UTSW 16 93,579,307 (GRCm39) missense probably damaging 1.00
R1988:Dop1b UTSW 16 93,563,061 (GRCm39) missense probably damaging 1.00
R2029:Dop1b UTSW 16 93,566,323 (GRCm39) missense probably benign 0.36
R2139:Dop1b UTSW 16 93,567,895 (GRCm39) missense possibly damaging 0.78
R2355:Dop1b UTSW 16 93,567,565 (GRCm39) missense probably damaging 1.00
R3609:Dop1b UTSW 16 93,536,220 (GRCm39) missense probably damaging 1.00
R3792:Dop1b UTSW 16 93,568,734 (GRCm39) missense possibly damaging 0.54
R4364:Dop1b UTSW 16 93,567,812 (GRCm39) missense probably benign 0.00
R4380:Dop1b UTSW 16 93,513,120 (GRCm39) missense possibly damaging 0.53
R4455:Dop1b UTSW 16 93,563,103 (GRCm39) missense probably damaging 1.00
R4779:Dop1b UTSW 16 93,553,969 (GRCm39) missense probably damaging 1.00
R4820:Dop1b UTSW 16 93,589,978 (GRCm39) missense probably benign 0.00
R4834:Dop1b UTSW 16 93,536,892 (GRCm39) start codon destroyed probably null 0.70
R4866:Dop1b UTSW 16 93,560,318 (GRCm39) critical splice donor site probably null
R4882:Dop1b UTSW 16 93,549,802 (GRCm39) missense possibly damaging 0.95
R4900:Dop1b UTSW 16 93,560,318 (GRCm39) critical splice donor site probably null
R5153:Dop1b UTSW 16 93,570,891 (GRCm39) missense probably damaging 0.98
R5176:Dop1b UTSW 16 93,536,931 (GRCm39) missense probably damaging 1.00
R5206:Dop1b UTSW 16 93,598,472 (GRCm39) missense probably damaging 1.00
R5320:Dop1b UTSW 16 93,536,874 (GRCm39) missense probably damaging 1.00
R5361:Dop1b UTSW 16 93,567,392 (GRCm39) missense probably damaging 1.00
R5380:Dop1b UTSW 16 93,560,298 (GRCm39) missense probably damaging 0.96
R5476:Dop1b UTSW 16 93,570,801 (GRCm39) splice site probably null
R5502:Dop1b UTSW 16 93,590,114 (GRCm39) missense probably benign 0.00
R5543:Dop1b UTSW 16 93,595,808 (GRCm39) missense probably damaging 0.98
R5557:Dop1b UTSW 16 93,560,819 (GRCm39) missense probably damaging 0.96
R5901:Dop1b UTSW 16 93,566,639 (GRCm39) missense possibly damaging 0.88
R5907:Dop1b UTSW 16 93,598,469 (GRCm39) missense probably damaging 1.00
R6174:Dop1b UTSW 16 93,563,110 (GRCm39) missense probably damaging 1.00
R6256:Dop1b UTSW 16 93,604,102 (GRCm39) missense possibly damaging 0.94
R6383:Dop1b UTSW 16 93,579,136 (GRCm39) missense possibly damaging 0.76
R6525:Dop1b UTSW 16 93,606,304 (GRCm39) missense probably damaging 1.00
R6554:Dop1b UTSW 16 93,557,346 (GRCm39) missense probably benign 0.22
R6823:Dop1b UTSW 16 93,552,373 (GRCm39) missense possibly damaging 0.75
R7036:Dop1b UTSW 16 93,574,378 (GRCm39) missense probably benign 0.01
R7058:Dop1b UTSW 16 93,573,878 (GRCm39) missense probably benign 0.00
R7061:Dop1b UTSW 16 93,558,951 (GRCm39) missense probably benign 0.00
R7209:Dop1b UTSW 16 93,566,733 (GRCm39) missense probably benign
R7214:Dop1b UTSW 16 93,607,023 (GRCm39) missense possibly damaging 0.69
R7232:Dop1b UTSW 16 93,557,373 (GRCm39) critical splice donor site probably null
R7255:Dop1b UTSW 16 93,567,034 (GRCm39) missense probably damaging 1.00
R7335:Dop1b UTSW 16 93,544,396 (GRCm39) missense probably benign 0.04
R7535:Dop1b UTSW 16 93,603,249 (GRCm39) missense probably damaging 1.00
R7700:Dop1b UTSW 16 93,595,649 (GRCm39) splice site probably null
R7763:Dop1b UTSW 16 93,552,402 (GRCm39) missense probably benign 0.00
R7814:Dop1b UTSW 16 93,596,859 (GRCm39) missense probably damaging 1.00
R7839:Dop1b UTSW 16 93,560,829 (GRCm39) missense probably damaging 1.00
R7862:Dop1b UTSW 16 93,546,851 (GRCm39) missense probably damaging 1.00
R7894:Dop1b UTSW 16 93,607,092 (GRCm39) missense probably benign 0.01
R7952:Dop1b UTSW 16 93,546,848 (GRCm39) missense possibly damaging 0.93
R7956:Dop1b UTSW 16 93,567,916 (GRCm39) critical splice donor site probably null
R8033:Dop1b UTSW 16 93,566,371 (GRCm39) missense probably benign
R8061:Dop1b UTSW 16 93,546,884 (GRCm39) missense probably damaging 1.00
R8067:Dop1b UTSW 16 93,562,336 (GRCm39) nonsense probably null
R8146:Dop1b UTSW 16 93,546,827 (GRCm39) missense possibly damaging 0.95
R8184:Dop1b UTSW 16 93,573,881 (GRCm39) missense probably benign 0.13
R8221:Dop1b UTSW 16 93,546,847 (GRCm39) missense probably benign 0.01
R8263:Dop1b UTSW 16 93,559,083 (GRCm39) missense possibly damaging 0.87
R8329:Dop1b UTSW 16 93,568,675 (GRCm39) missense probably damaging 1.00
R8555:Dop1b UTSW 16 93,568,698 (GRCm39) missense probably damaging 1.00
R8683:Dop1b UTSW 16 93,570,809 (GRCm39) missense probably benign
R8683:Dop1b UTSW 16 93,568,699 (GRCm39) missense probably damaging 0.98
R8716:Dop1b UTSW 16 93,577,673 (GRCm39) nonsense probably null
R8807:Dop1b UTSW 16 93,558,973 (GRCm39) missense probably benign 0.03
R8840:Dop1b UTSW 16 93,607,005 (GRCm39) missense probably benign 0.08
R8851:Dop1b UTSW 16 93,559,398 (GRCm39) missense probably benign 0.39
R8884:Dop1b UTSW 16 93,556,550 (GRCm39) missense probably benign
R8976:Dop1b UTSW 16 93,558,969 (GRCm39) missense probably benign 0.01
R9219:Dop1b UTSW 16 93,567,184 (GRCm39) missense probably damaging 1.00
R9238:Dop1b UTSW 16 93,546,018 (GRCm39) missense probably benign 0.14
R9284:Dop1b UTSW 16 93,557,196 (GRCm39) missense probably damaging 1.00
R9289:Dop1b UTSW 16 93,568,681 (GRCm39) missense probably damaging 1.00
R9298:Dop1b UTSW 16 93,597,087 (GRCm39) missense probably damaging 0.96
R9338:Dop1b UTSW 16 93,600,448 (GRCm39) missense probably damaging 1.00
R9346:Dop1b UTSW 16 93,577,702 (GRCm39) critical splice donor site probably null
R9500:Dop1b UTSW 16 93,607,171 (GRCm39) missense probably benign
R9601:Dop1b UTSW 16 93,544,531 (GRCm39) missense possibly damaging 0.87
R9793:Dop1b UTSW 16 93,598,503 (GRCm39) missense probably benign 0.30
Z1088:Dop1b UTSW 16 93,560,214 (GRCm39) missense probably benign 0.00
Z1176:Dop1b UTSW 16 93,604,756 (GRCm39) missense possibly damaging 0.82
Z1176:Dop1b UTSW 16 93,600,434 (GRCm39) missense probably damaging 1.00
Z1176:Dop1b UTSW 16 93,566,469 (GRCm39) missense probably benign 0.00
Z1177:Dop1b UTSW 16 93,560,783 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTAGCTAGGTCACTCTGGTG -3'
(R):5'- ACAGCACTTCAGGACTGTG -3'

Sequencing Primer
(F):5'- GGCTTTGGGTCTTTCTACAGGAAATC -3'
(R):5'- AGGGTTGGTTCAAATCCCC -3'
Posted On 2022-06-15