Incidental Mutation 'R9445:Med13l'
ID |
713872 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Med13l
|
Ensembl Gene |
ENSMUSG00000018076 |
Gene Name |
mediator complex subunit 13-like |
Synonyms |
9030618F05Rik, Trap240L, 6330591G05Rik, Thrap2, 2210413I17Rik |
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.968)
|
Stock # |
R9445 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
118698744-118903503 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 118862214 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Threonine
at position 386
(S386T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000098379
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100816]
[ENSMUST00000201010]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000100816
AA Change: S386T
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000098379 Gene: ENSMUSG00000018076 AA Change: S386T
Domain | Start | End | E-Value | Type |
Pfam:Med13_N
|
1 |
380 |
2.5e-116 |
PFAM |
low complexity region
|
442 |
460 |
N/A |
INTRINSIC |
low complexity region
|
542 |
558 |
N/A |
INTRINSIC |
low complexity region
|
1020 |
1031 |
N/A |
INTRINSIC |
low complexity region
|
1044 |
1060 |
N/A |
INTRINSIC |
low complexity region
|
1541 |
1593 |
N/A |
INTRINSIC |
low complexity region
|
1601 |
1611 |
N/A |
INTRINSIC |
Pfam:Med13_C
|
1675 |
2197 |
1e-142 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000201010
AA Change: S386T
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000144092 Gene: ENSMUSG00000018076 AA Change: S386T
Domain | Start | End | E-Value | Type |
Pfam:Med13_N
|
1 |
380 |
1e-112 |
PFAM |
low complexity region
|
442 |
460 |
N/A |
INTRINSIC |
low complexity region
|
542 |
558 |
N/A |
INTRINSIC |
low complexity region
|
1020 |
1031 |
N/A |
INTRINSIC |
low complexity region
|
1044 |
1060 |
N/A |
INTRINSIC |
low complexity region
|
1541 |
1593 |
N/A |
INTRINSIC |
low complexity region
|
1601 |
1611 |
N/A |
INTRINSIC |
Pfam:Med13_C
|
1675 |
2206 |
1.7e-138 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
Validation Efficiency |
99% (72/73) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700024B05Rik |
T |
A |
14: 41,818,174 (GRCm39) |
H23Q |
possibly damaging |
Het |
Abca14 |
T |
C |
7: 119,877,691 (GRCm39) |
S1069P |
probably benign |
Het |
Abo |
A |
G |
2: 26,733,720 (GRCm39) |
W160R |
probably damaging |
Het |
Adgrb1 |
A |
T |
15: 74,435,807 (GRCm39) |
|
probably benign |
Het |
Ahnak2 |
T |
C |
12: 112,745,978 (GRCm39) |
Q1624R |
|
Het |
Amy2a1 |
T |
A |
3: 113,325,324 (GRCm39) |
N90I |
possibly damaging |
Het |
Bod1l |
C |
T |
5: 41,974,619 (GRCm39) |
V2232I |
probably benign |
Het |
Brsk2 |
T |
A |
7: 141,538,149 (GRCm39) |
H98Q |
probably damaging |
Het |
Caskin2 |
C |
T |
11: 115,694,576 (GRCm39) |
V342I |
probably damaging |
Het |
Ccdc13 |
T |
C |
9: 121,627,156 (GRCm39) |
N707S |
probably benign |
Het |
Cdv3 |
T |
C |
9: 103,241,240 (GRCm39) |
E109G |
probably damaging |
Het |
Coro2a |
C |
T |
4: 46,540,558 (GRCm39) |
E454K |
probably benign |
Het |
Cpq |
A |
T |
15: 33,213,391 (GRCm39) |
I137F |
possibly damaging |
Het |
Ctsj |
G |
A |
13: 61,151,838 (GRCm39) |
T73I |
possibly damaging |
Het |
Dchs2 |
A |
G |
3: 83,146,284 (GRCm39) |
D710G |
probably damaging |
Het |
Drd4 |
T |
C |
7: 140,872,162 (GRCm39) |
V71A |
probably damaging |
Het |
Eef2k |
T |
C |
7: 120,457,694 (GRCm39) |
C18R |
probably benign |
Het |
Ercc4 |
C |
A |
16: 12,945,474 (GRCm39) |
D386E |
probably benign |
Het |
F2rl2 |
A |
C |
13: 95,837,622 (GRCm39) |
L222F |
probably benign |
Het |
Fkbp4 |
T |
C |
6: 128,413,580 (GRCm39) |
D68G |
probably damaging |
Het |
Fsip2 |
A |
T |
2: 82,806,132 (GRCm39) |
D817V |
probably damaging |
Het |
Gm19410 |
G |
A |
8: 36,239,652 (GRCm39) |
R116H |
possibly damaging |
Het |
Gm9376 |
A |
T |
14: 118,504,502 (GRCm39) |
|
probably benign |
Het |
Golim4 |
A |
T |
3: 75,813,775 (GRCm39) |
F150I |
probably damaging |
Het |
Gtpbp2 |
G |
A |
17: 46,478,757 (GRCm39) |
V525M |
probably damaging |
Het |
Hook1 |
A |
G |
4: 95,901,499 (GRCm39) |
N486D |
probably benign |
Het |
Hook1 |
A |
G |
4: 95,903,049 (GRCm39) |
S513G |
probably benign |
Het |
Hoxd9 |
A |
T |
2: 74,528,415 (GRCm39) |
T6S |
probably damaging |
Het |
Hsd3b2 |
A |
T |
3: 98,619,051 (GRCm39) |
L298Q |
possibly damaging |
Het |
Idh3b |
A |
C |
2: 130,123,572 (GRCm39) |
S172A |
probably benign |
Het |
Ifnar1 |
C |
T |
16: 91,292,367 (GRCm39) |
P207L |
probably benign |
Het |
Ighv5-17 |
T |
A |
12: 113,822,858 (GRCm39) |
T88S |
possibly damaging |
Het |
Il16 |
T |
A |
7: 83,337,380 (GRCm39) |
K112* |
probably null |
Het |
Irag1 |
A |
T |
7: 110,545,161 (GRCm39) |
I45N |
possibly damaging |
Het |
Kalrn |
T |
A |
16: 33,805,600 (GRCm39) |
I2646F |
probably benign |
Het |
Kcnt1 |
G |
T |
2: 25,767,959 (GRCm39) |
G23C |
probably damaging |
Het |
Kirrel2 |
T |
A |
7: 30,150,260 (GRCm39) |
I523F |
probably damaging |
Het |
Lrrc3b |
A |
T |
14: 15,358,552 (GRCm38) |
L18H |
probably damaging |
Het |
Mettl6 |
C |
T |
14: 31,209,527 (GRCm39) |
|
probably null |
Het |
Mocs2 |
C |
T |
13: 114,961,879 (GRCm39) |
A120V |
possibly damaging |
Het |
Mrpl39 |
T |
C |
16: 84,531,346 (GRCm39) |
T74A |
probably benign |
Het |
Myh2 |
T |
C |
11: 67,069,754 (GRCm39) |
F367L |
probably damaging |
Het |
N4bp1 |
G |
A |
8: 87,587,238 (GRCm39) |
Q567* |
probably null |
Het |
Naf1 |
A |
G |
8: 67,336,097 (GRCm39) |
I341M |
probably damaging |
Het |
Ncoa6 |
A |
T |
2: 155,250,063 (GRCm39) |
N1080K |
probably benign |
Het |
Nell1 |
C |
A |
7: 49,632,474 (GRCm39) |
L36I |
possibly damaging |
Het |
Nrxn2 |
A |
G |
19: 6,522,448 (GRCm39) |
D446G |
probably damaging |
Het |
Nrxn3 |
T |
A |
12: 89,499,737 (GRCm39) |
C709* |
probably null |
Het |
Or13p4 |
T |
G |
4: 118,547,416 (GRCm39) |
T78P |
probably damaging |
Het |
Or2ag17 |
A |
G |
7: 106,389,464 (GRCm39) |
V248A |
probably damaging |
Het |
Or2n1 |
A |
C |
17: 38,486,694 (GRCm39) |
T240P |
probably damaging |
Het |
Or2t26 |
C |
G |
11: 49,039,879 (GRCm39) |
A265G |
probably benign |
Het |
Or8g19 |
T |
A |
9: 39,055,766 (GRCm39) |
Y123* |
probably null |
Het |
Ovgp1 |
T |
C |
3: 105,893,883 (GRCm39) |
|
probably benign |
Het |
Pbx3 |
A |
G |
2: 34,114,555 (GRCm39) |
|
probably benign |
Het |
Pcnx1 |
T |
C |
12: 81,964,981 (GRCm39) |
S383P |
probably damaging |
Het |
Pde6h |
T |
G |
6: 136,936,359 (GRCm39) |
F34C |
probably damaging |
Het |
Pnliprp1 |
A |
G |
19: 58,720,628 (GRCm39) |
|
probably benign |
Het |
Pramel21 |
T |
C |
4: 143,343,795 (GRCm39) |
L365P |
probably damaging |
Het |
Prl8a9 |
C |
T |
13: 27,748,498 (GRCm39) |
|
probably null |
Het |
Qdpr |
T |
C |
5: 45,596,669 (GRCm39) |
N165S |
probably benign |
Het |
Rabl2 |
A |
G |
15: 89,468,148 (GRCm39) |
F158L |
probably damaging |
Het |
Rrp7a |
G |
T |
15: 83,004,084 (GRCm39) |
C117* |
probably null |
Het |
Ryr2 |
T |
C |
13: 11,787,463 (GRCm39) |
Y970C |
probably damaging |
Het |
Sf3b3 |
T |
C |
8: 111,552,774 (GRCm39) |
T503A |
possibly damaging |
Het |
Sipa1 |
T |
C |
19: 5,704,198 (GRCm39) |
E708G |
probably damaging |
Het |
Skor2 |
T |
A |
18: 76,948,811 (GRCm39) |
S844R |
possibly damaging |
Het |
Slc6a7 |
C |
T |
18: 61,138,815 (GRCm39) |
C231Y |
probably damaging |
Het |
Smgc |
A |
T |
15: 91,729,665 (GRCm39) |
E206D |
probably benign |
Het |
Tanc2 |
T |
C |
11: 105,758,290 (GRCm39) |
S684P |
possibly damaging |
Het |
Tep1 |
T |
C |
14: 51,082,967 (GRCm39) |
T1014A |
possibly damaging |
Het |
Tex19.1 |
A |
G |
11: 121,038,283 (GRCm39) |
S214G |
probably benign |
Het |
Trmt6 |
G |
A |
2: 132,650,774 (GRCm39) |
S278L |
probably benign |
Het |
Use1 |
T |
C |
8: 71,821,200 (GRCm39) |
S156P |
probably benign |
Het |
Znrf1 |
G |
A |
8: 112,335,954 (GRCm39) |
V152M |
probably damaging |
Het |
|
Other mutations in Med13l |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00232:Med13l
|
APN |
5 |
118,862,136 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01012:Med13l
|
APN |
5 |
118,872,093 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01316:Med13l
|
APN |
5 |
118,900,846 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01529:Med13l
|
APN |
5 |
118,880,400 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01731:Med13l
|
APN |
5 |
118,880,472 (GRCm39) |
missense |
probably benign |
0.05 |
IGL01790:Med13l
|
APN |
5 |
118,731,587 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02394:Med13l
|
APN |
5 |
118,886,898 (GRCm39) |
missense |
probably benign |
0.37 |
IGL02432:Med13l
|
APN |
5 |
118,876,465 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL02698:Med13l
|
APN |
5 |
118,900,894 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02801:Med13l
|
APN |
5 |
118,883,178 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03242:Med13l
|
APN |
5 |
118,885,510 (GRCm39) |
missense |
probably benign |
|
IGL03270:Med13l
|
APN |
5 |
118,869,495 (GRCm39) |
missense |
probably damaging |
1.00 |
Basics
|
UTSW |
5 |
118,897,329 (GRCm39) |
critical splice donor site |
probably null |
|
firmament
|
UTSW |
5 |
118,883,071 (GRCm39) |
splice site |
probably null |
|
Fundament
|
UTSW |
5 |
118,859,539 (GRCm39) |
missense |
probably damaging |
1.00 |
Root
|
UTSW |
5 |
118,731,510 (GRCm39) |
missense |
probably damaging |
1.00 |
P0035:Med13l
|
UTSW |
5 |
118,880,685 (GRCm39) |
missense |
probably benign |
0.00 |
R0051:Med13l
|
UTSW |
5 |
118,880,720 (GRCm39) |
missense |
probably damaging |
1.00 |
R0051:Med13l
|
UTSW |
5 |
118,880,720 (GRCm39) |
missense |
probably damaging |
1.00 |
R0136:Med13l
|
UTSW |
5 |
118,862,115 (GRCm39) |
missense |
probably benign |
0.15 |
R0158:Med13l
|
UTSW |
5 |
118,880,514 (GRCm39) |
missense |
unknown |
|
R0197:Med13l
|
UTSW |
5 |
118,809,067 (GRCm39) |
splice site |
probably benign |
|
R0370:Med13l
|
UTSW |
5 |
118,879,891 (GRCm39) |
missense |
probably benign |
0.14 |
R0492:Med13l
|
UTSW |
5 |
118,876,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R0532:Med13l
|
UTSW |
5 |
118,897,188 (GRCm39) |
missense |
possibly damaging |
0.78 |
R0726:Med13l
|
UTSW |
5 |
118,886,749 (GRCm39) |
missense |
probably damaging |
0.99 |
R0738:Med13l
|
UTSW |
5 |
118,889,698 (GRCm39) |
missense |
probably damaging |
0.99 |
R0827:Med13l
|
UTSW |
5 |
118,864,312 (GRCm39) |
splice site |
probably benign |
|
R0883:Med13l
|
UTSW |
5 |
118,809,067 (GRCm39) |
splice site |
probably benign |
|
R0959:Med13l
|
UTSW |
5 |
118,892,350 (GRCm39) |
missense |
possibly damaging |
0.89 |
R1458:Med13l
|
UTSW |
5 |
118,876,524 (GRCm39) |
missense |
probably benign |
0.00 |
R1562:Med13l
|
UTSW |
5 |
118,876,584 (GRCm39) |
missense |
probably damaging |
1.00 |
R1577:Med13l
|
UTSW |
5 |
118,859,457 (GRCm39) |
missense |
probably damaging |
1.00 |
R1661:Med13l
|
UTSW |
5 |
118,887,813 (GRCm39) |
missense |
probably damaging |
1.00 |
R1665:Med13l
|
UTSW |
5 |
118,887,813 (GRCm39) |
missense |
probably damaging |
1.00 |
R1720:Med13l
|
UTSW |
5 |
118,880,060 (GRCm39) |
missense |
probably damaging |
1.00 |
R1929:Med13l
|
UTSW |
5 |
118,866,898 (GRCm39) |
missense |
probably benign |
0.01 |
R1967:Med13l
|
UTSW |
5 |
118,899,387 (GRCm39) |
missense |
probably damaging |
0.99 |
R2301:Med13l
|
UTSW |
5 |
118,731,512 (GRCm39) |
missense |
probably damaging |
1.00 |
R3691:Med13l
|
UTSW |
5 |
118,859,562 (GRCm39) |
missense |
probably benign |
0.16 |
R3895:Med13l
|
UTSW |
5 |
118,899,388 (GRCm39) |
missense |
probably null |
0.99 |
R4043:Med13l
|
UTSW |
5 |
118,731,528 (GRCm39) |
missense |
probably damaging |
1.00 |
R4593:Med13l
|
UTSW |
5 |
118,880,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R4902:Med13l
|
UTSW |
5 |
118,883,195 (GRCm39) |
missense |
probably damaging |
1.00 |
R4995:Med13l
|
UTSW |
5 |
118,869,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5010:Med13l
|
UTSW |
5 |
118,731,615 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5057:Med13l
|
UTSW |
5 |
118,856,558 (GRCm39) |
missense |
probably damaging |
1.00 |
R5369:Med13l
|
UTSW |
5 |
118,862,075 (GRCm39) |
missense |
probably benign |
0.02 |
R5446:Med13l
|
UTSW |
5 |
118,880,462 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5564:Med13l
|
UTSW |
5 |
118,880,105 (GRCm39) |
missense |
probably damaging |
1.00 |
R5566:Med13l
|
UTSW |
5 |
118,866,730 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5580:Med13l
|
UTSW |
5 |
118,889,695 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5634:Med13l
|
UTSW |
5 |
118,698,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
R5748:Med13l
|
UTSW |
5 |
118,731,510 (GRCm39) |
missense |
probably damaging |
1.00 |
R5764:Med13l
|
UTSW |
5 |
118,866,707 (GRCm39) |
missense |
probably damaging |
0.99 |
R5765:Med13l
|
UTSW |
5 |
118,866,707 (GRCm39) |
missense |
probably damaging |
0.99 |
R6083:Med13l
|
UTSW |
5 |
118,859,551 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6504:Med13l
|
UTSW |
5 |
118,892,386 (GRCm39) |
missense |
probably benign |
0.34 |
R6546:Med13l
|
UTSW |
5 |
118,859,539 (GRCm39) |
missense |
probably damaging |
1.00 |
R6797:Med13l
|
UTSW |
5 |
118,897,329 (GRCm39) |
critical splice donor site |
probably null |
|
R6911:Med13l
|
UTSW |
5 |
118,893,723 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6942:Med13l
|
UTSW |
5 |
118,883,071 (GRCm39) |
splice site |
probably null |
|
R7018:Med13l
|
UTSW |
5 |
118,890,051 (GRCm39) |
missense |
probably damaging |
0.99 |
R7096:Med13l
|
UTSW |
5 |
118,859,991 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7113:Med13l
|
UTSW |
5 |
118,864,330 (GRCm39) |
missense |
probably benign |
0.09 |
R7136:Med13l
|
UTSW |
5 |
118,859,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7140:Med13l
|
UTSW |
5 |
118,880,037 (GRCm39) |
missense |
probably benign |
0.27 |
R7345:Med13l
|
UTSW |
5 |
118,880,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R7409:Med13l
|
UTSW |
5 |
118,892,386 (GRCm39) |
missense |
probably benign |
0.34 |
R7410:Med13l
|
UTSW |
5 |
118,698,897 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7432:Med13l
|
UTSW |
5 |
118,890,003 (GRCm39) |
missense |
probably damaging |
0.99 |
R7486:Med13l
|
UTSW |
5 |
118,866,539 (GRCm39) |
missense |
probably benign |
0.17 |
R7509:Med13l
|
UTSW |
5 |
118,886,995 (GRCm39) |
missense |
probably damaging |
0.97 |
R7722:Med13l
|
UTSW |
5 |
118,885,472 (GRCm39) |
missense |
probably benign |
0.32 |
R7802:Med13l
|
UTSW |
5 |
118,866,655 (GRCm39) |
missense |
probably benign |
0.03 |
R8081:Med13l
|
UTSW |
5 |
118,866,333 (GRCm39) |
missense |
probably damaging |
1.00 |
R8260:Med13l
|
UTSW |
5 |
118,886,794 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8266:Med13l
|
UTSW |
5 |
118,880,174 (GRCm39) |
missense |
probably damaging |
1.00 |
R8347:Med13l
|
UTSW |
5 |
118,880,662 (GRCm39) |
missense |
probably benign |
|
R8365:Med13l
|
UTSW |
5 |
118,866,709 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8508:Med13l
|
UTSW |
5 |
118,892,386 (GRCm39) |
missense |
probably benign |
0.34 |
R8920:Med13l
|
UTSW |
5 |
118,885,543 (GRCm39) |
nonsense |
probably null |
|
R8970:Med13l
|
UTSW |
5 |
118,883,164 (GRCm39) |
missense |
probably damaging |
1.00 |
R8994:Med13l
|
UTSW |
5 |
118,866,226 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9045:Med13l
|
UTSW |
5 |
118,880,816 (GRCm39) |
missense |
probably benign |
|
R9401:Med13l
|
UTSW |
5 |
118,883,089 (GRCm39) |
missense |
probably benign |
0.14 |
R9446:Med13l
|
UTSW |
5 |
118,876,567 (GRCm39) |
missense |
probably benign |
0.11 |
R9714:Med13l
|
UTSW |
5 |
118,866,438 (GRCm39) |
missense |
probably benign |
0.44 |
R9777:Med13l
|
UTSW |
5 |
118,887,024 (GRCm39) |
missense |
probably benign |
|
R9781:Med13l
|
UTSW |
5 |
118,868,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
R9797:Med13l
|
UTSW |
5 |
118,880,144 (GRCm39) |
missense |
probably damaging |
1.00 |
X0065:Med13l
|
UTSW |
5 |
118,867,948 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Med13l
|
UTSW |
5 |
118,887,706 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCTTGCTTTCCAGGAGAG -3'
(R):5'- TTGGCAGATGTCACATCAACAAC -3'
Sequencing Primer
(F):5'- GCTTTCCAGGAGAGAGCGG -3'
(R):5'- ATCAGGTAAAGCAATGTTCTGC -3'
|
Posted On |
2022-06-15 |