Incidental Mutation 'R9446:Zfp970'
ID 713933
Institutional Source Beutler Lab
Gene Symbol Zfp970
Ensembl Gene ENSMUSG00000078866
Gene Name zinc finger protein 970
Synonyms Gm14420
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.223) question?
Stock # R9446 (G1)
Quality Score 206.009
Status Not validated
Chromosome 2
Chromosomal Location 177156526-177169922 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 177167064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 213 (K213*)
Ref Sequence ENSEMBL: ENSMUSP00000104580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099002] [ENSMUST00000108952]
AlphaFold Q08BU3
Predicted Effect probably benign
Transcript: ENSMUST00000099002
SMART Domains Protein: ENSMUSP00000096600
Gene: ENSMUSG00000078866

DomainStartEndE-ValueType
KRAB 4 66 3.68e-13 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108952
AA Change: K213*
SMART Domains Protein: ENSMUSP00000104580
Gene: ENSMUSG00000078866
AA Change: K213*

DomainStartEndE-ValueType
KRAB 4 66 1.13e-13 SMART
ZnF_C2H2 78 97 1.53e2 SMART
ZnF_C2H2 103 125 8.75e0 SMART
ZnF_C2H2 131 153 1.28e-3 SMART
ZnF_C2H2 159 181 3.89e-3 SMART
ZnF_C2H2 187 209 3.63e-3 SMART
ZnF_C2H2 215 237 3.89e-3 SMART
ZnF_C2H2 243 265 1.58e-3 SMART
ZnF_C2H2 271 293 7.9e-4 SMART
ZnF_C2H2 299 321 3.69e-4 SMART
ZnF_C2H2 327 349 2.12e-4 SMART
ZnF_C2H2 355 377 1.56e-2 SMART
ZnF_C2H2 383 405 1.12e-3 SMART
ZnF_C2H2 411 433 1.79e-2 SMART
ZnF_C2H2 439 461 3.69e-4 SMART
ZnF_C2H2 467 489 3.21e-4 SMART
ZnF_C2H2 495 517 7.9e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adal T G 2: 120,976,530 (GRCm39) I90S probably null Het
Adck2 G T 6: 39,551,221 (GRCm39) probably benign Het
Adgrf3 G T 5: 30,401,957 (GRCm39) D690E probably benign Het
Aff3 C T 1: 38,574,337 (GRCm39) G175S probably benign Het
Atf7 T C 15: 102,459,923 (GRCm39) H159R probably damaging Het
BB014433 GGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCAGGTTGGGGGCTCTGCACACAGCTTTGGAGGTGTACACACCGGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGGGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCAGGTTGGGGGCTCTGCACACAGCTTTGGAGGTGTACACACCGGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG GGGTTGGGGGCTCTGCACACAGCTTTGGAGGTGTACACACCGGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGGGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCAGGTTGGGGGCTCTGCACACAGCTTTGGAGGTGTACACACCGGGGTTGGGGCCTCTGCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG 8: 15,091,810 (GRCm39) probably benign Het
Birc6 A G 17: 74,925,491 (GRCm39) K2241R probably damaging Het
Cacna1s A G 1: 136,045,362 (GRCm39) E1670G probably benign Het
Clca4b C T 3: 144,638,134 (GRCm39) A43T probably benign Het
Clock T A 5: 76,396,288 (GRCm39) I154L probably benign Het
Dnah10 A T 5: 124,823,677 (GRCm39) D566V probably damaging Het
Eml1 T C 12: 108,481,465 (GRCm39) W443R probably damaging Het
Ghitm A G 14: 36,853,606 (GRCm39) I78T possibly damaging Het
Gm4181 A T 14: 51,873,062 (GRCm39) M1K probably null Het
Gm9195 T C 14: 72,717,957 (GRCm39) Y187C probably damaging Het
Htt A G 5: 34,919,272 (GRCm39) M8V probably benign Het
Ighv1-9 T C 12: 114,547,388 (GRCm39) Y51C probably benign Het
Kif13b G A 14: 64,984,470 (GRCm39) E636K probably damaging Het
Mamdc4 T A 2: 25,453,645 (GRCm39) M1179L probably benign Het
Map3k4 G A 17: 12,451,375 (GRCm39) A1506V probably damaging Het
Mbtd1 T C 11: 93,834,508 (GRCm39) S622P unknown Het
Med13l T A 5: 118,876,567 (GRCm39) D914E probably benign Het
Mettl9 T A 7: 120,675,531 (GRCm39) D310E possibly damaging Het
Myh13 T G 11: 67,255,325 (GRCm39) V1565G probably benign Het
Nrf1 A G 6: 30,090,019 (GRCm39) T33A probably damaging Het
Oas1d A G 5: 121,054,947 (GRCm39) K173R probably benign Het
Or12e10 A T 2: 87,640,199 (GRCm39) M12L probably benign Het
Or1e34 T A 11: 73,778,530 (GRCm39) T223S probably benign Het
Or4k6 A G 14: 50,475,974 (GRCm39) Y123H probably damaging Het
Or8g54 A T 9: 39,707,342 (GRCm39) S224C probably damaging Het
Pde6a T A 18: 61,419,067 (GRCm39) D814E probably benign Het
Pilrb2 T C 5: 137,869,429 (GRCm39) D57G possibly damaging Het
Psg21 T A 7: 18,388,865 (GRCm39) T76S probably benign Het
Ralgapa1 A G 12: 55,754,808 (GRCm39) V1161A probably damaging Het
Rtl1 C G 12: 109,556,604 (GRCm39) *1745S probably null Het
Samd8 T C 14: 21,833,769 (GRCm39) C296R Het
Selplg GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT 5: 113,957,756 (GRCm39) probably benign Het
Sfmbt1 T C 14: 30,506,697 (GRCm39) I247T possibly damaging Het
Smarca4 G A 9: 21,547,155 (GRCm39) A227T unknown Het
Trmt6 G A 2: 132,650,774 (GRCm39) S278L probably benign Het
Trpm6 T C 19: 18,815,462 (GRCm39) S1183P possibly damaging Het
Trpm7 T A 2: 126,672,185 (GRCm39) probably null Het
Wnt10a C A 1: 74,842,728 (GRCm39) F401L possibly damaging Het
Other mutations in Zfp970
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02900:Zfp970 APN 2 177,166,610 (GRCm39) splice site probably benign
R1817:Zfp970 UTSW 2 177,167,976 (GRCm39) missense probably damaging 1.00
R1992:Zfp970 UTSW 2 177,166,663 (GRCm39) missense possibly damaging 0.55
R2252:Zfp970 UTSW 2 177,166,614 (GRCm39) splice site probably null
R2253:Zfp970 UTSW 2 177,166,614 (GRCm39) splice site probably null
R4576:Zfp970 UTSW 2 177,167,473 (GRCm39) missense probably damaging 0.99
R4617:Zfp970 UTSW 2 177,167,961 (GRCm39) missense probably benign 0.16
R4828:Zfp970 UTSW 2 177,167,146 (GRCm39) missense probably damaging 0.98
R5801:Zfp970 UTSW 2 177,165,151 (GRCm39) missense probably damaging 1.00
R6198:Zfp970 UTSW 2 177,167,253 (GRCm39) missense probably damaging 1.00
R6540:Zfp970 UTSW 2 177,167,388 (GRCm39) missense probably damaging 1.00
R6793:Zfp970 UTSW 2 177,167,338 (GRCm39) missense probably damaging 1.00
R7092:Zfp970 UTSW 2 177,167,085 (GRCm39) missense probably damaging 1.00
R7289:Zfp970 UTSW 2 177,167,086 (GRCm39) missense probably damaging 1.00
R7830:Zfp970 UTSW 2 177,167,338 (GRCm39) missense probably damaging 1.00
R8854:Zfp970 UTSW 2 177,165,088 (GRCm39) missense probably damaging 0.98
R9003:Zfp970 UTSW 2 177,167,010 (GRCm39) missense probably damaging 1.00
R9183:Zfp970 UTSW 2 177,167,536 (GRCm39) missense probably damaging 1.00
R9197:Zfp970 UTSW 2 177,167,878 (GRCm39) missense probably benign 0.03
R9625:Zfp970 UTSW 2 177,167,790 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAGCCTTTGCATGTCAGAGTC -3'
(R):5'- GCAAAGGCTTTACCACATTGC -3'

Sequencing Primer
(F):5'- CCCTATGAATGTAACCACTGTGG -3'
(R):5'- CCACATTGCTTACATTCATAGGG -3'
Posted On 2022-06-15