Incidental Mutation 'R9447:Cadps2'
| ID |
713988 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, A230044C21Rik, cpd2 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9447 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
23262772-23839420 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 23323297 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 1007
(I1007K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111018
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000125350]
[ENSMUST00000142913]
[ENSMUST00000163871]
[ENSMUST00000166458]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000018122
AA Change: I1057K
PolyPhen 2
Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
AA Change: I1057K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
AA Change: I1050K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000115358
AA Change: I1017K
PolyPhen 2
Score 0.855 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
AA Change: I1017K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115361
AA Change: I1007K
PolyPhen 2
Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
AA Change: I1007K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125350
AA Change: I652K
PolyPhen 2
Score 0.298 (Sensitivity: 0.91; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000115866
Gene: ENSMUSG00000017978
AA Change: I652K
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
14 |
112 |
1.51e-1 |
SMART |
|
PH
|
137 |
241 |
2.94e-11 |
SMART |
|
DUF1041
|
446 |
537 |
1.9e-49 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000142913
AA Change: I1028K
PolyPhen 2
Score 0.641 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
AA Change: I1028K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163871
AA Change: I1057K
PolyPhen 2
Score 0.773 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
AA Change: I1057K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166458
AA Change: I1028K
PolyPhen 2
Score 0.773 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
AA Change: I1028K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2fm2 |
T |
A |
3: 59,651,051 (GRCm39) |
Y58N |
probably damaging |
Het |
| Ago4 |
G |
A |
4: 126,402,151 (GRCm39) |
P572S |
probably benign |
Het |
| Akr1c19 |
A |
G |
13: 4,296,838 (GRCm39) |
I295V |
probably benign |
Het |
| Cd47 |
C |
A |
16: 49,715,822 (GRCm39) |
T196K |
|
Het |
| Cdrt4 |
T |
G |
11: 62,883,418 (GRCm39) |
L40R |
probably damaging |
Het |
| Cox16 |
A |
T |
12: 81,406,109 (GRCm39) |
C72S |
probably benign |
Het |
| Cyp2t4 |
G |
A |
7: 26,854,717 (GRCm39) |
V66M |
possibly damaging |
Het |
| Daxx |
A |
T |
17: 34,132,247 (GRCm39) |
D497V |
unknown |
Het |
| Ddt |
A |
G |
10: 75,608,671 (GRCm39) |
V62A |
possibly damaging |
Het |
| Dhx57 |
A |
G |
17: 80,549,523 (GRCm39) |
V1294A |
probably damaging |
Het |
| Dnaaf5 |
A |
G |
5: 139,163,743 (GRCm39) |
T667A |
probably damaging |
Het |
| Dnase2a |
A |
C |
8: 85,635,786 (GRCm39) |
S90R |
probably damaging |
Het |
| Dytn |
A |
G |
1: 63,700,302 (GRCm39) |
V276A |
|
Het |
| Efcab8 |
G |
C |
2: 153,646,861 (GRCm39) |
V397L |
unknown |
Het |
| Enpp6 |
A |
T |
8: 47,483,600 (GRCm39) |
R131W |
probably damaging |
Het |
| Epm2a |
C |
T |
10: 11,324,432 (GRCm39) |
H174Y |
possibly damaging |
Het |
| Fcho1 |
A |
G |
8: 72,169,913 (GRCm39) |
L70P |
probably damaging |
Het |
| Fhip1b |
G |
T |
7: 105,034,155 (GRCm39) |
T492K |
probably benign |
Het |
| Fstl4 |
G |
T |
11: 53,077,166 (GRCm39) |
C641F |
probably damaging |
Het |
| Ganab |
C |
T |
19: 8,886,894 (GRCm39) |
H327Y |
probably damaging |
Het |
| Gkn1 |
A |
G |
6: 87,323,322 (GRCm39) |
Y164H |
probably benign |
Het |
| Gm57858 |
A |
G |
3: 36,074,195 (GRCm39) |
V318A |
possibly damaging |
Het |
| Hpf1 |
A |
G |
8: 61,348,618 (GRCm39) |
D111G |
probably damaging |
Het |
| Hs3st2 |
C |
T |
7: 120,992,289 (GRCm39) |
R113W |
probably damaging |
Het |
| Ighm |
A |
T |
12: 113,384,794 (GRCm39) |
L353Q |
|
Het |
| Krbox5 |
A |
G |
13: 67,981,953 (GRCm39) |
E55G |
probably damaging |
Het |
| Ksr1 |
T |
C |
11: 78,909,159 (GRCm39) |
D782G |
unknown |
Het |
| Lpin2 |
A |
G |
17: 71,539,087 (GRCm39) |
K392E |
unknown |
Het |
| Lrrc4 |
A |
G |
6: 28,830,650 (GRCm39) |
S322P |
probably benign |
Het |
| Man2a1 |
T |
C |
17: 64,966,001 (GRCm39) |
V313A |
possibly damaging |
Het |
| Mctp1 |
A |
G |
13: 76,727,904 (GRCm39) |
S9G |
probably benign |
Het |
| Morn5 |
A |
T |
2: 35,969,525 (GRCm39) |
|
probably null |
Het |
| Mroh2b |
C |
T |
15: 4,960,823 (GRCm39) |
A795V |
probably damaging |
Het |
| Ncf4 |
G |
T |
15: 78,146,499 (GRCm39) |
A310S |
probably benign |
Het |
| Nedd4 |
T |
C |
9: 72,577,381 (GRCm39) |
Y69H |
probably benign |
Het |
| Nras |
T |
C |
3: 102,967,673 (GRCm39) |
F90L |
possibly damaging |
Het |
| Nrxn3 |
T |
C |
12: 89,221,678 (GRCm39) |
F113L |
probably benign |
Het |
| Ntsr1 |
C |
T |
2: 180,180,540 (GRCm39) |
T282I |
probably benign |
Het |
| Or1e1d-ps1 |
G |
T |
11: 73,819,617 (GRCm39) |
C189F |
probably benign |
Het |
| Osbpl3 |
T |
A |
6: 50,321,857 (GRCm39) |
K310* |
probably null |
Het |
| Pcca |
T |
C |
14: 122,854,290 (GRCm39) |
V194A |
probably damaging |
Het |
| Plekha5 |
A |
G |
6: 140,525,192 (GRCm39) |
Y900C |
probably damaging |
Het |
| Prss22 |
T |
C |
17: 24,212,837 (GRCm39) |
D300G |
probably benign |
Het |
| Rad17 |
A |
T |
13: 100,764,119 (GRCm39) |
Y451N |
probably damaging |
Het |
| Rnf181 |
G |
T |
6: 72,337,570 (GRCm39) |
T97K |
probably damaging |
Het |
| Sec24d |
T |
C |
3: 123,084,162 (GRCm39) |
S114P |
probably benign |
Het |
| Siae |
C |
A |
9: 37,557,743 (GRCm39) |
Q517K |
probably benign |
Het |
| Smurf2 |
A |
T |
11: 106,715,548 (GRCm39) |
V653D |
probably damaging |
Het |
| Sqor |
C |
A |
2: 122,649,520 (GRCm39) |
T359K |
possibly damaging |
Het |
| Taf6 |
A |
T |
5: 138,176,970 (GRCm39) |
*637R |
probably null |
Het |
| Tas2r109 |
A |
C |
6: 132,957,270 (GRCm39) |
M220R |
probably damaging |
Het |
| Tlr2 |
T |
A |
3: 83,748,445 (GRCm39) |
|
probably null |
Het |
| Tm7sf3 |
C |
T |
6: 146,525,179 (GRCm39) |
D89N |
possibly damaging |
Het |
| Tmem8b |
T |
G |
4: 43,685,766 (GRCm39) |
L179R |
probably damaging |
Het |
| Tnfrsf10b |
T |
A |
14: 70,013,608 (GRCm39) |
H179Q |
probably damaging |
Het |
| Trip11 |
T |
A |
12: 101,850,148 (GRCm39) |
K1305N |
probably damaging |
Het |
| Ttn |
C |
A |
2: 76,582,862 (GRCm39) |
W22677L |
probably damaging |
Het |
| Ube2r2 |
T |
C |
4: 41,190,655 (GRCm39) |
V183A |
probably damaging |
Het |
| Ubqln4 |
T |
A |
3: 88,464,124 (GRCm39) |
D208E |
probably benign |
Het |
| Ugt2a3 |
T |
A |
5: 87,473,330 (GRCm39) |
N529I |
probably benign |
Het |
| Vmn1r125 |
A |
G |
7: 21,006,627 (GRCm39) |
N175S |
probably benign |
Het |
| Xirp2 |
T |
A |
2: 67,338,950 (GRCm39) |
I397K |
probably damaging |
Het |
| Zfp821 |
G |
A |
8: 110,450,816 (GRCm39) |
V270I |
probably damaging |
Het |
| Zfp935 |
A |
G |
13: 62,602,842 (GRCm39) |
V99A |
possibly damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,873 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,172 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,461 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,274 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,731 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,808 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,659 (GRCm39) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,600 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0193:Cadps2
|
UTSW |
6 |
23,599,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,781 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0571:Cadps2
|
UTSW |
6 |
23,583,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,703 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,739 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,775 (GRCm39) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,472 (GRCm39) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1956:Cadps2
|
UTSW |
6 |
23,287,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,121 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,339 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,977 (GRCm39) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,530 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,987 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,859 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,667 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5389:Cadps2
|
UTSW |
6 |
23,329,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,804 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Cadps2
|
UTSW |
6 |
23,329,162 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6323:Cadps2
|
UTSW |
6 |
23,263,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,333 (GRCm39) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,955 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,428 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,934 (GRCm39) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,607 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,641 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,942 (GRCm39) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,862 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,897 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,918 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,303 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,536 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,223 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,262 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9484:Cadps2
|
UTSW |
6 |
23,626,646 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,238 (GRCm39) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,571 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,982 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,800 (GRCm39) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,477 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCAGAGAGATATGCAGGG -3'
(R):5'- CAGTGGAAGCTCATGGTGTTC -3'
Sequencing Primer
(F):5'- CAATTCCATGGTTCCCCAGGATTAAG -3'
(R):5'- CAGTGGAAGCTCATGGTGTTCTTTTG -3'
|
| Posted On |
2022-06-15 |
Incidental Mutation