Incidental Mutation 'R9448:Tnfsf15'
ID 714052
Institutional Source Beutler Lab
Gene Symbol Tnfsf15
Ensembl Gene ENSMUSG00000050395
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1A, VEGI, TL1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R9448 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 63642837-63663296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 63663305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 6 (V6D)
Ref Sequence ENSEMBL: ENSMUSP00000050144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062246]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000062246
AA Change: V6D

PolyPhen 2 Score 0.457 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050144
Gene: ENSMUSG00000050395
AA Change: V6D

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
TNF 114 270 1.25e-28 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
Adcy1 T C 11: 7,099,575 (GRCm39) V685A possibly damaging Het
Atg9a G T 1: 75,162,849 (GRCm39) T417K probably benign Het
Atp6v1a T A 16: 43,931,872 (GRCm39) K139* probably null Het
Baz1b T C 5: 135,239,656 (GRCm39) I252T probably damaging Het
Ccdc191 T A 16: 43,759,338 (GRCm39) W380R Het
Cep290 T G 10: 100,395,546 (GRCm39) V2118G probably benign Het
Crb2 A G 2: 37,677,773 (GRCm39) D352G probably benign Het
Csmd3 T C 15: 47,460,315 (GRCm39) D2581G Het
Diras2 T A 13: 52,662,122 (GRCm39) T62S possibly damaging Het
Dmrt1 T C 19: 25,523,255 (GRCm39) V202A possibly damaging Het
Dok1 T C 6: 83,009,972 (GRCm39) K46E probably damaging Het
Dph7 A T 2: 24,861,952 (GRCm39) K455M probably damaging Het
Efcab8 G C 2: 153,646,861 (GRCm39) V397L unknown Het
Ehbp1 T C 11: 22,087,881 (GRCm39) N426S probably benign Het
Exo5 A G 4: 120,778,888 (GRCm39) W326R probably damaging Het
Fam149a T A 8: 45,792,411 (GRCm39) probably null Het
Flii T C 11: 60,606,393 (GRCm39) N1099S probably benign Het
Flvcr1 T C 1: 190,744,406 (GRCm39) T381A possibly damaging Het
Foxl1 T C 8: 121,855,608 (GRCm39) V303A probably benign Het
Fsd1l G T 4: 53,694,826 (GRCm39) E427* probably null Het
Galnt18 A T 7: 111,153,649 (GRCm39) I325N probably damaging Het
Gm5478 T C 15: 101,553,662 (GRCm39) N274S probably damaging Het
Grm7 A T 6: 111,335,193 (GRCm39) T535S probably benign Het
Heatr5b T C 17: 79,068,015 (GRCm39) D1791G probably benign Het
Igkv12-98 T C 6: 68,548,156 (GRCm39) I95T probably damaging Het
Il1rl2 A G 1: 40,366,604 (GRCm39) Y46C probably benign Het
Inhca G T 9: 103,149,781 (GRCm39) Q259K probably benign Het
Kdr T C 5: 76,102,569 (GRCm39) E1186G probably benign Het
Knstrn T C 2: 118,644,975 (GRCm39) probably null Het
Krt9 TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC 11: 100,079,903 (GRCm39) probably benign Het
Ltbp1 C T 17: 75,666,455 (GRCm39) Q1383* probably null Het
Mep1a T C 17: 43,805,869 (GRCm39) probably null Het
Mep1b A G 18: 21,217,199 (GRCm39) D106G probably damaging Het
Moxd2 T C 6: 40,864,160 (GRCm39) N90S probably benign Het
Ms4a4c T A 19: 11,392,317 (GRCm39) probably null Het
Nlrp4e A T 7: 23,000,956 (GRCm39) M84L probably benign Het
Noc2l C A 4: 156,320,781 (GRCm39) R66S probably benign Het
Nox4 A T 7: 87,045,001 (GRCm39) L580F unknown Het
Numb A G 12: 83,888,990 (GRCm39) probably null Het
Or1l4 A G 2: 37,091,221 (GRCm39) probably benign Het
Or5w13 A T 2: 87,523,824 (GRCm39) V134E probably damaging Het
Parp8 T A 13: 117,039,360 (GRCm39) K274* probably null Het
Pcdh1 G A 18: 38,330,492 (GRCm39) P976L probably damaging Het
Pcnt T C 10: 76,256,360 (GRCm39) K627E probably damaging Het
Pdzk1 A T 3: 96,761,922 (GRCm39) D178V probably damaging Het
Phldb1 G T 9: 44,622,546 (GRCm39) L36M possibly damaging Het
Pip5k1c A G 10: 81,141,645 (GRCm39) E111G probably damaging Het
Plcb4 G A 2: 135,752,045 (GRCm39) E84K possibly damaging Het
Prpf39 T A 12: 65,108,034 (GRCm39) Y646N probably benign Het
Psmc6 T C 14: 45,568,483 (GRCm39) F69L probably benign Het
Ptk2 T A 15: 73,215,041 (GRCm39) S46C possibly damaging Het
Ptpn6 G A 6: 124,709,771 (GRCm39) R23W probably damaging Het
Ptprb T A 10: 116,149,819 (GRCm39) Y143* probably null Het
Qrich2 T C 11: 116,338,091 (GRCm39) E141G probably benign Het
Rsf1 G GCCGGCGGCT 7: 97,229,116 (GRCm39) probably benign Het
Scn5a A G 9: 119,381,127 (GRCm39) L136P probably damaging Het
Slc12a6 T C 2: 112,179,704 (GRCm39) F676S probably damaging Het
Spata31f1a A T 4: 42,850,250 (GRCm39) Y635* probably null Het
Spata31f1e T C 4: 42,793,440 (GRCm39) R231G probably benign Het
Spata32 C T 11: 103,099,648 (GRCm39) G286R probably damaging Het
Tbx19 T C 1: 164,981,090 (GRCm39) K135E probably damaging Het
Tdrd6 T C 17: 43,936,567 (GRCm39) T1494A probably benign Het
Tmem62 A C 2: 120,808,211 (GRCm39) D71A probably damaging Het
Tulp4 T C 17: 6,248,948 (GRCm39) V182A possibly damaging Het
Vmn2r73 A T 7: 85,522,027 (GRCm39) V104D probably benign Het
Zdhhc8 C A 16: 18,039,558 (GRCm39) G159C Het
Zfy2 A G Y: 2,109,904 (GRCm39) W338R probably damaging Het
Znfx1 T G 2: 166,888,844 (GRCm39) Q788P probably benign Het
Zscan26 A G 13: 21,632,431 (GRCm39) V100A probably benign Het
Other mutations in Tnfsf15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00674:Tnfsf15 APN 4 63,652,483 (GRCm39) splice site probably benign
IGL00743:Tnfsf15 APN 4 63,652,518 (GRCm39) missense probably benign 0.00
IGL03189:Tnfsf15 APN 4 63,648,289 (GRCm39) splice site probably benign
R0158:Tnfsf15 UTSW 4 63,648,229 (GRCm39) missense possibly damaging 0.95
R1824:Tnfsf15 UTSW 4 63,651,588 (GRCm39) missense probably benign 0.03
R3122:Tnfsf15 UTSW 4 63,652,522 (GRCm39) missense probably benign 0.00
R4595:Tnfsf15 UTSW 4 63,648,180 (GRCm39) nonsense probably null
R5025:Tnfsf15 UTSW 4 63,648,125 (GRCm39) missense probably benign 0.01
R6123:Tnfsf15 UTSW 4 63,663,162 (GRCm39) missense probably benign 0.00
R6376:Tnfsf15 UTSW 4 63,663,267 (GRCm39) missense probably damaging 0.98
R7104:Tnfsf15 UTSW 4 63,647,887 (GRCm39) missense probably damaging 1.00
R7173:Tnfsf15 UTSW 4 63,647,889 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTGCGAGGATGGGAAATG -3'
(R):5'- AGAGCACATGAGCATACTGTAC -3'

Sequencing Primer
(F):5'- TGACAACAGGCAGCAGGTG -3'
(R):5'- ATATGCTTGGGAAAGCTTTCTCC -3'
Posted On 2022-06-15