Incidental Mutation 'R9450:Vmn1r1'
ID 714167
Institutional Source Beutler Lab
Gene Symbol Vmn1r1
Ensembl Gene ENSMUSG00000091013
Gene Name vomeronasal 1 receptor 1
Synonyms Gm6628
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock # R9450 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 182154704-182164486 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 182157205 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 298 (C298*)
Ref Sequence ENSEMBL: ENSMUSP00000133035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169123] [ENSMUST00000227586] [ENSMUST00000227629]
AlphaFold E9PVR6
Predicted Effect probably null
Transcript: ENSMUST00000169123
AA Change: C298*
SMART Domains Protein: ENSMUSP00000133035
Gene: ENSMUSG00000091013
AA Change: C298*

DomainStartEndE-ValueType
Pfam:V1R 38 301 8e-79 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000227586
AA Change: C298*
Predicted Effect probably null
Transcript: ENSMUST00000227629
AA Change: C298*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700007K13Rik TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC 2: 28,466,110 probably benign Het
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 29,247,623 probably benign Het
2810004N23Rik T C 8: 124,840,476 K229E probably damaging Het
4931409K22Rik T A 5: 24,549,449 I395F probably benign Het
9030624J02Rik T C 7: 118,752,895 probably null Het
Abca8b T C 11: 109,969,104 T523A probably damaging Het
Adamts18 G T 8: 113,764,310 D508E probably benign Het
Arap2 T C 5: 62,698,419 E558G probably benign Het
Arid4a A T 12: 71,072,600 D331V Het
Ash1l A T 3: 89,007,832 K1923M possibly damaging Het
Atad2b T A 12: 5,013,859 S947T probably benign Het
B4galt1 A T 4: 40,853,804 M1K probably null Het
BC025446 T A 15: 75,220,725 C98S probably damaging Het
Ccpg1 G A 9: 72,997,421 S4N unknown Het
Cfap43 A T 19: 47,897,871 L102M probably benign Het
Clic6 T C 16: 92,530,756 I483T possibly damaging Het
Col6a6 A T 9: 105,784,174 D245E probably benign Het
Cpsf7 G A 19: 10,540,849 probably null Het
Depdc5 A G 5: 32,934,010 D721G probably benign Het
Dhx29 C T 13: 112,947,328 T639I possibly damaging Het
Dock7 T C 4: 98,973,189 E1397G unknown Het
Dsp C T 13: 38,192,403 T1388M probably damaging Het
Fam186b C T 15: 99,285,544 G73D probably damaging Het
Ganab A G 19: 8,915,712 D960G probably damaging Het
Gm12394 G T 4: 42,793,833 Q100K probably benign Het
Gria1 T C 11: 57,309,789 V764A probably damaging Het
Grk3 T C 5: 112,915,047 K645E probably benign Het
Hecw2 A T 1: 53,839,029 Y1339* probably null Het
Hmcn2 C A 2: 31,426,833 T3808N probably damaging Het
Il20rb A T 9: 100,473,002 N129K possibly damaging Het
Itgb4 T C 11: 115,983,271 Y340H probably damaging Het
Itgb6 T C 2: 60,628,028 I460M probably benign Het
Kat14 T C 2: 144,400,819 I599T possibly damaging Het
Kif1b A C 4: 149,238,010 D817E probably benign Het
Lamb2 T A 9: 108,480,561 C94* probably null Het
Larp1 T C 11: 58,051,064 S743P probably damaging Het
Ldlrap1 T C 4: 134,747,179 N267S probably damaging Het
Ltbp2 G A 12: 84,791,090 P1192L probably benign Het
Ltf T C 9: 111,021,996 L92P probably damaging Het
Mns1 C A 9: 72,452,608 Q347K probably benign Het
Myof A T 19: 37,960,926 F611I probably damaging Het
Nop56 T C 2: 130,275,681 L76P probably damaging Het
Nphp1 T C 2: 127,774,088 H114R Het
Olfr1280 T A 2: 111,316,053 N191K probably benign Het
Olfr1512 G C 14: 52,372,653 Y133* probably null Het
Olfr390 C A 11: 73,787,275 N112K possibly damaging Het
Park2 C A 17: 11,838,634 H301N possibly damaging Het
Pcdha12 A G 18: 37,020,939 D237G probably damaging Het
Pitpnm3 A T 11: 72,061,586 M593K possibly damaging Het
Plxdc1 C T 11: 97,954,855 V211I probably damaging Het
Prpf38a A T 4: 108,572,875 H143Q probably damaging Het
Sdk2 T C 11: 113,806,279 T1769A probably benign Het
Stab1 T C 14: 31,162,939 D153G possibly damaging Het
Tm7sf3 C T 6: 146,623,681 D89N possibly damaging Het
Tnrc6b T A 15: 80,880,436 M713K probably benign Het
Top2a T C 11: 99,003,608 K966E possibly damaging Het
Vars2 T C 17: 35,662,135 T421A probably damaging Het
Vwa3a T C 7: 120,804,030 probably null Het
Vwa5b1 G T 4: 138,588,629 Q601K possibly damaging Het
Zbtb46 T C 2: 181,395,488 K454E probably damaging Het
Zfp426 T C 9: 20,470,281 H470R probably benign Het
Other mutations in Vmn1r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0535:Vmn1r1 UTSW 1 182157951 missense probably benign 0.00
R1330:Vmn1r1 UTSW 1 182158007 missense probably damaging 1.00
R1696:Vmn1r1 UTSW 1 182158059 missense probably benign 0.26
R1809:Vmn1r1 UTSW 1 182157806 missense possibly damaging 0.82
R4661:Vmn1r1 UTSW 1 182157224 missense possibly damaging 0.90
R4717:Vmn1r1 UTSW 1 182157209 missense possibly damaging 0.66
R4765:Vmn1r1 UTSW 1 182157906 missense probably benign 0.00
R4772:Vmn1r1 UTSW 1 182157546 missense probably benign 0.41
R4864:Vmn1r1 UTSW 1 182157767 missense probably benign
R5369:Vmn1r1 UTSW 1 182157776 missense possibly damaging 0.87
R5594:Vmn1r1 UTSW 1 182157407 missense probably damaging 1.00
R6240:Vmn1r1 UTSW 1 182157621 missense probably damaging 1.00
R6667:Vmn1r1 UTSW 1 182157777 missense probably benign 0.22
R7075:Vmn1r1 UTSW 1 182158032 missense probably benign 0.00
R7686:Vmn1r1 UTSW 1 182158025 missense probably damaging 1.00
R7908:Vmn1r1 UTSW 1 182157350 missense probably benign 0.45
R8514:Vmn1r1 UTSW 1 182157573 missense probably benign 0.04
R8951:Vmn1r1 UTSW 1 182157744 missense probably damaging 1.00
R9332:Vmn1r1 UTSW 1 182157437 missense probably damaging 1.00
R9459:Vmn1r1 UTSW 1 182157938 missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- TATGCCAAAAGTAGGTTTAACGGAG -3'
(R):5'- AGCATTTCCCGCAAAGCATC -3'

Sequencing Primer
(F):5'- ACGGAGAAAGCATTTCAATGTC -3'
(R):5'- CGTCCGGAACATTCTGTTGCTAG -3'
Posted On 2022-06-15