Incidental Mutation 'R9450:Il20rb'
ID 714197
Institutional Source Beutler Lab
Gene Symbol Il20rb
Ensembl Gene ENSMUSG00000044244
Gene Name interleukin 20 receptor beta
Synonyms LOC213208, Il20R2, Fndc6
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9450 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 100339772-100368526 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 100355055 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 129 (N129K)
Ref Sequence ENSEMBL: ENSMUSP00000096057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098458]
AlphaFold E9Q9A6
Predicted Effect possibly damaging
Transcript: ENSMUST00000098458
AA Change: N129K

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000096057
Gene: ENSMUSG00000044244
AA Change: N129K

DomainStartEndE-ValueType
FN3 30 117 9.09e0 SMART
Pfam:Interfer-bind 131 222 7.6e-9 PFAM
transmembrane domain 228 250 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
PHENOTYPE: Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
2810004N23Rik T C 8: 125,567,215 (GRCm39) K229E probably damaging Het
Abca8b T C 11: 109,859,930 (GRCm39) T523A probably damaging Het
Adamts18 G T 8: 114,490,942 (GRCm39) D508E probably benign Het
Arap2 T C 5: 62,855,762 (GRCm39) E558G probably benign Het
Arid4a A T 12: 71,119,374 (GRCm39) D331V Het
Ash1l A T 3: 88,915,139 (GRCm39) K1923M possibly damaging Het
Atad2b T A 12: 5,063,859 (GRCm39) S947T probably benign Het
B4galt1 A T 4: 40,853,804 (GRCm39) M1K probably null Het
Ccpg1 G A 9: 72,904,703 (GRCm39) S4N unknown Het
Cfap43 A T 19: 47,886,310 (GRCm39) L102M probably benign Het
Clic6 T C 16: 92,327,644 (GRCm39) I483T possibly damaging Het
Col6a6 A T 9: 105,661,373 (GRCm39) D245E probably benign Het
Cpsf7 G A 19: 10,518,213 (GRCm39) probably null Het
Depdc5 A G 5: 33,091,354 (GRCm39) D721G probably benign Het
Dhx29 C T 13: 113,083,862 (GRCm39) T639I possibly damaging Het
Dock7 T C 4: 98,861,426 (GRCm39) E1397G unknown Het
Dsp C T 13: 38,376,379 (GRCm39) T1388M probably damaging Het
Fam186b C T 15: 99,183,425 (GRCm39) G73D probably damaging Het
Ganab A G 19: 8,893,076 (GRCm39) D960G probably damaging Het
Gria1 T C 11: 57,200,615 (GRCm39) V764A probably damaging Het
Grk3 T C 5: 113,062,913 (GRCm39) K645E probably benign Het
Hecw2 A T 1: 53,878,188 (GRCm39) Y1339* probably null Het
Hmcn2 C A 2: 31,316,845 (GRCm39) T3808N probably damaging Het
Iqca1l T A 5: 24,754,447 (GRCm39) I395F probably benign Het
Itgb4 T C 11: 115,874,097 (GRCm39) Y340H probably damaging Het
Itgb6 T C 2: 60,458,372 (GRCm39) I460M probably benign Het
Kat14 T C 2: 144,242,739 (GRCm39) I599T possibly damaging Het
Kif1b A C 4: 149,322,467 (GRCm39) D817E probably benign Het
Lamb2 T A 9: 108,357,760 (GRCm39) C94* probably null Het
Larp1 T C 11: 57,941,890 (GRCm39) S743P probably damaging Het
Ldlrap1 T C 4: 134,474,490 (GRCm39) N267S probably damaging Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Ltf T C 9: 110,851,064 (GRCm39) L92P probably damaging Het
Ly6g2 T A 15: 75,092,574 (GRCm39) C98S probably damaging Het
Mns1 C A 9: 72,359,890 (GRCm39) Q347K probably benign Het
Myof A T 19: 37,949,374 (GRCm39) F611I probably damaging Het
Nop56 T C 2: 130,117,601 (GRCm39) L76P probably damaging Het
Nphp1 T C 2: 127,616,008 (GRCm39) H114R Het
Or10g3 G C 14: 52,610,110 (GRCm39) Y133* probably null Het
Or1e30 C A 11: 73,678,101 (GRCm39) N112K possibly damaging Het
Or4k36 T A 2: 111,146,398 (GRCm39) N191K probably benign Het
Pcdha12 A G 18: 37,153,992 (GRCm39) D237G probably damaging Het
Pierce1 TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC 2: 28,356,122 (GRCm39) probably benign Het
Pitpnm3 A T 11: 71,952,412 (GRCm39) M593K possibly damaging Het
Plxdc1 C T 11: 97,845,681 (GRCm39) V211I probably damaging Het
Prkn C A 17: 12,057,521 (GRCm39) H301N possibly damaging Het
Prpf38a A T 4: 108,430,072 (GRCm39) H143Q probably damaging Het
Sdk2 T C 11: 113,697,105 (GRCm39) T1769A probably benign Het
Spata31f1e G T 4: 42,793,833 (GRCm39) Q100K probably benign Het
Stab1 T C 14: 30,884,896 (GRCm39) D153G possibly damaging Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Tnrc6b T A 15: 80,764,637 (GRCm39) M713K probably benign Het
Top2a T C 11: 98,894,434 (GRCm39) K966E possibly damaging Het
Vars2 T C 17: 35,973,027 (GRCm39) T421A probably damaging Het
Vmn1r1 A T 1: 181,984,770 (GRCm39) C298* probably null Het
Vps35l T C 7: 118,352,118 (GRCm39) probably null Het
Vwa3a T C 7: 120,403,253 (GRCm39) probably null Het
Vwa5b1 G T 4: 138,315,940 (GRCm39) Q601K possibly damaging Het
Zbtb46 T C 2: 181,037,281 (GRCm39) K454E probably damaging Het
Zfp426 T C 9: 20,381,577 (GRCm39) H470R probably benign Het
Other mutations in Il20rb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01490:Il20rb APN 9 100,355,207 (GRCm39) missense probably damaging 1.00
IGL02943:Il20rb APN 9 100,348,305 (GRCm39) missense probably benign 0.00
IGL03368:Il20rb APN 9 100,341,174 (GRCm39) utr 3 prime probably benign
IGL03396:Il20rb APN 9 100,341,251 (GRCm39) missense probably damaging 0.99
IGL03412:Il20rb APN 9 100,357,049 (GRCm39) missense probably benign 0.00
R0157:Il20rb UTSW 9 100,355,132 (GRCm39) missense probably damaging 1.00
R4591:Il20rb UTSW 9 100,357,043 (GRCm39) missense possibly damaging 0.61
R4948:Il20rb UTSW 9 100,343,592 (GRCm39) splice site probably benign
R5622:Il20rb UTSW 9 100,368,371 (GRCm39) missense probably benign 0.15
R6448:Il20rb UTSW 9 100,356,986 (GRCm39) missense probably benign 0.03
R7013:Il20rb UTSW 9 100,343,481 (GRCm39) missense probably benign 0.10
R7502:Il20rb UTSW 9 100,350,479 (GRCm39) missense probably damaging 0.98
R7916:Il20rb UTSW 9 100,348,304 (GRCm39) missense probably benign 0.01
R8015:Il20rb UTSW 9 100,356,947 (GRCm39) missense probably damaging 1.00
R8234:Il20rb UTSW 9 100,341,263 (GRCm39) missense probably benign 0.01
R9143:Il20rb UTSW 9 100,356,936 (GRCm39) missense probably damaging 1.00
R9381:Il20rb UTSW 9 100,343,541 (GRCm39) missense possibly damaging 0.60
R9595:Il20rb UTSW 9 100,368,311 (GRCm39) missense possibly damaging 0.91
R9727:Il20rb UTSW 9 100,357,001 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAATAAGAATCCCAGTGCCCATG -3'
(R):5'- TACGAGAGCCTGTACATGAGC -3'

Sequencing Primer
(F):5'- TGGAATGTCCATACCCGTGG -3'
(R):5'- TGTACATGAGCCACATCTGG -3'
Posted On 2022-06-15