Incidental Mutation 'R9451:Or4k51'
ID 714235
Institutional Source Beutler Lab
Gene Symbol Or4k51
Ensembl Gene ENSMUSG00000057149
Gene Name olfactory receptor family 4 subfamily K member 51
Synonyms Olfr1301, MOR248-5, GA_x6K02T2Q125-72805651-72806589
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # R9451 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111584596-111585534 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111585218 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 208 (V208A)
Ref Sequence ENSEMBL: ENSMUSP00000146530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080094] [ENSMUST00000207590]
AlphaFold Q8VGE7
Predicted Effect probably benign
Transcript: ENSMUST00000080094
AA Change: V208A

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000078993
Gene: ENSMUSG00000057149
AA Change: V208A

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 4.1e-53 PFAM
Pfam:7tm_1 41 287 2.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207590
AA Change: V208A

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (73/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh8a1 T A 10: 21,265,032 (GRCm39) S220T probably benign Het
Ankrd66 A G 17: 43,845,811 (GRCm39) V192A probably benign Het
Aoc1l3 A G 6: 48,965,774 (GRCm39) Y594C probably damaging Het
Atp1a2 A G 1: 172,103,494 (GRCm39) Y1009H probably benign Het
Bptf A C 11: 106,935,411 (GRCm39) M142R probably damaging Het
Brwd1 C T 16: 95,845,703 (GRCm39) R740Q probably damaging Het
C3 A G 17: 57,531,169 (GRCm39) M339T probably benign Het
Catsperg1 A G 7: 28,897,772 (GRCm39) probably null Het
Cep295nl T A 11: 118,224,446 (GRCm39) K133* probably null Het
Copg2 A T 6: 30,793,786 (GRCm39) probably benign Het
Coro7 A T 16: 4,488,402 (GRCm39) D89E probably damaging Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Ddx54 G T 5: 120,765,209 (GRCm39) R826L probably damaging Het
Dlg4 G T 11: 69,922,065 (GRCm39) K162N probably damaging Het
Dna2 T A 10: 62,790,072 (GRCm39) L185H probably benign Het
Dock9 C T 14: 121,787,601 (GRCm39) probably benign Het
Efcab8 G C 2: 153,646,861 (GRCm39) V397L unknown Het
Etl4 A G 2: 20,813,926 (GRCm39) I1322V probably benign Het
Exd1 T C 2: 119,355,064 (GRCm39) K284E possibly damaging Het
Flnc A G 6: 29,445,462 (GRCm39) T786A probably damaging Het
Gm29106 A C 1: 118,127,644 (GRCm39) E445D possibly damaging Het
Gm5592 T C 7: 40,935,876 (GRCm39) L126P probably damaging Het
Grep1 A G 17: 23,936,187 (GRCm39) Y19H unknown Het
Gtf3c2 T G 5: 31,325,773 (GRCm39) T389P probably damaging Het
Hhipl1 C A 12: 108,294,100 (GRCm39) R669S probably benign Het
Hivep1 A G 13: 42,337,252 (GRCm39) T2444A probably benign Het
Hspg2 A G 4: 137,238,380 (GRCm39) E289G probably damaging Het
Htatip2 C A 7: 49,408,987 (GRCm39) T9K unknown Het
Ifngr1 T C 10: 19,483,041 (GRCm39) V265A possibly damaging Het
Ift140 A G 17: 25,252,925 (GRCm39) N359D probably benign Het
Mat1a A G 14: 40,836,803 (GRCm39) R178G probably damaging Het
Mknk2 C T 10: 80,505,496 (GRCm39) R154H probably benign Het
Myh14 C T 7: 44,273,743 (GRCm39) probably null Het
Myof A G 19: 37,966,096 (GRCm39) probably null Het
Nfe2l1 G T 11: 96,718,453 (GRCm39) D27E probably damaging Het
Or1ad6 A G 11: 50,859,950 (GRCm39) Y35C Het
Or4a15 A T 2: 89,193,243 (GRCm39) C177S probably damaging Het
Or5p61 A G 7: 107,758,468 (GRCm39) V204A probably benign Het
Or8s5 A G 15: 98,238,144 (GRCm39) V242A possibly damaging Het
Plec C A 15: 76,067,987 (GRCm39) Q1139H unknown Het
Plxna2 T A 1: 194,326,692 (GRCm39) S209T probably benign Het
Plxnd1 T C 6: 115,940,277 (GRCm39) E1369G possibly damaging Het
Psd3 T C 8: 68,363,487 (GRCm39) I3V unknown Het
Pwp1 T A 10: 85,714,428 (GRCm39) F195L probably damaging Het
Rab3ip C T 10: 116,775,354 (GRCm39) M1I probably null Het
Rad54l2 T C 9: 106,585,488 (GRCm39) K759R probably benign Het
Rims2 G T 15: 39,300,724 (GRCm39) V344L probably damaging Het
Robo1 G A 16: 72,803,718 (GRCm39) R1088Q probably benign Het
Rtf2 A G 2: 172,282,745 (GRCm39) probably benign Het
Serhl A C 15: 82,987,167 (GRCm39) K131N possibly damaging Het
Sidt1 T A 16: 44,075,392 (GRCm39) probably null Het
Slc27a1 T A 8: 72,032,808 (GRCm39) Y248* probably null Het
Slitrk3 T A 3: 72,958,616 (GRCm39) E52V possibly damaging Het
Snx2 T C 18: 53,343,415 (GRCm39) V271A probably benign Het
Snx9 C A 17: 5,949,768 (GRCm39) P156Q probably damaging Het
Spag6 C A 2: 18,715,369 (GRCm39) Y71* probably null Het
Speer4a3 T A 5: 26,156,569 (GRCm39) K137* probably null Het
Speg A G 1: 75,394,377 (GRCm39) D1724G probably damaging Het
Syt7 A G 19: 10,421,532 (GRCm39) N572S probably damaging Het
Thoc2l C A 5: 104,668,644 (GRCm39) S1055R probably benign Het
Ticam2 A G 18: 46,693,766 (GRCm39) I107T probably damaging Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Tmem268 G A 4: 63,488,256 (GRCm39) V135M probably benign Het
Toporsl A G 4: 52,611,663 (GRCm39) T519A possibly damaging Het
Trim43b G A 9: 88,973,608 (GRCm39) L42F possibly damaging Het
Ttf2 A C 3: 100,852,089 (GRCm39) V1019G probably damaging Het
Ugt3a1 A G 15: 9,292,158 (GRCm39) D97G probably benign Het
Uncx A G 5: 139,532,475 (GRCm39) N180S probably damaging Het
Vmn2r23 A G 6: 123,710,352 (GRCm39) T552A probably damaging Het
Vmn2r51 A T 7: 9,833,816 (GRCm39) H407Q probably damaging Het
Wdfy4 C T 14: 32,855,518 (GRCm39) E699K Het
Wdr95 A G 5: 149,504,165 (GRCm39) T324A probably benign Het
Other mutations in Or4k51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Or4k51 APN 2 111,584,771 (GRCm39) missense probably damaging 1.00
IGL01396:Or4k51 APN 2 111,584,848 (GRCm39) missense probably benign 0.01
IGL01396:Or4k51 APN 2 111,584,948 (GRCm39) missense probably damaging 1.00
IGL01538:Or4k51 APN 2 111,585,350 (GRCm39) missense probably damaging 0.98
IGL01795:Or4k51 APN 2 111,584,731 (GRCm39) missense probably benign 0.00
IGL02007:Or4k51 APN 2 111,584,824 (GRCm39) missense probably damaging 0.99
IGL02738:Or4k51 APN 2 111,584,699 (GRCm39) missense probably damaging 1.00
IGL03365:Or4k51 APN 2 111,584,772 (GRCm39) missense possibly damaging 0.95
R0014:Or4k51 UTSW 2 111,585,119 (GRCm39) missense probably damaging 1.00
R0115:Or4k51 UTSW 2 111,584,930 (GRCm39) missense probably damaging 1.00
R0481:Or4k51 UTSW 2 111,584,930 (GRCm39) missense probably damaging 1.00
R1441:Or4k51 UTSW 2 111,585,347 (GRCm39) missense probably damaging 1.00
R1583:Or4k51 UTSW 2 111,584,770 (GRCm39) missense probably damaging 0.98
R2091:Or4k51 UTSW 2 111,584,731 (GRCm39) missense probably benign 0.00
R2301:Or4k51 UTSW 2 111,584,621 (GRCm39) missense probably benign 0.01
R2363:Or4k51 UTSW 2 111,585,139 (GRCm39) missense probably damaging 0.97
R2511:Or4k51 UTSW 2 111,584,661 (GRCm39) missense probably benign 0.00
R3686:Or4k51 UTSW 2 111,584,914 (GRCm39) missense probably benign 0.00
R4841:Or4k51 UTSW 2 111,584,679 (GRCm39) missense probably benign 0.00
R4915:Or4k51 UTSW 2 111,584,725 (GRCm39) missense probably benign 0.00
R4961:Or4k51 UTSW 2 111,584,750 (GRCm39) missense probably damaging 1.00
R5123:Or4k51 UTSW 2 111,584,897 (GRCm39) missense probably damaging 1.00
R5417:Or4k51 UTSW 2 111,585,265 (GRCm39) missense possibly damaging 0.50
R5654:Or4k51 UTSW 2 111,585,326 (GRCm39) missense probably damaging 1.00
R5753:Or4k51 UTSW 2 111,585,146 (GRCm39) missense possibly damaging 0.51
R6361:Or4k51 UTSW 2 111,584,940 (GRCm39) missense probably damaging 1.00
R6525:Or4k51 UTSW 2 111,585,329 (GRCm39) missense probably benign 0.09
R6682:Or4k51 UTSW 2 111,584,980 (GRCm39) missense probably damaging 1.00
R7099:Or4k51 UTSW 2 111,585,421 (GRCm39) missense probably benign 0.00
R7946:Or4k51 UTSW 2 111,585,163 (GRCm39) missense probably benign 0.00
R8925:Or4k51 UTSW 2 111,585,107 (GRCm39) missense probably benign 0.02
R8927:Or4k51 UTSW 2 111,585,107 (GRCm39) missense probably benign 0.02
R9272:Or4k51 UTSW 2 111,584,965 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATGTGGCCATCTGCAAACCAC -3'
(R):5'- GATACTGAGGGGCCACACATAG -3'

Sequencing Primer
(F):5'- GTTAACTTCCTGGGCAATTGC -3'
(R):5'- GCCACACATAGATGAAGATGC -3'
Posted On 2022-06-15