Incidental Mutation 'R9452:Zfp882'
ID 714338
Institutional Source Beutler Lab
Gene Symbol Zfp882
Ensembl Gene ENSMUSG00000089857
Gene Name zinc finger protein 882
Synonyms ENSMUSG00000052439
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.167) question?
Stock # R9452 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 72662452-72670198 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 72668831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 553 (H553Y)
Ref Sequence ENSEMBL: ENSMUSP00000105629 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110002] [ENSMUST00000125802] [ENSMUST00000126607] [ENSMUST00000131544]
AlphaFold E9Q4R4
Predicted Effect probably damaging
Transcript: ENSMUST00000110002
AA Change: H553Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857
AA Change: H553Y

DomainStartEndE-ValueType
KRAB 4 61 8.58e-14 SMART
ZnF_C2H2 84 106 1.47e-3 SMART
ZnF_C2H2 168 190 8.47e-4 SMART
ZnF_C2H2 196 218 2.27e-4 SMART
ZnF_C2H2 224 246 6.31e1 SMART
ZnF_C2H2 251 273 1.16e-1 SMART
ZnF_C2H2 279 301 1.25e-1 SMART
ZnF_C2H2 307 329 5.42e-2 SMART
ZnF_C2H2 335 357 1.47e-3 SMART
ZnF_C2H2 363 385 7.26e-3 SMART
ZnF_C2H2 391 413 1.26e-2 SMART
ZnF_C2H2 419 441 3.29e1 SMART
ZnF_C2H2 447 469 2.67e-1 SMART
ZnF_C2H2 475 497 1.04e-3 SMART
ZnF_C2H2 503 525 4.11e-2 SMART
ZnF_C2H2 531 553 4.87e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125802
SMART Domains Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857

DomainStartEndE-ValueType
KRAB 12 69 8.58e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126607
SMART Domains Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857

DomainStartEndE-ValueType
KRAB 44 101 8.58e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131544
SMART Domains Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880

DomainStartEndE-ValueType
KRAB 4 56 1.08e-10 SMART
ZnF_C2H2 167 189 8.47e-4 SMART
ZnF_C2H2 195 217 8.34e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 A G 5: 24,612,382 (GRCm39) Y564C probably null Het
Ablim2 A T 5: 36,015,198 (GRCm39) D470V probably benign Het
Actr10 T C 12: 71,006,818 (GRCm39) probably null Het
Adam4 T A 12: 81,467,071 (GRCm39) I517L probably benign Het
Ank1 C A 8: 23,622,429 (GRCm39) D1659E probably benign Het
Arnt2 A G 7: 83,933,334 (GRCm39) V308A probably benign Het
Avl9 T C 6: 56,706,726 (GRCm39) V184A probably damaging Het
Bag1 A T 4: 40,947,733 (GRCm39) I157N probably benign Het
Bicc1 A T 10: 70,792,981 (GRCm39) D224E probably damaging Het
C2 T G 17: 35,095,319 (GRCm39) I209L probably benign Het
Cacna1e A T 1: 154,289,720 (GRCm39) probably null Het
Capn1 T C 19: 6,057,287 (GRCm39) Y387C probably damaging Het
Cebpa A G 7: 34,819,033 (GRCm39) I64V possibly damaging Het
Celf4 T G 18: 25,624,219 (GRCm39) M436L probably benign Het
Cfb C A 17: 35,078,084 (GRCm39) V436L probably benign Het
Ciart C T 3: 95,788,527 (GRCm39) C104Y probably benign Het
Cmya5 A G 13: 93,232,394 (GRCm39) L898P probably benign Het
Cyp2c68 A T 19: 39,687,833 (GRCm39) M388K possibly damaging Het
Cypt12 T C 3: 18,002,843 (GRCm39) V72A probably benign Het
Dlec1 A G 9: 118,941,541 (GRCm39) D309G probably benign Het
Dnah1 A G 14: 31,018,448 (GRCm39) V1394A probably benign Het
Dpp3 A C 19: 4,973,750 (GRCm39) S108A probably benign Het
Eif5b C T 1: 38,084,861 (GRCm39) P903S probably damaging Het
Erc2 A G 14: 27,733,690 (GRCm39) D580G probably damaging Het
Fam98c A G 7: 28,852,901 (GRCm39) V44A probably benign Het
Fer A G 17: 64,231,067 (GRCm39) K273E probably benign Het
Gzme T A 14: 56,355,854 (GRCm39) I153F probably benign Het
Ice1 A T 13: 70,744,462 (GRCm39) N2040K probably damaging Het
Ifi214 G T 1: 173,356,894 (GRCm39) Q70K possibly damaging Het
Itpripl1 C A 2: 126,983,334 (GRCm39) E263* probably null Het
Kat8 A G 7: 127,524,421 (GRCm39) K433R probably benign Het
Klra5 C A 6: 129,883,686 (GRCm39) W147L possibly damaging Het
Lefty1 A T 1: 180,762,849 (GRCm39) T59S probably benign Het
Lig3 C T 11: 82,681,448 (GRCm39) T481M probably damaging Het
Lrfn1 A T 7: 28,159,157 (GRCm39) I359F probably damaging Het
Lrp1b A T 2: 41,850,726 (GRCm39) C90* probably null Het
Micall2 T G 5: 139,703,311 (GRCm39) probably null Het
Mtmr3 G T 11: 4,441,037 (GRCm39) L539I probably damaging Het
Obscn C A 11: 58,924,962 (GRCm39) probably null Het
Olfml3 T C 3: 103,643,575 (GRCm39) T269A probably benign Het
Oprl1 C T 2: 181,360,454 (GRCm39) A170V possibly damaging Het
Or4c112 C T 2: 88,854,234 (GRCm39) G38R Het
Pdgfrb G A 18: 61,198,798 (GRCm39) V319M possibly damaging Het
Pirb G A 7: 3,720,617 (GRCm39) R294C possibly damaging Het
Piwil1 T C 5: 128,824,957 (GRCm39) S552P probably benign Het
Pkd2 T C 5: 104,614,841 (GRCm39) F228L probably damaging Het
Pkhd1 T A 1: 20,682,953 (GRCm39) D83V possibly damaging Het
Plcl1 A G 1: 55,734,992 (GRCm39) D111G probably damaging Het
Plpp2 A G 10: 79,363,702 (GRCm39) S162P probably damaging Het
Prex2 T A 1: 11,256,151 (GRCm39) I1174K probably benign Het
Prkdc T A 16: 15,485,465 (GRCm39) Y431N possibly damaging Het
Pter A G 2: 12,985,111 (GRCm39) D147G probably benign Het
Rbsn T C 6: 92,178,745 (GRCm39) D134G possibly damaging Het
Rnf220 T C 4: 117,153,339 (GRCm39) D299G probably benign Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,133 (GRCm39) probably benign Het
Scn2a G A 2: 65,595,163 (GRCm39) S2004N probably benign Het
Slc7a4 T A 16: 17,391,271 (GRCm39) N593I probably damaging Het
Spata31e3 T C 13: 50,400,808 (GRCm39) H506R possibly damaging Het
Speg T C 1: 75,399,152 (GRCm39) S2200P probably benign Het
Thoc2l T A 5: 104,669,610 (GRCm39) N1377K probably benign Het
Tle1 A T 4: 72,040,596 (GRCm39) H654Q probably benign Het
Ttll6 G A 11: 96,026,588 (GRCm39) R124H probably damaging Het
Vmn2r111 A G 17: 22,778,132 (GRCm39) C516R probably damaging Het
Vmn2r89 T C 14: 51,693,288 (GRCm39) S213P probably damaging Het
Vmn2r-ps158 A T 7: 42,697,257 (GRCm39) L771F possibly damaging Het
Washc4 A G 10: 83,396,387 (GRCm39) N399S probably benign Het
Wdr37 G A 13: 8,897,663 (GRCm39) H198Y Het
Zfp407 A G 18: 84,580,579 (GRCm39) L178P probably benign Het
Zfp956 T C 6: 47,940,370 (GRCm39) V243A probably benign Het
Other mutations in Zfp882
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00676:Zfp882 APN 8 72,667,671 (GRCm39) missense probably benign
R0244:Zfp882 UTSW 8 72,667,367 (GRCm39) missense possibly damaging 0.79
R0270:Zfp882 UTSW 8 72,668,459 (GRCm39) missense probably benign 0.05
R0636:Zfp882 UTSW 8 72,668,181 (GRCm39) missense probably benign 0.01
R0840:Zfp882 UTSW 8 72,668,530 (GRCm39) nonsense probably null
R1299:Zfp882 UTSW 8 72,667,317 (GRCm39) missense probably damaging 1.00
R4439:Zfp882 UTSW 8 72,667,453 (GRCm39) missense probably damaging 0.97
R4829:Zfp882 UTSW 8 72,668,233 (GRCm39) missense probably damaging 1.00
R5028:Zfp882 UTSW 8 72,668,498 (GRCm39) missense possibly damaging 0.70
R5296:Zfp882 UTSW 8 72,668,204 (GRCm39) missense probably damaging 1.00
R5882:Zfp882 UTSW 8 72,667,303 (GRCm39) critical splice acceptor site probably null
R5974:Zfp882 UTSW 8 72,666,999 (GRCm39) missense probably damaging 1.00
R6052:Zfp882 UTSW 8 72,668,349 (GRCm39) missense probably benign 0.01
R6383:Zfp882 UTSW 8 72,668,484 (GRCm39) missense probably damaging 1.00
R6888:Zfp882 UTSW 8 72,668,130 (GRCm39) missense probably benign 0.01
R6987:Zfp882 UTSW 8 72,668,517 (GRCm39) missense probably benign 0.01
R7045:Zfp882 UTSW 8 72,667,093 (GRCm39) critical splice donor site probably null
R7780:Zfp882 UTSW 8 72,668,073 (GRCm39) missense possibly damaging 0.89
R7793:Zfp882 UTSW 8 72,666,985 (GRCm39) missense probably damaging 1.00
R8386:Zfp882 UTSW 8 72,667,962 (GRCm39) missense probably benign 0.00
R9694:Zfp882 UTSW 8 72,667,915 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCCTTCATTGCCATGAAAGG -3'
(R):5'- GATAAGTTTCCACTGTGTCCCC -3'

Sequencing Primer
(F):5'- CATTGCCATGAAAGGACTCATACTGG -3'
(R):5'- CCAGAACATGCTAAGGCTT -3'
Posted On 2022-06-15