Incidental Mutation 'R9453:Zfp563'
ID 714421
Institutional Source Beutler Lab
Gene Symbol Zfp563
Ensembl Gene ENSMUSG00000067424
Gene Name zinc finger protein 563
Synonyms zinc finger protein, Zfp413
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R9453 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 33308284-33329679 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 33308565 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 9 (V9E)
Gene Model predicted gene model for transcript(s): [ENSMUST00000131722] [ENSMUST00000140829]
AlphaFold B8JJZ9
Predicted Effect probably benign
Transcript: ENSMUST00000131722
SMART Domains Protein: ENSMUSP00000118809
Gene: ENSMUSG00000067424

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
ZnF_C2H2 197 219 9.88e-5 SMART
ZnF_C2H2 225 247 3.16e-3 SMART
ZnF_C2H2 253 275 5.81e-2 SMART
ZnF_C2H2 281 303 2.4e-3 SMART
ZnF_C2H2 309 331 1.82e-3 SMART
ZnF_C2H2 337 359 1.72e-4 SMART
ZnF_C2H2 365 387 4.54e-4 SMART
ZnF_C2H2 393 415 7.78e-3 SMART
ZnF_C2H2 421 443 3.63e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140829
SMART Domains Protein: ENSMUSP00000121678
Gene: ENSMUSG00000067424

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
Pfam:zf-C2H2_4 197 209 9.4e-2 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000119142
Gene: ENSMUSG00000067424
AA Change: V9E

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
KRAB 45 102 5.45e-16 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik G A 11: 58,771,054 (GRCm39) A179T probably benign Het
Abca6 A G 11: 110,138,090 (GRCm39) probably null Het
Agps A C 2: 75,662,585 (GRCm39) D10A probably damaging Het
Atad2b T A 12: 5,081,578 (GRCm39) D1162E probably benign Het
Atp13a4 T C 16: 29,239,659 (GRCm39) K851R unknown Het
Cdh15 A G 8: 123,586,029 (GRCm39) D136G probably damaging Het
Cdk5rap1 A T 2: 154,190,585 (GRCm39) Y459N probably damaging Het
Cep192 A T 18: 67,989,354 (GRCm39) K1834* probably null Het
Cfap221 C T 1: 119,853,361 (GRCm39) V778I probably benign Het
Chpf G A 1: 75,452,854 (GRCm39) T362I probably benign Het
Cyp4x1 T C 4: 114,991,069 (GRCm39) R36G probably damaging Het
D16Ertd472e T A 16: 78,342,052 (GRCm39) Q276L probably damaging Het
Dapk3 T C 10: 81,025,825 (GRCm39) Y39H probably damaging Het
Eefsec T C 6: 88,353,337 (GRCm39) T111A probably damaging Het
Ehbp1l1 G A 19: 5,758,371 (GRCm39) R1714C unknown Het
Flcn A G 11: 59,694,609 (GRCm39) V121A probably damaging Het
Gaa G T 11: 119,165,958 (GRCm39) D423Y probably damaging Het
Gaa A C 11: 119,165,959 (GRCm39) D423A probably benign Het
Garnl3 A G 2: 32,893,881 (GRCm39) I694T probably damaging Het
Gm5114 T A 7: 39,058,242 (GRCm39) Q459L probably damaging Het
H1f0 C T 15: 78,912,947 (GRCm39) P9L probably damaging Het
Hmmr A G 11: 40,612,655 (GRCm39) probably null Het
Klra5 C A 6: 129,883,686 (GRCm39) W147L possibly damaging Het
Lmnb1 G A 18: 56,873,114 (GRCm39) probably null Het
Lrp2 T C 2: 69,288,832 (GRCm39) Y3678C probably damaging Het
Map7 T C 10: 20,153,981 (GRCm39) V699A unknown Het
Mme G T 3: 63,272,306 (GRCm39) G635V possibly damaging Het
Mroh8 A T 2: 157,071,948 (GRCm39) I519N possibly damaging Het
Mrps11 T C 7: 78,442,390 (GRCm39) S157P probably damaging Het
Muc16 T C 9: 18,572,061 (GRCm39) T153A unknown Het
Nlrp1b A G 11: 71,072,913 (GRCm39) V310A probably damaging Het
Oas1f T C 5: 120,993,592 (GRCm39) V268A probably damaging Het
Or56a3b T A 7: 104,770,817 (GRCm39) I51N Het
Or6y1 A T 1: 174,276,233 (GRCm39) T15S probably benign Het
Padi4 A G 4: 140,479,950 (GRCm39) L401P probably benign Het
Pdzd7 A G 19: 45,016,056 (GRCm39) *1022Q probably null Het
Plcl2 C A 17: 50,915,391 (GRCm39) T800K probably damaging Het
Polr1has TCACCACCACCACCACCACCACCAC TCACCACCACCACCACCACCAC 17: 37,275,939 (GRCm39) probably benign Het
Ppp1r37 A T 7: 19,295,796 (GRCm39) F54I probably damaging Het
Prl7c1 T A 13: 27,957,870 (GRCm39) Y190F probably benign Het
Prpf8 A G 11: 75,397,212 (GRCm39) E2015G possibly damaging Het
Rpap3 A G 15: 97,579,641 (GRCm39) V457A Het
Samd13 A T 3: 146,368,510 (GRCm39) D27E Het
Sephs1 A T 2: 4,889,174 (GRCm39) probably benign Het
Slc22a20 T G 19: 6,023,024 (GRCm39) Q373P probably damaging Het
Sp100 A G 1: 85,629,179 (GRCm39) *483W probably null Het
Src A T 2: 157,307,852 (GRCm39) T254S probably damaging Het
St6galnac2 A T 11: 116,569,344 (GRCm39) M301K possibly damaging Het
Tnfsf13 A T 11: 69,576,010 (GRCm39) W26R probably damaging Het
Trbv28 T A 6: 41,248,687 (GRCm39) D72E probably benign Het
Trim75 T A 8: 65,436,561 (GRCm39) probably benign Het
Ttc39d T C 17: 80,524,754 (GRCm39) F471S probably damaging Het
Vav1 C T 17: 57,613,191 (GRCm39) P621L probably benign Het
Vezt A T 10: 93,832,856 (GRCm39) L185* probably null Het
Vmn2r42 T C 7: 8,187,295 (GRCm39) I826V probably benign Het
Vmn2r67 G A 7: 84,800,697 (GRCm39) T413M probably benign Het
Vnn1 G A 10: 23,776,723 (GRCm39) C358Y probably damaging Het
Wdr83os G C 8: 85,808,638 (GRCm39) W106C probably damaging Het
Wdr95 T C 5: 149,475,917 (GRCm39) S72P probably damaging Het
Zfp423 T A 8: 88,508,251 (GRCm39) T698S probably damaging Het
Zfp521 G A 18: 13,977,293 (GRCm39) T1040I probably damaging Het
Zmym2 T A 14: 57,180,770 (GRCm39) V894E probably damaging Het
Other mutations in Zfp563
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01629:Zfp563 APN 17 33,323,600 (GRCm39) missense probably damaging 1.00
IGL01981:Zfp563 APN 17 33,324,383 (GRCm39) missense probably benign 0.16
IGL02407:Zfp563 APN 17 33,323,795 (GRCm39) missense probably benign 0.00
IGL02662:Zfp563 APN 17 33,321,253 (GRCm39) missense probably damaging 1.00
IGL03220:Zfp563 APN 17 33,323,661 (GRCm39) missense probably benign 0.44
R0241:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0241:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0537:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0552:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R1544:Zfp563 UTSW 17 33,324,187 (GRCm39) missense probably benign 0.01
R3763:Zfp563 UTSW 17 33,323,902 (GRCm39) nonsense probably null
R3979:Zfp563 UTSW 17 33,324,701 (GRCm39) missense probably benign 0.03
R4938:Zfp563 UTSW 17 33,324,683 (GRCm39) missense probably damaging 1.00
R5280:Zfp563 UTSW 17 33,323,812 (GRCm39) missense probably damaging 0.99
R5383:Zfp563 UTSW 17 33,323,681 (GRCm39) missense probably benign
R5485:Zfp563 UTSW 17 33,308,540 (GRCm39) unclassified probably benign
R5524:Zfp563 UTSW 17 33,321,515 (GRCm39) critical splice acceptor site probably null
R5567:Zfp563 UTSW 17 33,308,431 (GRCm39) unclassified probably benign
R5736:Zfp563 UTSW 17 33,323,960 (GRCm39) missense possibly damaging 0.91
R5758:Zfp563 UTSW 17 33,323,894 (GRCm39) missense probably damaging 1.00
R6034:Zfp563 UTSW 17 33,323,935 (GRCm39) missense probably damaging 0.96
R6034:Zfp563 UTSW 17 33,323,935 (GRCm39) missense probably damaging 0.96
R6532:Zfp563 UTSW 17 33,324,672 (GRCm39) missense probably benign 0.21
R9241:Zfp563 UTSW 17 33,321,520 (GRCm39) missense probably benign 0.10
R9360:Zfp563 UTSW 17 33,324,428 (GRCm39) missense probably benign 0.38
R9410:Zfp563 UTSW 17 33,321,320 (GRCm39) missense probably damaging 1.00
RF007:Zfp563 UTSW 17 33,323,999 (GRCm39) missense probably benign
X0023:Zfp563 UTSW 17 33,324,695 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAGTCACAGGTATCCGTTCAG -3'
(R):5'- CCTAGAGTGCAGAGAAACCCTG -3'

Sequencing Primer
(F):5'- ACAGGTATCCGTTCAGGGTCC -3'
(R):5'- GTGCAGAGAAACCCTGAGTCC -3'
Posted On 2022-06-15